{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:00:28Z","timestamp":1791108028664,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,7,15]]},"DOI":"10.1093\/cvr\/cvu115","type":"journal-article","created":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T04:36:39Z","timestamp":1398918999000},"page":"324-336","source":"Crossref","is-referenced-by-count":67,"title":["Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1\/CX3CR1 axis"],"prefix":"10.1093","volume":"103","author":[{"given":"Sergio","family":"Mart\u00ednez-Herv\u00e1s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela","family":"Vinu\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Andr\u00e9s-Blasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Piqueras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Tom\u00e1s","family":"Real","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Francisco","family":"Ascaso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah Jane","family":"Burks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herminia","family":"Gonz\u00e1lez-Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,4,29]]},"reference":[{"key":"key\n\t\t\t\t20170523015746_CVU115C1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1056\/NEJMp068177","article-title":"Obesity and diabetes in the developing world\u2014a growing challenge","volume":"356","author":"Hossain","year":"2007","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170523015746_CVU115C2","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523015746_CVU115C3","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1172\/JCI29024","article-title":"Insulin resistance and atherosclerosis","volume":"116","author":"Semenkovich","year":"2006","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170523015746_CVU115C4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cmet.2004.12.001","article-title":"Why syndrome X? From Harold Himsworth to the insulin resistance syndrome","volume":"1","author":"Reaven","year":"2005","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t20170523015746_CVU115C5","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global prevalence of diabetes: estimates for the year 2000 and projections for 2030","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t20170523015746_CVU115C6","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0021-9150(01)00588-3","article-title":"Plasma free fatty acid levels and the risk of ischemic heart disease in men: prospective results from the Quebec Cardiovascular Study","volume":"160","author":"Pirro","year":"2002","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t20170523015746_CVU115C7","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1007\/s00125-010-1684-1","article-title":"Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009","volume":"53","author":"DeFronzo","year":"2010","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t20170523015746_CVU115C8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S1054-8807(03)00072-3","article-title":"Towards understanding acute destabilization of vulnerable atherosclerotic plaques","volume":"12","author":"Dickson","year":"2003","journal-title":"Cardiovasc Pathol"},{"key":"key\n\t\t\t\t20170523015746_CVU115C9","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0092-8674(01)00238-0","article-title":"Atherosclerosis: the road ahead","volume":"104","author":"Glass","year":"2001","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170523015746_CVU115C10","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nm1102-1211","article-title":"Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime","volume":"8","author":"Steinberg","year":"2002","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170523015746_CVU115C11","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1161\/CIRCRESAHA.108.175976","article-title":"Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration","volume":"102","author":"Clarke","year":"2008","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170523015746_CVU115C12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1161\/CIRCRESAHA.111.261388","article-title":"Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence","volume":"111","author":"Wang","year":"2012","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170523015746_CVU115C13","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1161\/ATVBAHA.110.206094","article-title":"The endoplasmic reticulum stress-C\/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques","volume":"30","author":"Tsukano","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20170523015746_CVU115C14","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.cmet.2011.07.015","article-title":"Insulin resistance, hyperglycemia, and atherosclerosis","volume":"14","author":"Bornfeldt","year":"2011","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t20170523015746_CVU115C15","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2337\/db11-0518","article-title":"Silence of TRIB3 suppresses atherosclerosis and stabilizes plaques in diabetic ApoE\u2212\/\u2212\/LDL receptor\u2212\/\u2212 mice","volume":"61","author":"Wang","year":"2012","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20170523015746_CVU115C16","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1161\/CIRCRESAHA.109.208488","article-title":"The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression","volume":"106","author":"Tabas","year":"2010","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170523015746_CVU115C17","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1161\/01.ATV.0000158307.66945.b4","article-title":"Insulin signaling in arteries prevents smooth muscle apoptosis","volume":"25","author":"Nakazawa","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20170523015746_CVU115C18","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1161\/ATVBAHA.108.181727","article-title":"Insulin-like growth factor-1 receptor expression masks the antiinflammatory and glucose uptake capacity of insulin in vascular smooth muscle cells","volume":"29","author":"Engberding","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20170523015746_CVU115C19","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.thromres.2007.04.005","article-title":"CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients: impact of pre-inflammatory stimuli and renin-angiotensin system modulators","volume":"121","author":"Apostolakis","year":"2007","journal-title":"Thromb Res"},{"key":"key\n\t\t\t\t20170523015746_CVU115C20","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1172\/JCI28180","article-title":"Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines","volume":"117","author":"Cheng","year":"2007","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170523015746_CVU115C21","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t20170523015746_CVU115C22","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1161\/ATVBAHA.108.175299","article-title":"Molecular mechanisms of atherosclerosis in metabolic syndrome: role of reduced IRS2-dependent signaling","volume":"28","author":"Gonzalez-Navarro","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20170523015746_CVU115C23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/12631","article-title":"IRS-2 