{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:27:50Z","timestamp":1789014470891,"version":"build-2803163510"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1093\/cvr\/cvx045","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T15:34:03Z","timestamp":1488814443000},"page":"737-748","source":"Crossref","is-referenced-by-count":80,"title":["Inhibition of sarcolemmal FAT\/CD36 by sulfo-N-succinimidyl oleate rapidly corrects metabolism and restores function in the diabetic heart following hypoxia\/reoxygenation"],"prefix":"10.1093","volume":"113","author":[{"given":"Latt S.","family":"Mansor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria da Luz","family":"Sousa Fialho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Yea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Will A.","family":"Coumans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Kerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn A.","family":"Carr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost J.F.P.","family":"Luiken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan F.C.","family":"Glatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhys D.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian L.","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian J.","family":"Tyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kieran","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa C.","family":"Heather","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,4,17]]},"reference":[{"key":"key\n\t\t\t\t20170519042941_cvx045-B1","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.jacc.2009.04.074","article-title":"Altered myocardial substrate metabolism and decreased diastolic function in nonischemic human diabetic cardiomyopathy: studies with cardiac positron emission tomography and magnetic resonance imaging","volume":"54","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B2","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1161\/01.CIR.103.13.1734","article-title":"Effect of non-insulin-dependent diabetes mellitus on myocardial insulin responsiveness in patients with ischemic heart disease","volume":"103","year":"2001","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B3","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1161\/01.CIR.0000127959.28627.F8","article-title":"Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women","volume":"109","year":"2004","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B4","doi-asserted-by":"crossref","first-page":"H1763","DOI":"10.1152\/ajpheart.01063.2005","article-title":"Perfused hearts from Type 2 diabetic (db\/db) mice show metabolic responsiveness to insulin","volume":"290","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B5","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.2337\/diabetes.53.9.2366","article-title":"Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob\/ob mouse hearts","volume":"53","year":"2004","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B6","doi-asserted-by":"crossref","first-page":"H1373","DOI":"10.1152\/ajpheart.01264.2008","article-title":"Increased O2 cost of basal metabolism and excitation-contraction coupling in hearts from type 2 diabetic mice","volume":"296","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B7","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1113\/JP271242","article-title":"Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation","volume":"594","year":"2016","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B8","doi-asserted-by":"crossref","first-page":"E612","DOI":"10.1152\/ajpendo.00011.2002","article-title":"Changes in fatty acid transport and transporters are related to the severity of insulin deficiency","volume":"283","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/13813450701422617","article-title":"Mechanisms responsible for enhanced fatty acid utilization by perfused hearts from type 2 diabetic db\/db mice","volume":"113","year":"2007","journal-title":"Arch Physiol Biochem"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B10","first-page":"785","article-title":"The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus","volume":"1","year":"1963","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1042\/cs0990027","article-title":"First clinical trial with etomoxir in patients with chronic congestive heart failure","volume":"99","year":"2000","journal-title":"Clin Sci"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B12","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1161\/CIRCULATIONAHA.105.551457","article-title":"Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment","volume":"112","year":"2005","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B13","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/ncpcardio0583","article-title":"Modification of myocardial substrate use as a therapy for heart failure","volume":"3","year":"2006","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B14","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.jacc.2013.02.011","article-title":"Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina)","volume":"61","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B15","first-page":"E18","article-title":"Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy","volume":"146","year":"2003","journal-title":"Am Heart J"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B16","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1055\/s-2007-980016","article-title":"Improvement of myocardial function and metabolism in diabetic rats by the carnitine palmitoyl transferase inhibitor Etomoxir","volume":"27","year":"1995","journal-title":"Horm Metab Res"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B17","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1161\/01.RES.0000264104.25265.b6","article-title":"CD36 deficiency rescues lipotoxic cardiomyopathy","volume":"100","year":"2007","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B18","doi-asserted-by":"crossref","first-page":"E870","DOI":"10.1152\/ajpendo.00233.2005","article-title":"Cardiac metabolism in mice: tracer method developments and in vivo application revealing profound metabolic inflexibility in diabetes","volume":"290","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B19","doi-asserted-by":"crossref","first-page":"E452","DOI":"10.1152\/ajpendo.00437.2015","article-title":"Assessment of myocardial metabolic flexibility and work efficiency in human type 2 diabetes using 16-[18F]fluoro-4-thiapalmitate, a novel PET fatty acid tracer","volume":"310","year":"2016","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1748-1716.2009.02024.x","article-title":"Impaired contractile function and mitochondrial respiratory capacity in response to oxygen deprivation in a rat model of pre-diabetes","volume":"197","year":"2009","journal-title":"Acta physiologica"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B21","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000177596","article-title":"Effects of anoxia and low free fatty acid on myocardial energy metabolism in streptozotocin-diabetic rats","volume":"34","year":"1990","journal-title":"Ann Nutr Metab"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B22","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1161\/01.RES.88.5.513","article-title":"No-flow ischemia inhibits insulin signaling in heart by decreasing intracellular pH","volume":"88","year":"2001","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B23","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1136\/thx.2005.057745","article-title":"Prevalence of obstructive sleep apnoea in men with type 2 diabetes","volume":"61","year":"2006","journal-title":"Thorax"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B24","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1464-5491.2010.03073.x","article-title":"Systematic review of the association between lung function and Type 2 diabetes mellitus","volume":"27","year":"2010","journal-title":"Diabet