{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:07:30Z","timestamp":1790446050038,"version":"4.1.0"},"reference-count":104,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2017,4,29]],"date-time":"2017-04-29T00:00:00Z","timestamp":1493424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"crossref","award":["GR-2009-1596220"],"award-info":[{"award-number":["GR-2009-1596220"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Health","award":["1R01HL118455-01A1"],"award-info":[{"award-number":["1R01HL118455-01A1"]}]},{"name":"Centers of Excellence of Genomic Science","award":["1P50HG004233"],"award-info":[{"award-number":["1P50HG004233"]}]},{"name":"CardioEpigen","award":["# 294609"],"award-info":[{"award-number":["# 294609"]}]},{"name":"National Research, Development, and Innovation Office","award":["OTKA K 109737, OTKA ANN 107803, NVKP 16-1-2016-0017"],"award-info":[{"award-number":["OTKA K 109737, OTKA ANN 107803, NVKP 16-1-2016-0017"]}]},{"name":"European Research Council","award":["311549"],"award-info":[{"award-number":["311549"]}]},{"name":"European Research Council","award":["918-156-47"],"award-info":[{"award-number":["918-156-47"]}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organization for Health Research and Development","doi-asserted-by":"crossref","award":["91612147"],"award-info":[{"award-number":["91612147"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Netherlands Heart Foundation","award":["2013T056"],"award-info":[{"award-number":["2013T056"]}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"crossref","award":["FS\/10\/039\/28270"],"award-info":[{"award-number":["FS\/10\/039\/28270"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,1]]},"abstract":"<jats:p>Despite advances in myocardial reperfusion therapies, acute myocardial ischaemia\/reperfusion injury and consequent ischaemic heart failure represent the number one cause of morbidity and mortality in industrialized societies. Although different therapeutic interventions have been shown beneficial in preclinical settings, an effective cardioprotective or regenerative therapy has yet to be successfully introduced in the clinical arena. Given the complex pathophysiology of the ischaemic heart, large scale, unbiased, global approaches capable of identifying multiple branches of the signalling networks activated in the ischaemic\/reperfused heart might be more successful in the search for novel diagnostic or therapeutic targets. High-throughput techniques allow high-resolution, genome-wide investigation of genetic variants, epigenetic modifications, and associated gene expression profiles. Platforms such as proteomics and metabolomics (not described here in detail) also offer simultaneous readouts of hundreds of proteins and metabolites. Isolated omics analyses usually provide Big Data requiring large data storage, advanced computational resources and complex bioinformatics tools. The possibility of integrating different omics approaches gives new hope to better understand the molecular circuitry activated by myocardial ischaemia, putting it in the context of the human \u2018diseasome\u2019. Since modifications of cardiac gene expression have been consistently linked to pathophysiology of the ischaemic heart, the integration of epigenomic and transcriptomic data seems a promising approach to identify crucial disease networks. Thus, the scope of this Position Paper will be to highlight potentials and limitations of these approaches, and to provide recommendations to optimize the search for novel diagnostic or therapeutic targets for acute ischaemia\/reperfusion injury and ischaemic heart failure in the post-genomic era.<\/jats:p>","DOI":"10.1093\/cvr\/cvx070","type":"journal-article","created":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T15:11:14Z","timestamp":1493305874000},"page":"725-736","source":"Crossref","is-referenced-by-count":124,"title":["Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart"],"prefix":"10.1093","volume":"113","author":[{"given":"Cinzia","family":"Perrino","sequence":"first","affiliation":[{"name":"1Department of Advanced Biomedical Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert-Laszl\u00f3","family":"Barab\u00e1si","sequence":"additional","affiliation":[{"name":"2Center for Complex Networks Research and Department of Physics, Northeastern University, Boston, MA, USA;"},{"name":"3Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA;"},{"name":"4Center for Network Science, Central European University, Budapest, Hungary;"},{"name":"5Department of Medicine, and Division of Network Medicine, Brigham and Womens Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Condorelli","sequence":"additional","affiliation":[{"name":"6Department of Cardiovascular Medicine, Humanitas Research Hospital and Humanitas University, Rozzano, Italy;"},{"name":"7Institute of Genetic and Biomedical Research, National Research Council of Italy, Rozzano, Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean