{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:31:22Z","timestamp":1792276282917,"version":"4.4.0"},"reference-count":96,"publisher":"Oxford University Press (OUP)","issue":"4","funder":[{"DOI":"10.13039\/501100003130","name":"FWO","doi-asserted-by":"publisher","award":["G.0412.16\u2009N"],"award-info":[{"award-number":["G.0412.16\u2009N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/13\/14\/30314 and PG\/16\/11\/32021"],"award-info":[{"award-number":["RG\/13\/14\/30314 and PG\/16\/11\/32021"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,15]]},"DOI":"10.1093\/cvr\/cvy007","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T12:11:48Z","timestamp":1516191108000},"page":"622-634","source":"Crossref","is-referenced-by-count":549,"title":["Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis"],"prefix":"10.1093","volume":"114","author":[{"given":"Mandy O J","family":"Grootaert","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Box 110, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Moulis","sequence":"additional","affiliation":[{"name":"INSERM, UMR-1048, Institute of Metabolic and Cardiovascular Diseases and University Paul Sabatier, F-31342 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Roth","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Martinet","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Vindis","sequence":"additional","affiliation":[{"name":"INSERM, UMR-1048, Institute of Metabolic and Cardiovascular Diseases and University Paul Sabatier, F-31342 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin R","family":"Bennett","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Box 110, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido R Y","family":"De Meyer","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"key":"key\n\t\t\t\t20180625113812_cvy007-B1","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/CIRCRESAHA.115.306361","article-title":"Vascular smooth muscle cells in atherosclerosis","volume":"118","author":"Bennett","year":"2016","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B2","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0008-6363(99)00235-7","article-title":"Apoptosis in atherosclerosis: beneficial or detrimental?","volume":"45","author":"Kockx","year":"2000","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B3","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/sj.bjp.0703407","article-title":"Apoptosis in the vasculature: mechanisms and functional importance","volume":"130","author":"Mallat","year":"2000","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B4","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1056\/NEJMoa035655","article-title":"Intraplaque hemorrhage and progression of coronary atheroma","volume":"349","author":"Kolodgie","year":"2003","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B5","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.2353\/ajpath.2006.050473","article-title":"Interferon-gamma induces Fas trafficking and sensitization to apoptosis in vascular smooth muscle cells via a PI3K- and Akt-dependent mechanism","volume":"168","author":"Rosner","year":"2006","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B6","doi-asserted-by":"crossref","first-page":"C709","DOI":"10.1152\/ajpcell.2001.280.3.C709","article-title":"Fas\/Fas ligand-mediated death pathway is involved in oxLDL-induced apoptosis in vascular smooth muscle cells","volume":"280","author":"Lee","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1126\/science.282.5387.290","article-title":"Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis","volume":"282","author":"Bennett","year":"1998","journal-title":"Science"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B8","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1161\/01.RES.81.4.591","article-title":"Increased sensitivity of human vascular smooth muscle cells from atherosclerotic plaques to p53-mediated apoptosis","volume":"81","author":"Bennett","year":"1997","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B9","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1172\/JCI117917","article-title":"Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques","volume":"95","author":"Bennett","year":"1995","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B10","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1161\/01.RES.82.6.704","article-title":"Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic plaques","volume":"82","author":"Bennett","year":"1998","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B11","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1161\/01.ATV.0000041843.44312.12","article-title":"Gene expression profiling of apoptosis-related genes in human atherosclerosis: upregulation of death-associated protein kinase","volume":"22","author":"Martinet","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B12","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/nm1459","article-title":"Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis","volume":"12","author":"Clarke","year":"2006","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B13","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1161\/CIRCRESAHA.108.175976","article-title":"Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration","volume":"102","author":"Clarke","year":"2008","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B14","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1182\/blood.V89.12.4378","article-title":"Thrombin generation by apoptotic vascular smooth muscle