{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:51:02Z","timestamp":1788875462435,"version":"build-2803163510"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T00:00:00Z","timestamp":1538697600000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["STE-1053\/3-1"],"award-info":[{"award-number":["STE-1053\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["STE-1053\/5-1"],"award-info":[{"award-number":["STE-1053\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1123 TP A1"],"award-info":[{"award-number":["SFB1123 TP A1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"ERC","doi-asserted-by":"publisher","award":["AdG 249929"],"award-info":[{"award-number":["AdG 249929"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"German Centre for Cardiovascular Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"DZHK","doi-asserted-by":"publisher","award":["MHA VD1.2"],"award-info":[{"award-number":["MHA VD1.2"]}],"id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"name":"F\u00f6rderung von Forschung und Lehre"},{"DOI":"10.13039\/501100005722","name":"Ludwig-Maximilians-University Munich","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005722","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Myocardial infarction (MI) leads to an enhanced release of endocannabinoids and a massive accumulation of neutrophils and monocytes within the ischaemic myocardium. These myeloid cells originate from haematopoietic precursors in the bone marrow and are rapidly mobilized in response to MI. We aimed to determine whether endocannabinoid signalling is involved in myeloid cell mobilization and cardiac recruitment after ischaemia onset.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Intravenous administration of endocannabinoid 2-arachidonoylglycerol (2-AG) into wild type (WT) C57BL6 mice induced a rapid increase of blood neutrophil and monocyte counts as measured by flow cytometry. This effect was blunted when using cannabinoid receptor 2 knockout mice. In response to MI induced in WT mice, the lipidomic analysis revealed significantly elevated plasma and cardiac levels of the endocannabinoid 2-AG 24\u2009h after infarction, but no changes in anandamide, palmitoylethanolamide, and oleoylethanolamide. This was a consequence of an increased expression of 2-AG synthesizing enzyme diacylglycerol lipase and a decrease of metabolizing enzyme monoacylglycerol lipase (MAGL) in infarcted hearts, as determined by quantitative RT\u2013PCR analysis. The opposite mRNA expression pattern was observed in bone marrow. Pharmacological blockade of MAGL with JZL184 and thus increased systemic 2-AG levels in WT mice subjected to MI resulted in elevated cardiac CXCL1, CXCL2, and MMP9 protein levels as well as higher cardiac neutrophil and monocyte counts 24\u2009h after infarction compared with vehicle-treated mice. Increased post-MI inflammation in these mice led to an increased infarct size, an impaired ventricular scar formation assessed by histology and a worsened cardiac function in echocardiography evaluations up to 21\u2009days. Likewise, JZL184-administration in a myocardial ischaemia-reperfusion model increased cardiac myeloid cell recruitment and resulted in a larger fibrotic scar size.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These findings suggest that changes in endocannabinoid gradients due to altered tissue levels contribute to myeloid cell recruitment from the bone marrow to the infarcted heart, with crucial consequences on cardiac healing and function.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvy242","type":"journal-article","created":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T16:24:22Z","timestamp":1538670262000},"page":"602-613","source":"Crossref","is-referenced-by-count":39,"title":["2-Arachidonoylglycerol mobilizes myeloid cells and worsens heart function after acute myocardial infarction"],"prefix":"10.1093","volume":"115","author":[{"given":"Maximilian J","family":"Schloss","sequence":"first","affiliation":[{"name":"Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University (LMU) Munich, Pettenkoferstr. 9, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Horckmans","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University (LMU) Munich, Pettenkoferstr. 9, Munich, Germany"},{"name":"Institut de Recherche Interdisciplinaire en Biologie Humaine et Mol\u00e9culaire (IRIBHM), Universit\u00e9 Libre de Bruxelles (U.L.B.), Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Guillamat-Prats","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University (LMU) Munich, Pettenkoferstr. 9, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hering","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University (LMU) Munich, Pettenkoferstr. 9, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Lauer","sequence":"additional","affiliation":[{"name":"Unit of Toxicology, CURML, Lausanne University Hospital, Geneva University Hospitals, rue Michel-Servet 1, Geneva CH-1211, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Lenglet","sequence":"additional","affiliation":[{"name":"Unit of Toxicology, CURML, Lausanne University Hospital, Geneva University Hospitals, rue Michel-Servet 1, Geneva CH-1211, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Weber","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University (LMU) Munich, Pettenkoferstr. 