{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T10:35:48Z","timestamp":1771842948954,"version":"3.50.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"DOI":"10.1093\/cvr\/cvu239","type":"journal-article","created":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T02:21:45Z","timestamp":1415758905000},"page":"107-117","source":"Crossref","is-referenced-by-count":31,"title":["FGFR1 mediates recombinant thrombomodulin domain-induced angiogenesis"],"prefix":"10.1093","volume":"105","author":[{"given":"Cheng-Hsiang","family":"Kuo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Chen","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Ku","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bi-Ing","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Tzu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Fong","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai-Tzu","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ching","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Heng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guey-Yueh","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chwan-Yau","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua-Lin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,11,11]]},"reference":[{"key":"key\n\t\t\t\t20170523015405_CVU239C1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2011.08.039","article-title":"Basic and therapeutic aspects of angiogenesis","volume":"146","author":"Potente","year":"2011","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170523015405_CVU239C2","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/47260","article-title":"EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF","volume":"402","author":"Prenzel","year":"1999","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170523015405_CVU239C3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0092-8674(94)90200-3","article-title":"Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma","volume":"79","author":"O'Reilly","year":"1994","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170523015405_CVU239C4","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nrc2780","article-title":"Fibroblast growth factor signalling: from development to cancer","volume":"10","author":"Turner","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"key\n\t\t\t\t20170523015405_CVU239C5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF02644769","article-title":"Interaction of angiogenic basic fibroblast growth factor with endothelial cell heparan sulfate proteoglycans. Biological implications in neovascularization","volume":"26","author":"Rusnati","year":"1996","journal-title":"Int J Clin Lab Res"},{"key":"key\n\t\t\t\t20170523015405_CVU239C6","doi-asserted-by":"crossref","first-page":"4724","DOI":"10.1021\/bi0352320","article-title":"Kinetic model for FGF, FGFR, and proteoglycan signal transduction complex assembly","volume":"43","author":"Ibrahimi","year":"2004","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170523015405_CVU239C7","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0969-2126(03)00096-0","article-title":"Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP","volume":"11","author":"Kiselyov","year":"2003","journal-title":"Structure"},{"key":"key\n\t\t\t\t20170523015405_CVU239C8","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(91)90512-W","article-title":"Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor","volume":"64","author":"Yayon","year":"1991","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170523015405_CVU239C9","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1083\/jcb.200112145","article-title":"Fibroblast growth factor-specific modulation of cellular response by syndecan-4","volume":"157","author":"Horowitz","year":"2002","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170523015405_CVU239C10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/MOH.0b013e3282f97d98","article-title":"Fibroblast growth factor regulation of neovascularization","volume":"15","author":"Murakami","year":"2008","journal-title":"Curr Opin Hematol"},{"key":"key\n\t\t\t\t20170523015405_CVU239C11","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jnr.10773","article-title":"Specific inhibitor of FGF receptor signaling: FGF-2-mediated effects on proliferation, differentiation, and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells","volume":"74","author":"Bansal","year":"2003","journal-title":"J Neurosci Res"},{"key":"key\n\t\t\t\t20170523015405_CVU239C12","doi-asserted-by":"crossref","first-page":"5896","DOI":"10.1093\/emboj\/17.20.5896","article-title":"Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain","volume":"17","author":"Mohammadi","year":"1998","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170523015405_CVU239C13","doi-asserted-by":"crossref","first-page":"26S","DOI":"10.1378\/chest.124.3_suppl.26S","article-title":"The protein C pathway","volume":"124","author":"Esmon","year":"2003","journal-title":"Chest"},{"key":"key\n\t\t\t\t20170523015405_CVU239C14","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1067-1927.2005.00130311.x","article-title":"Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing","volume":"13","author":"Jackson","year":"2005","journal-title":"Wound Repair Regen"},{"key":"key\n\t\t\t\t20170523015405_CVU239C15","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1161\/01.RES.0000133680.87668.FA","article-title":"Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo","volume":"95","author":"Uchiba","year":"2004","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170523015405_CVU239C16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00281-011-0282-8","article-title":"Thrombomodulin