cells","volume":"89","author":"Flynn","year":"1997","journal-title":"Blood"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B15","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1161\/01.RES.87.11.1055","article-title":"Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies","volume":"87","author":"Proudfoot","year":"2000","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B16","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/ATVBAHA.113.302642","article-title":"Has our understanding of calcification in human coronary atherosclerosis progressed?","volume":"34","author":"Otsuka","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B17","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/CIRCRESAHA.109.208389","article-title":"Vascular smooth muscle cell apoptosis induces interleukin-1-directed inflammation: effects of hyperlipidemia-mediated inhibition of phagocytosis","volume":"106","author":"Clarke","year":"2010","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B18","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1161\/01.CIR.0000105724.30980.CD","article-title":"Antirestenotic effects of a locally delivered caspase inhibitor in a balloon injury model","volume":"109","author":"Beohar","year":"2003","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/3087469","article-title":"Caspase-3 deletion promotes necrosis in atherosclerotic plaques of ApoE knockout mice","volume":"2016","author":"Grootaert","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.semcdb.2014.02.006","article-title":"Molecular mechanisms of regulated necrosis","volume":"35","author":"Galluzzi","year":"2014","journal-title":"Semin Cell Dev Biol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B22","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00395-011-0192-x","article-title":"Necrotic cell death in atherosclerosis","volume":"106","author":"Martinet","year":"2011","journal-title":"Basic Res Cardiol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B23","doi-asserted-by":"crossref","first-page":"e520.","DOI":"10.1038\/cddis.2013.47","article-title":"Role of protein kinase C delta in ER stress and apoptosis induced by oxidized LDL in human vascular smooth muscle cells","volume":"4","author":"Larroque-Cardoso","year":"2013","journal-title":"Cell Death Dis"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B24","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1111\/j.1582-4934.2008.00593.x","article-title":"TRPC1 is regulated by caveolin-1 and is involved in oxidized LDL-induced apoptosis of vascular smooth muscle cells","volume":"13","author":"Ingueneau","year":"2009","journal-title":"J Cell Mol Med"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B25","doi-asserted-by":"crossref","first-page":"13978","DOI":"10.1073\/pnas.96.24.13978","article-title":"Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion","volume":"96","author":"Ha","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.1376506","article-title":"Necrotic death as a cell fate","volume":"20","author":"Zong","year":"2006","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B27","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cardiores.2006.09.005","article-title":"Phagocytosis in atherosclerosis: molecular mechanisms and implications for plaque progression and stability","volume":"73","author":"Schrijvers","year":"2007","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B28","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1161\/01.ATV.0000184783.04864.9f","article-title":"Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency","volume":"25","author":"Tabas","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B29","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/imammb\/dqr012","article-title":"Growth of necrotic cores in atherosclerotic plaque","volume":"29","author":"Fok","year":"2012","journal-title":"Math Med Biol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature00858","article-title":"Release of chromatin protein HMGB1 by necrotic cells triggers inflammation","volume":"418","author":"Scaffidi","year":"2002","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B31","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.atherosclerosis.2016.06.045","article-title":"NecroX-7 reduces necrotic core formation in atherosclerotic plaques of ApoE knockout mice","volume":"252","author":"Grootaert","year":"2016","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B32","doi-asserted-by":"crossref","first-page":"e1600224.","DOI":"10.1126\/sciadv.1600224","article-title":"Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis","volume":"2","author":"Karunakaran","year":"2016","journal-title":"Sci Adv"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B33","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1161\/CIRCRESAHA.116.303804","article-title":"Autophagy in vascular disease","volume":"116","author":"De Meyer","year":"2015","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B34","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1161\/01.CIR.97.23.2307","article-title":"Apoptosis and related proteins in different stages of human atherosclerotic plaques","volume":"97","author":"Kockx","year":"1998","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B35","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1161\/01.ATV.0000146266.65820.a1","article-title":"7-ketocholesterol induces protein ubiquitination, myelin figure formation, and light chain 3 processing in vascular smooth muscle cells","volume":"24","author":"Martinet","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.micron.2013.03.007","article-title":"The use of electron microscopy for the detection of autophagy in human atherosclerosis","volume":"50","author":"Perrotta","year":"2013","journal-title":"Micron"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B37","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1042\/BJ20121344","article-title":"PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress","volume":"451","author":"Salabei","year":"2013","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B38","doi-asserted-by":"crossref","first-page":"H1319","DOI":"10.1152\/ajpheart.00160.2012","article-title":"Sonic