Med"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S2213-8587(14)70219-0","article-title":"Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1.9 million people","volume":"3","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B26","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.2337\/db14-1560","article-title":"Increasing pyruvate dehydrogenase flux as a treatment for diabetic cardiomyopathy: a combined 13C hyperpolarized magnetic resonance and echocardiography study","volume":"64","year":"2015","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/1475-2840-12-136","article-title":"Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin","volume":"12","year":"2013","journal-title":"Cardiovasc Diabetol"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B28","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.2337\/diabetes.54.6.1846","article-title":"Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism","volume":"54","year":"2005","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B29","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1242\/dmm.001941","article-title":"Rodent models of diabetic cardiomyopathy","volume":"2","year":"2009","journal-title":"Dis Model Mech"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B30","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1021\/bi00260a008","article-title":"N-hydroxysulfosuccinimide active esters: bis(N-hydroxysulfosuccinimide) esters of two dicarboxylic acids are hydrophilic, membrane-impermeant, protein cross-linkers","volume":"21","year":"1982","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1023\/A:1006875823561","article-title":"Measurements of fatty acid and carbohydrate metabolism in the isolated working rat heart","volume":"172","year":"1997","journal-title":"Mol Cell Biochem"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B32","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","year":"1957","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B33","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1006\/jmcc.1997.0512","article-title":"The effects of hypertrophy and diabetes on cardiac pyruvate dehydrogenase activity","volume":"29","year":"1997","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/nbm.740","article-title":"A comparison of cell and tissue extraction techniques using high-resolution 1H-NMR spectroscopy","volume":"15","year":"2002","journal-title":"NMR Biomed"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B35","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.cardiores.2006.08.020","article-title":"Fatty acid transporter levels and palmitate oxidation rate correlate with ejection fraction in the infarcted rat heart","volume":"72","year":"2006","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B36","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.2337\/diabetes.51.10.3113","article-title":"Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT\/CD36","volume":"51","year":"2002","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B37","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1210\/en.2009-0593","article-title":"Adenosine monophosphate-activated protein kinase activation, substrate transporter translocation, and metabolism in the contracting hyperthyroid rat heart","volume":"151","year":"2010","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B38","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1172\/JCI0214080","article-title":"The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus","volume":"109","year":"2002","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B39","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1073\/pnas.0336724100","article-title":"A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content","volume":"100","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B40","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF01951559","article-title":"Labeling of adipocyte membranes by sulfo-N-succinimidyl derivatives of long-chain fatty acids: inhibition of fatty acid transport","volume":"121","year":"1991","journal-title":"J Membr Biol"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B41","first-page":"43","article-title":"Binding of sulfosuccinimidyl fatty acids to adipocyte membrane proteins: isolation and amino-terminal sequence of an 88-kD protein implicated in transport of long-chain fatty acids","volume":"133","year":"1993","journal-title":"J Membr Biol"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B42","doi-asserted-by":"crossref","first-page":"17665","DOI":"10.1016\/S0021-9258(17)46753-6","article-title":"Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36","volume":"268","year":"1993","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B43","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0022-2275(20)37241-2","article-title":"Uptake and metabolism of palmitate by isolated cardiac myocytes from adult rats: involvement of sarcolemmal proteins","volume":"38","year":"1997","journal-title":"J Lipid Res"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B44","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1023\/A:1020539932353","article-title":"Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT\/CD36)-mediated cellular fatty acid uptake","volume":"239","year":"2002","journal-title":"Mol Cell Biochem"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B45","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1042\/BJ20120060","article-title":"CD36 inhibition prevents lipid accumulation and contractile dysfunction in rat cardiomyocytes","volume":"448","year":"2012","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B46","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1113\/expphysiol.2012.070235","article-title":"Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia","volume":"98","year":"2013","journal-title":"Exp Physiol"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B47","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.2337\/diab.39.12.1485","article-title":"Increased susceptibility to hypoxia of prolonged action potential duration in ventricular papillary muscles from diabetic rats","volume":"39","year":"1990","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B48","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.bbamcr.2012.08.009","article-title":"Regulation and dysregulation of glucose transport in cardiomyocytes","volume":"1833","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B49","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature13909","article-title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","volume":"515","year":"2014","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B50","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.yjmcc.2014.10.015","article-title":"Impaired cytosolic NADH shuttling and elevated UCP3 contribute to inefficient citric acid cycle flux support of postischemic cardiac work in diabetic hearts","volume":"79","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B51","doi-asserted-by":"crossref","first-page":"50230","DOI":"10.1074\/jbc.M200958200","article-title":"Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle","volume":"277","year":"2002","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170519042941_cvx045-B52","doi-asserted-by":"crossref","first-page":"H2124","DOI":"10.1152\/ajpheart.2000.279.5.H2124","article-title":"A metabolic role for mitochondria in palmitate-induced cardiac myocyte apoptosis","volume":"279","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/113\/7\/737\/17160603\/cvx045.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T04:05:02Z","timestamp":1658721902000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-lookup\/doi\/10.1093\/cvr\/cvx045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,17]]},"references-count":52,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,4,17]]},"published-print":{"date-parts":[[2017,6]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvx045","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,17]]}}}