9, Munich, Germany"},{"name":"Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site, Munich Heart Alliance, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelien","family":"Thomas","sequence":"additional","affiliation":[{"name":"Unit of Toxicology, CURML, Lausanne University Hospital, Geneva University Hospitals, rue Michel-Servet 1, Geneva CH-1211, Switzerland"},{"name":"Faculty of Biology and Medicine, University of Lausanne, Vulliette 04, Lausanne 1000, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Steffens","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University (LMU) Munich, Pettenkoferstr. 9, Munich, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site, Munich Heart Alliance, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,9,28]]},"reference":[{"key":"2019090909384698700_cvy242-B1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.plipres.2011.01.001","article-title":"Is lipid signaling through cannabinoid 2 receptors part of a protective system?","volume":"50","author":"Pacher","year":"2011","journal-title":"Prog Lipid Res"},{"key":"2019090909384698700_cvy242-B2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/ni.1710","article-title":"Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids","volume":"10","author":"Pereira","year":"2009","journal-title":"Nat Immunol"},{"key":"2019090909384698700_cvy242-B3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0014-5793(98)00581-X","article-title":"2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: identification as one of the major species of monoacylglycerols in various rat tissues, and evidence for its generation through CA2+-dependent and -independent mechanisms","volume":"429","author":"Kondo","year":"1998","journal-title":"FEBS Lett"},{"key":"2019090909384698700_cvy242-B4","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2174\/138920112798868665","article-title":"Targeting the endocannabinod system to limit myocardial and cerebral ischemic and reperfusion injury","volume":"13","author":"Tuma","year":"2012","journal-title":"Curr Pharm Biotechnol"},{"key":"2019090909384698700_cvy242-B5","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/sj.bjp.0705666","article-title":"The endocannabinoid system: a general view and latest additions","volume":"141","author":"De Petrocellis","year":"2004","journal-title":"Br J Pharmacol"},{"key":"2019090909384698700_cvy242-B6","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1096\/fj.09-129478","article-title":"The cannabinoid receptor type 2 promotes cardiac myocyte and fibroblast survival and protects against ischemia\/reperfusion-induced cardiomyopathy","volume":"23","author":"Defer","year":"2009","journal-title":"FASEB J"},{"key":"2019090909384698700_cvy242-B7","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00395-014-0425-x","article-title":"The endocannabinoid-CB2 receptor axis protects the ischemic heart at the early stage of cardiomyopathy","volume":"109","author":"Duerr","year":"2014","journal-title":"Basic Res Cardiol"},{"key":"2019090909384698700_cvy242-B8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.lfs.2014.11.005","article-title":"Impaired border zone formation and adverse remodeling after reperfused myocardial infarction in cannabinoid CB2 receptor deficient mice","volume":"138","author":"Duerr","year":"2015","journal-title":"Life Sci"},{"key":"2019090909384698700_cvy242-B9","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1161\/CIRCULATIONAHA.117.028833","article-title":"Pericardial adipose tissue regulates granulopoiesis, fibrosis, and cardiac function after myocardial infarction","volume":"137","author":"Horckmans","year":"2018","journal-title":"Circulation"},{"key":"2019090909384698700_cvy242-B10","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.yjmcc.2008.12.014","article-title":"CB(2) cannabinoid receptor activation is cardioprotective in a mouse model of ischemia\/reperfusion","volume":"46","author":"Montecucco","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"2019090909384698700_cvy242-B11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/sj.bjp.0707523","article-title":"CB2 receptor-mediated migration of immune cells: it can go either way","volume":"153","author":"Miller","year":"2008","journal-title":"Br J Pharmacol"},{"key":"2019090909384698700_cvy242-B12","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1161\/CIRCULATIONAHA.109.916346","article-title":"Monocytes: protagonists of infarct inflammation and repair after myocardial infarction","volume":"121","author":"Nahrendorf","year":"2010","journal-title":"Circulation"},{"key":"2019090909384698700_cvy242-B13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nri.2017.10","article-title":"Neutrophils as protagonists and targets in chronic