{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:07:27Z","timestamp":1792678047976,"version":"4.5.0"},"reference-count":187,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"DOI":"10.1093\/cvr\/cvx159","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T23:15:15Z","timestamp":1502320515000},"page":"1441-1452","source":"Crossref","is-referenced-by-count":77,"title":["Role of cardiac inflammation in right ventricular failure"],"prefix":"10.1093","volume":"113","author":[{"given":"Xiao-Qing","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Abbate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harm-Jan","family":"Bogaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,8,14]]},"reference":[{"key":"key\n\t\t\t\t20171012014552_cvx159-B1","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1093\/eurheartj\/ehl477","article-title":"Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension","volume":"28","year":"2007","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1165\/rcmb.2008-0271OC","article-title":"Resistin-like molecule-beta in scleroderma-associated pulmonary hypertension","volume":"41","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B3","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1164\/rccm.201105-0927OC","article-title":"Pulmonary lymphoid neogenesis in idiopathic pulmonary arterial hypertension","volume":"185","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B4","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1183\/13993003.01448-2015","article-title":"Role of interleukin-1 receptor 1\/MyD88 signalling in the development and progression of pulmonary hypertension","volume":"48","year":"2016","journal-title":"Eur Respir J"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1161\/CIRCRESAHA.113.301141","article-title":"Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension","volume":"115","year":"2014","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B6","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1080\/14779072.2016.1180976","article-title":"Challenges and opportunities in treating inflammation associated with pulmonary hypertension","volume":"14","year":"2016","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B7","first-page":"450","article-title":"Pulmonary embolism causes endomyocarditis in the human heart","volume":"94","year":"2008","journal-title":"Heart"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0379-0738(03)00138-5","article-title":"Right ventricular damage due to pulmonary embolism: examination of the number of infiltrating macrophages","volume":"134","year":"2003","journal-title":"Forensic Sci Int"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B9","doi-asserted-by":"crossref","first-page":"1.","DOI":"10.1155\/2010\/604615","article-title":"Characteristics of interstitial fibrosis and inflammatory cell infiltration in right ventricles of systemic sclerosis-associated pulmonary arterial hypertension","volume":"2010","year":"2010","journal-title":"Int J Rheumatol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B10","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/eurjhf\/hfq066","article-title":"Early inflammatory response during the development of right ventricular heart failure in a rat model","volume":"12","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B11","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/eurheartj\/ehr111","article-title":"Prolonged overcirculation-induced pulmonary arterial hypertension as a cause of right ventricular failure","volume":"33","year":"2012","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","article-title":"The inflammatory response in myocardial injury, repair, and remodelling","volume":"11","year":"2014","journal-title":"Nat Rev Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B13","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1161\/01.RES.0000043825.01705.1B","article-title":"Inflammatory mediators and the failing heart: past, present, and the foreseeable future","volume":"91","year":"2002","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11897-014-0231-7","article-title":"Targeting interleukin-1 in heart failure and inflammatory heart disease","volume":"12","year":"2015","journal-title":"Curr Heart Fail Rep"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B15","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S1071-9164(96)80047-9","article-title":"Basic mechanisms in heart failure: the cytokine hypothesis","volume":"2","year":"1996","journal-title":"J Card Fail"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B16","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/S0735-1097(96)00268-9","article-title":"Circulating levels of cytokines and their endogenous modulators in patients with mild to severe congestive heart failure due to coronary artery disease or hypertension","volume":"28","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/01.RES.81.2.187","article-title":"Hemodynamic regulation of tumor necrosis factor-alpha gene and protein expression in adult feline myocardium","volume":"81","year":"1997","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B18","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1161\/01.RES.81.5.664","article-title":"Increased expression of interleukin-1 beta and monocyte chemotactic and activating factor\/monocyte chemoattractant protein-1 in the hypertrophied and failing heart with pressure overload","volume":"81","year":"1997","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B19","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1096\/fasebj.13.10.1137","article-title":"Is NF-kappaB the sensor of oxidative stress?","volume":"13","year":"1999","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B20","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1161\/CIRCULATIONAHA.106.643585","article-title":"Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state","volume":"115","year":"2007","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1161\/CIRCULATIONAHA.108.829713","article-title":"Opposite effects of training in rats with stable and progressive pulmonary hypertension","volume":"120","year":"2009","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B22","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3109\/10408449209146311","article-title":"Mechanisms and pathology of monocrotaline pulmonary toxicity","volume":"22","year":"1992","journal-title":"Crit Rev Toxicol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1152\/japplphysiol.01509.2005","article-title":"Decreased left ventricular function, myocarditis, and coronary arteriolar medial thickening following monocrotaline administration in adult rats","volume":"103","year":"2007","journal-title":"J Appl Physiol (1985)"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B24","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1161\/CIRCRESAHA.115.306919","article-title":"FoxO4 