{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:33:29Z","timestamp":1790645609668,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"DOI":"10.1093\/cvr\/cvu166","type":"journal-article","created":{"date-parts":[[2014,7,13]],"date-time":"2014-07-13T00:09:12Z","timestamp":1405210152000},"page":"597-606","source":"Crossref","is-referenced-by-count":32,"title":["T-type calcium channels are involved in hypoxic pulmonary hypertension"],"prefix":"10.1093","volume":"103","author":[{"given":"Marc","family":"Chevalier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Roux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipe","family":"Lory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Marthan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Savineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Quignard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,7,11]]},"reference":[{"key":"key\n\t\t\t\t20170518150210_CVU166C1","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1164\/rccm.201203-0377UP","article-title":"Update in pulmonary vascular diseases 2011","volume":"185","author":"Hassoun","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20170518150210_CVU166C2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1465-9921-12-30","article-title":"Role of the gap junctions in the contractile response to agonists in pulmonary artery from two rat models of pulmonary hypertension","volume":"12","author":"Billaud","year":"2011","journal-title":"Respir Res"},{"key":"key\n\t\t\t\t20170518150210_CVU166C3","doi-asserted-by":"crossref","first-page":"9488","DOI":"10.1073\/pnas.1633724100","article-title":"Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension","volume":"100","author":"Bonnet","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170518150210_CVU166C4","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.1113\/jphysiol.2008.160440","article-title":"Smooth muscle cell calcium activation mechanisms","volume":"586","author":"Berridge","year":"2008","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170518150210_CVU166C5","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/978-94-007-0265-3_36","article-title":"Expression and physiological roles of TRP channels in smooth muscle cells","volume":"704","author":"Guibert","year":"2011","journal-title":"Adv Exp Med Biol"},{"key":"key\n\t\t\t\t20170518150210_CVU166C6","doi-asserted-by":"crossref","first-page":"H1546","DOI":"10.1152\/ajpheart.00944.2011","article-title":"New mechanisms of pulmonary arterial hypertension: role of Ca(2)(+) signaling","volume":"302","author":"Kuhr","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170518150210_CVU166C7","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4103\/2045-8932.78103","article-title":"Functional ion channels in human pulmonary artery smooth muscle cells: voltage-dependent cation channels","volume":"1","author":"Firth","year":"2011","journal-title":"Pulm Circ"},{"issue":"Suppl 1","key":"key\n\t\t\t\t20170518150210_CVU166C8","first-page":"1","article-title":"Voltage-dependent calcium channels","volume":"24","author":"Lacinova","year":"2005","journal-title":"Gen Physiol Biophys"},{"key":"key\n\t\t\t\t20170518150210_CVU166C9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1152\/physrev.00018.2002","article-title":"Molecular physiology of low-voltage-activated t-type calcium channels","volume":"83","author":"Perez-Reyes","year":"2003","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170518150210_CVU166C10","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/nrcardio.2011.104","article-title":"Treatment of pulmonary arterial hypertension with targeted therapies","volume":"8","author":"O'Callaghan","year":"2011","journal-title":"Nat Rev Cardiol"},{"key":"key\n\t\t\t\t20170518150210_CVU166C11","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1161\/HYPERTENSIONAHA.108.125831","article-title":"Heterogeneity of L- and T-channels in the vasculature: rationale for the efficacy of combined L- and T-blockade","volume":"53","author":"Ball","year":"2009","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20170518150210_CVU166C12","doi-asserted-by":"crossref","first-page":"L154","DOI":"10.1152\/ajplung.00313.2012","article-title":"Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2","volume":"305","author":"Wan","year":"2013","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20170518150210_CVU166C13","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.bcp.2012.02.025","article-title":"Dehydroepiandrosterone (DHEA) inhibits voltage-gated T-type calcium channels","volume":"83","author":"Chevalier","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"key\n\t\t\t\t20170518150210_CVU166C14","first-page":"H2616","article-title":"Possible role of T-type Ca2+ channels in L-NNA vasoconstriction of hypertensive rat lungs","volume":"272","author":"Muramatsu","year":"1997","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170518150210_CVU166C15","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1476-5381.2009.00519.x","article-title":"Mechanisms