{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:20:27Z","timestamp":1787631627302,"version":"build-2736575974"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,1]]},"DOI":"10.1093\/cvr\/cvv152","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T01:35:23Z","timestamp":1432604123000},"page":"66-77","source":"Crossref","is-referenced-by-count":23,"title":["Oestrogen enhances cardiotoxicity induced by Sunitinib by regulation of drug transport and metabolism"],"prefix":"10.1093","volume":"107","author":[{"given":"Pamela Ann","family":"Harvey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie Anne","family":"Leinwand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,5,25]]},"reference":[{"key":"key\n\t\t\t\t20170519080215_CVV152C1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nrc2559","article-title":"Targeting cancer with small molecule kinase inhibitors","volume":"9","author":"Zhang","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"key\n\t\t\t\t20170519080215_CVV152C2","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1016\/S0140-6736(07)61865-0","article-title":"Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib","volume":"370","author":"Chu","year":"2007","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170519080215_CVV152C3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jchf.2012.09.001","article-title":"The frequency and severity of cardiovascular toxicity from targeted therapy in advanced renal cell carcinoma patients","volume":"1","author":"Hall","year":"2013","journal-title":"JACC Heart Failure"},{"key":"key\n\t\t\t\t20170519080215_CVV152C4","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1093\/annonc\/mdn168","article-title":"Cardiotoxicity associated with the cancer therapeutic agent sunitinib malate","volume":"19","author":"Telli","year":"2008","journal-title":"Ann Oncol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C5","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/nm1446","article-title":"Cardiotoxicity of the cancer therapeutic agent imatinib mesylate","volume":"12","author":"Kerkela","year":"2006","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170519080215_CVV152C6","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1056\/NEJMoa1003825","article-title":"Sunitinib malate for the treatment of pancreatic neuroendocrine tumors","volume":"364","author":"Raymond","year":"2011","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170519080215_CVV152C7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nbt1358","article-title":"A quantitative analysis of kinase inhibitor selectivity","volume":"26","author":"Karaman","year":"2008","journal-title":"Nat Biotechnol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1752-8062.2008.00090.x","article-title":"Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of amp-activated protein kinase","volume":"2","author":"Kerkela","year":"2009","journal-title":"Clin Transl Sci"},{"key":"key\n\t\t\t\t20170519080215_CVV152C9","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1124\/mol.108.050104","article-title":"Mechanisms of myocyte cytotoxicity induced by the multiple receptor tyrosine kinase inhibitor sunitinib","volume":"74","author":"Hasinoff","year":"2008","journal-title":"Mol Pharmacol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C10","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/sj.bjc.6604456","article-title":"Predictive factors for severe toxicity of sunitinib in unselected patients with advanced renal cell cancer","volume":"99","author":"van der Veldt","year":"2008","journal-title":"Br J Cancer"},{"key":"key\n\t\t\t\t20170519080215_CVV152C11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/978-1-59745-030-0_18","article-title":"Cardiomyocyte preparation, culture, and gene transfer","volume":"366","author":"Maass","year":"2007","journal-title":"Methods Mol Biol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C12","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.1210\/en.2012-1391","article-title":"Estrogenic compounds are not always cardioprotective and can be lethal in males with genetic heart disease","volume":"153","author":"Haines","year":"2012","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170519080215_CVV152C13","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.carpath.2011.12.003","article-title":"Increased myocardial prevalence of C-reactive protein in human coronary heart disease: Direct effects on microvessel density and endothelial cell survival","volume":"21","author":"Joshi","year":"2012","journal-title":"Cardiovasc Pathol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24676","article-title":"Soy diet worsens heart disease in