promotes early inflammatory response upon myocardial infarction via endothelial Arg1","volume":"117","year":"2015","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.phrs.2008.06.007","article-title":"The immune system and cardiac repair","volume":"58","year":"2008","journal-title":"Pharmacol Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B26","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.cardiores.2006.10.026","article-title":"Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: effect on myocardial contractility","volume":"73","year":"2007","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B27","doi-asserted-by":"crossref","first-page":"H2238","DOI":"10.1152\/ajpheart.00740.2007","article-title":"HSP60 in heart failure: abnormal distribution and role in cardiac myocyte apoptosis","volume":"293","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B28","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/01.CIR.75.5.996","article-title":"Hemodynamically important right ventricular infarction: follow-up evaluation of right ventricular systolic function at rest and during exercise with radionuclide ventriculography and respiratory gas exchange","volume":"75","year":"1987","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B29","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1203\/pdr.0b013e31805365a6","article-title":"Microvascular development in porcine right and left ventricular walls","volume":"61","year":"2007","journal-title":"Pediatr Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B30","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1161\/CIRCULATIONAHA.109.883843","article-title":"Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure","volume":"120","year":"2009","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B31","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cjca.2015.01.023","article-title":"Right ventricular adaptation and failure in pulmonary arterial hypertension","volume":"31","year":"2015","journal-title":"Can J Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B32","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1136\/ard.62.9.890","article-title":"Detection of early impairment of coronary flow reserve in patients with systemic sclerosis","volume":"62","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B33","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1161\/CIRCULATIONAHA.109.933762","article-title":"Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension","volume":"122","year":"2010","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B34","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1183\/09031936.00145708","article-title":"Impaired cardiac autonomic control relates to disease severity in pulmonary hypertension","volume":"34","year":"2009","journal-title":"Eur Respir J"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B35","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1164\/rccm.200912-1856OC","article-title":"Prognostic significance of sympathetic nervous system activation in pulmonary arterial hypertension","volume":"181","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B36","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1161\/01.CIR.101.20.2338","article-title":"Chronic beta-adrenergic stimulation induces myocardial proinflammatory cytokine expression","volume":"101","year":"2000","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B37","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1161\/01.CIR.0000015603.84788.47","article-title":"Angiotensin II induces tumor necrosis factor biosynthesis in the adult mammalian heart through a protein kinase C-dependent pathway","volume":"105","year":"2002","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B38","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1161\/01.CIR.101.17.2103","article-title":"beta-adrenergic blockade in developing heart failure: effects on myocardial inflammatory cytokines, nitric oxide, and remodeling","volume":"101","year":"2000","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1161\/CIRCHEARTFAILURE.111.964494","article-title":"Bisoprolol delays progression towards right heart failure in experimental pulmonary hypertension","volume":"5","year":"2012","journal-title":"Circ Heart Fail"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B40","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S0735-1097(02)02860-7","article-title":"Cardiac fibrosis occurs early and involves endothelin and AT-1 receptors in hypertension due to endogenous angiotensin II","volume":"41","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B41","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cardiores.2003.11.026","article-title":"The endothelin system in pulmonary arterial hypertension","volume":"61","year":"2004","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B42","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0006-291X(90)91948-R","article-title":"Interleukin 1 increases the production of endothelin-1 by cultured endothelial cells","volume":"166","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B43","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1097\/00005344-199506263-00018","article-title":"Cytokine regulation of endothelin-1 release from bovine aortic endothelial cells","volume":"26","year":"1995","journal-title":"J Cardiovasc Pharmacol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B44","first-page":"R1064","article-title":"Cardiovascular, renal, and endocrine responses to intravenous endothelin in conscious dogs","volume":"255","year":"1988","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B45","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1172\/JCI113876","article-title":"Integrated cardiac, renal, and endocrine actions of endothelin","volume":"83","year":"1989","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B46","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1161\/01.CIR.0000105701.98663.D4","article-title":"Conditional cardiac overexpression of endothelin-1 induces inflammation and dilated cardiomyopathy in mice","volume":"109","year":"2004","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B47","doi-asserted-by":"crossref","first-page":"22274","DOI":"10.3390\/ijms141122274","article-title":"The NO\/ONOO-cycle as the central cause of heart failure","volume":"14","year":"2013","journal-title":"Int J Mol Sci"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B48","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/S0735-1097(00)00526-X","article-title":"Cytokine-induced nitric oxide production inhibits mitochondrial energy production and impairs contractile function in rat cardiac myocytes","volume":"35","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B49","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1161\/01.CIR.90.1.375","article-title":"Induction