{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T03:58:54Z","timestamp":1774670334277,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,1]]},"DOI":"10.1093\/cvr\/cvv151","type":"journal-article","created":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T01:03:04Z","timestamp":1431651784000},"page":"153-163","source":"Crossref","is-referenced-by-count":27,"title":["Soluble Notch ligand and receptor peptides act antagonistically during angiogenesis"],"prefix":"10.1093","volume":"107","author":[{"given":"Ralph","family":"Klose","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Moll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Gordian","family":"Adam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Mohr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hellmut G.","family":"Augustin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,5,14]]},"reference":[{"key":"key\n\t\t\t\t20170519080201_CVV151C1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cell.2009.03.045","article-title":"The canonical Notch signaling pathway: unfolding the activation mechanism","volume":"137","author":"Kopan","year":"2009","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170519080201_CVV151C2","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.semcdb.2012.01.010","article-title":"Notch signaling in human development and disease","volume":"23","author":"Penton","year":"2012","journal-title":"Semin Cell Dev Biol"},{"key":"key\n\t\t\t\t20170519080201_CVV151C3","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrm2183","article-title":"Molecular regulation of angiogenesis and lymphangiogenesis","volume":"8","author":"Adams","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key\n\t\t\t\t20170519080201_CVV151C4","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170519080201_CVV151C5","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1158\/1078-0432.CCR-14-0809","article-title":"Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer","volume":"21","author":"Previs","year":"2014","journal-title":"Clin Cancer Res"},{"key":"key\n\t\t\t\t20170519080201_CVV151C6","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/nature05355","article-title":"Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis","volume":"444","author":"Noguera-Troise","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170519080201_CVV151C7","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nature05313","article-title":"Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis","volume":"444","author":"Ridgway","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170519080201_CVV151C8","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/nature08878","article-title":"Therapeutic antibody targeting of individual Notch receptors","volume":"464","author":"Wu","year":"2010","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170519080201_CVV151C9","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1073\/pnas.0611206104","article-title":"Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting","volume":"104","author":"Lobov","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170519080201_CVV151C10","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.cell.2009.03.025","article-title":"The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis","volume":"137","author":"Benedito","year":"2009","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170519080201_CVV151C11","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1158\/0008-5472.CAN-07-6499","article-title":"A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis","volume":"68","author":"Funahashi","year":"2008","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170519080201_CVV151C12","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1158\/2159-8290.CD-14-0650","article-title":"NOTCH decoys that selectively block DLL\/NOTCH or JAG\/NOTCH disrupt angiogenesis by unique mechanisms to inhibit tumor growth","volume":"5","author":"Kangsamaksin","year":"2015","journal-title":"Cancer Discov"},{"key":"key\n\t\t\t\t20170519080201_CVV151C13","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0092-8674(91)90064-6","article-title":"Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor","volume":"67","author":"Rebay","year":"1991","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170519080201_CVV151C14","doi-asserted-by":"crossref","first-page":"30158","DOI":"10.1074\/jbc.M505569200","article-title":"Regions of Drosophila Notch that contribute to ligand binding and the modulatory influence of Fringe","volume":"280","author":"Xu","year":"2005","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170519080201_CVV151C15","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nsmb.1457","article-title":"A conserved face of the Jagged\/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition","volume":"15","author":"Cordle","year":"2008","journal-title":"Nat Struct Mol Biol"},{"key":"key\n\t\t\t\t20170519080201_CVV151C16","doi-asserted-by":"crossref","first-page":"25477","DOI":"10.1074\/jbc.M113.454850","article-title":"Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1","volume":"288","author":"Andrawes","year":"2013","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170519080201_CVV151C17","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1534\/genetics.106.061630","article-title":"Structure-function analysis of delta trafficking, receptor binding and signaling in Drosophila","volume":"174","author":"Parks","year":"2006","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170519080201_CVV151C18","doi-asserted-by":"crossref","first-page":"32961","DOI":"10.1074\/jbc.274.46.32961","article-title":"Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods","volume":"274","author":"Shimizu","year":"1999","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170519080201_CVV151C19","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/43191","article-title":"Fringe modulates Notch-ligand interactions","volume":"387","author":"Panin","year":"1997","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170519080201_CVV151C20","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1091\/mbc.E04-07-0614","article-title":"Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1","volume":"16","author":"Yang","year":"2005","journal-title":"Mol Biol Cell"},{"key":"key\n\t\t\t\t20170519080201_CVV151C21","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/CIRCRESAHA.113.301686","article-title":"Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis","volume":"113","author":"Adam","year":"2013","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170519080201_CVV151C22","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1161\/CIRCRESAHA.110.217257","article-title":"Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis","volume":"107","author":"Brutsch","year":"2010","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170519080201_CVV151C23","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1101\/gad.291004","article-title":"The Notch target genes Hey1 and Hey2 are required for embryonic vascular