{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:15:47Z","timestamp":1789924547441,"version":"4.0.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"DOI":"10.1093\/cvr\/cvx113","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T15:08:45Z","timestamp":1496761725000},"page":"1403-1417","source":"Crossref","is-referenced-by-count":19,"title":["Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant"],"prefix":"10.1093","volume":"113","author":[{"given":"Christos","family":"Tzimas","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Center of Basic Research, Biomedical Research Foundation, Academy of Athens, Soranou Efessiou 4, 115 27, Athens, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrio J","family":"Santiago","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Vafiadaki","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Center of Basic Research, Biomedical Research Foundation, Academy of Athens, Soranou Efessiou 4, 115 27, Athens, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrios A","family":"Arvanitis","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Center of Basic Research, Biomedical Research Foundation, Academy of Athens, Soranou Efessiou 4, 115 27, Athens, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos H","family":"Davos","sequence":"additional","affiliation":[{"name":"Department of Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation, Academy of Athens, Athens, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimilia","family":"Varela","sequence":"additional","affiliation":[{"name":"Department of Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation, Academy of Athens, Athens, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos C","family":"Athanasiadis","sequence":"additional","affiliation":[{"name":"Department of Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation, Academy of Athens, Athens, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos","family":"Dimitriou","sequence":"additional","affiliation":[{"name":"Department of Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation, Academy of Athens, Athens, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michalis","family":"Katsimpoulas","sequence":"additional","affiliation":[{"name":"Department of Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation, Academy of Athens, Athens, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Sonntag","sequence":"additional","affiliation":[{"name":"PolyGene AG, R\u00fcmlang, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariya","family":"Kryzhanovska","sequence":"additional","affiliation":[{"name":"PolyGene AG, R\u00fcmlang, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Shmerling","sequence":"additional","affiliation":[{"name":"PolyGene AG, R\u00fcmlang, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan E","family":"Lehnart","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pulmonology, Heart Research Center Goettingen, University Medical Center Goettingen, Goettingen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin R","family":"Sipido","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia G","family":"Kranias","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Center of Basic Research, Biomedical Research Foundation, Academy of Athens, Soranou Efessiou 4, 115 27, Athens, Greece;"},{"name":"Department of Pharmacology and Cell Biophysics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despina","family":"Sanoudou","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Center of Basic Research, Biomedical Research Foundation, Academy of Athens, Soranou Efessiou 4, 115 27, Athens, Greece;"},{"name":"4th Department of Internal Medicine, Clinical Genomics and Pharmacogenomics Unit, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Rimini 1, Chaidari 124 62, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,7,1]]},"reference":[{"key":"2019060508351800700_cvx113-B1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.yjmcc.2010.08.021","article-title":"Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling","volume":"50","author":"Arvanitis","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"2019060508351800700_cvx113-B2","doi-asserted-by":"crossref","first-page":"H1581","DOI":"10.1152\/ajpheart.00278.2007","article-title":"Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase","volume":"293","author":"Arvanitis","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2019060508351800700_cvx113-B3","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1023\/A:1005580609414","article-title":"Interaction of triadin with histidine-rich Ca(2+)-binding protein at the triadic junction in skeletal muscle fibers","volume":"20","author":"Sacchetto","year":"1999","journal-title":"J Muscle Res Cell Motil"},{"key":"2019060508351800700_cvx113-B4","doi-asserted-by":"crossref","first-page":"23389","DOI":"10.1074\/jbc.272.37.23389","article-title":"Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane","volume":"272","author":"Zhang","year":"1997","journal-title":"J Biol Chem"},{"key":"2019060508351800700_cvx113-B5","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.yjmcc.2006.02.003","article-title":"Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac function","volume":"40","author":"Gregory","year":"2006","journal-title":"J Mol Cell Cardiol"},{"key":"2019060508351800700_cvx113-B6","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s00395-013-0344-2","article-title":"Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress","volume":"108","author":"Park","year":"2013","journal-title":"Basic Res Cardiol"},{"key":"2019060508351800700_cvx113-B7","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1093\/eurheartj\/ehn328","article-title":"The Ser96Ala variant in histidine-rich calcium-binding protein is associated with life-threatening ventricular arrhythmias in idiopathic dilated cardiomyopathy","volume":"29","author":"Arvanitis","year":"2008","journal-title":"Eur