hedgehog promotes autophagy of vascular smooth muscle cells","volume":"303","author":"Li","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B39","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.exger.2009.07.004","article-title":"Microarray analysis of senescent vascular smooth muscle cells: a link to atherosclerosis and vascular calcification","volume":"44","author":"Burton","year":"2009","journal-title":"Exp Gerontol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B40","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/ki.2012.482","article-title":"Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release","volume":"83","author":"Dai","year":"2013","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B41","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000356656","article-title":"Atorvastatin protects vascular smooth muscle cells from TGF-beta1-stimulated calcification by inducing autophagy via suppression of the beta-catenin pathway","volume":"33","author":"Liu","year":"2014","journal-title":"Cell Physiol Biochem"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B42","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tibs.2010.07.007","article-title":"Regulation of autophagy by ROS: physiology and pathology","volume":"36","author":"Scherz-Shouval","year":"2011","journal-title":"Trends Biochem Sci"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B43","doi-asserted-by":"crossref","first-page":"H557","DOI":"10.1152\/ajpheart.00659.2014","article-title":"Defective autophagy in vascular smooth muscle cells alters contractility and Ca(2)(+) homeostasis in mice","volume":"308","author":"Michiels","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B44","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.ijcard.2012.12.045","article-title":"Regulation of autophagy and apoptosis in response to ox-LDL in vascular smooth muscle cells, and the modulatory effects of the microRNA hsa-let-7 g","volume":"168","author":"Ding","year":"2013","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B45","doi-asserted-by":"crossref","first-page":"28821","DOI":"10.18632\/oncotarget.8936","article-title":"Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids","volume":"7","author":"Swiader","year":"2016","journal-title":"Oncotarget"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B46","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1042\/BJ20071063","article-title":"Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells","volume":"410","author":"Hill","year":"2008","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B47","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.ajpath.2013.04.028","article-title":"7-Ketocholesterol induces autophagy in vascular smooth muscle cells through Nox4 and Atg4B","volume":"183","author":"He","year":"2013","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B48","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1600-065X.2010.00995.x","article-title":"Autophagy in immunity and cell-autonomous defense against intracellular microbes","volume":"240","author":"Deretic","year":"2011","journal-title":"Immunol Rev"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B49","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1440-1711.2006.01454.x","article-title":"Insulin-like growth factor-1 and TNF-alpha regulate autophagy through c-jun N-terminal kinase and Akt pathways in human atherosclerotic vascular smooth cells","volume":"84","author":"Jia","year":"2006","journal-title":"Immunol Cell Biol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B50","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/jcp.22709","article-title":"Osteopontin stimulates autophagy via integrin\/CD44 and p38 MAPK signaling pathways in vascular smooth muscle cells","volume":"227","author":"Zheng","year":"2012","journal-title":"J Cell Physiol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B51","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.4161\/cc.24929","article-title":"Intermittent injections of osteocalcin reverse autophagic dysfunction and endoplasmic reticulum stress resulting from diet-induced obesity in the vascular tissue via the NFkappaB-p65-dependent mechanism","volume":"12","author":"Zhou","year":"2013","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B52","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3892\/ijmm.2012.891","article-title":"ERK and Akt signaling pathways are involved in advanced glycation end product-induced autophagy in rat vascular smooth muscle cells","volume":"29","author":"Hu","year":"2012","journal-title":"Int J Mol Med"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B53","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1165\/rcmb.2012-0446OC","article-title":"Adenosine monophosphate-activated protein kinase is required for pulmonary artery smooth muscle cell survival and the development of hypoxic pulmonary hypertension","volume":"49","author":"Ibe","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B54","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/bjp.2008.181","article-title":"Interactions between cell death induced by statins and 7-ketocholesterol in rabbit aorta smooth muscle cells","volume":"154","author":"Martinet","year":"2008","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B55","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1172\/JCI26390","article-title":"Autophagy in cell death: an innocent convict?","volume":"115","author":"Levine","year":"2005","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B56","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.freeradbiomed.2013.08.003","article-title":"Implications