Michael","family":"Davidson","sequence":"additional","affiliation":[{"name":"8The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, London, UK;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"De Windt","sequence":"additional","affiliation":[{"name":"9Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Dimmeler","sequence":"additional","affiliation":[{"name":"10Institute for Cardiovascular Regeneration, University Frankfurt, Frankfurt, Germany;"},{"name":"11German Center for Cardiovascular Research (DZHK), RheinMain, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix Benedikt","family":"Engel","sequence":"additional","affiliation":[{"name":"12Experimental Renal and Cardiovascular Research, Department of Nephropathology, Institute of Pathology, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg (FAU), Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek John","family":"Hausenloy","sequence":"additional","affiliation":[{"name":"13The Hatter Cardiovascular Institute, University College London, London, UK;"},{"name":"14The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK;"},{"name":"15Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore;"},{"name":"16National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore;"},{"name":"17Yong Loo Lin School of Medicine, National University Singapore, Singapore;"},{"name":"18Barts Heart Centre, St Bartholomew's Hospital, London, UK;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Addison","family":"Hill","sequence":"additional","affiliation":[{"name":"19Departments of Medicine (Cardiology) and Molecular Biology, UT Southwestern Medical Center, Dallas, TX, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda Wilhelmina","family":"Van Laake","sequence":"additional","affiliation":[{"name":"20Division of Heart and Lungs, Hubrecht Institute, University Medical Center Utrecht, Utrecht, The Netherlands;"},{"name":"21UMC Utrecht Regenerative Medicine Center and Hubrecht Institute, Utrecht, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Lecour","sequence":"additional","affiliation":[{"name":"22Hatter Cardiovascular Research Institute, University of Cape Town, Cape Town, South Africa;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Leor","sequence":"additional","affiliation":[{"name":"23Neufeld Cardiac Research Institute, Tel-Aviv University, Tel-Aviv, Israel;"},{"name":"24Tamman Cardiovascular Research Institute, Sheba Medical Center; Sheba Center for Regenerative Medicine, Stem Cell, and Tissue Engineering, Tel Hashomer, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalinda","family":"Madonna","sequence":"additional","affiliation":[{"name":"25Center of Aging Sciences and Translational Medicine \u2013 CESI-MeT, \u201cG. d\u2019Annunzio\u201d University, Chieti, Italy; Institute of Cardiology, Department of Neurosciences, Imaging, and Clinical Sciences, \u201cG. d\u2019Annunzio\u201d University, Chieti, Italy;"},{"name":"26The Texas Heart Institute and Center for Cardiovascular Biology and Atherosclerosis Research, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mayr","sequence":"additional","affiliation":[{"name":"27King's British Heart Foundation Centre, King's College London, London, UK;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Prunier","sequence":"additional","affiliation":[{"name":"28Department of Cardiology, Institut MITOVASC, University of Angers, University Hospital of Angers, Angers, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost Petrus Geradus","family":"Sluijter","sequence":"additional","affiliation":[{"name":"29Cardiology and UMC Utrecht Regenerative Medicine Center, University Medical Center Utrecht, Utrecht, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Schulz","sequence":"additional","affiliation":[{"name":"30Institute of Physiology, Justus Liebig University Giessen, Giessen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Thum","sequence":"additional","affiliation":[{"name":"31Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsti","family":"Ytrehus","sequence":"additional","affiliation":[{"name":"32Department of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, Troms\u00f8, Norway;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Ferdinandy","sequence":"additional","affiliation":[{"name":"33Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary;"},{"name":"34Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Szeged, Hungary;"},{"name":"35Pharmahungary Group, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,4,29]]},"reference":[{"key":"2026091105264361400_cvx070-B1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrcardio.2014.26","article-title":"Epidemiological studies of CHD and the evolution of preventive cardiology","volume":"11","author":"Wong","year":"2014","journal-title":"Nat Rev Cardiol"},{"key":"2026091105264361400_cvx070-B2","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1113\/JP270953","article-title":"Cardioprotection in ischaemia-reperfusion injury: novel mechanisms and clinical translation","volume":"593","author":"Altamirano","year":"2015","journal-title":"J