{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:12:12Z","timestamp":1789873932892,"version":"4.0.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T00:00:00Z","timestamp":1534204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"PNS","award":["SAF2016-76819-R"],"award-info":[{"award-number":["SAF2016-76819-R"]}]},{"name":"PNS","award":["2015-71653-R"],"award-info":[{"award-number":["2015-71653-R"]}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"FEDER","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituto de Salud Carlos III CIBERCV","award":["CN16\/11\/00411"],"award-info":[{"award-number":["CN16\/11\/00411"]}]},{"name":"Muy Ilustr\u00edsima Administraci\u00f3n"},{"name":"Hospital de la Santa Creu I Sant Pau"},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat of Catalunya","doi-asserted-by":"crossref","award":["2014SGR1303"],"award-info":[{"award-number":["2014SGR1303"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fundacion Investigaci\u00f3n Cardiovascular"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"DOI":"10.1093\/cvr\/cvy201","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T07:11:58Z","timestamp":1534144318000},"page":"1860-1870","source":"Crossref","is-referenced-by-count":41,"title":["P2Y12 antagonists and cardiac repair post-myocardial infarction: global and regional heart function analysis and molecular assessments in pigs"],"prefix":"10.1093","volume":"114","author":[{"given":"Gemma","family":"Vilahur","sequence":"first","affiliation":[{"name":"Program ICCC, IR-Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, c\/Sant Antoni Ma Claret 167, Barcelona, Spain"},{"name":"CIBERCV, Instituto Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Program ICCC, IR-Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, c\/Sant Antoni Ma Claret 167, Barcelona, Spain"},{"name":"Radiology Unit, Hospital de la Santa Creu i Sant Pau (HSCSP), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Casani","sequence":"additional","affiliation":[{"name":"Program ICCC, IR-Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, c\/Sant Antoni Ma Claret 167, Barcelona, Spain"},{"name":"CIBERCV, Instituto Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Lambert","sequence":"additional","affiliation":[{"name":"Program ICCC, IR-Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, c\/Sant Antoni Ma Claret 167, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiomar","family":"Mendieta","sequence":"additional","affiliation":[{"name":"Program ICCC, IR-Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, c\/Sant Antoni Ma Claret 167, Barcelona, Spain"},{"name":"Cardiology Department, Hospital Clinico, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumaya","family":"Ben-Aicha","sequence":"additional","affiliation":[{"name":"Program ICCC, IR-Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, c\/Sant Antoni Ma Claret 167, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Capdevila","sequence":"additional","affiliation":[{"name":"Radiology Unit, Hospital de la Santa Creu i Sant Pau (HSCSP), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillem","family":"Pons-Llad\u00f3","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Hospital de la Santa Creu i Sant Pau (HSCSP), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Carreras","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Hospital de la Santa Creu i Sant Pau (HSCSP), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, M\u00f6lndal, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Hidalgo","sequence":"additional","affiliation":[{"name":"Radiology Unit, Hospital de la Santa Creu i Sant Pau (HSCSP), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Badimon","sequence":"additional","affiliation":[{"name":"Program ICCC, IR-Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, c\/Sant Antoni Ma Claret 167, Barcelona, Spain"},{"name":"CIBERCV, Instituto Salud Carlos III, Madrid, Spain"},{"name":"Cardiovascular Research Chair UAB (Autonomous University of Barcelona), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,8,14]]},"reference":[{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B1","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1161\/01.CIR.101.6.590","article-title":"A randomized comparison of clopidogrel and aspirin versus ticlopidine and aspirin after the placement of coronary-artery stents","volume":"101","author":"Muller","year":"2000","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B2","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1161\/CIRCULATIONAHA.116.024014","article-title":"Protective effects of ticagrelor on myocardial injury after infarction","volume":"134","author":"Vilahur","year":"2016","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B3","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10557-015-6609-2","article-title":"Cardioprotective properties of the platelet P2Y12 receptor inhibitor, cangrelor: protective in diabetics and reliant upon the presence of blood","volume":"29","author":"Bell","year":"2015","journal-title":"Cardiovasc Drugs Ther"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B4","doi-asserted-by":"crossref","first-page":"275.","DOI":"10.1007\/s00395-012-0275-3","article-title":"Cardioprotection by clopidogrel in acute ST-elevated myocardial infarction patients: a retrospective analysis","volume":"107","author":"Roubille","year":"2012","journal-title":"Basic Res Cardiol"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B5","doi-asserted-by":"crossref","first-page":"B70","DOI":"10.1016\/j.jacc.2016.09.313","article-title":"TCT-171 effect of ticagrelor compared with clopidogrel on myocardial infarct size in patients undergoing primary percutaneous