of autophagy for vascular smooth muscle cell function and plasticity","volume":"65","author":"Salabei","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B57","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.mad.2013.04.004","article-title":"The autophagy enhancer spermidine reverses arterial aging","volume":"134","author":"LaRocca","year":"2013","journal-title":"Mech Ageing Dev"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B58","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1080\/15548627.2015.1096485","article-title":"Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis","volume":"11","author":"Grootaert","year":"2015","journal-title":"Autophagy"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B59","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.jacc.2006.09.047","article-title":"Selective clearance of macrophages in atherosclerotic plaques by autophagy","volume":"49","author":"Verheye","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B60","doi-asserted-by":"crossref","first-page":"3018190.","DOI":"10.1155\/2017\/3018190","article-title":"Moderate autophagy inhibits vascular smooth muscle cell senescence to stabilize progressed atherosclerotic plaque via the mTORC1\/ULK1\/ATG13 signal pathway","volume":"2017","author":"Luo","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B61","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.atherosclerosis.2016.07.899","article-title":"Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction of autophagy","volume":"251","author":"Michiels","year":"2016","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B62","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrm2233","article-title":"Cellular senescence: when bad things happen to good cells","volume":"8","author":"Campisi","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B63","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1161\/CIRCRESAHA.111.261388","article-title":"Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence","volume":"111","author":"Wang","year":"2012","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B64","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1172\/JCI64098","article-title":"Cellular senescence and the senescent secretory phenotype: therapeutic opportunities","volume":"123","author":"Tchkonia","year":"2013","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B65","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1113\/JP270923","article-title":"Ageing induced vascular smooth muscle cell senescence in atherosclerosis","volume":"594","author":"Uryga","year":"2016","journal-title":"J Physiol (London)"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B66","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cardiores.2006.06.004","article-title":"Vascular smooth muscle cell senescence in atherosclerosis","volume":"72","author":"Gorenne","year":"2006","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B67","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/01.RES.0000233315.38086.bc","article-title":"Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress","volume":"99","author":"Matthews","year":"2006","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/B:BGEN.0000017682.96395.10","article-title":"Mechanisms of cellular senescence in human and mouse cells","volume":"5","author":"Itahana","year":"2004","journal-title":"Biogerontology"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B69","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1161\/CIRCULATIONAHA.115.016457","article-title":"Vascular smooth muscle cell senescence promotes atherosclerosis and features of plaque vulnerability","volume":"132","author":"Wang","year":"2015","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B70","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/acel.12458","article-title":"Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice","volume":"15","author":"Roos","year":"2016","journal-title":"Aging Cell"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B71","doi-asserted-by":"crossref","first-page":"87.","DOI":"10.1186\/1476-511X-9-87","article-title":"Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender","volume":"9","author":"Pereira","year":"2010","journal-title":"Lipids Health Dis"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B72","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.aaf6659","article-title":"Senescent intimal foam cells are deleterious at all stages of atherosclerosis","volume":"354","author":"Childs","year":"2016","journal-title":"Science"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B73","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.18632\/aging.100991","article-title":"Aging of mice is associated with p16(Ink4a)- and beta-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells","volume":"8","author":"Hall","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B74","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev-physiol-021115-105127","article-title":"DNA damage and repair in vascular disease","volume":"78","author":"Uryga","year":"2015","journal-title":"Annu Rev Physiol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B75","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1126\/science.1069523","article-title":"Senescence induced by altered telomere state, not telomere loss","volume":"295","author":"Karlseder","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B76","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B77","doi-asserted-by":"crossref","first-page":"H2779","DOI":"10.1152\/ajpheart.2001.280.6.H2779","article-title":"Aging, oxidative responses, and proliferative capacity in cultured mouse aortic smooth