of nitric oxide synthase gene by interleukin-1 beta in cultured rat cardiocytes","volume":"90","year":"1994","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B50","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1097\/QAD.0000000000000426","article-title":"Myocardial and microvascular inflammation\/infection in patients with HIV-associated pulmonary artery hypertension","volume":"28","year":"2014","journal-title":"Aids"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B51","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1136\/ard.2006.066068","article-title":"Changes in causes of death in systemic sclerosis, 1972-2002","volume":"66","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B52","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1161\/CIRCHEARTFAILURE.112.000008","article-title":"Right ventricular dysfunction in systemic sclerosis-associated pulmonary arterial hypertension","volume":"6","year":"2013","journal-title":"Circ Heart Fail"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B53","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1183\/09031936.00135407","article-title":"Right ventricular contractility in systemic sclerosis-associated and idiopathic pulmonary arterial hypertension","volume":"31","year":"2008","journal-title":"Eur Respir J"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B54","doi-asserted-by":"crossref","first-page":"L1013","DOI":"10.1152\/ajplung.00217.2009","article-title":"Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure","volume":"297","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B55","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1161\/01.CIR.103.2.314","article-title":"Effectiveness of a nonselective ET(A\/B) and a selective ET(A) antagonist in rats with monocrotaline-induced pulmonary hypertension","volume":"103","year":"2001","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B56","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1096\/fj.00-0343com","article-title":"Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension","volume":"15","year":"2001","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B57","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ejphar.2014.07.026","article-title":"Role of oxidative stress, inflammation, nitric oxide and transforming growth factor-beta in the protective effect of diosgenin in monocrotaline-induced pulmonary hypertension in rats","volume":"740","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B58","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ejps.2016.11.009","article-title":"Activation of GPER ameliorates experimental pulmonary hypertension in male rats","volume":"97","year":"2017","journal-title":"Eur J Pharm Sci"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B59","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.ijcard.2015.11.066","article-title":"Exercise preconditioning prevents MCT-induced right ventricle remodeling through the regulation of TNF superfamily cytokines","volume":"203","year":"2016","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B60","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.3109\/21691401.2015.1111235","article-title":"Curcumin nanoparticles attenuate cardiac remodeling due to pulmonary arterial hypertension","volume":"44","year":"2016","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B61","doi-asserted-by":"crossref","first-page":"57.","DOI":"10.1007\/s00395-015-0514-5","article-title":"Cardioprotective effects of early and late aerobic exercise training in experimental pulmonary arterial hypertension","volume":"110","year":"2015","journal-title":"Basic Res Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B62","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s10557-016-6702-1","article-title":"Evaluation and treatment of endoplasmic reticulum (ER) stress in right ventricular dysfunction during monocrotaline-induced rat pulmonary arterial hypertension","volume":"30","year":"2016","journal-title":"Cardiovasc Drugs Ther"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B63","doi-asserted-by":"crossref","first-page":"R197","DOI":"10.1152\/ajpregu.00358.2016","article-title":"High-intensity interval training, but not continuous training, reverses right ventricular hypertrophy and dysfunction in a rat model of pulmonary hypertension","volume":"312","year":"2017","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B64","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1152\/japplphysiol.01350.2011","article-title":"Chemokines regulate small leucine-rich proteoglycans in the extracellular matrix of the pressure-overloaded right ventricle","volume":"112","year":"2012","journal-title":"J Appl Physiol (1985)"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B65","article-title":"Deletion of Fn14 receptor protects from right heart fibrosis and dysfunction","volume":"108","year":"2013","journal-title":"Basic Res Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B66","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s00392-011-0318-z","article-title":"Soluble TWEAK predicts hemodynamic impairment and functional capacity in patients with pulmonary arterial hypertension","volume":"100","year":"2011","journal-title":"Clin Res Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B67","doi-asserted-by":"crossref","first-page":"S198.","DOI":"10.1016\/j.cardfail.2016.07.244","article-title":"Inhibition of nuclear factor-kappaB-mediated inflammation reverses fibrosis and improves RV function in rats with pulmonary artery banding","volume":"22","year":"2016","journal-title":"J Card Fail"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B68","doi-asserted-by":"crossref","first-page":"e69470.","DOI":"10.1371\/journal.pone.0069470","article-title":"Heme oxygenase-1 and inflammation in experimental right ventricular failure on prolonged overcirculation-induced pulmonary hypertension","volume":"8","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B69","doi-asserted-by":"crossref","first-page":"L873","DOI":"10.1152\/ajplung.00006.2015","article-title":"Estradiol improves right ventricular function in rats with severe angioproliferative pulmonary hypertension: effects of endogenous and exogenous sex hormones","volume":"308","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B70","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.jtcvs.2009.11.028","article-title":"Right ventricular failure secondary to chronic overload in congenital heart disease: an experimental model for therapeutic innovation","volume":"139","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B71","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0002-8703(97)70085-1","article-title":"Echocardiography Doppler in pulmonary embolism: right ventricular dysfunction as a predictor of mortality rate","volume":"134","year":"1997","journal-title":"Am