coronary intervention","volume":"68","author":"Hahn","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B6","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1160\/TH09-12-0823","article-title":"Adjunctive treatment with ticagrelor, but not clopidogrel, added to tPA enables sustained coronary artery recanalisation with recovery of myocardium perfusion in a canine coronary thrombosis model","volume":"104","author":"Wang","year":"2010","journal-title":"Thromb Haemost"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B7","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1161\/ATVBAHA.114.304002","article-title":"Chronic treatment with ticagrelor limits myocardial infarct size: an adenosine and cyclooxygenase-2-dependent effect","volume":"34","author":"Nanhwan","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B8","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1161\/ATVBAHA.115.305655","article-title":"Ticagrelor protects the heart against reperfusion injury and improves remodeling after myocardial infarction","volume":"35","author":"Ye","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1177\/1074248412467692","article-title":"Platelet P2Y(1)(2) blockers confer direct postconditioning-like protection in reperfused rabbit hearts","volume":"18","author":"Yang","year":"2013","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B10","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/ehjci\/jes271","article-title":"Final infarct size measured by cardiovascular magnetic resonance in patients with ST elevation myocardial infarction predicts long-term clinical outcome: an observational study","volume":"14","author":"Lonborg","year":"2013","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B11","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1056\/NEJMoa0904327","article-title":"Ticagrelor versus clopidogrel in patients with acute coronary syndromes","volume":"361","author":"Wallentin","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B12","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(09)62191-7","article-title":"Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study","volume":"375","author":"Cannon","year":"2010","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1177\/1074248413511693","article-title":"Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1","volume":"19","author":"Armstrong","year":"2014","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B14","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF00374659","article-title":"Involvement of endogenous adenosine in ischaemic preconditioning in swine","volume":"430","author":"Schulz","year":"1995","journal-title":"Pflugers Arch"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B15","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/S0140-6736(14)60107-0","article-title":"Cardiovascular remodelling in coronary artery disease and heart failure","volume":"383","author":"Heusch","year":"2014","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B16","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1161\/01.CIR.101.25.2981","article-title":"Left ventricular remodeling after myocardial infarction: pathophysiology and therapy","volume":"101","author":"Sutton","year":"2000","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B17","doi-asserted-by":"crossref","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B18","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1939-1676.1993.tb01015.x","article-title":"Recommendations for standards in transthoracic two-dimensional echocardiography in the dog and cat. Echocardiography Committee of the Specialty of Cardiology, American College of Veterinary Internal Medicine","volume":"7","author":"Thomas","year":"1993","journal-title":"J Vet Intern Med"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.atherosclerosis.2009.02.009","article-title":"Induction of RISK by HMG-CoA reductase inhibition affords cardioprotection after myocardial infarction","volume":"206","author":"Vilahur","year":"2009","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B20","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1016\/j.jacc.2015.08.901","article-title":"Hypercholesterolemia abolishes high-density lipoprotein-related cardioprotective effects in the setting of myocardial infarction","volume":"66","author":"Vilahur","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B21","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ijcard.2009.09.551","article-title":"The cardioprotection granted by metoprolol is restricted to its administration prior to coronary reperfusion","volume":"147","author":"Ibanez","year":"2011","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B22","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1161\/01.CIR.86.1.338","article-title":"Standardization of cardiac tomographic imaging. From the Committee on Advanced Cardiac Imaging and Technology, Council on Clinical Cardiology, American Heart Association; Cardiovascular Imaging Committee, American College of Cardiology; and Board of Directors, Cardiovascular Council, Society of Nuclear Medicine","volume":"86","year":"1992","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B23","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0300-8932(04)77202-4","article-title":"[Reliability of cardiac magnetic resonance imaging indicators of myocardial viability for predicting the recovery of systolic function after a first acute myocardial infarction with a patent culprit artery]","volume":"57","author":"L\u00f3pez Lereu","year":"2004","journal-title":"Rev Esp Cardiol"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B24","doi-asserted-by":"crossref","first-page":"e411","DOI":"10.1097\/CCM.0b013e31829866dc","article-title":"Connection