{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:53:38Z","timestamp":1783450418534,"version":"3.55.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T00:00:00Z","timestamp":1521504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Rusche Forschungsprojekt"},{"DOI":"10.13039\/501100005970","name":"Deutsche Stiftung f\u00fcr Herzforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005970","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DSH"},{"name":"Deutsche Gesellschaft f\u00fcr Thorax-, Herz- und Gef\u00e4\u00dfchirurgie"},{"name":"DGTHG"},{"name":"Deutsches Zentrum f\u00fcr Herz Kreislauf Forschung","award":["DZHK B 15-005"],"award-info":[{"award-number":["DZHK B 15-005"]}]},{"name":"Deutsches Zentrum f\u00fcr Herz Kreislauf Forschung","award":["DZHK B 15-039SE"],"award-info":[{"award-number":["DZHK B 15-039SE"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004807","name":"DFG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sachmittelantrag","award":["KR3770\/7-1"],"award-info":[{"award-number":["KR3770\/7-1"]}]},{"name":"Sachmittelantrag","award":["KR3770\/9-1"],"award-info":[{"award-number":["KR3770\/9-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The contribution of resident stem or progenitor cells to cardiomyocyte renewal after injury in adult mammalian hearts remains a matter of considerable debate. We evaluated a cell population in the adult mouse heart induced by myocardial infarction (MI) and characterized by an activated Nkx2.5 enhancer element that is specific for multipotent cardiac progenitor cells (CPCs) during embryonic development. We hypothesized that these MI-induced cells (MICs) harbour cardiomyogenic properties similar to their embryonic counterparts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>MICs reside in the heart and mainly localize to the infarction area and border zone. Interestingly, gene expression profiling of purified MICs 1 week after infarction revealed increased expression of stem cell markers and embryonic cardiac transcription factors (TFs) in these cells as compared to the non-mycoyte cell fraction of adult hearts. A subsequent global transcriptome comparison with embryonic CPCs and fibroblasts and in vitro culture of MICs unveiled that (myo-)fibroblastic features predominated and that cardiac TFs were only expressed at background levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Adult injury-induced reactivation of a cardiac-specific Nkx2.5 enhancer element known to specifically mark myocardial progenitor cells during embryonic development does not reflect hypothesized embryonic cardiomyogenic properties. Our data suggest a decreasing plasticity of cardiac progenitor (-like) cell populations with increasing age. A re-expression of embryonic, stem or progenitor cell features in the adult heart must be interpreted very carefully with respect to the definition of cardiac resident progenitor cells. Albeit, the abundance of scar formation after cardiac injury suggests a potential to target predestinated activated profibrotic cells to push them towards cardiomyogenic differentiation to improve regeneration.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvy069","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T16:11:06Z","timestamp":1521216666000},"page":"1098-1114","source":"Crossref","is-referenced-by-count":16,"title":["Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis"],"prefix":"10.1093","volume":"114","author":[{"given":"Marcus-Andr\u00e9","family":"Deutsch","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, German Heart Center Munich at the Technische Universit\u00e4t M\u00fcnchen, Lazarettstra\u00dfe 36, 80636 Munich, Germany"},{"name":"Department of Cardiovascular Surgery, German Heart Center, Insure (Institute for Translational Cardiac Surgery), Technische Universit\u00e4t M\u00fcnchen, Lothstra\u00dfe 11, 80636 Munich, Germany"},{"name":"DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie A","family":"Doppler","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, German Heart Center Munich at the Technische Universit\u00e4t M\u00fcnchen, Lazarettstra\u00dfe 36, 80636 Munich, Germany"},{"name":"Department of Cardiovascular Surgery, German Heart Center, Insure (Institute for Translational Cardiac Surgery), Technische Universit\u00e4t M\u00fcnchen, Lothstra\u00dfe 11, 80636 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, German Heart Center Munich at the Technische Universit\u00e4t M\u00fcnchen, Lazarettstra\u00dfe 36, 80636 Munich, Germany"},{"name":"Department of Cardiovascular Surgery, German Heart Center, Insure (Institute for Translational Cardiac Surgery), Technische Universit\u00e4t M\u00fcnchen, Lothstra\u00dfe 11, 80636 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Lahm","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, German Heart Center Munich at the Technische Universit\u00e4t M\u00fcnchen, Lazarettstra\u00dfe 36, 80636 Munich, Germany"},{"name":"Department of Cardiovascular Surgery, German Heart Center, Insure (Institute for Translational Cardiac Surgery), Technische Universit\u00e4t M\u00fcnchen, Lothstra\u00dfe 11, 80636 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Santamaria","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, Department of Experimental and Clinical Medicine, Research Center of Advanced Biochemistry and Molecular Biology"},{"name":"CIS (Centro Interdisciplinare Servizi), University \u2018Magna Graecia\u2019 of Catanzaro, Viale Europa, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Cuda","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, Department of Experimental and Clinical Medicine, Research Center of Advanced Biochemistry and Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Eichhorn","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, German Heart Center Munich at the Technische Universit\u00e4t M\u00fcnchen, Lazarettstra\u00dfe 36, 80636 Munich, Germany"},{"name":"Department of Cardiovascular Surgery, German Heart Center, Insure (Institute for Translational Cardiac Surgery), Technische Universit\u00e4t M\u00fcnchen, Lothstra\u00dfe 11, 80636 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ratschiller","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Kepler University Hospital, 4021 Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elda","family":"Dzilic","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, German Heart Center Munich at the Technische Universit\u00e4t M\u00fcnchen, Lazarettstra\u00dfe 36, 80636 Munich, Germany"},{"name":"Department of Cardiovascular Surgery, German Heart Center, Insure (Institute for Translational Cardiac Surgery), Technische Universit\u00e4t M\u00fcnchen, Lothstra\u00dfe 11, 80636 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Dre\u00dfen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, German Heart Center Munich at the Technische Universit\u00e4t 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Gilsbach","sequence":"additional","affiliation":[{"name":"Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Albertstra\u00dfe 25, 79104 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Hein","sequence":"additional","affiliation":[{"name":"Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Albertstra\u00dfe 25, 79104 Freiburg, Germany"},{"name":"BIOSS Centre for Biological Signaling Studies, University of Freiburg, Sch\u00e4nzlestra\u00dfe 18, 79104 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd K","family":"Fleischmann","sequence":"additional","affiliation":[{"name":"Institute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, 53105 Bonn, 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