Heart J"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B72","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0140-6736(93)90274-K","article-title":"Alteplase versus heparin in acute pulmonary embolism: randomised trial assessing right-ventricular function and pulmonary perfusion","volume":"341","year":"1993","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B73","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1161\/01.CIR.101.24.2817","article-title":"Short-term clinical outcome of patients with acute pulmonary embolism, normal blood pressure, and echocardiographic right ventricular dysfunction","volume":"101","year":"2000","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B74","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0379-0738(00)00367-4","article-title":"Two cases of right ventricular ischemic injury due to massive pulmonary embolism","volume":"116","year":"2001","journal-title":"Forensic Sci Int"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B75","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.yjmcc.2006.05.011","article-title":"Cardiac inflammation contributes to right ventricular dysfunction following experimental pulmonary embolism in rats","volume":"41","year":"2006","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B76","doi-asserted-by":"crossref","first-page":"L1072","DOI":"10.1152\/ajplung.00283.2002","article-title":"Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat","volume":"284","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B77","doi-asserted-by":"crossref","first-page":"7820","DOI":"10.4049\/jimmunol.179.11.7820","article-title":"Inhibition of CINC-1 decreases right ventricular damage caused by experimental pulmonary embolism in rats","volume":"179","year":"2007","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B78","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.healun.2015.05.004","article-title":"Myocardial inflammation in experimental acute right ventricular failure: effects of prostacyclin therapy","volume":"34","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B79","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1097\/CCM.0b013e3181de8bd3","article-title":"Activation of apoptotic pathways in experimental acute afterload-induced right ventricular failure","volume":"38","year":"2010","journal-title":"Crit Care Med"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B80","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/icvts\/ivt547","article-title":"A modified Glenn shunt reduces venous congestion during acute right ventricular failure due to pulmonary banding: a randomized experimental study","volume":"18","year":"2014","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B81","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.healun.2016.05.014","article-title":"Roles of inflammation and apoptosis in experimental brain death-induced right ventricular failure","volume":"35","year":"2016","journal-title":"J Heart Lung Transplant"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B82","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1161\/01.CIR.102.3.326","article-title":"Tumor necrosis factor-alpha is expressed in donor heart and predicts right ventricular failure after human heart transplantation","volume":"102","year":"2000","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B83","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1083\/jcb.152.5.857","article-title":"alpha(4)-integrin mediates neutrophil-induced free radical injury to cardiac myocytes","volume":"152","year":"2001","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B84","first-page":"H253","article-title":"Activated macrophages decrease rat cardiac myocyte contractility: importance of ICAM-1-dependent adhesion","volume":"277","year":"1999","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B85","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1172\/JCI115424","article-title":"Adherence of neutrophils to canine cardiac myocytes in vitro is dependent on intercellular adhesion molecule-1","volume":"88","year":"1991","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B86","doi-asserted-by":"crossref","first-page":"H1013","DOI":"10.1152\/ajpheart.01177.2003","article-title":"Novel regulatory mechanism of cardiomyocyte contractility involving ICAM-1 and the cytoskeleton","volume":"287","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B87","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cardiores.2006.06.029","article-title":"Cardiac ICAM-1 mediates leukocyte-dependent decreased ventricular contractility in endotoxemic mice","volume":"72","year":"2006","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B88","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1164\/ajrccm.155.6.9196105","article-title":"Leukocytes and decreased left-ventricular contractility during endotoxemia in rabbits","volume":"155","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B89","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/CIRCHEARTFAILURE.115.002225","article-title":"Left ventricular T-cell recruitment contributes to the pathogenesis of heart failure","volume":"8","year":"2015","journal-title":"Circ Heart Fail"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B90","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1161\/CIRCULATIONAHA.113.007101","article-title":"CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload","volume":"129","year":"2014","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B91","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1007\/s004240100612","article-title":"Endotoxin and cytokines alter contractile protein expression in cardiac myocytes in vivo","volume":"442","year":"2001","journal-title":"Pflugers Arch"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B92","doi-asserted-by":"crossref","first-page":"H1813","DOI":"10.1152\/ajpheart.00036.2004","article-title":"In vivo TNF-alpha inhibition ameliorates cardiac mitochondrial dysfunction, oxidative stress, and apoptosis in experimental heart failure","volume":"287","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B93","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1161\/CIRCRESAHA.115.303910","article-title":"A miR-208-Mef2 axis drives the decompensation of right ventricular function in pulmonary hypertension","volume":"116","year":"2015","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B94","first-page":"H141","article-title":"Suppression of beta-adrenergic responsiveness of L-type Ca2+ current by IL-1beta in rat ventricular myocytes","volume":"276","year":"1999","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B95","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s00424-002-0921-y","article-title":"Chronic exposure to interleukin 1beta induces a delayed and reversible alteration in excitation-contraction