{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:15:40Z","timestamp":1791591340405,"version":"4.3.4"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"13","funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"ERDF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2014GR-141"],"award-info":[{"award-number":["2014GR-141"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"DOI":"10.1093\/cvr\/cvx088","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T07:07:19Z","timestamp":1493795239000},"page":"1574-1584","source":"Crossref","is-referenced-by-count":44,"title":["Fgf21 is required for cardiac remodeling in pregnancy"],"prefix":"10.1093","volume":"113","author":[{"given":"Ibon","family":"Redondo-Angulo","sequence":"first","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biologia Molecular, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, 08028 Barcelona, Spain;"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Mas-Stachurska","sequence":"additional","affiliation":[{"name":"Cardiology Department, Thorax Institute, Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona, 08036 Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Sitges","sequence":"additional","affiliation":[{"name":"Cardiology Department, Thorax Institute, Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona, 08036 Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Jos\u00e9","family":"Tinahones","sequence":"additional","affiliation":[{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), Barcelona, Spain;"},{"name":"Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital, Teatinos Campus, 29010 Malaga, Spain;"},{"name":"Investigation Unit (IBIMA), Virgen de la Victoria Hospital, 29010 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Giralt","sequence":"additional","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biologia Molecular, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, 08028 Barcelona, Spain;"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Villarroya","sequence":"additional","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biologia Molecular, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, 08028 Barcelona, Spain;"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Planavila","sequence":"additional","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biologia Molecular, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, 08028 Barcelona, Spain;"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,5,4]]},"reference":[{"key":"key\n\t\t\t\t20180328155038_cvx088-B1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.cmet.2007.05.002","article-title":"Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states","volume":"5","author":"Badman","year":"2007","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cmet.2008.06.014","article-title":"The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man","volume":"8","author":"Galman","year":"2008","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B3","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.cmet.2007.05.003","article-title":"Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21","volume":"5","author":"Inagaki","year":"2007","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B4","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1124\/mol.108.044826","article-title":"Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states","volume":"74","author":"Muise","year":"2008","journal-title":"Mol Pharmacol"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B5","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1016\/j.febslet.2008.10.021","article-title":"FGF21 is an Akt-regulated myokine","volume":"582","author":"Izumiya","year":"2008","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B6","doi-asserted-by":"crossref","first-page":"12983","DOI":"10.1074\/jbc.M110.215889","article-title":"Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue","volume":"286","author":"Hondares","year":"2011","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/jcp.21357","article-title":"FGF-21\/FGF-21 receptor interaction and activation is determined by betaKlotho","volume":"215","author":"Kharitonenkov","year":"2008","journal-title":"J Cell Physiol"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B8","doi-asserted-by":"crossref","first-page":"26687","DOI":"10.1074\/jbc.M704165200","article-title":"Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21","volume":"282","author":"Kurosu","year":"2007","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B9","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1172\/JCI23606","article-title":"FGF-21 as a novel metabolic regulator","volume":"115","author":"Kharitonenkov","year":"2005","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.cmet.2010.02.001","article-title":"Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat","volume":"11","author":"Hondares","year":"2010","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1101\/gad.177857.111","article-title":"FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis","volume":"26","author":"Fisher","year":"2012","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B12","doi-asserted-by":"crossref","first-page":"2019.","DOI":"10.1038\/ncomms3019","article-title":"Fibroblast growth factor 21 protects against cardiac hypertrophy in mice","volume":"4","author":"Planavila","year":"2013","journal-title":"Nat Commun"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/cvr\/cvu263","article-title":"Fibroblast