Physiol"},{"key":"2026091105264361400_cvx070-B3","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/cvr\/cvx049","article-title":"Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart","volume":"113","author":"Hausenloy","year":"2017","journal-title":"Cardiovasc Res"},{"key":"2026091105264361400_cvx070-B4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/cvr\/cvu225","article-title":"ESC working group cellular biology of the heart: position paper: improving the preclinical assessment of novel cardioprotective therapies","volume":"104","author":"Lecour","year":"2014","journal-title":"Cardiovasc Res"},{"key":"2026091105264361400_cvx070-B5","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1093\/eurheartj\/ehw113","article-title":"Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure","volume":"37","author":"Madonna","year":"2016","journal-title":"Eur Heart J"},{"key":"2026091105264361400_cvx070-B6","doi-asserted-by":"crossref","first-page":"904","DOI":"10.2174\/1389450116666150427154203","article-title":"Functional genomics of cardioprotection by ischemic conditioning and the influence of comorbid conditions: implications in target identification","volume":"16","author":"Varga","year":"2015","journal-title":"Curr Drug Targets"},{"key":"2026091105264361400_cvx070-B7","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1016\/j.jacc.2016.10.039","article-title":"Genetics: implications for prevention and management of coronary artery disease","volume":"68","author":"Assimes","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2026091105264361400_cvx070-B8","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1124\/pr.113.008300","article-title":"Interaction of risk factors, comorbidities, and comedications with ischemia\/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioning","volume":"66","author":"Ferdinandy","year":"2014","journal-title":"Pharmacol Rev"},{"key":"2026091105264361400_cvx070-B9","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome","volume":"409","author":"Lander","year":"2001","journal-title":"Nature"},{"key":"2026091105264361400_cvx070-B10","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1161\/CIR.0000000000000211","article-title":"Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association","volume":"131","author":"Fox","year":"2015","journal-title":"Circulation"},{"key":"2026091105264361400_cvx070-B11","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1126\/science.aaa1807","article-title":"Genomics and proteomics. Roadmap to the epitranscriptome","volume":"346","author":"Dominissini","year":"2014","journal-title":"Science"},{"key":"2026091105264361400_cvx070-B12","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1161\/CIRCGENETICS.113.000129","article-title":"Cardiovascular transcriptomics and epigenomics using next-generation sequencing: challenges, progress, and opportunities","volume":"7","author":"Wu","year":"2014","journal-title":"Circ Cardiovasc Genet"},{"key":"2026091105264361400_cvx070-B13","doi-asserted-by":"crossref","first-page":"H946","DOI":"10.1152\/ajpheart.00878.2003","article-title":"Ischemic preconditioning exaggerates cardiac damage in PKC-delta null mice","volume":"287","author":"Mayr","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026091105264361400_cvx070-B14","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature13909","article-title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"},{"key":"2026091105264361400_cvx070-B15","doi-asserted-by":"crossref","first-page":"7155","DOI":"10.1038\/ncomms8155","article-title":"Proteins that bind regulatory regions identified by histone modification chromatin immunoprecipitations and mass spectrometry","volume":"6","author":"Engelen","year":"2015","journal-title":"Nat Commun"},{"key":"2026091105264361400_cvx070-B16","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1586\/14789450.2015.1084231","article-title":"Progress in epigenetic histone modification analysis by mass spectrometry for clinical investigations","volume":"12","author":"Onder","year":"2015","journal-title":"Expert Rev Proteomics"},{"key":"2026091105264361400_cvx070-B17","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.recesp.2013.04.010","article-title":"Proteomics and metabolomics for mechanistic insights and biomarker discovery in cardiovascular disease","volume":"66","author":"Barallobre-Barreiro","year":"2013","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"2026091105264361400_cvx070-B18","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1161\/CIR.0000000000000226","article-title":"Transformative impact of proteomics on cardiovascular health and disease: a scientific statement from the American Heart Association","volume":"132","author":"Lindsey","year":"2015","journal-title":"Circulation"},{"key":"2026091105264361400_cvx070-B19","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1080\/14789450.2016.1217775","article-title":"Proteomics and metabolomics in biomarker discovery for cardiovascular diseases: progress and potential","volume":"13","author":"Tunon","year":"2016","journal-title":"Expert Rev