involved in the regulation of bovine pulmonary vascular tone by the 5-HT1B receptor","volume":"159","author":"McKenzie","year":"2010","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20170518150210_CVU166C16","doi-asserted-by":"crossref","first-page":"H1304","DOI":"10.1152\/ajpheart.00528.2009","article-title":"T-type calcium channels are regulated by hypoxia\/reoxygenation in ventricular myocytes","volume":"297","author":"Pluteanu","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170518150210_CVU166C17","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/01.RES.0000163066.07472.ff","article-title":"Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes","volume":"96","author":"Rodman","year":"2005","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170518150210_CVU166C18","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1113\/jphysiol.2010.199497","article-title":"T-type calcium channels and vascular function: the new kid on the block.","volume":"589","author":"Kuo","year":"2011","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170518150210_CVU166C19","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1124\/jpet.103.060814","article-title":"NNC 55\u20130396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2, 3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels","volume":"309","author":"Huang","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"key\n\t\t\t\t20170518150210_CVU166C20","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1172\/JCI36954","article-title":"Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice","volume":"119","author":"Uebele","year":"2009","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170518150210_CVU166C21","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1126\/science.1089268","article-title":"Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels","volume":"302","author":"Chen","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20170518150210_CVU166C22","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/cvr\/cvm008","article-title":"beta-adrenergic relaxation in pulmonary arteries: preservation of the endothelial nitric oxide-dependent beta2 component in pulmonary hypertension","volume":"77","author":"Leblais","year":"2008","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170518150210_CVU166C23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1113\/jphysiol.1977.sp011990","article-title":"Excitation-contraction coupling in the smooth muscle cells of the rabbit main pulmonary artery","volume":"271","author":"Casteels","year":"1977","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170518150210_CVU166C24","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000151767","article-title":"The role of L- and T-type calcium channels in local and remote calcium responses in rat mesenteric terminal arterioles","volume":"46","author":"Braunstein","year":"2009","journal-title":"J Vasc Res"},{"key":"key\n\t\t\t\t20170518150210_CVU166C25","doi-asserted-by":"crossref","first-page":"H279","DOI":"10.1152\/ajpheart.00743.2013","article-title":"Nitric oxide suppresses vascular voltage-gated T-type Ca2+ channels through cGMP\/PKG signaling","volume":"306","author":"Harraz","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170518150210_CVU166C26","doi-asserted-by":"crossref","first-page":"H58","DOI":"10.1152\/ajpheart.00476.2012","article-title":"Identification of L- and T- type Ca2+ channels in rat cerebral arteries: role in myogenic tone development","volume":"304","author":"Abd El-Rahman","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170518150210_CVU166C27","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/cvr\/cvt043","article-title":"Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium channel contribution to vascular tone of rodent arteries and arterioles","volume":"98","author":"Howitt","year":"2013","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170518150210_CVU166C28","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ceca.2006.04.026","article-title":"T-type Ca2+ channels in vascular smooth muscle: multiple functions","volume":"40","author":"Cribbs","year":"2006","journal-title":"Cell Calcium"},{"key":"key\n\t\t\t\t20170518150210_CVU166C29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1113\/jphysiol.2005.089342","article-title":"The involvement of Cav3.2\/alpha1H T-type calcium channels in excitability of mouse embryonic primary vestibular neurones","volume":"567","author":"Autret","year":"2005","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170518150210_CVU166C30","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/cvr\/cvs257","article-title":"The Cav3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice","volume":"96","author":"Tzeng","year":"2012","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170518150210_CVU166C31","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/sj.ki.5002793","article-title":"T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy","volume":"73","author":"Sugano","year":"2008","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20170518150210_CVU166C32","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0008-6363(01)00548-X","article-title":"Reversal