{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:05:27Z","timestamp":1793171127693,"version":"4.5.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"3","funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["13POST17060120"],"award-info":[{"award-number":["13POST17060120"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16POST30960067"],"award-info":[{"award-number":["16POST30960067"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"CIRM","doi-asserted-by":"publisher","award":["TG2-01154"],"award-info":[{"award-number":["TG2-01154"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL123626"],"award-info":[{"award-number":["HL123626"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL130295"],"award-info":[{"award-number":["HL130295"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL106968"],"award-info":[{"award-number":["HL106968"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL123626"],"award-info":[{"award-number":["HL123626"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL119967"],"award-info":[{"award-number":["HL119967"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL123747"],"award-info":[{"award-number":["HL123747"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL128773-01"],"award-info":[{"award-number":["HL128773-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30 NS047101"],"award-info":[{"award-number":["P30 NS047101"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"DOI":"10.1093\/cvr\/cvx205","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T15:11:33Z","timestamp":1507734693000},"page":"378-388","source":"Crossref","is-referenced-by-count":42,"title":["Luma is not essential for murine cardiac development and function"],"prefix":"10.1093","volume":"114","author":[{"given":"Matthew J","family":"Stroud","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Guimar\u00e3es-Camboa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Veevers","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy D","family":"Dalton","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusu","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H","family":"Bradford","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk L","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia M","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Gerace","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"key":"key\n\t\t\t\t20180803080201_cvx205-B1","first-page":"536","article-title":"Luma interacts with emerin and influences its distribution at the inner nuclear membrane","volume":"121","author":"Bengtsson","year":"2008","journal-title":"J Cell Sci"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B2","first-page":"809","article-title":"Arrhythmogenic right ventricular cardiomyopathy type 5 is a fully penetrant, lethal arrhythmic disorder caused by a missense mutation in the TMEM43 gene","volume":"82","author":"Merner","year":"2008","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B3","first-page":"11943","article-title":"Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane","volume":"98","author":"Dreger","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B4","first-page":"1005","article-title":"TMEM43 mutations in Emery\u2013Dreifuss muscular dystrophy-related myopathy","volume":"69","author":"Liang","year":"2011","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B5","first-page":"538","article-title":"Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease","volume":"114","author":"Stroud","year":"2014","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B6","first-page":"1380","article-title":"Nuclear membrane proteins with potential disease links found by subtractive proteomics","volume":"301","author":"Schirmer","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B7","first-page":"1035","article-title":"LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins","volume":"149","author":"Sosa","year":"2012","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B8","first-page":"41","article-title":"Coupling of the nucleus and cytoplasm: role of the LINC complex","volume":"172","author":"Crisp","year":"2006","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B9","first-page":"3738","article-title":"SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton","volume":"26","author":"Haque","year":"2006","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B10","first-page":"3419","article-title":"The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope","volume":"118","author":"Padmakumar","year":"2005","journal-title":"J Cell Sci"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B11","first-page":"406","article-title":"Role of ANC-1 in tethering nuclei to the actin cytoskeleton","volume":"298","author":"Starr","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B12","first-page":"421","article-title":"Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges","volume":"26","author":"Starr","year":"2010","journal-title":"Annu Rev Cell Dev Biol"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B13","first-page":"63","article-title":"Mechanotransduction gone awry","volume":"10","author":"Jaalouk","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B14","first-page":"1729","article-title":"Keeping the LINC: the importance of nucleocytoskeletal coupling in intracellular force transmission and cellular function","volume":"39","author":"Lombardi","year":"2011","journal-title":"Biochem Soc Trans"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B15","first-page":"3061","article-title":"Mechanosensitive mechanisms in transcriptional regulation","volume":"125","author":"Mammoto","year":"2012","journal-title":"J Cell Sci"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B16","first-page":"162","article-title":"Gene expression, chromosome position and lamin A\/C mutations","volume":"2","author":"Puckelwartz","year":"2011","journal-title":"Nucleus"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B17","first-page":"75","article-title":"Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus","volume":"10","author":"Wang","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B18","first-page":"e1004114","article-title":"Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response","volume":"10","author":"Banerjee","year":"2014","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B19","first-page":"507","article-title":"Lamin A\/C and emerin regulate MKL1-SRF activity by modulating actin dynamics","volume":"497","author":"Ho","year":"2013","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B20","first-page":"781","article-title":"Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells","volume":"170","author":"Lammerding","year":"2005","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B21","first-page":"370","article-title":"Lamin A\/C deficiency causes defective nuclear mechanics and mechanotransduction","volume":"113","author":"Lammerding","year":"2004","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B22","first-page":"600","article-title":"Nesprin-1 mutations in human and murine cardiomyopathy","volume":"48","author":"Puckelwartz","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B23","first-page":"329","article-title":"Nesprin 1 is critical for nuclear positioning and anchorage","volume":"19","author":"Zhang","year":"2010","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B24","first-page":"323","article-title":"Identification of a novel X-linked gene responsible for Emery\u2013Dreifuss muscular dystrophy","volume":"8","author":"Bione","year":"1994","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B25","first-page":"285","article-title":"Mutations in the gene encoding lamin A\/C cause autosomal dominant Emery\u2013Dreifuss muscular dystrophy","volume":"21","author":"Bonne","year":"1999","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B26","first-page":"2167","article-title":"Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice","volume":"14","author":"Mounkes","year":"2005","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B27","first-page":"155","article-title":"Mouse model carrying