Proteomics"},{"key":"2026091105264361400_cvx070-B20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.yjmcc.2014.05.002","article-title":"BET-ting on chromatin-based therapeutics for heart failure","volume":"74","author":"Haldar","year":"2014","journal-title":"J Mol Cell Cardiol"},{"key":"2026091105264361400_cvx070-B21","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.febslet.2009.12.014","article-title":"A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase","volume":"584","author":"Monovich","year":"2010","journal-title":"FEBS Lett"},{"key":"2026091105264361400_cvx070-B22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrg2485","article-title":"The many roles of histone deacetylases in development and physiology: implications for disease and therapy","volume":"10","author":"Haberland","year":"2009","journal-title":"Nat Rev Genet"},{"key":"2026091105264361400_cvx070-B23","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/j.jacc.2014.01.050","article-title":"microRNAs in cardiovascular diseases: current knowledge and the road ahead","volume":"63","author":"Condorelli","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2026091105264361400_cvx070-B24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2015.11.021","article-title":"State-of-the-art on non-coding RNA bioinformatics, diagnostics and therapeutics in cardiovascular diseases: preface to SI non-coding RNAs in cardiovascular disease","volume":"89","author":"De Windt","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"2026091105264361400_cvx070-B25","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/nrcardio.2015.71","article-title":"Epigenetic modifications and noncoding RNAs in cardiac hypertrophy and failure","volume":"12","author":"Greco","year":"2015","journal-title":"Nat Rev Cardiol"},{"key":"2026091105264361400_cvx070-B26","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1161\/CIRCRESAHA.116.303549","article-title":"Long noncoding RNAs and microRNAs in cardiovascular pathophysiology","volume":"116","author":"Thum","year":"2015","journal-title":"Circ Res"},{"key":"2026091105264361400_cvx070-B27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.tcm.2012.12.006","article-title":"HDAC-dependent ventricular remodeling","volume":"23","author":"Xie","year":"2013","journal-title":"Trends Cardiovasc Med"},{"key":"2026091105264361400_cvx070-B28","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1161\/CIRCRESAHA.116.303630","article-title":"Readers, writers, and erasers: chromatin as the whiteboard of heart disease","volume":"116","author":"Gillette","year":"2015","journal-title":"Circ Res"},{"key":"2026091105264361400_cvx070-B29","doi-asserted-by":"crossref","first-page":"20164","DOI":"10.1073\/pnas.1315155110","article-title":"Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy","volume":"110","author":"Papait","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026091105264361400_cvx070-B30","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1038\/ncomms6288","article-title":"Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease","volume":"5","author":"Gilsbach","year":"2014","journal-title":"Nat Commun"},{"key":"2026091105264361400_cvx070-B31","doi-asserted-by":"crossref","first-page":"12418","DOI":"10.1038\/ncomms12418","article-title":"DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy","volume":"7","author":"Greco","year":"2016","journal-title":"Nat Commun"},{"key":"2026091105264361400_cvx070-B32","doi-asserted-by":"crossref","first-page":"e004076","DOI":"10.1161\/JAHA.116.004076","article-title":"Ischemic preconditioning confers epigenetic repression of Mtor and induction of autophagy through G9a-dependent H3K9 dimethylation","volume":"5","author":"Gidlof","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"2026091105264361400_cvx070-B33","doi-asserted-by":"crossref","first-page":"e8564","DOI":"10.1371\/journal.pone.0008564","article-title":"Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure","volume":"5","author":"Movassagh","year":"2010","journal-title":"PLoS One"},{"key":"2026091105264361400_cvx070-B34","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1161\/CIRCULATIONAHA.111.040071","article-title":"Distinct epigenomic features in end-stage failing human hearts","volume":"124","author":"Movassagh","year":"2011","journal-title":"Circulation"},{"key":"2026091105264361400_cvx070-B35","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/emmm.201201553","article-title":"Alterations in cardiac DNA methylation in human dilated cardiomyopathy","volume":"5","author":"Haas","year":"2013","journal-title":"EMBO Mol Med"},{"key":"2026091105264361400_cvx070-B36","doi-asserted-by":"crossref","first-page":"R90","DOI":"10.1186\/gb-2012-13-10-r90","article-title":"The landscape of DNA repeat elements in human heart failure","volume":"13","author":"Haider","year":"2012","journal-title":"Genome Biol"},{"key":"2026091105264361400_cvx070-B37","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1161\/CIRCULATIONAHA.113.002416","article-title":"Histone deacetylase inhibition blunts ischemia\/reperfusion injury by inducing cardiomyocyte