growth factor 21 protects the heart from oxidative stress","volume":"106","author":"Planavila","year":"2015","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B14","doi-asserted-by":"crossref","first-page":"2767.","DOI":"10.1038\/srep02767","article-title":"Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue","volume":"3","author":"Liu","year":"2013","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B15","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bbrc.2015.02.081","article-title":"FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism","volume":"459","author":"Joki","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B16","doi-asserted-by":"crossref","first-page":"R290","DOI":"10.1152\/ajpregu.00554.2013","article-title":"Hepatic FGF21 production is increased in late pregnancy in the mouse","volume":"307","author":"Cui","year":"2014","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B17","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1161\/01.RES.0000170652.71414.16","article-title":"Molecular and functional signature of heart hypertrophy during pregnancy","volume":"96","author":"Eghbali","year":"2005","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000057675","article-title":"Left ventricular hypertrophy and diastolic dysfunction in healthy pregnant women","volume":"97","author":"Schannwell","year":"2002","journal-title":"Cardiology"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B19","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.ijcard.2015.10.005","article-title":"C\/EBPbeta is required in pregnancy-induced cardiac hypertrophy","volume":"202","author":"Redondo-Angulo","year":"2016","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B20","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/cvr\/cvu009","article-title":"Maternal cardiac metabolism in pregnancy","volume":"101","author":"Liu","year":"2014","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B21","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2174\/138955706776073457","article-title":"Peroxisome proliferator-activated receptors and the control of fatty acid oxidation in cardiac hypertrophy","volume":"6","author":"Planavila","year":"2006","journal-title":"Mini Rev Med Chem"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B22","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/cvr\/cvq376","article-title":"Sirt1 acts in association with PPAR{alpha} to protect the heart from hypertrophy, metabolic dysregulation, and inflammation","volume":"90","author":"Planavila","year":"2011","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B23","doi-asserted-by":"crossref","first-page":"17464","DOI":"10.1074\/jbc.M414220200","article-title":"Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy","volume":"280","author":"Planavila","year":"2005","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B24","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.yjmcc.2012.07.019","article-title":"Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: a role for Sirt1-Mef2 in adult heart","volume":"53","author":"Planavila","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B25","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.2337\/db10-0193","article-title":"Obesity is a fibroblast growth factor 21 (FGF21)-resistant state","volume":"59","author":"Fisher","year":"2010","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbalip.2004.11.004","article-title":"Atorvastatin improves peroxisome proliferator-activated receptor signaling in cardiac hypertrophy by preventing nuclear factor-kappa B activation","volume":"1687","author":"Planavila","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nature08778","article-title":"SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation","volume":"464","author":"Hirschey","year":"2010","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B28","doi-asserted-by":"crossref","first-page":"7432","DOI":"10.1073\/pnas.0701600104","article-title":"BetaKlotho is required for metabolic activity of fibroblast growth factor 21","volume":"104","author":"Ogawa","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B29","doi-asserted-by":"crossref","first-page":"e00242","DOI":"10.1002\/phy2.242","article-title":"Diet-induced obesity in mice reduces placental efficiency and inhibits placental mTOR signaling","volume":"2","author":"Lager","year":"2014","journal-title":"Physiol Rep"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B30","doi-asserted-by":"crossref","first-page":"611.","DOI":"10.1016\/j.placenta.2012.05.006","article-title":"Placental weight and efficiency in relation to maternal body mass index and the risk of pregnancy complications in women delivering singleton babies","volume":"33","author":"Wallace","year":"2012","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B31","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.placenta.2014.05.006","article-title":"Maternal prepregnancy obesity is associated with higher risk of placental pathological lesions","volume":"35","author":"Huang","year":"2014","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0301-2115(97)02734-6","article-title":"Coagulation and fibrinolysis changes in normal pregnancy. Increased levels of procoagulants and reduced levels of inhibitors during pregnancy induce a hypercoagulable state, combined with a reactive fibrinolysis","volume":"73","author":"Cerneca","year":"1997","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B33","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1530\/JME-11-0030","article-title":"The