mice","volume":"116","author":"Stauffer","year":"2006","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170519080215_CVV152C15","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.1242\/jcs.00709","article-title":"Mutations in the motor domain modulate myosin activity and myofibril organization","volume":"116","author":"Wang","year":"2003","journal-title":"J Cell Sci"},{"key":"key\n\t\t\t\t20170519080215_CVV152C16","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.ajpath.2012.08.040","article-title":"Interferon-gamma causes cardiac myocyte atrophy via selective degradation of myosin heavy chain in a model of chronic myocarditis","volume":"181","author":"Cosper","year":"2012","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C17","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/FTD.0000000000000004","article-title":"Plasma concentrations of tyrosine kinase inhibitors imatinib, erlotinib, and sunitinib in routine clinical outpatient cancer care","volume":"36","author":"Lankheet","year":"2014","journal-title":"Ther Drug Monit"},{"key":"key\n\t\t\t\t20170519080215_CVV152C18","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/anatox\/35.8.558","article-title":"Determination of sunitinib and its active metabolite n-desethylsunitinib in sweat of a patient","volume":"35","author":"Lankheet","year":"2011","journal-title":"J Anal Toxicol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C19","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1083\/jcb.201101100","article-title":"The cell biology of disease: Cellular mechanisms of cardiomyopathy","volume":"194","author":"Harvey","year":"2011","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C20","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/j.1582-4934.2008.00523.x","article-title":"Re-expression of alpha skeletal actin as a marker for dedifferentiation in cardiac pathologies","volume":"13","author":"Driesen","year":"2009","journal-title":"J Cell Mol Med"},{"key":"key\n\t\t\t\t20170519080215_CVV152C21","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev.bi.62.070193.002321","article-title":"Signalling by receptor tyrosine kinases","volume":"62","author":"Fantl","year":"1993","journal-title":"Annu Rev Biochem"},{"key":"key\n\t\t\t\t20170519080215_CVV152C22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1472-8206.2005.00333.x","article-title":"Impaired alpha1-adrenergic responses in aged rat hearts","volume":"19","author":"Montagne","year":"2005","journal-title":"Fundam Clin Pharmacol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C23","doi-asserted-by":"crossref","first-page":"C2269","DOI":"10.1152\/ajpcell.00441.2006","article-title":"Phenylephrine hypertrophy, Ca2+-ATPase (SERCA2), and Ca2+ signaling in neonatal rat cardiac myocytes","volume":"292","author":"Prasad","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C24","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1161\/01.CIR.0000012750.08480.55","article-title":"Cardiovascular influences of alpha1b-adrenergic receptor defect in mice","volume":"105","author":"Vecchione","year":"2002","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170519080215_CVV152C25","doi-asserted-by":"crossref","first-page":"26645","DOI":"10.1074\/jbc.M311525200","article-title":"AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase C","volume":"279","author":"Lee","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170519080215_CVV152C26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000119748","article-title":"Practical management recommendations for anti-ErbB2 therapy with lapatinib","volume":"3","author":"Chatsiproios","year":"2008","journal-title":"Breast Care (Basel)"},{"key":"key\n\t\t\t\t20170519080215_CVV152C27","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/CIRCULATIONAHA.108.776831","article-title":"Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics","volume":"118","author":"Chen","year":"2008","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170519080215_CVV152C28","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.talanta.2008.12.031","article-title":"Quartz crystal microbalance sensor array for the detection of volatile organic compounds","volume":"78","author":"Xu","year":"2009","journal-title":"Talanta"},{"key":"key\n\t\t\t\t20170519080215_CVV152C29","doi-asserted-by":"crossref","first-page":"5204","DOI":"10.1200\/JCO.2007.15.6331","article-title":"Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma","volume":"26","author":"Schmidinger","year":"2008","journal-title":"J Clin Oncol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C30","article-title":"Sex-specific cytochrome p450 as a cause of sex- and species-related differences in drug