{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:59:39Z","timestamp":1785869979979,"version":"3.56.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"13","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL093490"],"award-info":[{"award-number":["HL093490"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL119095"],"award-info":[{"award-number":["HL119095"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1-HL55438, PO1-HL094291, and RO1-108175"],"award-info":[{"award-number":["RO1-HL55438, PO1-HL094291, and RO1-108175"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"DOI":"10.1093\/cvr\/cvx167","type":"journal-article","created":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T15:11:01Z","timestamp":1503933061000},"page":"1688-1699","source":"Crossref","is-referenced-by-count":18,"title":["Triggered intracellular calcium waves in dog and human left atrial myocytes from normal and failing hearts"],"prefix":"10.1093","volume":"113","author":[{"given":"Gary L.","family":"Aistrup","sequence":"first","affiliation":[{"name":"Department of Medicine (Cardiology) and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology) and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Grubb","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology) and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology) and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Toren","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology) and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manvinder","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology) and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Kunamalla","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology) and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Marszalec","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology) and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tej","family":"Motiwala","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology) and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology) and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Yamakawa","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology) and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satya","family":"Yerrabolu","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology) and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Alvarado","sequence":"additional","affiliation":[{"name":"The Center for Arrhythmia Research, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector H.","family":"Valdivia","sequence":"additional","affiliation":[{"name":"The Center for Arrhythmia Research, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Masonic Medical Research Laboratory, Utica, NY 13501, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohannes","family":"Shiferaw","sequence":"additional","affiliation":[{"name":"Department of Physics, California State University Northridge, Northridge, CA 91330, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Andrew","family":"Wasserstrom","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology) and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"key\n\t\t\t\t20180328140635_cvx167-B1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1152\/physrev.00011.2006","article-title":"Calcium and arrhythmogenesis","volume":"87","author":"Ter Keurs","year":"2007","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B2","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1016\/j.hrthm.2011.06.012","article-title":"Arrhythmia triggers in heart failure: the smoking gun of [Ca2+]i dysregulation","volume":"8","author":"Aistrup","year":"2011","journal-title":"Heart Rhythm"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1152\/physrev.00031.2009","article-title":"Pathophysiological mechanisms of atrial fibrillation: a translational appraisal","volume":"91","author":"Schotten","year":"2011","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1161\/CIRCULATIONAHA.113.006641","article-title":"Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation","volume":"129","author":"Voigt","year":"2014","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B5","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.1172\/JCI70102","article-title":"Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes","volume":"124","author":"Greiser","year":"2014","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B6","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1161\/CIRCULATIONAHA.111.067306","article-title":"Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+\u2013Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation","volume":"125","author":"Voigt","year":"2012","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B7","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/cvr\/cvt018","article-title":"Calcium signalling microdomains and the t-tubular system in atrial mycoytes: potential roles in cardiac disease and arrhythmias","volume":"98","author":"Trafford","year":"2013","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B8","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1161\/01.CIR.0000065578.00869.7C","article-title":"Reinduction of atrial fibrillation immediately after termination of the arrhythmia is mediated by late phase 3 early afterdepolarization-induced triggered activity","volume":"107","author":"Burashnikov","year":"2003","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1161\/CIRCHEARTFAILURE.108.811539","article-title":"Multiple defects in intracellular calcium cycling in whole failing rat heart","volume":"2","author":"Wasserstrom","year":"2009","journal-title":"Circ Heart Fail"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B10","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1007\/s00018-013-1410-5","article-title":"The transverse-axial tubular system of cardiomyocytes","volume":"70","author":"Ferrantini","year":"2013","journal-title":"Cell