inflammatory changes of adipose tissue in late pregnant mice","volume":"47","author":"Zhang","year":"2011","journal-title":"J Mol Endocrinol"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B34","doi-asserted-by":"crossref","first-page":"238.","DOI":"10.1007\/s00395-011-0238-0","article-title":"Reverse chamber remodelling following adrenergic-induced advanced cardiac dilatation and pump dysfunction","volume":"107","author":"Booysen","year":"2012","journal-title":"Basic Res Cardiol"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.pharmthera.2010.04.005","article-title":"Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies","volume":"128","author":"Bernardo","year":"2010","journal-title":"Pharmacol Ther"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B36","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.cyto.2013.02.019","article-title":"Serum levels of the adipokine fibroblast growth factor-21 are increased in preeclampsia","volume":"62","author":"Stepan","year":"2013","journal-title":"Cytokine"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B37","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s12020-014-0309-8","article-title":"Fibroblast growth factor 21 expressions in white blood cells and sera of patients with gestational diabetes mellitus during gestation and postpartum","volume":"48","author":"Li","year":"2015","journal-title":"Endocrine"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B38","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.metabol.2009.07.003","article-title":"Serum fibroblast growth factor 21 levels in gestational diabetes mellitus in relation to insulin resistance and dyslipidemia","volume":"59","author":"Stein","year":"2010","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B39","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1210\/en.2012-1193","article-title":"TNF-alpha represses beta-Klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway","volume":"153","author":"Diaz-Delfin","year":"2012","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B40","doi-asserted-by":"crossref","first-page":"e87102.","DOI":"10.1371\/journal.pone.0087102","article-title":"Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts","volume":"9","author":"Patel","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B41","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1194\/jlr.M044784","article-title":"Fgf21 is induced upon cardiac stress and alters cardiac lipid homeostasis","volume":"55","author":"Brahma","year":"2014","journal-title":"J Lipid Res"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B42","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/cvr\/cvu013","article-title":"Pregnancy as a cardiac stress model","volume":"101","author":"Chung","year":"2014","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B43","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1152\/japplphysiol.00027.2012","article-title":"Akt and MAPK signaling mediate pregnancy-induced cardiac adaptation","volume":"112","author":"Chung","year":"2012","journal-title":"J Appl Physiol (1985)"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B44","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1172\/JCI10947","article-title":"A novel mouse model of lipotoxic cardiomyopathy","volume":"107","author":"Chiu","year":"2001","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B45","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1096\/fasebj.13.8.805","article-title":"Requirement for the heart-type fatty acid binding protein in cardiac fatty acid utilization","volume":"13","author":"Binas","year":"1999","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B46","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1161\/01.HYP.11.5.416","article-title":"Effects of moderate hypertension on cardiac function and metabolism in the rabbit","volume":"11","author":"Taegtmeyer","year":"1988","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B47","doi-asserted-by":"crossref","first-page":"133.","DOI":"10.3389\/fendo.2015.00133","article-title":"FGF21 and cardiac physiopathology","volume":"6","author":"Planavila","year":"2015","journal-title":"Front Endocrinol (Lausanne)"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B48","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1161\/CIRCIMAGING.111.970012","article-title":"Morphological and functional adaptation of the maternal heart during pregnancy","volume":"5","author":"Savu","year":"2012","journal-title":"Circ Cardiovasc Imaging"},{"key":"key\n\t\t\t\t20180328155038_cvx088-B49","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1161\/HYPERTENSIONAHA.115.06667","article-title":"Maternal cardiovascular function in normal pregnancy: evidence of maladaptation to chronic volume overload","volume":"67","author":"Melchiorre","year":"2016","journal-title":"Hypertension"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/113\/13\/1574\/21349829\/cvx088.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T22:45:33Z","timestamp":1569192333000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/113\/13\/1574\/3797836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,4]]},"references-count":49,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2017,5,4]]},"published-print":{"date-parts":[[2017,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvx088","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,11]]},"published":{"date-parts":[[2017,5,4]]}}}