{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:55:46Z","timestamp":1761155746595,"version":"3.40.4"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"DOI":"10.1093\/cvr\/cvt274","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T01:26:19Z","timestamp":1386638779000},"page":"473-481","source":"Crossref","is-referenced-by-count":32,"title":["DJ-1\/park7 modulates vasorelaxation and blood pressure via epigenetic modification of endothelial nitric oxide synthase"],"prefix":"10.1093","volume":"101","author":[{"given":"Kyung Jong","family":"Won","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hyo","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Hyun","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang Pa","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwan Myung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Youb","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Seok","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junghwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bokyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,12,9]]},"reference":[{"key":"key\n\t\t\t\t20170523004006_CVT274C1","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s00424-009-0765-9","article-title":"Cellular signaling and NO production","volume":"459","author":"Michel","year":"2010","journal-title":"Pflugers Arch"},{"key":"key\n\t\t\t\t20170523004006_CVT274C2","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00424-010-0822-4","article-title":"Human endothelial dysfunction: EDRFs","volume":"459","author":"Flammer","year":"2010","journal-title":"Pflugers Arch"},{"key":"key\n\t\t\t\t20170523004006_CVT274C3","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.vph.2006.08.002","article-title":"Nitric oxide and the endothelium: history and impact on cardiovascular disease","volume":"45","author":"Yetik-Anacak","year":"2006","journal-title":"Vascul Pharmacol"},{"key":"key\n\t\t\t\t20170523004006_CVT274C4","doi-asserted-by":"crossref","first-page":"H1862","DOI":"10.1152\/ajpheart.00513.2011","article-title":"Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension","volume":"301","author":"Pojoga","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170523004006_CVT274C5","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1002\/pmic.200800973","article-title":"Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels","volume":"9","author":"Lee","year":"2009","journal-title":"Proteomics"},{"key":"key\n\t\t\t\t20170523004006_CVT274C6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tcm.2006.11.005","article-title":"Basic mechanisms of oxidative stress and reactive oxygen species in cardiovascular injury","volume":"17","author":"Papaharalambus","year":"2007","journal-title":"Trends Cardiovasc Med"},{"key":"key\n\t\t\t\t20170523004006_CVT274C7","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1161\/CIRCRESAHA.108.178699","article-title":"Gene transfer of redox factor-1 inhibits neointimal formation: involvement of PDGF-\u03b2 receptor signaling via the inhibition of the ROS-mediated Syk pathway","volume":"104","author":"Lee","year":"2009","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170523004006_CVT274C8","doi-asserted-by":"crossref","first-page":"L480","DOI":"10.1152\/ajplung.00283.2004","article-title":"Endothelin-1 decreases endothelial NOS expression and activity through ETA receptor-mediated generation of hydrogen peroxide","volume":"288","author":"Wedgwood","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170523004006_CVT274C9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1152\/physrev.00012.2010","article-title":"Epigenetic regulation of gene expression in physiological and pathological brain processes","volume":"91","author":"Gr\u00e4ff","year":"2011","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170523004006_CVT274C10","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s13277-012-0322-6","article-title":"Epigenetic changes induced by oxidative stress in colorectal cancer cells: methylation of tumor suppressor RUNX3","volume":"33","author":"Kang","year":"2012","journal-title":"Tumor Biol"},{"key":"key\n\t\t\t\t20170523004006_CVT274C11","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/01.HYP.0000201540.91234.8f","article-title":"Pleiotropic effects of hydrogen peroxide in arteries and veins from normotensive and hypertensive rats","volume":"47","author":"Thakali","year":"2006","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20170523004006_CVT274C12","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1161\/hy1101.093423","article-title":"NADH\/NADPH oxidase and enhanced superoxide production in the mineralocorticoid hypertensive rat","volume":"38","author":"Beswick","year":"2001","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20170523004006_CVT274C13","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1006\/bbrc.1997.6132","article-title":"DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras","volume":"231","author":"Nagakubo","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170523004006_CVT274C14","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.1077209","article-title":"Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism","volume":"299","author":"Bonifati","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20170523004006_CVT274C15","doi-asserted-by":"crossref","first-page":"15091","DOI":"10.1073\/pnas.0607260103","article-title":"DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2","volume":"103","author":"Clements","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170523004006_CVT274C16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.embor.7400074","article-title":"DJ-1 has a role in antioxidative stress to prevent cell death","volume":"5","author":"Taira","year":"2004","journal-title":"EMBO Rep"},{"key":"key\n\t\t\t\t20170523004006_CVT274C17","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.jaci.2012.10.012","article-title":"DJ-1 regulates mast cell activation and IgE-mediated allergic responses","volume":"131","author":"Kim","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"key\n\t\t\t\t20170523004006_CVT274C18","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/cvr\/cvs363","article-title":"DJ-1\/park7 protects against neointimal formation via the inhibition of vascular smooth muscle cell growth","volume":"97","author":"Won","year":"2012","journal-title":"Cardiovas Res"},{"key":"key\n\t\t\t\t20170523004006_CVT274C19","doi-asserted-by":"crossref","first-page":"6455","DOI":"10.1002\/pmic.200600124","article-title":"Proteomic profiling and identification of cofilin responding to oxidative stress in vascular smooth