coupling of cultured cardiomyocytes","volume":"445","year":"2002","journal-title":"Pflugers Arch"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B96","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1476-5381.1995.tb14901.x","article-title":"The role of nitric oxide in cardiac depression induced by interleukin-1 beta and tumour necrosis factor-alpha","volume":"114","year":"1995","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B97","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1161\/01.RES.81.4.493","article-title":"Interleukin-1 beta inhibits phospholamban gene expression in cultured cardiomyocytes","volume":"81","year":"1997","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B98","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s003950050007","article-title":"Leukemia Inhibitory Factor and Interleukin-6 downregulate sarcoplasmic reticulum Ca2+ ATPase (SERCA2) in cardiac myocytes","volume":"95","year":"2000","journal-title":"Basic Res Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B99","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/01.CIR.0000156469.96135.0D","article-title":"Interleukin-6 causes myocardial failure and skeletal muscle atrophy in rats","volume":"111","year":"2005","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B100","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1172\/JCI30634","article-title":"IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system","volume":"117","year":"2007","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B101","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1161\/01.CIR.0000038705.69871.D9","article-title":"Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction","volume":"106","year":"2002","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B102","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1161\/CIRCHEARTFAILURE.108.833707","article-title":"Serum levels of the interleukin-1 receptor family member ST2, cardiac structure and function, and long-term mortality in patients with acute dyspnea","volume":"2","year":"2009","journal-title":"Circ Heart Fail"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B103","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1161\/CIRCHEARTFAILURE.110.958223","article-title":"High-sensitivity ST2 for prediction of adverse outcomes in chronic heart failure","volume":"4","year":"2011","journal-title":"Circ Heart Fail"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B104","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.ijcard.2012.12.031","article-title":"Serum soluble ST2 and interleukin-33 levels in patients with pulmonary arterial hypertension","volume":"168","year":"2013","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B105","doi-asserted-by":"crossref","first-page":"e004382.","DOI":"10.1161\/JAHA.116.004382","article-title":"Suppression of tumorigenicity 2 in heart failure with preserved ejection fraction","volume":"6","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B106","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1161\/CIRCULATIONAHA.112.001357","article-title":"Macrophage microRNA-155 promotes cardiac hypertrophy and failure","volume":"128","year":"2013","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B107","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ijcard.2015.06.099","article-title":"ATF3-dependent cross-talk between cardiomyocytes and macrophages promotes cardiac maladaptive remodeling","volume":"198","year":"2015","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B108","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1172\/JCI118095","article-title":"Interleukin-1 beta modulates the growth and phenotype of neonatal rat cardiac myocytes","volume":"96","year":"1995","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B109","doi-asserted-by":"crossref","first-page":"9535","DOI":"10.1074\/jbc.271.16.9535","article-title":"Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130\/leukemia inhibitory factor receptor-dependent pathways","volume":"271","year":"1996","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B110","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/jmcc.2001.1505","article-title":"Involvement of reactive oxygen species-mediated NF-kappa B activation in TNF-alpha-induced cardiomyocyte hypertrophy","volume":"34","year":"2002","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B111","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1161\/01.CIR.95.5.1247","article-title":"Tumor necrosis factor-alpha provokes a hypertrophic growth response in adult cardiac myocytes","volume":"95","year":"1997","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B112","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1161\/01.CIR.97.14.1382","article-title":"Pathophysiologically relevant concentrations of tumor necrosis factor-alpha promote progressive left ventricular dysfunction and remodeling in rats","volume":"97","year":"1998","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B113","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cyto.2013.05.009","article-title":"TWEAK\/Fn14 axis is a positive regulator of cardiac hypertrophy","volume":"64","year":"2013","journal-title":"Cytokine"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B114","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1161\/CIRCULATIONAHA.108.837286","article-title":"A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure","volume":"119","year":"2009","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B115","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.cyto.2006.04.010","article-title":"TNF-alpha-induced impairment of mitochondrial integrity and apoptosis mediated by caspase-8 in adult ventricular myocytes","volume":"34","year":"2006","journal-title":"Cytokine"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B116","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1172\/JCI119114","article-title":"Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death","volume":"98","year":"1996","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B117","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s13105-014-0345-0","article-title":"Tumor necrosis factor-alpha-induced nuclear factor-kappaB activation in human cardiomyocytes is mediated by NADPH oxidase","volume":"70","year":"2014","journal-title":"J Physiol Biochem"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B118","doi-asserted-by":"crossref","first-page":"C679","DOI":"10.1152\/ajpcell.00351.2009","article-title":"Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner","volume":"298","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B119","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S0008-6363(02)00719-8","article-title":"Matrix metalloproteinase-2 mediates cytokine-induced myocardial contractile