H222P-Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies","volume":"14","author":"Arimura","year":"2005","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B28","first-page":"1715","article-title":"Missense mutations in the rod domain of the lamin A\/C gene as causes of dilated cardiomyopathy and conduction-system disease","volume":"341","author":"Fatkin","year":"1999","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B29","first-page":"566","article-title":"Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy","volume":"26","author":"Taylor","year":"2005","journal-title":"Hum Mutat"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B30","first-page":"2816","article-title":"Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity","volume":"16","author":"Zhang","year":"2007","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B31","first-page":"40","article-title":"LINC complexes in health and disease","volume":"1","author":"Mejat","year":"2010","journal-title":"Nucleus"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B32","first-page":"607","article-title":"Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice","volume":"18","author":"Puckelwartz","year":"2009","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B33","first-page":"256","article-title":"Mutation analysis and evaluation of the cardiac localization of TMEM43 in arrhythmogenic right ventricular cardiomyopathy","volume":"80","author":"Christensen","year":"2011","journal-title":"Clin Genet"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B34","first-page":"321","article-title":"The natural history of a genetic subtype of arrhythmogenic right ventricular cardiomyopathy caused by a p.S358L mutation in TMEM43","volume":"83","author":"Hodgkinson","year":"2013","journal-title":"Clin Genet"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B35","first-page":"21","article-title":"Functional effects of the TMEM43 Ser358Leu mutation in the pathogenesis of arrhythmogenic right ventricular cardiomyopathy","volume":"13","author":"Rajkumar","year":"2012","journal-title":"BMC Med Genet"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B36","first-page":"872","article-title":"The TMEM43 Newfoundland mutation p.S358L causing ARVC-5 was imported from Europe and increases the stiffness of the cell nucleus","volume":"36","author":"Milting","year":"2015","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B37","first-page":"2813","article-title":"TMEM43\/Luma is a key signaling component mediating EGFR-induced NF-kappaB activation and tumor progression","volume":"36","author":"Jiang","year":"2017","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B38","first-page":"e109128","article-title":"TMEM43 mutation p.S358L alters intercalated disc protein expression and reduces conduction velocity in arrhythmogenic right ventricular cardiomyopathy","volume":"9","author":"Siragam","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B39","first-page":"159","article-title":"Protein LUMA is a cytoplasmic plaque constituent of various epithelial adherens junctions and composite junctions of myocardial intercalated disks: a unifying finding for cell biology and cardiology","volume":"357","author":"Franke","year":"2014","journal-title":"Cell Tissue Res"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B40","first-page":"1708","article-title":"Normalization of Naxos plakoglobin levels restores cardiac function in mice","volume":"125","author":"Zhang","year":"2015","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B41","first-page":"S97","article-title":"Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain","volume":"119(Suppl. 1)","author":"Hayashi","year":"2002","journal-title":"Mech Dev"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B42","first-page":"42244","article-title":"CRISPR\/Cas9-mediated gene manipulation to create single-amino-acid-substituted and floxed mice with a cloning-free method","volume":"7","author":"Ma","year":"2017","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B43","first-page":"1209","article-title":"Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease","volume":"122","author":"Sheikh","year":"2012","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B44","first-page":"3189","article-title":"Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy","volume":"127","author":"Fang","year":"2017","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B45","first-page":"8277","article-title":"Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy","volume":"88","author":"Rockman","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B46","first-page":"3023","article-title":"Probing chromatin landscape reveals roles of endocardial TBX20 in septation","volume":"126","author":"Boogerd","year":"2016","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B47","first-page":"2672","article-title":"GAS2-like proteins mediate communication between microtubules and actin through interactions with end-binding proteins","volume":"127","author":"Stroud","year":"2014","journal-title":"J Cell Sci"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B48","first-page":"1915","article-title":"Nesprin 1alpha2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle","volume":"216","author":"Stroud","year":"2017","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B49","first-page":"24987","article-title":"Characterization of G2L3 (GAS2-like 3), a new microtubule- and actin-binding protein related to spectraplakins","volume":"286","author":"Stroud","year":"2011","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B50","first-page":"e89908","article-title":"Adipocyte-specific loss of PPARgamma attenuates cardiac hypertrophy","volume":"1","author":"Fang","year":"2016","journal-title":"JCI Insight"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B51","first-page":"569","article-title":"Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation","volume":"127","author":"Hirai","year":"2017","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B52","first-page":"2921","article-title":"Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis","volume":"124","author":"Moore-Morris","year":"2014","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B53","first-page":"2640","article-title":"Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum","volume":"122","author":"Lange","year":"2009","journal-title":"J Cell Sci"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B54","first-page":"345","article-title":"Pericytes of multiple organs do not behave as mesenchymal stem cells in vivo","volume":"20","author":"Guimaraes-Camboa","year":"2017","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B55","first-page":"274","article-title":"Desmosomal junctions are necessary for adult sinus node function","volume":"111","author":"Mezzano","year":"2016","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B56","first-page":"1887","article-title":"Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin","volume":"121","author":"Luke","year":"2008","journal-title":"J Cell Sci"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B57","first-page":"2542","article-title":"Nuclear lamin A\/C deficiency induces defects in cell mechanics, polarization, and migration","volume":"93","author":"Lee","year":"2007","journal-title":"Biophys J"},{"key":"key\n\t\t\t\t20180803080201_cvx205-B58","first-page":"1290","article-title":"Attenuated hypertrophic response to pressure overload in a lamin A\/C haploinsufficiency mouse","volume":"48","author":"Cupesi","year":"2010","journal-title":"J Mol Cell Cardiol"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/114\/3\/378\/25418981\/cvx205.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T08:03:03Z","timestamp":1533283383000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/114\/3\/378\/4460764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,12]]},"references-count":58,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,10,12]]},"published-print":{"date-parts":[[2018,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvx205","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,3,1]]},"published":{"date-parts":[[2017,10,12]]}}}