{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:10:43Z","timestamp":1791648643287,"version":"4.3.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001700","name":"MEXT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JSPS KAKENHI","award":["25670193"],"award-info":[{"award-number":["25670193"]}]},{"name":"JSPS KAKENHI","award":["23390057"],"award-info":[{"award-number":["23390057"]}]},{"name":"JSPS KAKENHI","award":["18H02603"],"award-info":[{"award-number":["18H02603"]}]},{"name":"JSPS KAKENHI","award":["15K18987"],"award-info":[{"award-number":["15K18987"]}]},{"name":"JSPS KAKENHI","award":["15K08232"],"award-info":[{"award-number":["15K08232"]}]},{"DOI":"10.13039\/100007434","name":"Suzuken Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007434","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Platform Project for Supporting Drug Discovery and Life Science Research"},{"name":"Basis for Supporting Innovative Drug Discovery and Life Science Research"},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP18am0101084"],"award-info":[{"award-number":["JP18am0101084"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"DOI":"10.1093\/cvr\/cvy254","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T17:02:43Z","timestamp":1539190963000},"page":"765-775","source":"Crossref","is-referenced-by-count":20,"title":["Blockade of NKG2D\/NKG2D ligand interaction attenuated cardiac remodelling after myocardial infarction"],"prefix":"10.1093","volume":"115","author":[{"given":"Kotaro","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Obana","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arisa","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Kihara","sequence":"additional","affiliation":[{"name":"Laboratory for Animal Resource Development, RIKEN Center for Biosystems Dynamics Research, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Shioi","sequence":"additional","affiliation":[{"name":"Laboratory for Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Maeda","sequence":"additional","affiliation":[{"name":"Project Laboratory of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Sawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan"},{"name":"Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Fujio","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, Japan"},{"name":"Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,10,11]]},"reference":[{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/cvr\/cvn335","article-title":"Oxidative stress and left ventricular remodelling after myocardial infarction","volume":"81","author":"Hori","year":"2009","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/cvr\/cvp264","article-title":"Targeting calcium transport in ischaemic heart disease","volume":"84","author":"Talukder","year":"2009","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B3","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1089\/152308603770380098","article-title":"Oxidative stress-induced signal transduction pathways in cardiac myocytes: involvement of ROS in heart diseases","volume":"5","author":"Takano","year":"2003","journal-title":"Antioxid Redox Signal"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1755-1536-6-11","article-title":"Neutrophil roles in left ventricular remodeling following myocardial infarction","volume":"6","author":"Ma","year":"2013","journal-title":"Fibrogenesis Tissue Repair"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B5","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1093\/eurheartj\/ehv453","article-title":"Innate immune cells in ischaemic heart disease: does myocardial infarction beget myocardial infarction?","volume":"3","author":"Nahrendorf","year":"2016","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B6","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-immunol-032712-095951","article-title":"Regulation of ligands for the NKG2D activating receptor","volume":"31","author":"Raulet","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B7","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nri1199","article-title":"Roles of the NKG2D immunoreceptor and its ligands","volume":"3","author":"Raulet","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.0105-2896.2010.00893.x","article-title":"Effect of NKG2D ligand expression on host immune responses","volume":"235","author":"Champsaur","year":"2010","journal-title":"Immunol Rev"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B9","first-page":"3313","article-title":"Enhanced proliferative potential in culture of cells from p53-deficient mice","volume":"8","author":"Tsukada","year":"1993","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1172\/JCI119509","article-title":"Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo","volume":"100","author":"Agah","year":"1997","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B11","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1161\/CIRCULATIONAHA.109.893677","article-title":"Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction","volume":"121","author":"Obana","year":"2010","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B12","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/s41598-017-01426-8","article-title":"Adult murine cardiomyocytes exhibit regenerative activity with cell cycle reentry through STAT3 in the healing process of myocarditis","volume":"7","author":"Miyawaki","year":"2017","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B13","doi-asserted-by":"crossref","first-page":"H501","DOI":"10.1152\/ajpheart.00601.2016","article-title":"Caveolae-specific activation loop between CaMKII and L-type Ca(2+) channel aggravates cardiac hypertrophy in alpha1-adrenergic stimulation","volume":"312","author":"Tonegawa","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B14","doi-asserted-by":"crossref","first-page":"7140","DOI":"10.1038\/ncomms8140","article-title":"Prmt5 is a regulator of muscle stem cell expansion in adult mice","volume":"6","author":"Zhang","year":"2015","journal-title":"Nat Commun"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B15","doi-asserted-by":"crossref","first-page":"200","DOI":"10.5551\/jat.6437","article-title":"Atorvastatin prevents ischemic limb loss in type 2 diabetes: role of p53","volume":"18","author":"Morimoto","year":"2011","journal-title":"J Atheroscler