toxicity","volume":"64\u201365","author":"Kato","year":"1992","journal-title":"Toxicol Lett"},{"key":"key\n\t\t\t\t20170519080215_CVV152C31","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1124\/dmd.112.050245","article-title":"Drug metabolism and transport during pregnancy: How does drug disposition change during pregnancy and what are the mechanisms that cause such changes?","volume":"41","author":"Isoherranen","year":"2013","journal-title":"Drug Metab Dispos"},{"key":"key\n\t\t\t\t20170519080215_CVV152C32","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00204-012-0996-y","article-title":"Sunitinib, a tyrosine kinase inhibitor, induces cytochrome P450 1A1 gene in human breast cancer MCF7 cells through ligand-independent aryl hydrocarbon receptor activation","volume":"87","author":"Maayah","year":"2013","journal-title":"Arch Toxicol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C33","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0009-2797(01)00280-0","article-title":"Estrogen-mediated suppression of cytochrome P4501A (CYP1a) expression in rainbow trout hepatocytes: role of estrogen receptor","volume":"138","author":"Navas","year":"2001","journal-title":"Chem Biol Interact"},{"key":"key\n\t\t\t\t20170519080215_CVV152C34","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.yjmcc.2004.08.002","article-title":"Phenylephrine induces activation of CREP in adult rat cardiac myocytes through MSK1 and PKA signaling pathways","volume":"37","author":"Markou","year":"2004","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C35","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1161\/01.CIR.101.10.1172","article-title":"The cardiac Fas (APO-1\/CD95) receptor\/Fas ligand system: relation to diastolic wall stress in volume-overload hypertrophy in vivo and activation of the transcription factor AP-1 in cardiac myocytes","volume":"101","author":"Wollert","year":"2000","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170519080215_CVV152C36","first-page":"H445","article-title":"Expression of Fas adjacent to fibrotic foci in the failing human heart is not associated with increased apoptosis","volume":"277","author":"Filippatos","year":"1999","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C37","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1038\/jid.2014.218","article-title":"Fas\/Fas ligand mediates keratinocyte death in sunitinib-induced hand-foot skin reaction","volume":"134","author":"Yeh","year":"2014","journal-title":"J Invest Dermatol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C38","first-page":"2369","article-title":"Verapamil-mediated sensitization of doxorubicin-selected pleiotropic resistance in human sarcoma cells: selectivity for drugs which produce DNA scission","volume":"46","author":"Harker","year":"1986","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170519080215_CVV152C39","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1124\/jpet.105.097931","article-title":"Verapamil p-glycoprotein transport across the rat blood-brain barrier: cyclosporine, a concentration inhibition analysis, and comparison with human data","volume":"317","author":"Hsiao","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"key\n\t\t\t\t20170519080215_CVV152C40","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1158\/1078-0432.CCR-10-1828","article-title":"Genetic polymorphisms associated with a prolonged progression-free survival in patients with metastatic renal cell cancer treated with sunitinib","volume":"17","author":"van der Veldt","year":"2011","journal-title":"Clin Cancer Res"},{"key":"key\n\t\t\t\t20170519080215_CVV152C41","doi-asserted-by":"crossref","first-page":"9023","DOI":"10.1073\/pnas.1200731109","article-title":"Heat shock factor-1 knockout induces multidrug resistance gene, MDR1b, and enhances P-glycoprotein (ABCB1)-based drug extrusion in the heart","volume":"109","author":"Krishnamurthy","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170519080215_CVV152C42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1369\/jhc.6A7026.2006","article-title":"Expression of the MDR-1 gene-encoded P-glycoprotein in cardiomyocytes of conscious sheep undergoing acute myocardial ischemia followed by reperfusion","volume":"55","author":"Laguens","year":"2007","journal-title":"J Histochem Cytochem"},{"key":"key\n\t\t\t\t20170519080215_CVV152C43","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/cvr\/cvt011","article-title":"FGF-2 protects cardiomyocytes from doxorubicin damage via protein kinase c-dependent effects on efflux transporters","volume":"98","author":"Wang","year":"2013","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170519080215_CVV152C44","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial","volume":"288","author":"Rossouw","year":"2002","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170519080215_CVV152C45","first-page":"193","article-title":"Protective