Heart J"},{"key":"2019060508351800700_cvx113-B8","first-page":"130","article-title":"Abstract 20362: the Ser96Ala variant of the histidine-rich calcium-binding protein is associated with appropriate ICD shocks in cardiomyopathy patients","author":"Anthony","year":"2014","journal-title":"Circulation"},{"key":"2019060508351800700_cvx113-B9","doi-asserted-by":"crossref","first-page":"H1588","DOI":"10.1152\/ajpheart.01153.2010","article-title":"Catecholaminergic-induced arrhythmias in failing cardiomyocytes associated with human HRCS96A variant overexpression","volume":"301","author":"Han","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2019060508351800700_cvx113-B10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00395-015-0485-6","article-title":"Complement system modulation as a target for treatment of arrhythmogenic cardiomyopathy","volume":"110","author":"Mavroidis","year":"2015","journal-title":"Basic Res Cardiol"},{"key":"2019060508351800700_cvx113-B11","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1161\/CIRCULATIONAHA.105.583351","article-title":"The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling","volume":"113","author":"Zhao","year":"2006","journal-title":"Circulation"},{"key":"2019060508351800700_cvx113-B12","doi-asserted-by":"crossref","first-page":"e000460","DOI":"10.1161\/JAHA.113.000460","article-title":"Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein","volume":"2","author":"Singh","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"2019060508351800700_cvx113-B13","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1113\/jphysiol.2002.025619","article-title":"Mechanisms underlying the frequency dependence of contraction and [Ca(2+)](i) transients in mouse ventricular myocytes","volume":"543","author":"Antoons","year":"2002","journal-title":"J Physiol"},{"key":"2019060508351800700_cvx113-B14","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.hrthm.2015.03.043","article-title":"Calcium\/calmodulin-dependent protein kinase II (CaMKII) inhibition ameliorates arrhythmias elicited by junctin ablation under stress conditions","volume":"12","author":"Tzimas","year":"2015","journal-title":"Heart Rhythm"},{"key":"2019060508351800700_cvx113-B15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.tcm.2009.12.004","article-title":"Cardiac aging in mice and humans: the role of mitochondrial oxidative stress","volume":"19","author":"Dai","year":"2009","journal-title":"Trends Cardiovasc Med"},{"key":"2019060508351800700_cvx113-B16","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.yjmcc.2007.02.012","article-title":"Stress and high heart rate provoke ventricular tachycardia in mice expressing triadin","volume":"42","author":"Kirchhof","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"2019060508351800700_cvx113-B17","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1126\/science.1094301","article-title":"Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2","volume":"304","author":"Wehrens","year":"2004","journal-title":"Science"},{"key":"2019060508351800700_cvx113-B18","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/415198a","article-title":"Cardiac excitation-contraction coupling","volume":"415","author":"Bers","year":"2002","journal-title":"Nature"},{"key":"2019060508351800700_cvx113-B19","doi-asserted-by":"crossref","DOI":"10.3791\/54057","article-title":"Assessment of myofilament Ca2+ sensitivity underlying cardiac excitation-contraction coupling","author":"Zhao","year":"2016","journal-title":"J Vis Exp"},{"key":"2019060508351800700_cvx113-B20","doi-asserted-by":"crossref","first-page":"9607","DOI":"10.1073\/pnas.0500353102","article-title":"Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure","volume":"102","author":"Wehrens","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2019060508351800700_cvx113-B21","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1161\/CIRCRESAHA.107.157552","article-title":"Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice","volume":"101","author":"Chopra","year":"2007","journal-title":"Circ Res"},{"key":"2019060508351800700_cvx113-B22","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.bpj.2010.01.042","article-title":"Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes","volume":"98","author":"Santiago","year":"2010","journal-title":"Biophys J"},{"key":"2019060508351800700_cvx113-B23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/cvr\/cvt021","article-title":"L-type calcium channel targeting and local signalling in cardiac myocytes","volume":"98","author":"Shaw","year":"2013","journal-title":"Cardiovasc Res"},{"key":"2019060508351800700_cvx113-B24","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1172\/JCI37649","article-title":"Role of chronic ryanodine receptor phosphorylation in heart failure and beta-adrenergic receptor blockade in mice","volume":"120","author":"Shan","year":"2010","journal-title":"J Clin Invest"},{"key":"2019060508351800700_cvx113-B25","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1161\/CIRCULATIONAHA.110.982298","article-title":"Ryanodine receptor phosphorylation by calcium\/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure","volume":"122","author":"van Oort","year":"2010","journal-title":"Circulation"},{"key":"2019060508351800700_cvx113-B26","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nrm1151","article-title":"Phospholamban: a crucial regulator of cardiac contractility","volume":"4","author":"MacLennan","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2019060508351800700_cvx113-B27","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1161\/CIRCRESAHA.111.259754","article-title":"Modulation of cardiac contractility by the phospholamban\/SERCA2a regulatome","volume":"110","author":"Kranias","year":"2012","journal-title":"Circ Res"},{"key":"2019060508351800700_cvx113-B28","doi-asserted-by":"crossref","first-page":"5.","DOI":"10.3389\/fphar.2014.00005","article-title":"The