of chronic hypoxia-induced alterations in pulmonary artery smooth muscle electromechanical coupling upon air breathing","volume":"53","author":"Bonnet","year":"2002","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170518150210_CVU166C33","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1161\/01.RES.0000225862.14314.49","article-title":"Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1\/alpha1G T-type calcium channels","volume":"98","author":"Mangoni","year":"2006","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170518150210_CVU166C34","doi-asserted-by":"crossref","first-page":"581S","DOI":"10.1378\/chest.128.6_suppl.581S","article-title":"The low-voltage-activated calcium channel CAV3.1 controls proliferation of human pulmonary artery myocytes","volume":"128","author":"Rodman","year":"2005","journal-title":"Chest"},{"key":"key\n\t\t\t\t20170518150210_CVU166C35","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1513\/pats.201101-004MW","article-title":"Functional and molecular heterogeneity of pulmonary endothelial cells","volume":"8","author":"Stevens","year":"2011","journal-title":"Proc Am Thorac Soc"},{"key":"key\n\t\t\t\t20170518150210_CVU166C36","doi-asserted-by":"crossref","first-page":"447","DOI":"10.4161\/chan.4.6.12870","article-title":"T-type calcium channel expression and function in the diseased heart","volume":"4","author":"Cribbs","year":"2010","journal-title":"Channels (Austin)"},{"key":"key\n\t\t\t\t20170518150210_CVU166C37","doi-asserted-by":"crossref","DOI":"10.1007\/s00424-013-1411-0","article-title":"5,6-EET potently inhibits T-type calcium channels: implication in the regulation of the vascular tone","author":"Cazade","year":"2014","journal-title":"Pflugers Arch"},{"key":"key\n\t\t\t\t20170518150210_CVU166C38","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1183\/09031936.00013908","article-title":"Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms","volume":"32","author":"Sommer","year":"2008","journal-title":"Eur Respir J"},{"key":"key\n\t\t\t\t20170518150210_CVU166C39","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1124\/jpet.110.171058","article-title":"In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice","volume":"335","author":"Kraus","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"key\n\t\t\t\t20170518150210_CVU166C40","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.pain.2012.10.023","article-title":"State-dependent properties of a new T-type calcium channel blocker enhance Ca(V)3.2 selectivity and support analgesic effects","volume":"154","author":"Francois","year":"2013","journal-title":"Pain"},{"key":"key\n\t\t\t\t20170518150210_CVU166C41","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/apha.12066","article-title":"Myogenic tone is impaired at low arterial pressure in mice deficient in the low-voltage-activated CaV 3.1 T-type Ca(2+) channel","volume":"207","author":"Bjorling","year":"2013","journal-title":"Acta Physiol (Oxf)"},{"key":"key\n\t\t\t\t20170518150210_CVU166C42","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1254\/jjp.85.339","article-title":"Molecular pharmacology of T-type Ca2+ channels","volume":"85","author":"Heady","year":"2001","journal-title":"Jpn J Pharmacol"},{"key":"key\n\t\t\t\t20170518150210_CVU166C43","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ceca.2005.12.003","article-title":"A role for voltage gated T-type calcium channels in mediating \u2018capacitative\u2019 calcium entry?","volume":"39","author":"Gackiere","year":"2006","journal-title":"Cell Calcium"},{"key":"key\n\t\t\t\t20170518150210_CVU166C44","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.ceca.2008.04.003","article-title":"Intracellular Ca(2+) oscillations induced by over-expressed Ca(V)3.1 T-type Ca(2+) channels in NG108-15 cells","volume":"44","author":"Chevalier","year":"2008","journal-title":"Cell Calcium"},{"key":"key\n\t\t\t\t20170518150210_CVU166C45","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s00424-013-1430-x","article-title":"Role of T-type channels in vasomotor function: team player or chameleon?","volume":"466","author":"Kuo","year":"2014","journal-title":"Pflugers Arch"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/103\/4\/597\/17194991\/cvu166.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T18:51:28Z","timestamp":1503600688000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvu166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,11]]},"references-count":45,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,7,11]]},"published-print":{"date-parts":[[2014,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvu166","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"value":"1755-3245","type":"electronic"},{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7,11]]}}}