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Such anomalies are detectable by imaging modalities and, according to various definitions, their prevalence ranges from 0.21 to 5.79%. This consensus document from the Development, Anatomy and Pathology Working Group of the European Society of Cardiology aims to provide: (i) a definition of normality that refers to essential anatomical and embryological features of coronary vessels, based on the integrated analysis of studies of normal and abnormal coronary embryogenesis and pathophysiology; (ii) an animal model-based systematic survey of the molecular and cellular mechanisms that regulate coronary blood vessel development; (iii) an organization of the wide spectrum of coronary artery anomalies, according to a comprehensive anatomical and embryological classification scheme; (iv) current knowledge of the pathophysiological mechanisms underlying symptoms and signs of coronary artery anomalies, with diagnostic and therapeutic implications. This document identifies the mosaic-like embryonic development of the coronary vascular system, as coronary cell types differentiate from multiple cell sources through an intricate network of molecular signals and haemodynamic cues, as the necessary framework for understanding the complex spectrum of coronary artery anomalies observed in human patients.<\/jats:p>","DOI":"10.1093\/cvr\/cvv251","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T21:10:24Z","timestamp":1452546624000},"page":"204-216","source":"Crossref","is-referenced-by-count":196,"title":["Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology\u2014a position statement of the development, anatomy, and pathology ESC Working Group"],"prefix":"10.1093","volume":"109","author":[{"given":"Jos\u00e9 Mar\u00eda","family":"P\u00e9rez-Pomares","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), Facultad de Ciencias, Universidad de M\u00e1laga 1 Departamento de Biolog\u00eda Animal , , Campus de Teatinos s\/n, M\u00e1laga ,","place":["Spain"]},{"name":"Andalusian Center for Nanomedicine and Biotechnology (BIONAND) 2 , Campanillas (M\u00e1laga) ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"de la Pompa","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC) 3 Intercellular Signalling in Cardiovascular Development and Disease Laboratory , , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Franco","sequence":"additional","affiliation":[{"name":"Universidad de Ja\u00e9n 4 Department of Experimental Biology , , Ja\u00e9n ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Henderson","sequence":"additional","affiliation":[{"name":"Institute of Genetic 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