role of CaMKII regulation of phospholamban activity in heart disease","volume":"5","author":"Mattiazzi","year":"2014","journal-title":"Front Pharmacol"},{"key":"2019060508351800700_cvx113-B29","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.bbrc.2006.05.066","article-title":"CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels","volume":"345","author":"Gao","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"2019060508351800700_cvx113-B30","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1152\/physiolgenomics.00032.2010","article-title":"SERCA2a superinhibition by human phospholamban triggers electrical and structural remodeling in mouse hearts","volume":"43","author":"Wang","year":"2011","journal-title":"Physiol Genomics"},{"key":"2019060508351800700_cvx113-B31","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1161\/01.RES.0000145047.14691.db","article-title":"What causes sudden death in heart failure?","volume":"95","author":"Tomaselli","year":"2004","journal-title":"Circ Res"},{"key":"2019060508351800700_cvx113-B32","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1161\/CIRCULATIONAHA.105.534784","article-title":"Remodeling in cells from different regions of the reentrant circuit during ventricular tachycardia","volume":"112","author":"Baba","year":"2005","journal-title":"Circulation"},{"key":"2019060508351800700_cvx113-B33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev-physiol-021014-071622","article-title":"Mechanisms of ventricular arrhythmias: from molecular fluctuations to electrical turbulence","volume":"77","author":"Qu","year":"2015","journal-title":"Annu Rev Physiol"},{"key":"2019060508351800700_cvx113-B34","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pharmthera.2011.12.001","article-title":"Alternative strategies in arrhythmia therapy: evaluation of Na\/Ca exchange as an anti-arrhythmic target","volume":"134","author":"Antoons","year":"2012","journal-title":"Pharmacol Ther"},{"key":"2019060508351800700_cvx113-B35","first-page":"2510","article-title":"Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia","volume":"116","author":"Knollmann","year":"2006","journal-title":"J Clin Invest"},{"key":"2019060508351800700_cvx113-B36","doi-asserted-by":"crossref","first-page":"7636","DOI":"10.1073\/pnas.0902919106","article-title":"Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias","volume":"106","author":"Chopra","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2019060508351800700_cvx113-B37","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1161\/01.RES.0000125626.33738.E2","article-title":"Ca2+\/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor","volume":"94","author":"Wehrens","year":"2004","journal-title":"Circ Res"},{"key":"2019060508351800700_cvx113-B38","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1161\/01.RES.0000252828.17939.00","article-title":"Increasing ryanodine receptor open probability alone does not produce arrhythmogenic calcium waves: threshold sarcoplasmic reticulum calcium content is required","volume":"100","author":"Venetucci","year":"2007","journal-title":"Circ Res"},{"key":"2019060508351800700_cvx113-B39","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1161\/01.CIR.103.2.196","article-title":"Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia","volume":"103","author":"Priori","year":"2001","journal-title":"Circulation"},{"key":"2019060508351800700_cvx113-B40","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1161\/CIRCULATIONAHA.106.654699","article-title":"Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity","volume":"115","author":"Yuan","year":"2007","journal-title":"Circulation"},{"key":"2019060508351800700_cvx113-B41","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.yjmcc.2014.04.019","article-title":"The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca(2+) release due to an impaired ability to buffer store Ca(2+)","volume":"74","author":"Zhang","year":"2014","journal-title":"J Mol Cell Cardiol"},{"key":"2019060508351800700_cvx113-B42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1113\/jphysiol.2003.058917","article-title":"Interplay between SERCA and sarcolemmal Ca2+ efflux pathways controls spontaneous release of Ca2+ from the sarcoplasmic reticulum in rat ventricular myocytes","volume":"559","author":"O'Neill","year":"2004","journal-title":"J Physiol"},{"key":"2019060508351800700_cvx113-B43","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1073\/pnas.0913760107","article-title":"CaV1.2 beta-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations","volume":"107","author":"Koval","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2019060508351800700_cvx113-B44","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/FJC.0b013e3181a25078","article-title":"Calcium\/calmodulin-dependent kinase II regulation of cardiac ion channels","volume":"54","author":"Bers","year":"2009","journal-title":"J Cardiovasc Pharmacol"},{"key":"2019060508351800700_cvx113-B45","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1159\/000185546","article-title":"Reduced calmodulin expression accelerates transient outward potassium current inactivation in diabetic rat heart","volume":"22","author":"Gallego","year":"2008","journal-title":"Cell Physiol Biochem"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/113\/11\/1403\/28768657\/cvx113.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T08:35:33Z","timestamp":1559723733000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/113\/11\/1403\/3915002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,1]]},"references-count":45,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,7,1]]},"published-print":{"date-parts":[[2017,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvx113","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,9]]},"published":{"date-parts":[[2017,7,1]]}}}