Mol Life Sci"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B11","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.hrthm.2016.09.022","article-title":"Regional distribution of T-tubule density in left and right atria in dogs","volume":"14","author":"Arora","year":"2017","journal-title":"Heart Rhythm"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B12","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/CIRCHEARTFAILURE.109.852228","article-title":"Characterization of an extensive transverse tubular network in sheep atrial myocytes and its depletion in heart failure","volume":"2","author":"Dibb","year":"2009","journal-title":"Circ Heart Fail"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B13","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1161\/CIRCEP.107.754788","article-title":"Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure","volume":"1","author":"Yeh","year":"2008","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B14","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0008-6363(01)00453-9","article-title":"Atrial fibrillation-induced atrial contractile dysfunction: a tachycardiomyopathy of a different sort","volume":"53","author":"Schotten","year":"2002","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B15","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0008-6363(99)00044-9","article-title":"Steady-state and nonsteady-state action potentials in fibrillating canine atrium: abnormal rate adaptation and its possible mechanisms","volume":"42","author":"Hara","year":"1999","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B16","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1111\/j.1440-1681.1996.tb01760.x","article-title":"Beta-adrenoceptor desensitization during the development of canine pacing-induced heart failure","volume":"23","author":"Vatner","year":"1996","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B17","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0002-9149(99)00266-0","article-title":"Beta-adrenergic receptor-G protein-adenylyl cyclase signal transduction in the failing heart","volume":"83","author":"Vatner","year":"1999","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B18","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.cardiores.2004.04.026","article-title":"Role of Ca2+\/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure","volume":"63","author":"Zhang","year":"2004","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tcm.2010.03.004","article-title":"Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation","volume":"20","author":"Dobrev","year":"2010","journal-title":"Trends Cardiovasc Med"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B20","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1172\/JCI26620","article-title":"Ca2+\/calmodulin-dependent protein kinase II regulates cardiac Na+ channels","volume":"116","author":"Wagner","year":"2006","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B21","doi-asserted-by":"crossref","first-page":"H1597","DOI":"10.1152\/ajpheart.00484.2007","article-title":"Modulation of late sodium current by Ca2+, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differences","volume":"294","author":"Maltsev","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10557-012-6430-0","article-title":"The late Na+ current: origin and pathophysiological relevance","volume":"27","author":"Zaza","year":"2013","journal-title":"Cardiovasc Drugs Ther"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B23","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.hrthm.2012.01.010","article-title":"Ranolazine stabilizes cardiac ryanodine receptors: a novel mechanism for the suppression of early afterdepolarization and torsades de pointes in long QT type 2","volume":"9","author":"Parikh","year":"2012","journal-title":"Heart Rhythm"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B24","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/cvr\/cvp324","article-title":"Na+ channel regulation by Ca2+\/calmodulin and Ca2+\/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes","volume":"85","author":"Aiba","year":"2010","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B25","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1172\/JCI88241","article-title":"Axial tubule junctions control rapid calcium signaling in atria","volume":"126","author":"Brandenburg","year":"2016","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B26","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1161\/CIRCEP.112.972273","article-title":"Recent insights into the role of the autonomic nervous system in the creation of substrate for atrial fibrillation: implications for therapies targeting the atrial autonomic nervous system","volume":"5","author":"Arora","year":"2012","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev-physiol-020911-153308","article-title":"Cardiac sarcoplasmic reticulum calcium leak: basis and roles in cardiac dysfunction","volume":"76","author":"Bers","year":"2014","journal-title":"Annu Rev Physiol"},{"key":"key\n\t\t\t\t20180328140635_cvx167-B28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/cvr\/cvs155","article-title":"Intracellular Ca2+ waves, afterdepolarizations, and triggered arrhythmias","volume":"95","author":"Shiferaw","year":"2012","journal-title":"Cardiovasc Res"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/113\/13\/1688\/24254251\/cvx167.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T15:43:24Z","timestamp":1522251804000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/113\/13\/1688\/4096653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,29]]},"references-count":28,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2017,8,29]]},"published-print":{"date-parts":[[2017,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvx167","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,11]]},"published":{"date-parts":[[2017,8,29]]}}}