autophagy","volume":"129","author":"Xie","year":"2014","journal-title":"Circulation"},{"key":"2026091105264361400_cvx070-B38","doi-asserted-by":"crossref","first-page":"ra34","DOI":"10.1126\/scisignal.aad5736","article-title":"Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression","volume":"9","author":"Morales","year":"2016","journal-title":"Sci Signal"},{"key":"2026091105264361400_cvx070-B39","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ijcard.2016.06.012","article-title":"Cardiovascular effects of histone deacetylase inhibitors epigenetic therapies: Systematic review of 62 studies and new hypotheses for future research","volume":"219","author":"Schiattarella","year":"2016","journal-title":"Int J Cardiol"},{"key":"2026091105264361400_cvx070-B40","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.molmed.2016.07.007","article-title":"An \u2032Omics\u2032 perspective on cardiomyopathies and heart failure","volume":"22","author":"Raghow","year":"2016","journal-title":"Trends Mol Med"},{"key":"2026091105264361400_cvx070-B41","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1161\/01.CIR.0000148178.19465.11","article-title":"Identification of a gene expression profile that differentiates between ischemic and nonischemic cardiomyopathy","volume":"110","author":"Kittleson","year":"2004","journal-title":"Circulation"},{"key":"2026091105264361400_cvx070-B42","first-page":"2441","article-title":"Bioinformatic analysis of microarray data reveals several key genes related to heart failure","volume":"17","author":"Zhang","year":"2013","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"2026091105264361400_cvx070-B43","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1152\/physiolgenomics.00148.2002","article-title":"Transcriptomal analysis of failing and nonfailing human hearts","volume":"12","author":"Steenman","year":"2003","journal-title":"Physiol Genomics"},{"key":"2026091105264361400_cvx070-B44","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1152\/physiolgenomics.00299.2007","article-title":"Genomic analysis reveals poor separation of human cardiomyopathies of ischemic and nonischemic etiologies","volume":"34","author":"Kuner","year":"2008","journal-title":"Physiol Genomics"},{"key":"2026091105264361400_cvx070-B45","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1161\/CIRCULATIONAHA.113.003863","article-title":"Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support","volume":"129","author":"Yang","year":"2014","journal-title":"Circulation"},{"key":"2026091105264361400_cvx070-B46","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0014-5793(03)00006-1","article-title":"Effect of classic preconditioning on the gene expression pattern of rat hearts: a DNA microarray study","volume":"536","author":"Onody","year":"2003","journal-title":"FEBS Lett"},{"key":"2026091105264361400_cvx070-B47","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00132580-200203000-00002","article-title":"Gene activity changes in ischemically preconditioned rabbit heart gene: discovery array study","volume":"4","author":"Simkhovich","year":"2002","journal-title":"Heart Dis"},{"key":"2026091105264361400_cvx070-B48","doi-asserted-by":"crossref","first-page":"H216","DOI":"10.1152\/ajpheart.00812.2013","article-title":"MicroRNAs associated with ischemia-reperfusion injury and cardioprotection by ischemic pre- and postconditioning: protectomiRs","volume":"307","author":"Varga","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026091105264361400_cvx070-B49","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.jtcvs.2005.03.050","article-title":"The remote ischemic preconditioning stimulus modifies gene expression in mouse myocardium","volume":"130","author":"Konstantinov","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026091105264361400_cvx070-B50","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.yjmcc.2014.01.004","article-title":"Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles","volume":"68","author":"Giricz","year":"2014","journal-title":"J Mol Cell Cardiol"},{"key":"2026091105264361400_cvx070-B51","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jss.2011.12.017","article-title":"Recovery from decompensated heart failure is associated with a distinct, phase-dependent gene expression profile","volume":"178","author":"Andersen","year":"2012","journal-title":"J Surg Res"},{"key":"2026091105264361400_cvx070-B52","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1590\/S0100-879X2010007500014","article-title":"Cardiac gene expression and systemic cytokine profile are complementary in a murine model of post-ischemic heart failure","volume":"43","author":"Lachtermacher","year":"2010","journal-title":"Braz J Med Biol Res"},{"key":"2026091105264361400_cvx070-B53","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1152\/physiolgenomics.00165.2004","article-title":"Cardiac gene expression profile in rats with terminal heart failure and cachexia","volume":"20","author":"Wellner","year":"2005","journal-title":"Physiol Genomics"},{"key":"2026091105264361400_cvx070-B54","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jjcc.2011.01.009","article-title":"Altered