effect of oestradiol on the heart of rats exposed to acute ischaemia","volume":"38","author":"Barta","year":"1989","journal-title":"Physiol Bohemoslov"},{"key":"key\n\t\t\t\t20170519080215_CVV152C46","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/1097-0142(19950101)75:1<11::AID-CNCR2820750104>3.0.CO;2-N","article-title":"Age and sex are independent predictors of 5-fluorouracil toxicity. Analysis of a large scale phase iii trial","volume":"75","author":"Stein","year":"1995","journal-title":"Cancer"},{"key":"key\n\t\t\t\t20170519080215_CVV152C47","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1471-2407-14-102","article-title":"The epidemiology of gastrointestinal stromal tumors in Taiwan, 1998\u20132008: a nation-wide cancer registry-based study","volume":"14","author":"Chiang","year":"2014","journal-title":"BMC Cancer"},{"key":"key\n\t\t\t\t20170519080215_CVV152C48","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nrurol.2010.46","article-title":"Epidemiology and risk factors for kidney cancer","volume":"7","author":"Chow","year":"2010","journal-title":"Nat Rev Urol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C49","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1053\/j.gastro.2013.01.068","article-title":"The epidemiology of pancreatitis and pancreatic cancer","volume":"144","author":"Yadav","year":"2013","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170519080215_CVV152C50","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/1476-4598-10-143","article-title":"Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines","volume":"10","author":"Alfieri","year":"2011","journal-title":"Mol Cancer"},{"key":"key\n\t\t\t\t20170519080215_CVV152C51","first-page":"725","article-title":"Development of cardiac hypertrophy by sunitinib in vivo and in vitro rat cardiomyocytes is influenced by the aryl hydrocarbon receptor signaling pathway","volume":"88","author":"Maayah","year":"2014","journal-title":"Arch Toxicol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C52","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1074\/jbc.274.6.3430","article-title":"Estrogen receptor reduces CYP1A1 induction in cultured human endometrial cells","volume":"274","author":"Ricci","year":"1999","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170519080215_CVV152C53","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/j.1349-7006.2006.00300.x","article-title":"Estrogen-mediated post transcriptional down-regulation of P-glycoprotein in MDR1-transduced human breast cancer cells","volume":"97","author":"Mutoh","year":"2006","journal-title":"Cancer Sci"},{"key":"key\n\t\t\t\t20170519080215_CVV152C54","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1161\/01.ATV.20.4.964","article-title":"Clinically used estrogens differentially inhibit human aortic smooth muscle cell growth and mitogen-activated protein kinase activity","volume":"20","author":"Dubey","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C55","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1161\/hh1501.094266","article-title":"F, bradykinin, opioids, and phenylephrine, but not adenosine, trigger preconditioning by generating free radicals and opening mitochondrial k(atp) channels","volume":"89","author":"Cohen","year":"2001","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170519080215_CVV152C56","doi-asserted-by":"crossref","first-page":"H1941","DOI":"10.1152\/ajpheart.2000.279.4.H1941","article-title":"Cardioprotection with kappa-opioid receptor stimulation is associated with a slowing of cross-bridge cycling","volume":"279","author":"Pyle","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170519080215_CVV152C57","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1161\/01.RES.78.5.737","article-title":"Alpha 1-adrenergic receptor subtypes. Molecular structure, function, and signaling","volume":"78","author":"Graham","year":"1996","journal-title":"Circ Res"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/107\/1\/66\/17235667\/cvv152.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T14:36:59Z","timestamp":1566743819000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvv152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,25]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,5,25]]},"published-print":{"date-parts":[[2015,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvv152","relation":{},"ISSN":["1755-3245","0008-6363"],"issn-type":[{"value":"1755-3245","type":"electronic"},{"value":"0008-6363","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5,25]]}}}