between cardiac vascular permeability, myocardial edema, and inflammation during sepsis: role of the \u03b11AMP-activated protein kinase isoform","volume":"41","author":"Castanares-Zapatero","year":"2013","journal-title":"Crit Care Med"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tem.2014.11.001","article-title":"Is AMPK the savior of the failing heart?","volume":"26","author":"Kim","year":"2014","journal-title":"Trends Endocrinol Metab"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jacc.2014.10.031","article-title":"Remote ischemic conditioning","volume":"65","author":"Heusch","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tcm.2005.03.001","article-title":"The reperfusion injury salvage kinase pathway: a common target for both ischemic preconditioning and postconditioning","volume":"15","author":"Hausenloy","year":"2005","journal-title":"Trends Cardiovasc Med"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B28","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/cvr\/cvu225","article-title":"ESC working group cellular biology of the heart: position paper: improving the preclinical assessment of novel cardioprotective therapies","volume":"104","author":"Lecour","year":"2014","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B29","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.yjmcc.2011.02.016","article-title":"The in-situ pig heart with regional ischemia\/reperfusion\u2014ready for translation","volume":"50","author":"Heusch","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B30","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.jacc.2015.06.023","article-title":"Pathophysiology underlying the bimodal edema phenomenon after myocardial ischemia\/reperfusion","volume":"66","author":"Fern\u00e1ndez-Jim\u00e9nez","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B31","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.yjmcc.2011.03.003","article-title":"A small molecule AMPK activator protects the heart against ischemia-reperfusion injury","volume":"51","author":"Kim","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B32","first-page":"179","article-title":"AMPK in cardiovascular diseases","volume":"107","author":"Daskalopoulos","year":"2016","journal-title":"EXS"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B33","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.yjmcc.2014.04.018","article-title":"Reduced scar maturation and contractility lead to exaggerated left ventricular dilation after myocardial infarction in mice lacking AMPKalpha1","volume":"74","author":"Noppe","year":"2014","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B34","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-94-024-1057-0_6","article-title":"Aquaporins in cardiovascular system","volume":"969","author":"Tie","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B35","doi-asserted-by":"crossref","first-page":"e0177315","DOI":"10.1371\/journal.pone.0177315","article-title":"Adenosine A1 receptor activation increases myocardial protein S-nitrosothiols and elicits protection from ischemia-reperfusion injury in male and female hearts","volume":"12","author":"Shao","year":"2017","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B36","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1161\/01.CIR.76.1.44","article-title":"Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction","volume":"76","author":"White","year":"1987","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B37","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1056\/NEJM198308113090602","article-title":"Risk stratification and survival after myocardial infarction","volume":"309","author":"Multicenter Postinfarction Research Group","year":"1983","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B38","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1161\/01.CIR.66.6.1146","article-title":"The stunned myocardium: prolonged, postischemic ventricular dysfunction","volume":"66","author":"Braunwald","year":"1982","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B39","first-page":"71","volume-title":"Post-MI Risk Stratification, in Multimodality Imaging in Cardiovascular Medicine","author":"Vesely","year":"2010"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B40","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.CIR.81.4.1161","article-title":"Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications","volume":"81","author":"Pfeffer","year":"1990","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B41","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1161\/hc0502.102867","article-title":"No-reflow phenomenon","volume":"105","author":"Rezkalla","year":"2002","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2018112603525470100_cvy201-B42","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1160\/TH09-07-0440","article-title":"Antagonism of P2Y12 or GPIIb\/IIIa receptors reduces platelet-mediated myocardial injury after ischaemia and reperfusion in isolated rat hearts","volume":"104","author":"Barrabes","year":"2010","journal-title":"Thromb Haemost"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/114\/14\/1860\/26744134\/cvy201.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T02:02:37Z","timestamp":1571709757000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/114\/14\/1860\/5074301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,14]]},"references-count":42,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2018,8,14]]},"published-print":{"date-parts":[[2018,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvy201","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,12,1]]},"published":{"date-parts":[[2018,8,14]]}}}