dysfunction","volume":"57","year":"2003","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B120","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1161\/CIRCULATIONAHA.108.802918","article-title":"Divergent tumor necrosis factor receptor-related remodeling responses in heart failure: role of nuclear factor-kappaB and inflammatory activation","volume":"119","year":"2009","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B121","doi-asserted-by":"crossref","first-page":"8231","DOI":"10.1007\/s11033-012-1671-3","article-title":"TWEAK\/Fn14 promotes the proliferation and collagen synthesis of rat cardiac fibroblasts via the NF-small ka, CyrillicB pathway","volume":"39","year":"2012","journal-title":"Mol Biol Rep"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B122","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00418-008-0541-5","article-title":"Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload","volume":"131","year":"2009","journal-title":"Histochem Cell Biol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B123","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0022-2828(95)90359-3","article-title":"Temporal differences in fibroblast proliferation and phenotype expression in response to chronic administration of angiotensin II or aldosterone","volume":"27","year":"1995","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B124","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.4049\/jimmunol.1301522","article-title":"The requirement of CD8+ T cells to initiate and augment acute cardiac inflammatory response to high blood pressure","volume":"192","year":"2014","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B125","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.ijcard.2016.11.159","article-title":"The cardiac maladaptive ATF3-dependent cross-talk between cardiomyocytes and macrophages is mediated by the IFNgamma-CXCL10-CXCR3 axis","volume":"228","year":"2017","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B126","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1038\/sj.gt.3302348","article-title":"Adeno-associated virus vector-mediated interleukin-10 gene transfer inhibits atherosclerosis in apolipoprotein E-deficient mice","volume":"11","year":"2004","journal-title":"Gene Ther"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B127","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1161\/CIRCRESAHA.107.153023","article-title":"Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats","volume":"101","year":"2007","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B128","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1146\/annurev.pharmtox.45.120403.095802","article-title":"The cardiac fibroblast: therapeutic target in myocardial remodeling and failure","volume":"45","year":"2005","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B129","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cardiores.2007.06.003","article-title":"Mechanism of TNFalpha-induced IL-1alpha, IL-1beta and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinediones","volume":"76","year":"2007","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B130","doi-asserted-by":"crossref","first-page":"H1117","DOI":"10.1152\/ajpheart.00372.2009","article-title":"Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts","volume":"297","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B131","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1006\/jmcc.1999.1007","article-title":"Tumor necrosis factor-alpha at acute myocardial infarction in rats and effects on cardiac fibroblasts","volume":"31","year":"1999","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B132","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1161\/01.RES.0000047090.08299.D5","article-title":"Tumor necrosis factor-alpha-induced AT1 receptor upregulation enhances angiotensin II-mediated cardiac fibroblast responses that favor fibrosis","volume":"91","year":"2002","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B133","doi-asserted-by":"crossref","first-page":"25796","DOI":"10.1074\/jbc.273.40.25796","article-title":"Cardiac fibroblasts arrest at the G1\/S restriction point in response to interleukin (IL)-1beta. Evidence for IL-1beta-induced hypophosphorylation of the retinoblastoma protein","volume":"273","year":"1998","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B134","first-page":"H250","article-title":"Cytokine expression increases in nonmyocytes from rats with postinfarction heart failure","volume":"275","year":"1998","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B135","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1161\/CIRCRESAHA.109.216101","article-title":"Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction","volume":"107","year":"2010","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B136","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1161\/CIRCHEARTFAILURE.109.931451","article-title":"Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction","volume":"4","year":"2011","journal-title":"Circ Heart Fail"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B137","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1073\/pnas.1015623108","article-title":"Modulation of cardiac macrophages by phosphatidylserine-presenting liposomes improves infarct repair","volume":"108","year":"2011","journal-title":"Proc Natl Acad Sci Usa USA"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B138","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s00109-013-1064-7","article-title":"Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension","volume":"91","year":"2013","journal-title":"J Mol Med (Berl)"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B139","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00109-009-0524-6","article-title":"The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle","volume":"88","year":"2010","journal-title":"J Mol Med (Berl)"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B140","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1164\/rccm.201402-0383OC","article-title":"Impaired angiogenesis and peripheral muscle microcirculation loss contribute to exercise intolerance in pulmonary arterial hypertension","volume":"190","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B141","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1136\/thx.2004.029082","article-title":"Anti-endothelial cell antibodies in idiopathic and systemic sclerosis associated pulmonary arterial hypertension","volume":"60","year":"2005","journal-title":"Thorax"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B142","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1183\/09031936.00164209","article-title":"Prevalence of anti-endothelial cell antibodies in idiopathic pulmonary arterial hypertension","volume":"35","year":"2010","journal-title":"Eur Respir