microRNA expression associated with reduced catecholamine sensitivity in patients with chronic heart failure","volume":"57","author":"Funahashi","year":"2011","journal-title":"J Cardiol"},{"key":"2026091105264361400_cvx070-B55","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jtcvs.2008.03.016","article-title":"Gene expression profiling from endomyocardial biopsy tissue allows distinction between subentities of dilated cardiomyopathy","volume":"136","author":"Ruppert","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026091105264361400_cvx070-B56","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1161\/CIRCRESAHA.112.300658","article-title":"mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts","volume":"112","author":"Chen","year":"2013","journal-title":"Circ Res"},{"key":"2026091105264361400_cvx070-B57","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature11739","article-title":"Functional screening identifies miRNAs inducing cardiac regeneration","volume":"492","author":"Eulalio","year":"2012","journal-title":"Nature"},{"key":"2026091105264361400_cvx070-B58","doi-asserted-by":"crossref","first-page":"279ra238","DOI":"10.1126\/scitranslmed.3010841","article-title":"A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice","volume":"7","author":"Tian","year":"2015","journal-title":"Sci Transl Med"},{"key":"2026091105264361400_cvx070-B59","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.yjmcc.2015.09.017","article-title":"Harnessing the microRNA pathway for cardiac regeneration","volume":"89","author":"Giacca","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"2026091105264361400_cvx070-B60","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1016\/S0140-6736(13)62674-4","article-title":"DNA methylation and body-mass index: a genome-wide analysis","volume":"383","author":"Dick","year":"2014","journal-title":"Lancet"},{"key":"2026091105264361400_cvx070-B61","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/MOL.0b013e32834f319d","article-title":"Glycemic memory","volume":"23","author":"El-Osta","year":"2012","journal-title":"Curr Opin Lipidol"},{"key":"2026091105264361400_cvx070-B62","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1046\/j.1529-8817.2004.00081.x","article-title":"Age related changes in 5-methylcytosine content in human peripheral leukocytes and placentas: an HPLC-based study","volume":"68","author":"Fuke","year":"2004","journal-title":"Ann Hum Genet"},{"key":"2026091105264361400_cvx070-B63","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1161\/CIRCULATIONAHA.114.009158","article-title":"Epigenome-wide association study of fasting blood lipids in the Genetics of Lipid-lowering Drugs and Diet Network study","volume":"130","author":"Irvin","year":"2014","journal-title":"Circulation"},{"key":"2026091105264361400_cvx070-B64","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1161\/CIRCGENETICS.110.958744","article-title":"Cardiovascular epigenetics: basic concepts and results from animal and human studies","volume":"3","author":"Baccarelli","year":"2010","journal-title":"Circ Cardiovasc Genet"},{"key":"2026091105264361400_cvx070-B65","doi-asserted-by":"crossref","first-page":"17643","DOI":"10.3390\/ijms140917643","article-title":"Oxidative stress and epigenetic regulation in ageing and age-related diseases","volume":"14","author":"Cencioni","year":"2013","journal-title":"Int J Mol Sci"},{"key":"2026091105264361400_cvx070-B66","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1093\/eurheartj\/ehp549","article-title":"The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences","volume":"31","author":"Heidecker","year":"2010","journal-title":"Eur Heart J"},{"key":"2026091105264361400_cvx070-B67","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0014-5793(04)00189-9","article-title":"Cholesterol diet-induced hyperlipidemia influences gene expression pattern of rat hearts: a DNA microarray study","volume":"562","author":"Puskas","year":"2004","journal-title":"FEBS Lett"},{"key":"2026091105264361400_cvx070-B68","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1152\/physiolgenomics.00115.2011","article-title":"Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart","volume":"44","author":"Georgiadi","year":"2012","journal-title":"Physiol Genomics"},{"key":"2026091105264361400_cvx070-B69","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1152\/physiolgenomics.00001.2004","article-title":"Kinetic analysis of cardiac transcriptome regulation during chronic high-fat diet in dogs","volume":"19","author":"Philip-Couderc","year":"2004","journal-title":"Physiol Genomics"},{"key":"2026091105264361400_cvx070-B70","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.yjmcc.2013.05.009","article-title":"MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative\/nitrative stress and subsequent dysfunction in the heart","volume":"62","author":"Varga","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"2026091105264361400_cvx070-B71","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1096\/fj.03-1242fje","article-title":"Uncomplicated