muscle","volume":"6","author":"Lee","year":"2006","journal-title":"Proteomics"},{"key":"key\n\t\t\t\t20170523004006_CVT274C20","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1161\/HYPERTENSIONAHA.111.185744","article-title":"Role of renal DJ-1 in the pathogenesis of hypertension associated with increased reactive oxygen species production","volume":"59","author":"Cuevas","year":"2012","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20170523004006_CVT274C21","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1161\/01.HYP.0000125995.85427.fd","article-title":"p38 mitogen-activated protein kinase contributes to the diminished aortic contraction by endothelin-1 in DOCA-salt hypertensive rats","volume":"43","author":"Kim","year":"2004","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20170523004006_CVT274C22","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/01.RES.0000187447.03525.72","article-title":"Stoichiometric relationships between endothelial tetrahydrobiopterin, eNOS activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression","volume":"97","author":"Bendall","year":"2005","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170523004006_CVT274C23","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1161\/HYPERTENSIONAHA.111.182428","article-title":"Tissue-specific upregulation of angiotensin-converting enzyme 1 in spontaneously hypertensive rats through histone code modifications","volume":"59","author":"Lee","year":"2012","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20170523004006_CVT274C24","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1097\/01.ASN.0000132474.50966.DA","article-title":"Endothelial dysfunction","volume":"15","author":"Endemann","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t20170523004006_CVT274C25","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0031-6997(24)01495-9","article-title":"Vascular adrenoceptors: an update","volume":"53","author":"Guimar\u00e3es","year":"2001","journal-title":"Pharmacol Rev"},{"key":"key\n\t\t\t\t20170523004006_CVT274C26","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cardiores.2005.06.021","article-title":"Hydrogen peroxide regulation of endothelial function: origins, mechanisms, and consequences","volume":"68","author":"Cai","year":"2005","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170523004006_CVT274C27","doi-asserted-by":"crossref","first-page":"C803","DOI":"10.1152\/ajpcell.00457.2005","article-title":"Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression","volume":"291","author":"Searles","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"key\n\t\t\t\t20170523004006_CVT274C28","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/eurheartj\/ehn603","article-title":"Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease","volume":"30","author":"Pons","year":"2009","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20170523004006_CVT274C29","doi-asserted-by":"crossref","first-page":"17417","DOI":"10.1074\/jbc.M109.089250","article-title":"Redox signaling, alkylation (carbonylation) of conserved cysteines inactivates class I histone deacetylases 1, 2, and 3 and antagonizes their transcriptional repressor function","volume":"285","author":"Doyle","year":"2010","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170523004006_CVT274C30","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/01.RES.0000037983.07158.B1","article-title":"Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis","volume":"9","author":"R\u00f6ssig","year":"2002","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170523004006_CVT274C31","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1124\/mol.65.3.520","article-title":"Valproic acid inhibits angiogenesis in vitro and in vivo","volume":"65","author":"Michaelis","year":"2004","journal-title":"Mol Pharmacol"},{"key":"key\n\t\t\t\t20170523004006_CVT274C32","doi-asserted-by":"crossref","first-page":"24824","DOI":"10.1074\/jbc.M502115200","article-title":"The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code","volume":"280","author":"Fish","year":"2005","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170523004006_CVT274C33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbrc.2005.11.151","article-title":"Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells","volume":"340","author":"Gan","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170523004006_CVT274C34","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1073\/pnas.0501282102","article-title":"Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6 tetrahydropyrindine (MPTP) and oxidative stress","volume":"102","author":"Kim","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170523004006_CVT274C35","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/00005237-200604000-00005","article-title":"Free radicals in perinatal and neonatal care, part 2: oxidative stress during the perinatal and neonatal period","volume":"20","author":"Blackburn","year":"2006","journal-title":"J Perinat Neonatal Nurs"},{"key":"key\n\t\t\t\t20170523004006_CVT274C36","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1161\/hy09t1.096249","article-title":"Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis","volume":"38","author":"Intengan","year":"2001","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20170523004006_CVT274C37","doi-asserted-by":"crossref","first-page":"6702","DOI":"10.1073\/pnas.0802128105","article-title":"High blood pressure arising from a defect in vascular function","volume":"105","author":"Michael","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170523004006_CVT274C38","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1161\/CIRCULATIONAHA.112.103176","article-title":"Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid","volume":"126","author":"Zhao","year":"2012","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523004006_CVT274C39","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/HYPERTENSIONAHA.110.154567","article-title":"HDAC inhibition attenuates inflammatory, hypertrophic, and hypertensive responses in spontaneously hypertensive rats","volume":"56","author":"Cardinale","year":"2010","journal-title":"Hypertension"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/101\/3\/473\/17395089\/cvt274.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T03:49:35Z","timestamp":1746071375000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvt274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,9]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,12,9]]},"published-print":{"date-parts":[[2014,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvt274","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"type":"electronic","value":"1755-3245"},{"type":"print","value":"0008-6363"}],"subject":[],"published":{"date-parts":[[2013,12,9]]}}}