development","volume":"18","author":"Fischer","year":"2004","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170519080201_CVV151C24","doi-asserted-by":"crossref","first-page":"12640","DOI":"10.1073\/pnas.1000132107","article-title":"Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling","volume":"107","author":"Wustehube","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170519080201_CVV151C25","doi-asserted-by":"crossref","first-page":"e53074","DOI":"10.1371\/journal.pone.0053074","article-title":"No evidence for a functional role of bi-directional Notch signaling during angiogenesis","volume":"7","author":"Liebler","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170519080201_CVV151C26","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1096\/fj.04-3172fje","article-title":"Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis","volume":"19","author":"Sainson","year":"2005","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20170519080201_CVV151C27","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1096\/fj.05-4880fje","article-title":"Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K\/Akt pathways and requires MAML1","volume":"20","author":"Liu","year":"2006","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20170519080201_CVV151C28","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1242\/dev.120.9.2385","article-title":"The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD","volume":"120","author":"Kopan","year":"1994","journal-title":"Development"},{"key":"key\n\t\t\t\t20170519080201_CVV151C29","doi-asserted-by":"crossref","first-page":"6089","DOI":"10.1242\/dev.00834","article-title":"Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation","volume":"130","author":"Dahlqvist","year":"2003","journal-title":"Development"},{"key":"key\n\t\t\t\t20170519080201_CVV151C30","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1074\/jbc.274.11.7238","article-title":"Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis","volume":"274","author":"Kuroda","year":"1999","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170519080201_CVV151C31","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1083\/jcb.200302047","article-title":"VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia","volume":"161","author":"Gerhardt","year":"2003","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170519080201_CVV151C32","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nature05571","article-title":"Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis","volume":"445","author":"Hellstrom","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170519080201_CVV151C33","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.devcel.2012.02.005","article-title":"ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway","volume":"22","author":"Larrivee","year":"2012","journal-title":"Dev Cell"},{"key":"key\n\t\t\t\t20170519080201_CVV151C34","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/ncb2331","article-title":"VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling","volume":"13","author":"Tammela","year":"2011","journal-title":"Nat Cell Biol"},{"key":"key\n\t\t\t\t20170519080201_CVV151C35","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ymeth.2012.12.005","article-title":"Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions","volume":"59","author":"Seidel","year":"2013","journal-title":"Methods"},{"key":"key\n\t\t\t\t20170519080201_CVV151C36","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/ncb2103","article-title":"Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting","volume":"12","author":"Jakobsson","year":"2010","journal-title":"Nat Cell Biol"},{"key":"key\n\t\t\t\t20170519080201_CVV151C37","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.tig.2012.11.008","article-title":"Robustness in angiogenesis: notch and BMP shaping waves","volume":"29","author":"Beets","year":"2013","journal-title":"Trends Genet"},{"key":"key\n\t\t\t\t20170519080201_CVV151C38","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1182\/blood-2007-09-112748","article-title":"Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos","volume":"112","author":"Trindade","year":"2008","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170519080201_CVV151C39","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1593\/neo.13550","article-title":"Inhibition of tumor angiogenesis and tumor growth by the DSL domain of human Delta-like 1 targeted to vascular endothelial cells","volume":"15","author":"Zhao","year":"2013","journal-title":"Neoplasia"},{"key":"key\n\t\t\t\t20170519080201_CVV151C40","doi-asserted-by":"crossref","first-page":"e18709","DOI":"10.1371\/journal.pone.0018709","article-title":"Gamma-secretase inhibitor treatment promotes VEGF-A-driven blood vessel growth and vascular leakage but disrupts neovascular perfusion","volume":"6","author":"Kalen","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170519080201_CVV151C41","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-1-4939-1139-4_25","article-title":"Application of anti-ligand antibodies to inhibit Notch signaling","volume":"1187","author":"Koga","year":"2014","journal-title":"Methods Mol Biol"},{"key":"key\n\t\t\t\t20170519080201_CVV151C42","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/sj.cdd.4401036","article-title":"Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma","volume":"9","author":"Nickoloff","year":"2002","journal-title":"Cell Death Differ"},{"key":"key\n\t\t\t\t20170519080201_CVV151C43","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.4049\/jimmunol.169.8.4273","article-title":"The Notch ligand Jagged-1 is able to induce maturation of monocyte-derived human dendritic cells","volume":"169","author":"Weijzen","year":"2002","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170519080201_CVV151C44","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170519080201_CVV151C45","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1042\/BST0381072","article-title":"Developments in three-dimensional cell culture technology aimed at improving the accuracy of in vitro analyses","volume":"38","author":"Maltman","year":"2010","journal-title":"Biochem Soc T"},{"key":"key\n\t\t\t\t20170519080201_CVV151C46","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/jcp.24683","article-title":"3D cell culture systems: advantages and applications","volume":"230","author":"Ravi","year":"2015","journal-title":"J Cell Physiol"},{"key":"key\n\t\t\t\t20170519080201_CVV151C47","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1126\/science.1228745","article-title":"A mutation in EGF repeat-8 of Notch discriminates between Serrate\/Jagged and Delta family ligands","volume":"338","author":"Yamamoto","year":"2012","journal-title":"Science"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/107\/1\/153\/17235658\/cvv151.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T05:02:17Z","timestamp":1651986137000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvv151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,14]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,5,14]]},"published-print":{"date-parts":[[2015,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvv151","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"value":"1755-3245","type":"electronic"},{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5,14]]}}}