human obesity is associated with a specific cardiac transcriptome: involvement of the Wnt pathway","volume":"18","author":"Philip-Couderc","year":"2004","journal-title":"FASEB J"},{"key":"2026091105264361400_cvx070-B72","first-page":"104","article-title":"Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes","volume":"2005","author":"Wren","year":"2005","journal-title":"J Biomed Biotechnol"},{"key":"2026091105264361400_cvx070-B73","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1177\/2040622314529325","article-title":"The emerging role of epigenetics in cardiovascular disease","volume":"5","author":"Abi Khalil","year":"2014","journal-title":"Ther Adv Chronic Dis"},{"key":"2026091105264361400_cvx070-B74","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.2337\/db09-1003","article-title":"Epigenetics: a molecular link between environmental factors and type 2 diabetes","volume":"58","author":"Ling","year":"2009","journal-title":"Diabetes"},{"key":"2026091105264361400_cvx070-B75","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1101\/gr.116095.110","article-title":"Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells","volume":"21","author":"Pirola","year":"2011","journal-title":"Genome Res"},{"key":"2026091105264361400_cvx070-B76","doi-asserted-by":"crossref","first-page":"e6474","DOI":"10.1371\/journal.pone.0006474","article-title":"Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a","volume":"4","author":"Karakikes","year":"2009","journal-title":"PLoS One"},{"key":"2026091105264361400_cvx070-B77","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1475-2840-12-16","article-title":"Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats","volume":"12","author":"Sarkozy","year":"2013","journal-title":"Cardiovasc Diabetol"},{"key":"2026091105264361400_cvx070-B78","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/eurjhf\/hfp117","article-title":"The accelerated post-infarction progression of cardiac remodelling is associated with genetic changes in an untreated streptozotocin-induced diabetic rat model","volume":"11","author":"Song","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"2026091105264361400_cvx070-B79","first-page":"633","article-title":"Differentially expressed microRNAs and their target genes in the hearts of streptozotocin-induced diabetic mice","volume":"4","author":"Diao","year":"2011","journal-title":"Mol Med Rep"},{"key":"2026091105264361400_cvx070-B80","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.ajpath.2011.04.034","article-title":"MicroRNAs involved in the mitogen-activated protein kinase cascades pathway during glucose-induced cardiomyocyte hypertrophy","volume":"179","author":"Shen","year":"2011","journal-title":"Am J Pathol"},{"key":"2026091105264361400_cvx070-B81","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/FJC.0000000000000218","article-title":"Tissue-specific gene expression in rat hearts and aortas in a model of vascular nitrate tolerance","volume":"65","author":"Csont","year":"2015","journal-title":"J Cardiovasc Pharmacol"},{"key":"2026091105264361400_cvx070-B82","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ejphar.2008.01.043","article-title":"Systemic evaluation of gene expression changes in major target organs induced by atorvastatin","volume":"584","author":"Kato","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"2026091105264361400_cvx070-B83","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejphar.2013.03.022","article-title":"Comparative effects of statins on murine cardiac gene expression profiles in normal mice","volume":"707","author":"Kumazaki","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"2026091105264361400_cvx070-B84","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mito.2009.09.006","article-title":"Energetics, epigenetics, mitochondrial genetics","volume":"10","author":"Wallace","year":"2010","journal-title":"Mitochondrion"},{"key":"2026091105264361400_cvx070-B85","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1093\/hmg\/ddt256","article-title":"Coronary heart disease is associated with a mutation in mitochondrial tRNA","volume":"22","author":"Jia","year":"2013","journal-title":"Hum Mol Genet"},{"key":"2026091105264361400_cvx070-B86","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1515\/bmc-2013-0005","article-title":"Progress in mitochondrial epigenetics","volume":"4","author":"Manev","year":"2013","journal-title":"Biomol Concepts"},{"key":"2026091105264361400_cvx070-B87","first-page":"210","article-title":"Transcriptional profiling for understanding the basis of mitochondrial involvement in disease and toxicity using the mitochondria-specific MitoChip","volume":"616","author":"Desai","year":"2007","journal-title":"Mutat Res"},{"key":"2026091105264361400_cvx070-B88","first-page":"174","article-title":"The mitoscriptome in aging and disease","volume":"2","author":"Raju","year":"2011","journal-title":"Aging Dis"},{"key":"2026091105264361400_cvx070-B89","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrg3645","article-title":"Ribosome