inflammation","volume":"17","author":"Soehnlein","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"2019090909384698700_cvy242-B14","first-page":"187","article-title":"Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype","volume":"38","author":"Horckmans","year":"2017","journal-title":"Eur Heart J"},{"key":"2019090909384698700_cvy242-B15","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.yjmcc.2009.10.025","article-title":"Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure","volume":"48","author":"Weis","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"2019090909384698700_cvy242-B16","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1096\/fj.06-7451com","article-title":"Cannabinoid-2 receptor mediates protection against hepatic ischemia\/reperfusion injury","volume":"21","author":"B\u00e1tkai","year":"2007","journal-title":"FASEB J"},{"key":"2019090909384698700_cvy242-B17","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.jacc.2007.03.057","article-title":"Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity","volume":"50","author":"Mukhopadhyay","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"2019090909384698700_cvy242-B18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0014-2999(00)00211-9","article-title":"Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor","volume":"396","author":"Buckley","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"2019090909384698700_cvy242-B19","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/35097089","article-title":"An endogenous cannabinoid (2-AG) is neuroprotective after brain injury","volume":"413","author":"Panikashvili","year":"2001","journal-title":"Nature"},{"key":"2019090909384698700_cvy242-B20","doi-asserted-by":"crossref","first-page":"671.","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"2019090909384698700_cvy242-B21","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/rcm.3918","article-title":"Quantitative and qualitative profiling of endocannabinoids in human plasma using a triple quadrupole linear ion trap mass spectrometer with liquid chromatography","volume":"23","author":"Thomas","year":"2009","journal-title":"Rapid Commun Mass Spectrom"},{"key":"2019090909384698700_cvy242-B22","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1093\/eurheartj\/eht085","article-title":"Improvement in coronary circulatory function in morbidly obese individuals after gastric bypass-induced weight loss: relation to alterations in endocannabinoids and adipocytokines","volume":"34","author":"Quercioli","year":"2013","journal-title":"Eur Heart J"},{"key":"2019090909384698700_cvy242-B23","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1093\/eurheartj\/ehv453","article-title":"Innate immune cells in ischaemic heart disease: does myocardial infarction beget myocardial infarction?","volume":"37","author":"Nahrendorf","year":"2016","journal-title":"Eur Heart J"},{"key":"2019090909384698700_cvy242-B24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nri3800","article-title":"Role of innate and adaptive immune mechanisms in cardiac injury and repair","volume":"15","author":"Epelman","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"2019090909384698700_cvy242-B25","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1172\/JCI41649","article-title":"CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow","volume":"120","author":"Eash","year":"2010","journal-title":"J Clin Invest"},{"key":"2019090909384698700_cvy242-B26","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1182\/blood-2008-09-177287","article-title":"CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions","volume":"113","author":"Eash","year":"2009","journal-title":"Blood"},{"key":"2019090909384698700_cvy242-B27","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1182\/blood-2004-09-3417","article-title":"VCAM-1 expression in adult hematopoietic and nonhematopoietic cells is controlled by tissue-inductive signals and reflects their developmental origin","volume":"106","author":"Ulyanova","year":"2005","journal-title":"Blood"},{"key":"2019090909384698700_cvy242-B28","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.4049\/jimmunol.166.6.4115","article-title":"Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases","volume":"166","author":"Pereira","year":"2001","journal-title":"J Immunol"},{"key":"2019090909384698700_cvy242-B29","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.4049\/jimmunol.1403205","article-title":"Endocannabinoid system contributes to liver injury and inflammation by activation of bone marrow-derived monocytes\/macrophages in a CB1-dependent manner","volume":"195","author":"Mai","year":"2015","journal-title":"J Immunol"},{"key":"2019090909384698700_cvy242-B30","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.prostaglandins.2015.09.005","article-title":"Lipopolysaccharide suppresses carboxylesterase 2g activity and 2-arachidonoylglycerol hydrolysis: a possible mechanism to regulate inflammation","volume":"121","author":"Szafran","year":"2015","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"2019090909384698700_cvy242-B31","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1161\/CIRCULATIONAHA.108.811992","article-title":"Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macrophages","volume":"119","author":"Sugamura","year":"2009","journal-title":"Circulation"},{"key":"2019090909384698700_cvy242-B32","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nature11260","article-title":"Myocardial