coordinates IGF-1 receptor-mediated beta-cell development and peripheral insulin signalling","volume":"23","author":"Withers","year":"1999","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170523015746_CVU115C24","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1126\/science.292.5522.1728","article-title":"Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)","volume":"292","author":"Cho","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20170523015746_CVU115C25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cardiores.2006.06.004","article-title":"Vascular smooth muscle cell senescence in atherosclerosis","volume":"72","author":"Gorenne","year":"2006","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170523015746_CVU115C26","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1161\/01.CIR.0000057548.68243.42","article-title":"Decreased atherosclerotic lesion formation in CX3CR1\/apolipoprotein E double knockout mice","volume":"107","author":"Combadiere","year":"2003","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523015746_CVU115C27","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1161\/ATVBAHA.112.300948","article-title":"Insulin sensitivity and carotid intima-media thickness: relationship between insulin sensitivity and cardiovascular risk study","volume":"33","author":"Kozakova","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20170523015746_CVU115C28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1161\/STROKEAHA.109.566596","article-title":"Segment-specific associations of carotid intima-media thickness with cardiovascular risk factors: the Coronary Artery Risk Development in Young Adults (CARDIA) study","volume":"41","author":"Polak","year":"2010","journal-title":"Stroke"},{"key":"key\n\t\t\t\t20170523015746_CVU115C29","volume-title":"Heart and stroke Facts: 2001 Statistical Supplement","author":"American Heart Association","year":"2001"},{"key":"key\n\t\t\t\t20170523015746_CVU115C30","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/thoraxjnl-2012-202212","article-title":"Critical role of fractalkine (CX3CL1) in cigarette smoke-induced mononuclear cell adhesion to the arterial endothelium","volume":"68","author":"Rius","year":"2013","journal-title":"Thorax"},{"key":"key\n\t\t\t\t20170523015746_CVU115C31","doi-asserted-by":"crossref","first-page":"17795","DOI":"10.1073\/pnas.0408096101","article-title":"Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root","volume":"101","author":"Teupser","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170523015746_CVU115C32","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1161\/ATVBAHA.111.237412","article-title":"Fractalkine: a survivor's guide: chemokines as antiapoptotic mediators","volume":"32","author":"White","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20170523015746_CVU115C33","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.2337\/db11-0162","article-title":"Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness","volume":"60","author":"Cardellini","year":"2011","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20170523015746_CVU115C34","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cmet.2006.02.010","article-title":"Myeloid lineage cell-restricted insulin resistance protects apolipoprotein E-deficient mice against atherosclerosis","volume":"3","author":"Baumgartl","year":"2006","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t20170523015746_CVU115C35","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1172\/JCI19528","article-title":"Increased CD36 protein as a response to defective insulin signaling in macrophages","volume":"113","author":"Liang","year":"2004","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170523015746_CVU115C36","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cmet.2006.02.008","article-title":"Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions","volume":"3","author":"Han","year":"2006","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t20170523015746_CVU115C37","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1161\/01.CIR.93.10.1809","article-title":"Insulin sensitivity and atherosclerosis. The Insulin Resistance Atherosclerosis Study (IRAS) Investigators","volume":"93","author":"Howard","year":"1996","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523015746_CVU115C38","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1161\/ATVBAHA.110.210831","article-title":"Smooth muscle cell-specific insulin-like growth factor-1 overexpression in Apoe\u2212\/\u2212 mice does not alter atherosclerotic plaque burden but increases features of plaque stability","volume":"30","author":"Shai","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20170523015746_CVU115C39","doi-asserted-by":"crossref","first-page":"19739","DOI":"10.1074\/jbc.M710098200","article-title":"Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3","volume":"283","author":"Allard","year":"2008","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170523015746_CVU115C40","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1161\/ATVBAHA.109.196394","article-title":"Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis","volume":"29","author":"Fernandez-Hernando","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20170523015746_CVU115C41","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1074\/jbc.M204716200","article-title":"Distinct regulation of mitogen-activated protein kinases and p27Kip1 in smooth muscle cells from different vascular beds. A potential role in establishing regional phenotypic variance","volume":"278","author":"Castro","year":"2003","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170523015746_CVU115C42","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1172\/JCI18581","article-title":"Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes","volume":"112","author":"Hennige","year":"2003","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170523015746_CVU115C43","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.thromres.2005.12.016","article-title":"Effects of polymorphisms in chemokine ligands and receptors on susceptibility to coronary artery disease","volume":"119","author":"Apostolakis","year":"2007","journal-title":"Thromb Res"},{"key":"key\n\t\t\t\t20170523015746_CVU115C44","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1161\/01.CIR.0000097119.57756.EF","article-title":"Smooth muscle cells in human atherosclerotic plaques express the fractalkine receptor CX3CR1 and undergo chemotaxis to the CX3C chemokine fractalkine (CX3CL1)","volume":"108","author":"Lucas","year":"2003","journal-title":"Circulation"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/103\/2\/324\/17392735\/cvu115.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T16:58:01Z","timestamp":1503421081000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvu115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,29]]},"references-count":44,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,4,29]]},"published-print":{"date-parts":[[2014,7,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvu115","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"value":"1755-3245","type":"electronic"},{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4,29]]}}}