and its role in inflammation","volume":"34","author":"Conway","year":"2012","journal-title":"Semin Immunopathol"},{"key":"key\n\t\t\t\t20170523015405_CVU239C17","doi-asserted-by":"crossref","first-page":"46750","DOI":"10.1074\/jbc.M305216200","article-title":"Thrombomodulin-mediated cell adhesion: involvement of its lectin-like domain","volume":"278","author":"Huang","year":"2003","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170523015405_CVU239C18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1423-0127-19-34","article-title":"The role of thrombomodulin lectin-like domain in inflammation","volume":"19","author":"Li","year":"2012","journal-title":"J Biomed Sci"},{"key":"key\n\t\t\t\t20170523015405_CVU239C19","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1161\/01.CIR.0000160364.05405.B5","article-title":"Evidence of human thrombomodulin domain as a novel angiogenic factor","volume":"111","author":"Shi","year":"2005","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170523015405_CVU239C20","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1182\/blood-2011-08-376038","article-title":"The recombinant lectin-like domain of thrombomodulin inhibits angiogenesis through interaction with Lewis Y antigen","volume":"119","author":"Kuo","year":"2012","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170523015405_CVU239C21","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1182\/blood-2008-03-142760","article-title":"Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response","volume":"112","author":"Shi","year":"2008","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170523015405_CVU239C22","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1182\/blood.V86.1.225.bloodjournal861225","article-title":"The epidermal growth factor-like domain of recombinant human thrombomodulin exhibits mitogenic activity for Swiss 3T3 cells","volume":"86","author":"Hamada","year":"1995","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170523015405_CVU239C23","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1161\/ATVBAHA.111.235143","article-title":"Therapeutic angiogenesis of human early endothelial progenitor cells is enhanced by thrombomodulin","volume":"31","author":"Li","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20170523015405_CVU239C24","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ijcard.2014.01.009","article-title":"Soluble thrombomodulin is a paracrine anti-apoptotic factor for vascular endothelial protection","volume":"172","author":"Chao","year":"2014","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20170523015405_CVU239C25","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1016\/S0021-9258(18)53856-4","article-title":"Alanine-scanning mutagenesis of the epidermal growth factor-like domains of human thrombomodulin identifies critical residues for its cofactor activity","volume":"268","author":"Nagashima","year":"1993","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170523015405_CVU239C26","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1182\/blood.V99.10.3646","article-title":"Naturally occurring mutations in the thrombomodulin gene leading to impaired expression and function","volume":"99","author":"Kunz","year":"2002","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170523015405_CVU239C27","first-page":"1625","article-title":"A model of angiogenesis in the mouse cornea","volume":"37","author":"Kenyon","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key\n\t\t\t\t20170523015405_CVU239C28","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.jvs.2008.06.041","article-title":"Polydeoxyribonucleotide (PDRN) restores blood flow in an experimental model of peripheral artery occlusive disease","volume":"48","author":"Bitto","year":"2008","journal-title":"J Vasc Surg"},{"key":"key\n\t\t\t\t20170523015405_CVU239C29","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.2337\/diacare.27.12.2863","article-title":"The impact of the Micro-Lightguide O2C for the quantification of tissue ischemia in diabetic foot ulcers","volume":"27","author":"Beckert","year":"2004","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t20170523015405_CVU239C30","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1128\/MCB.16.3.977","article-title":"Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction","volume":"16","author":"Mohammadi","year":"1996","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170523015405_CVU239C31","doi-asserted-by":"crossref","first-page":"9095","DOI":"10.1074\/jbc.275.13.9095","article-title":"Activated protein C directly activates human endothelial gelatinase A","volume":"275","author":"Nguyen","year":"2000","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170523015405_CVU239C32","first-page":"153","article-title":"Activated protein C stimulates expression of angiogenic factors in human skin cells, angiogenesis in the chick embryo and cutaneous wound healing in rodents","volume":"34","author":"Xue","year":"2006","journal-title":"Clin Hemorheol Microcirc"},{"key":"key\n\t\t\t\t20170523015405_CVU239C33","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0092-8674(89)90987-2","article-title":"Domains of laminin with growth-factor activity","volume":"56","author":"Panayotou","year":"1989","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170523015405_CVU239C34","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1083\/jcb.200208145","article-title":"Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution","volume":"161","author":"Schenk","year":"2003","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170523015405_CVU239C35","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.1182\/blood-2009-08-236430","article-title":"Factor