Thromb"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B16","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.4161\/cc.10.19.17630","article-title":"Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2","volume":"10","author":"Li","year":"2011","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B17","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10495-006-4350-9","article-title":"Mechanisms of apoptosis after ischemia and reperfusion: role of the renin-angiotensin system","volume":"11","author":"Kossmehl","year":"2006","journal-title":"Apoptosis"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B18","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0008-6363(99)00349-1","article-title":"Apoptosis in relevant clinical situations: contribution of apoptosis in myocardial infarction","volume":"45","author":"Yaoita","year":"2000","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10741-016-9532-0","article-title":"Role of cell death in the progression of heart failure","volume":"21","author":"Moe","year":"2016","journal-title":"Heart Fail Rev"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B20","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1248\/bpb.b15-00288","article-title":"Cell death in the cardiac myocyte","volume":"38","author":"Marunouchi","year":"2015","journal-title":"Biol Pharm Bull"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1126\/science.1230719","article-title":"Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure","volume":"3","author":"Swirski","year":"2013","journal-title":"Science"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B22","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/01.RES.0000130526.20854.fa","article-title":"Inflammatory cytokines and postmyocardial infarction remodeling","volume":"94","author":"Nian","year":"2004","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B23","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/cvr\/cvu062","article-title":"Crosstalk between fibroblasts and inflammatory cells","volume":"102","author":"Van Linthout","year":"2014","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.yjmcc.2015.11.016","article-title":"Role of inflammatory cells in fibroblast activation","volume":"93","author":"Hartupee","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B25","doi-asserted-by":"crossref","first-page":"e004408","DOI":"10.1161\/JAHA.112.004408","article-title":"Deleterious effect of the IL-23\/IL-17A axis and gammadeltaT cells on left ventricular remodeling after myocardial infarction","volume":"1","author":"Yan","year":"2012","journal-title":"J Am Heart Assoc"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B26","doi-asserted-by":"crossref","first-page":"e0183584","DOI":"10.1371\/journal.pone.0183584","article-title":"RORgammat-expressing cells attenuate cardiac remodeling after myocardial infarction","volume":"12","author":"Enomoto","year":"2017","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B27","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/nature05602","article-title":"p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload","volume":"446","author":"Sano","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B28","doi-asserted-by":"crossref","first-page":"ra52","DOI":"10.1126\/scisignal.2002918","article-title":"p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice","volume":"5","author":"Lee","year":"2012","journal-title":"Sci Signal"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B29","first-page":"111","article-title":"STAT transcription in the ischemic heart","volume":"1","author":"Knight","year":"2012","journal-title":"JAKSTAT"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B30","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1111\/cas.13332","article-title":"Interleukin-6\/STAT3 signaling as a promising target to improve the efficacy of cancer immunotherapy","volume":"108","author":"Kitamura","year":"2017","journal-title":"Cancer Sci"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B31","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1254\/jphs.11R05CR","article-title":"Glycoprotein 130 cytokine signal as a therapeutic target against cardiovascular diseases","volume":"117","author":"Fujio","year":"2011","journal-title":"J Pharmacol Sci"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/med.20101","article-title":"STAT3: a critical transcription activator in angiogenesis","volume":"28","author":"Chen","year":"2008","journal-title":"Med Res Rev"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B33","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35025220","article-title":"Angiogenesis in cancer and other diseases","volume":"407","author":"Carmeliet","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B34","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrc.2017.109","article-title":"Targeting mutant p53 for efficient cancer therapy","volume":"18","author":"Bykov","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B35","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1200\/JCO.2002.20.5.1215","article-title":"Cardiac dysfunction in the trastuzumab clinical trials experience","volume":"20","author":"Seidman","year":"2002","journal-title":"J Clin Oncol"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B36","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s40261-014-0222-1","article-title":"Bevacizumab increases the risk of severe congestive heart failure in cancer patients: an up-to-date meta-analysis with a focus on different subgroups","volume":"34","author":"Qi","year":"2014","journal-title":"Clin Drug Invest"},{"key":"key\n\t\t\t\t2019040308501231700_cvy254-B37","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jcdr.2013.02.017","article-title":"Reversible myocardial dysfunction following intraocular bevacizumab admninistration","volume":"4","author":"Penumetsa","year":"2013","journal-title":"J Cardiovasc Dis Res"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/115\/4\/765\/28268209\/cvy254.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T09:14:29Z","timestamp":1554282869000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/115\/4\/765\/5126925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,11]]},"references-count":37,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,10,11]]},"published-print":{"date-parts":[[2019,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvy254","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,4,1]]},"published":{"date-parts":[[2018,10,11]]}}}