J"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B143","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1183\/09031936.00181410","article-title":"Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma","volume":"39","year":"2012","journal-title":"Eur Respir J"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B144","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1196\/annals.1422.017","article-title":"Induction of endothelial cell apoptosis by IgG antibodies from SLE patients with nephropathy: a potential role for anti-endothelial cell antibodies","volume":"1108","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B145","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1136\/ard.2005.035295","article-title":"Antiendothelial cell antibodies in vasculitis and connective tissue disease","volume":"65","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B146","doi-asserted-by":"crossref","first-page":"e0163085.","DOI":"10.1371\/journal.pone.0163085","article-title":"The level of IgA antibodies to endothelial cells correlates with histological evidence of disease activity in patients with lupus nephritis","volume":"11","year":"2016","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B147","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3109\/08916934.2013.812080","article-title":"Functional implications of IgG anti-endothelial cell antibodies in pulmonary arterial hypertension","volume":"46","year":"2013","journal-title":"Autoimmunity"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B148","first-page":"462","article-title":"Antiendothelial cell antibodies in scleroderma correlate with severe digital ischemia and pulmonary arterial hypertension","volume":"25","year":"1998","journal-title":"J Rheumatol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B149","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.lfs.2012.10.028","article-title":"Molecular and metabolic mechanisms of cardiac dysfunction in diabetes","volume":"92","year":"2013","journal-title":"Life Sci"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B150","doi-asserted-by":"crossref","first-page":"H1850","DOI":"10.1152\/ajpheart.01199.2008","article-title":"Feed-forward signaling of TNF-alpha and NF-kappaB via IKK-beta pathway contributes to insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice","volume":"296","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B151","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.2337\/db10-0704","article-title":"Activation of peroxisome proliferator-activated receptor-beta\/-delta (PPAR-beta\/-delta) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes","volume":"60","year":"2011","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B152","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF03347084","article-title":"PPARalpha agonist prevented the apoptosis induced by glucose and fatty acid in neonatal cardiomyocytes","volume":"34","year":"2011","journal-title":"J Endocrinol Invest"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B153","doi-asserted-by":"crossref","first-page":"8.","DOI":"10.1186\/1475-2840-8-8","article-title":"The signal transduction pathway of PKC\/NF-kappa B\/c-fos may be involved in the influence of high glucose on the cardiomyocytes of neonatal rats","volume":"8","year":"2009","journal-title":"Cardiovasc Diabetol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B154","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/cvr\/cvx012","article-title":"Inflammation and metabolic cardiomyopathy","volume":"113","year":"2017","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B155","first-page":"847827.","article-title":"Activation of toll-like receptors and inflammasome complexes in the diabetic cardiomyopathy-associated inflammation","volume":"2014","year":"2014","journal-title":"Int J Endocrinol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B156","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.2337\/db08-1361","article-title":"Nutrient stress activates inflammation and reduces glucose metabolism by suppressing AMP-activated protein kinase in the heart","volume":"58","year":"2009","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B157","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1161\/CIRCULATIONAHA.106.663120","article-title":"Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation","volume":"115","year":"2007","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B158","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1183\/09031936.00030312","article-title":"A potential role for insulin resistance in experimental pulmonary hypertension","volume":"41","year":"2013","journal-title":"Eur Respir J"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B159","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1476-5381.2009.00445.x","article-title":"Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension","volume":"158","year":"2009","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B160","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1086\/679705","article-title":"Impact of diabetes in patients with pulmonary hypertension","volume":"5","year":"2015","journal-title":"Pulm Circ"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B161","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1086\/675994","article-title":"Impact of diabetes on survival and right ventricular compensation in pulmonary arterial hypertension","volume":"4","year":"2014","journal-title":"Pulm Circ"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B162","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF02066486","article-title":"Quantitative approach to the histopathology of the biopsied right ventricular myocardium in patients with diabetes mellitus","volume":"1","year":"1985","journal-title":"Heart Vessels"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B163","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1513\/AnnalsATS.201608-605OC","article-title":"Abnormal glucose metabolism and high-energy expenditure in idiopathic pulmonary arterial hypertension","volume":"14","year":"2017","journal-title":"Ann Am Thorac Soc"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B164","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/eji.201141550","article-title":"A clinical perspective of IL-1beta as the gatekeeper of inflammation","volume":"41","year":"2011","journal-title":"Eur J Immunol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B165","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10741-006-9196-2","article-title":"Systemic inflammation in heart failure\u2014the whys and wherefores","volume":"11","year":"2006","journal-title":"Heart Fail Rev"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B166","doi-asserted-by":"crossref","first-page":"e33438.","DOI":"10.1371\/journal.pone.0033438","article-title":"Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure","volume":"7","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B167","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.amjcard.2013.08.047","article-title":"Effects