XII stimulates ERK1\/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis","volume":"115","author":"LaRusch","year":"2010","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170523015405_CVU239C36","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1126\/science.6199844","article-title":"Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor","volume":"223","author":"Shing","year":"1984","journal-title":"Science"},{"key":"key\n\t\t\t\t20170523015405_CVU239C37","doi-asserted-by":"crossref","first-page":"42573","DOI":"10.1074\/jbc.M509238200","article-title":"Transmembrane domain-induced oligomerization is crucial for the functions of syndecan-2 and syndecan-4","volume":"280","author":"Choi","year":"2005","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170523015405_CVU239C38","doi-asserted-by":"crossref","first-page":"14247","DOI":"10.1074\/jbc.M109.056945","article-title":"Heparan sulfate chain valency controls syndecan-4 function in cell adhesion","volume":"285","author":"Gopal","year":"2010","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170523015405_CVU239C39","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev.genet.42.110807.091628","article-title":"Rhomboid proteases and their biological functions","volume":"42","author":"Freeman","year":"2008","journal-title":"Annu Rev Genet"},{"key":"key\n\t\t\t\t20170523015405_CVU239C40","first-page":"236","article-title":"Diverse substrate recognition mechanisms for rhomboids; thrombomodulin is cleaved by mammalian rhomboids","volume":"14","author":"Lohi","year":"2004","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20170523015405_CVU239C41","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bbrc.2007.12.135","article-title":"Lysophosphatidic acid stimulates thrombomodulin lectin-like domain shedding in human endothelial cells","volume":"367","author":"Wu","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170523015405_CVU239C42","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1182\/blood.V76.10.2024.2024","article-title":"Plasma thrombomodulin in health and diseases","volume":"76","author":"Takano","year":"1990","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170523015405_CVU239C43","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1038\/jid.2011.230","article-title":"Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing","volume":"131","author":"Cheng","year":"2011","journal-title":"J Invest Dermatol"},{"key":"key\n\t\t\t\t20170523015405_CVU239C44","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1161\/ATVBAHA.112.251157","article-title":"Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase\/myeloid leukemia cell-1 signaling","volume":"32","author":"Ikezoe","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20170523015405_CVU239C45","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1101\/gad.8.24.3045","article-title":"Murine FGFR-1 is required for early postimplantation growth and axial organization","volume":"8","author":"Deng","year":"1994","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170523015405_CVU239C46","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1101\/gad.8.24.3032","article-title":"fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation","volume":"8","author":"Yamaguchi","year":"1994","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170523015405_CVU239C47","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1128\/MCB.20.6.2260-2268.2000","article-title":"Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice","volume":"20","author":"Miller","year":"2000","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170523015405_CVU239C48","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1038\/jid.2013.8","article-title":"Thrombomodulin regulates keratinocyte differentiation and promotes wound healing","volume":"133","author":"Cheng","year":"2013","journal-title":"J Invest Dermatol"},{"key":"key\n\t\t\t\t20170523015405_CVU239C49","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1083\/jcb.200910126","article-title":"Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis","volume":"188","author":"Yang","year":"2010","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170523015405_CVU239C50","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1677\/joe.1.06055","article-title":"Expression of fibroblast growth factors and their receptors during full-thickness skin wound healing in young and aged mice","volume":"186","author":"Komi-Kuramochi","year":"2005","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170523015405_CVU239C51","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1073\/pnas.92.3.850","article-title":"Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system","volume":"92","author":"Healy","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170523015405_CVU239C52","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0002-9440(10)65473-9","article-title":"Expression of thrombomodulin and consequences of thrombomodulin deficiency during healing of cutaneous wounds","volume":"155","author":"Peterson","year":"1999","journal-title":"Am J Pathol"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/105\/1\/107\/17391994\/cvu239.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T01:55:41Z","timestamp":1650592541000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvu239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,11]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,11,11]]},"published-print":{"date-parts":[[2015,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvu239","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"value":"1755-3245","type":"electronic"},{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11,11]]}}}