infarction accelerates atherosclerosis","volume":"487","author":"Dutta","year":"2012","journal-title":"Nature"},{"key":"2019090909384698700_cvy242-B33","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1517\/14728222.2016.1088005","article-title":"Targeting danger-associated molecular patterns after myocardial infarction","volume":"20","author":"van Hout","year":"2016","journal-title":"Expert Opin Ther Targets"},{"key":"2019090909384698700_cvy242-B34","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.4049\/jimmunol.167.5.2879","article-title":"A role for IL-18 in neutrophil activation","volume":"167","author":"Leung","year":"2001","journal-title":"J Immunol"},{"key":"2019090909384698700_cvy242-B35","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.4049\/jimmunol.164.7.3862","article-title":"Induction of functional IL-8 receptors by IL-4 and IL-13 in human monocytes","volume":"164","author":"Bonecchi","year":"2000","journal-title":"J Immunol"},{"key":"2019090909384698700_cvy242-B36","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.cellsig.2007.11.008","article-title":"Tumor necrosis factor-alpha (TNF-alpha) induces integrin CD11b\/CD18 (Mac-1) up-regulation and migration to the CC chemokine CCL3 (MIP-1alpha) on human neutrophils through defined signalling pathways","volume":"20","author":"Montecucco","year":"2008","journal-title":"Cell Signal"},{"key":"2019090909384698700_cvy242-B37","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.yjmcc.2015.11.015","article-title":"Monocyte and macrophage contributions to cardiac remodeling","volume":"93","author":"Hulsmans","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"2019090909384698700_cvy242-B38","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.yjmcc.2016.10.005","article-title":"Early matrix metalloproteinase-9 inhibition post-myocardial infarction worsens cardiac dysfunction by delaying inflammation resolution","volume":"100","author":"Iyer","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"2019090909384698700_cvy242-B39","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1152\/physiol.00029.2013","article-title":"Matrix Metalloproteinase-9: many shades of function in cardiovascular disease","volume":"28","author":"Yabluchanskiy","year":"2013","journal-title":"Physiology"},{"key":"2019090909384698700_cvy242-B40","doi-asserted-by":"crossref","first-page":"937","DOI":"10.15252\/emmm.201506083","article-title":"The time-of-day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment","volume":"8","author":"Schloss","year":"2016","journal-title":"EMBO Mol Med"},{"key":"2019090909384698700_cvy242-B41","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00018-013-1349-6","article-title":"The pathogenesis of cardiac fibrosis","volume":"71","author":"Kong","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"2019090909384698700_cvy242-B42","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nrcardio.2017.130","article-title":"Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad, and the ugly","volume":"15","author":"Pacher","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"2019090909384698700_cvy242-B43","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/eurheartj\/eht090","article-title":"Myocardial reperfusion injury: looking beyond primary PCI","volume":"34","author":"Frohlich","year":"2013","journal-title":"Eur Heart J"},{"key":"2019090909384698700_cvy242-B44","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.yjmcc.2007.06.011","article-title":"Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction","volume":"43","author":"Fang","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"2019090909384698700_cvy242-B45","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0002-8703(00)90314-4","article-title":"Neutrophilia and congestive heart failure after acute myocardial infarction","volume":"139","author":"Kyne","year":"2000","journal-title":"Am Heart J"},{"key":"2019090909384698700_cvy242-B46","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.amjcard.2008.09.085","article-title":"Association of leukocyte and neutrophil counts with infarct size, left ventricular function and outcomes after percutaneous coronary intervention for ST-elevation myocardial infarction","volume":"103","author":"Chia","year":"2009","journal-title":"Am J Cardiol"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/115\/3\/602\/29816295\/cvy242.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T22:30:15Z","timestamp":1569969015000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/115\/3\/602\/5115994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,28]]},"references-count":46,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,9,28]]},"published-print":{"date-parts":[[2019,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvy242","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,3,1]]},"published":{"date-parts":[[2018,9,28]]}}}