of interleukin-1 blockade with anakinra on aerobic exercise capacity in patients with heart failure and preserved ejection fraction (from the D-HART pilot study)","volume":"113","year":"2014","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B168","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/FJC.0000000000000378","article-title":"Interleukin-1 blockade in acute decompensated heart failure: a randomized, double-blinded, placebo-controlled pilot study","volume":"67","year":"2016","journal-title":"J Cardiovasc Pharmacol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B169","article-title":"Interleukin-1 blockade in recently decompensated systolic heart failure: the REcently Decompensated Heart failure Anakinra Response Trial (REDHART)","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B170","first-page":"1","article-title":"Interleukin-1 blockade in recently decompensated systolic heart failure: study design of the recently decompensated heart failure anakinra response trial (RED-HART)","volume":"2","year":"2015","journal-title":"J Clin Trial Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B171","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1161\/CIRCULATIONAHA.107.759191","article-title":"Tumor necrosis factor-alpha and mortality in heart failure: a community study","volume":"118","year":"2008","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B172","doi-asserted-by":"crossref","first-page":"12746","DOI":"10.1073\/pnas.97.23.12746","article-title":"Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor alpha can be modulated by anti-tumor necrosis factor alpha therapy","volume":"97","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B173","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1161\/01.CIR.0000077913.60364.D2","article-title":"Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-alpha, in patients with moderate-to-severe heart failure: results of the anti-TNF Therapy Against Congestive Heart Failure (ATTACH) trial","volume":"107","author":"Anti TNFTACHFI","year":"2003","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B174","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1161\/01.CIR.0000124490.27666.B2","article-title":"Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)","volume":"109","year":"2004","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B175","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.jacc.2008.11.046","article-title":"The immune system and chronic heart failure: is the heart in control?","volume":"53","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B176","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1084\/jem.175.2.323","article-title":"Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors","volume":"175","year":"1992","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B177","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1006\/cyto.1995.0091","article-title":"Functional comparisons of different tumour necrosis factor receptor\/IgG fusion proteins","volume":"7","year":"1995","journal-title":"Cytokine"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B178","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/S0003-4975(99)00988-1","article-title":"Bosentan prevents hypoxia-reoxygenation-induced pulmonary hypertension and improves pulmonary function","volume":"68","year":"1999","journal-title":"Ann Thorac Surg"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B179","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cardfail.2004.05.006","article-title":"Clinical effects of endothelin receptor antagonism with bosentan in patients with severe chronic heart failure: results of a pilot study","volume":"11","year":"2005","journal-title":"J Card Fail"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B180","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1164\/rccm.200410-1411OC","article-title":"Sildenafil versus Endothelin Receptor Antagonist for Pulmonary Hypertension (SERAPH) study","volume":"171","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B181","doi-asserted-by":"crossref","first-page":"374.","DOI":"10.1038\/nrcardio.2015.6-c1","article-title":"ACE2-angiotensin-(1-7)-Mas axis might be a promising therapeutic target for pulmonary arterial hypertension","volume":"12","year":"2015","journal-title":"Nat Rev Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B182","doi-asserted-by":"crossref","first-page":"H1560","DOI":"10.1152\/ajpheart.00941.2004","article-title":"Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor","volume":"289","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B183","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1113\/expphysiol.2011.056994","article-title":"Lentivirus-mediated overexpression of angiotensin-(1-7) attenuated ischaemia-induced cardiac pathophysiology","volume":"96","year":"2011","journal-title":"Exp Physiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B184","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1161\/CIRCRESAHA.108.184911","article-title":"Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart","volume":"103","year":"2008","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B185","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1161\/01.CIR.0000013847.07035.B9","article-title":"Angiotensin-(1-7) attenuates the development of heart failure after myocardial infarction in rats","volume":"105","year":"2002","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B186","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.ijcard.2014.08.021","article-title":"Decreased levels of serum Angiotensin-(1-7) in patients with pulmonary arterial hypertension due to congenital heart disease","volume":"176","year":"2014","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20171012014552_cvx159-B187","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1164\/rccm.200912-1840OC","article-title":"The angiotensin-converting enzyme 2\/angiogenesis-(1-7)\/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension","volume":"182","year":"2010","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/113\/12\/1441\/20139135\/cvx159.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T19:55:55Z","timestamp":1659297355000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article\/113\/12\/1441\/4082335\/Role-of-cardiac-inflammation-in-right-ventricular"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,14]]},"references-count":187,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,8,14]]},"published-print":{"date-parts":[[2017,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvx159","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,10]]},"published":{"date-parts":[[2017,8,14]]}}}