profiling: new views of translation, from single codons to genome scale","volume":"15","author":"Ingolia","year":"2014","journal-title":"Nat Rev Genet"},{"key":"2026091105264361400_cvx070-B90","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2013.09.011","article-title":"Mapping human epigenomes","volume":"155","author":"Rivera","year":"2013","journal-title":"Cell"},{"key":"2026091105264361400_cvx070-B91","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/ng1291","article-title":"Comparing genomic expression patterns across species identifies shared transcriptional profile in aging","volume":"36","author":"McCarroll","year":"2004","journal-title":"Nat Genet"},{"key":"2026091105264361400_cvx070-B92","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/prca.201300123","article-title":"Sizing up models of heart failure: proteomics from flies to humans","volume":"8","author":"Kooij","year":"2014","journal-title":"Proteomics Clin Appl"},{"key":"2026091105264361400_cvx070-B93","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1161\/01.CIR.0000014926.32463.89","article-title":"Genetic modifier loci affecting survival and cardiac function in murine dilated cardiomyopathy","volume":"105","author":"Suzuki","year":"2002","journal-title":"Circulation"},{"key":"2026091105264361400_cvx070-B94","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1161\/CIRCRESAHA.112.265066","article-title":"Cardiac-specific inducible and conditional gene targeting in mice","volume":"110","author":"Doetschman","year":"2012","journal-title":"Circ Res"},{"key":"2026091105264361400_cvx070-B95","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/CIRCRESAHA.115.306337","article-title":"Deciphering the epigenetic code of cardiac myocyte transcription","volume":"117","author":"Preissl","year":"2015","journal-title":"Circ Res"},{"key":"2026091105264361400_cvx070-B96","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.devcel.2016.10.001","article-title":"Single-cell resolution of temporal gene expression during heart development","volume":"39","author":"DeLaughter","year":"2016","journal-title":"Dev Cell"},{"key":"2026091105264361400_cvx070-B97","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.devcel.2016.10.014","article-title":"Transcriptomic profiling maps anatomically patterned subpopulations among single embryonic cardiac cells","volume":"39","author":"Li","year":"2016","journal-title":"Dev Cell"},{"key":"2026091105264361400_cvx070-B98","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1161\/CIRCRESAHA.116.308643","article-title":"Targeted ablation of periostin-expressing activated fibroblasts prevents adverse cardiac remodeling in mice","volume":"118","author":"Kaur","year":"2016","journal-title":"Circ Res"},{"key":"2026091105264361400_cvx070-B99","first-page":"522","article-title":"Gene network analysis: from heart development to cardiac therapy","volume":"113","author":"Ferrazzi","year":"2015","journal-title":"Thromb Haemost"},{"key":"2026091105264361400_cvx070-B100","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/bib\/bbv067","article-title":"The identification and characterization of novel transcripts from RNA-seq data","volume":"17","author":"Weirick","year":"2016","journal-title":"Brief Bioinform"},{"key":"2026091105264361400_cvx070-B101","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrg2918","article-title":"Network medicine: a network-based approach to human disease","volume":"12","author":"Barabasi","year":"2011","journal-title":"Nat Rev Genet"},{"key":"2026091105264361400_cvx070-B102","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.pharmthera.2013.01.016","article-title":"Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review","volume":"138","author":"Csermely","year":"2013","journal-title":"Pharmacol Ther"},{"key":"2026091105264361400_cvx070-B103","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.cell.2011.02.016","article-title":"Interactome networks and human disease","volume":"144","author":"Vidal","year":"2011","journal-title":"Cell"},{"key":"2026091105264361400_cvx070-B104","doi-asserted-by":"crossref","first-page":"1257601","DOI":"10.1126\/science.1257601","article-title":"Disease networks. Uncovering disease-disease relationships through the incomplete interactome","volume":"347","author":"Menche","year":"2015","journal-title":"Science"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/113\/7\/725\/70577632\/cardiovascres_113_7_725.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article-pdf\/113\/7\/725\/70577632\/cardiovascres_113_7_725.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:27:00Z","timestamp":1789118820000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/113\/7\/725\/3782684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,29]]},"references-count":104,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,4,29]]},"published-print":{"date-parts":[[2017,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvx070","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,6]]},"published":{"date-parts":[[2017,4,29]]}}}