muscle cells","volume":"280","author":"Moon","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B78","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.redox.2013.08.004","article-title":"A role for mitochondrial oxidants in stress-induced premature senescence of human vascular smooth muscle cells","volume":"1","author":"Mistry","year":"2013","journal-title":"Redox Biol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B79","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1128\/MCB.21.10.3336-3342.2001","article-title":"Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation","volume":"21","author":"Minamino","year":"2001","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B80","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1161\/01.RES.0000121104.05977.F3","article-title":"Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells","volume":"94","author":"Haendeler","year":"2004","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B81","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.bbabio.2015.05.017","article-title":"Mitochondria: are they causal players in cellular senescence?","volume":"1847","author":"Correia-Melo","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/acel.12287","article-title":"Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging","volume":"14","author":"Ziegler","year":"2015","journal-title":"Aging Cell"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B83","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1161\/ATVBAHA.115.305896","article-title":"Senescent vascular smooth muscle cells drive inflammation through an interleukin-1alpha-dependent senescence-associated secretory phenotype","volume":"35","author":"Gardner","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B84","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1161\/01.CIR.0000093274.82929.22","article-title":"Ras induces vascular smooth muscle cell senescence and inflammation in human atherosclerosis","volume":"108","author":"Minamino","year":"2003","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B85","doi-asserted-by":"crossref","first-page":"H1673","DOI":"10.1152\/ajpheart.00455.2009","article-title":"Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition","volume":"297","author":"Nakano-Kurimoto","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B86","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1161\/01.RES.0000249379.55535.21","article-title":"Vascular calcification: pathobiological mechanisms and clinical implications","volume":"99","author":"Johnson","year":"2006","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B87","doi-asserted-by":"crossref","DOI":"10.1039\/9781782626602-00001","article-title":"Anti-aging drugs: Where are We and Where are We Going?","volume-title":"Anti-aging Drugs: From Basic Research to Clinical Practice","author":"Vaiserman","year":"2017"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B88","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ebiom.2017.04.013","article-title":"Cellular senescence: a translational perspective","volume":"21","author":"Kirkland","year":"2017","journal-title":"EBioMedicine"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B89","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.molmed.2016.11.006","article-title":"The fountain of youth by targeting senescent cells?","volume":"23","author":"de Keizer","year":"2017","journal-title":"Trends Mol Med"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B90","doi-asserted-by":"crossref","first-page":"e1528.","DOI":"10.1038\/cddis.2014.489","article-title":"Characterization of novel markers of senescence and their prognostic potential in cancer","volume":"5","author":"Althubiti","year":"2014","journal-title":"Cell Death Dis"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B91","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/carcin\/bgs124","article-title":"Immune surveillance of senescent cells\u2013biological significance in cancer- and non-cancer pathologies","volume":"33","author":"Hoenicke","year":"2012","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B92","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/nm.4000","article-title":"Cellular senescence in aging and age-related disease: from mechanisms to therapy","volume":"21","author":"Childs","year":"2015","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B93","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/acel.12587","article-title":"Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism","volume":"16","author":"Wang","year":"2017","journal-title":"Aging Cell"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-016-2796-9","article-title":"The PI3K\/Akt\/mTOR pathway regulates the replicative senescence of human VSMCs","volume":"422","author":"Tan","year":"2016","journal-title":"Mol Cell Biochem"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B95","author":"Sung","year":"2017"},{"key":"key\n\t\t\t\t20180625113812_cvy007-B96","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2005.07.002","article-title":"Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy","volume":"122","author":"Pattingre","year":"2005","journal-title":"Cell"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/114\/4\/622\/25083862\/cvy007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T19:01:34Z","timestamp":1603652494000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/114\/4\/622\/4816257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,18]]},"references-count":96,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,1,18]]},"published-print":{"date-parts":[[2018,3,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvy007","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,3,15]]},"published":{"date-parts":[[2018,1,18]]}}}