{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:16:58Z","timestamp":1790813818633,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T00:00:00Z","timestamp":1547251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["CRC 1116"],"award-info":[{"award-number":["CRC 1116"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Leducq Transatlantic Network of Excellence"},{"name":"RHYTHM","award":["16CVD02"],"award-info":[{"award-number":["16CVD02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Sodium glucose cotransporter 2 (SGLT2) inhibitors have sodium\u2013hydrogen exchanger (NHE) inhibition properties in isolated cardiomyocytes, but it is unknown whether these properties extend to the intact heart during ischaemia\u2013reperfusion (IR) conditions. NHE inhibitors as Cariporide delay time to onset of contracture (TOC) during ischaemia and reduce IR injury. We hypothesized that, in the ex vivo heart, Empagliflozin (Empa) mimics Cariporide during IR by delaying TOC and reducing IR injury. To facilitate translation to in vivo conditions with insulin present, effects were examined in the absence and presence of insulin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Isolated C57Bl\/6NCrl mouse hearts were subjected to 25\u2009min I and 120\u2009min R without and with 50 mU\/L insulin. Without insulin, Empa and Cari delayed TOC by 100 and 129\u2009s, respectively, yet only Cariporide reduced IR injury [infarct size (mean\u2009\u00b1\u2009SEM in %) from 51\u2009\u00b1\u20096 to 34\u2009\u00b1\u20095]. Empa did not delay TOC in the presence of the NHE1 inhibitor Eniporide. Insulin perfusion increased tissue glycogen content at baseline (from 2\u2009\u00b1\u20092\u2009\u00b5mol to 42\u2009\u00b1\u20091\u2009\u00b5mol glycosyl units\/g heart dry weight), amplified G6P and lactate accumulation at end-ischaemia, thereby decreased mtHKII and exacerbated IR injury. Under these conditions, Empa (1\u2009\u00b5M) and Cariporide (10\u2009\u00b5M) were without effect on TOC and IR injury. Empa and Cariporide both inhibited NHE activity, in isolated cardiomyocytes, independent of insulin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the absence of insulin, Empa and Cariporide strongly delayed the time to onset of contracture during ischaemia. In the presence of insulin, both Empa and Cari were without effect on IR, possibly because of severe ischaemic acidification. Insulin exacerbates IR injury through increased glycogen depletion during ischaemia and consequently mtHKII dissociation. The data suggest that also in the ex vivo intact heart Empa exerts direct cardiac effects by inhibiting NHE during ischaemia, but not during reperfusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvz004","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T06:28:28Z","timestamp":1546928908000},"page":"1533-1545","source":"Crossref","is-referenced-by-count":98,"title":["Delayed ischaemic contracture onset by empagliflozin associates with NHE1 inhibition and is dependent on insulin in isolated mouse hearts"],"prefix":"10.1093","volume":"115","author":[{"given":"Laween","family":"Uthman","sequence":"first","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam Infection & Immunity, Meibergdreef 9, AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne","family":"Nederlof","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Physiology, Heinrich-Heine University D\u00fcsseldorf, D\u00fcsseldorf, Universit\u00e4tsstrasse 1, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Eerbeek","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Department of Medical Biology, Meibergdreef 9, AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonius","family":"Baartscheer","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Clinical and Experimental Cardiology; Amsterdam Cardiovascular Sciences, Meibergdreef 9, AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cees","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Clinical and Experimental Cardiology; Amsterdam Cardiovascular Sciences, Meibergdreef 9, AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nin\u00e9e","family":"Buchholtz","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam Infection & Immunity, Meibergdreef 9, AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus W","family":"Hollmann","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam Infection & Immunity, Meibergdreef 9, AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Coronel","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Clinical and Experimental Cardiology; Amsterdam Cardiovascular Sciences, Meibergdreef 9, AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina C","family":"Weber","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam Infection & Immunity, Meibergdreef 9, AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coert J","family":"Zuurbier","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam Infection & Immunity, Meibergdreef 9, AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,12]]},"reference":[{"key":"2019072309501523200_cvz004-B1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s00125-016-4134-x","article-title":"Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+\/H+ exchanger in rats and rabbits","volume":"60","author":"Baartscheer","year":"2017","journal-title":"Diabetologia"},{"key":"2019072309501523200_cvz004-B2","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1007\/s00125-017-4509-7","article-title":"Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+\/H+ exchanger, lowering of cytosolic Na+ and vasodilation","volume":"61","author":"Uthman","year":"2018","journal-title":"Diabetologia"},{"key":"2019072309501523200_cvz004-B3","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1161\/CIRCULATIONAHA.117.030418","article-title":"Activation and Inhibition of sodium-hydrogen exchanger is a mechanism that links the pathophysiology and treatment of diabetes mellitus with that of heart failure","volume":"136","author":"Packer","year":"2017","journal-title":"Circulation"},{"key":"2019072309501523200_cvz004-B4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/cvr\/cvx149","article-title":"Cardiac effects of SGLT2 inhibitors: the sodium hypothesis","volume":"114","author":"Bertero","year":"2018","journal-title":"Cardiovasc Res"},{"key":"2019072309501523200_cvz004-B5","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1056\/NEJMoa1504720","article-title":"Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes","volume":"373","author":"Zinman","year":"2015","journal-title":"N Engl J Med"},{"key":"2019072309501523200_cvz004-B6","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1056\/NEJMoa1611925","article-title":"Canagliflozin and cardiovascular and renal events in type 2 diabetes","volume":"377","author":"Neal","year":"2017","journal-title":"N Engl J Med"},{"key":"2019072309501523200_cvz004-B7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1023\/A:1024985931797","article-title":"Na+ overload during ischemia and reperfusion in rat hearts: comparison of the Na+\/H+ exchange blockers EIPA, cariporide and eniporide","volume":"250","author":"ten Hove","year":"2003","journal-title":"Mol Cell Biochem"},{"key":"2019072309501523200_cvz004-B8","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1006\/jmcc.1999.1029","article-title":"Blocking Na+-H+ exchange by cariporide reduces Na+-overload in ischemia and is cardioprotective","volume":"31","author":"Hartmann","year":"1999","journal-title":"J Mol Cell Cardiol"},{"key":"2019072309501523200_cvz004-B9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.yjmcc.2013.02.006","article-title":"NHE-1: still a viable therapeutic target","volume":"61","author":"Karmazyn","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"2019072309501523200_cvz004-B10","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1161\/01.RES.68.5.1250","article-title":"Amiloride delays the ischemia-induced rise in cytosolic free calcium","volume":"68","author":"Murphy","year":"1991","journal-title":"Circ Res"},{"key":"2019072309501523200_cvz004-B11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000331709","article-title":"The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na+\/H+ exchanger NHE1","volume":"28","author":"Andersen","year":"2011","journal-title":"Cell Physiol Biochem"},{"key":"2019072309501523200_cvz004-B12","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1161\/01.CIR.102.25.3032","article-title":"Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against necrosis (GUARDIAN) Investigators","volume":"102","author":"Theroux","year":"2000","journal-title":"Circulation"},{"key":"2019072309501523200_cvz004-B13","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/S0735-1097(01)01608-4","article-title":"The Na+\/H+ exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction","volume":"38","author":"Zeymer","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"2019072309501523200_cvz004-B14","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.athoracsur.2007.10.054","article-title":"Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study","volume":"85","author":"Mentzer","year":"2008","journal-title":"Ann Thorac Surg"},{"key":"2019072309501523200_cvz004-B15","doi-asserted-by":"crossref","first-page":"19716","DOI":"10.1074\/jbc.M701637200","article-title":"NHE1 inhibition by amiloride- and benzoylguanidine-type compounds: inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity","volume":"282","author":"Pedersen","year":"2007","journal-title":"J Biol Chem"},{"key":"2019072309501523200_cvz004-B16","doi-asserted-by":"crossref","first-page":"1077.","DOI":"10.3389\/fphys.2017.01077","article-title":"Empagliflozin limits myocardial infarction in vivo and cell death in vitro: role of STAT3, mitochondria, and redox aspects","volume":"8","author":"Andreadou","year":"2017","journal-title":"Front Physiol"},{"key":"2019072309501523200_cvz004-B17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1530\/JOE-17-0457","article-title":"Cardioprotection of dapagliflozin and vildagliptin in rats with cardiac ischemia-reperfusion injury","volume":"236","author":"Tanajak","year":"2018","journal-title":"J Endocrinol"},{"key":"2019072309501523200_cvz004-B18","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/cvr\/cvu132","article-title":"Effective glycaemic control critically determines insulin cardioprotection against ischaemia\/reperfusion injury in anaesthetized dogs","volume":"103","author":"Yu","year":"2014","journal-title":"Cardiovasc Res"},{"key":"2019072309501523200_cvz004-B19","first-page":"175","article-title":"A new sodium\/hydrogen exchange inhibitor, EMD 85131, limits infarct size in dogs when administered before or after coronary artery occlusion","volume":"286","author":"Gumina","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"2019072309501523200_cvz004-B20","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.yjmcc.2009.02.021","article-title":"What is the mitochondrial permeability transition pore?","volume":"46","author":"Halestrap","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"2019072309501523200_cvz004-B21","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1093\/cvr\/cvs116","article-title":"Calcium-mediated cell death during myocardial reperfusion","volume":"94","author":"Garcia-Dorado","year":"2012","journal-title":"Cardiovasc Res"},{"key":"2019072309501523200_cvz004-B22","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1046\/j.1432-1327.2000.01084.x","article-title":"Insulin stimulates NHE1 activity by sequential activation of phosphatidylinositol 3-kinase and protein kinase C[zeta] in human erythrocytes","volume":"267","author":"Sauvage","year":"2000","journal-title":"Eur J Biochem"},{"key":"2019072309501523200_cvz004-B23","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1161\/hh2401.101385","article-title":"Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling","volume":"89","author":"Jonassen","year":"2001","journal-title":"Circ Res"},{"key":"2019072309501523200_cvz004-B24","doi-asserted-by":"crossref","first-page":"12749.","DOI":"10.1038\/s41598-017-13096-7","article-title":"Cyclophilin D ablation is associated with increased end-ischemic mitochondrial hexokinase activity","volume":"7","author":"Nederlof","year":"2017","journal-title":"Sci Rep"},{"key":"2019072309501523200_cvz004-B25","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1152\/japplphysiol.90537.2008","article-title":"Ischemic preconditioning affects hexokinase activity and HKII in different subcellular compartments throughout cardiac ischemia-reperfusion","volume":"106","author":"Gurel","year":"2009","journal-title":"J Appl Physiol"},{"key":"2019072309501523200_cvz004-B26","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1152\/ajpheart.01182.2004","article-title":"Ischemic preconditioning, insulin, and morphine all cause hexokinase redistribution","volume":"289","author":"Zuurbier","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2019072309501523200_cvz004-B27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s13105-017-0555-3","article-title":"Reducing mitochondrial bound hexokinase II mediates transition from non-injurious into injurious ischemia\/reperfusion of the intact heart","volume":"73","author":"Nederlof","year":"2016","journal-title":"J Physiol Biochem"},{"key":"2019072309501523200_cvz004-B28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"2019072309501523200_cvz004-B29","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0022-2828(88)80135-4","article-title":"The cytoplasmic free energy of ATP hydrolysis in isolated rod-shaped rat ventricular myocytes","volume":"20","author":"Welle","year":"1988","journal-title":"J Mol Cell Cardiol"},{"key":"2019072309501523200_cvz004-B30","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/01.RES.78.3.482","article-title":"Is a high glycogen content beneficial or detrimental to the ischemic rat heart? A controversy resolved","volume":"78","author":"Cross","year":"1996","journal-title":"Circ Res"},{"key":"2019072309501523200_cvz004-B31","doi-asserted-by":"crossref","first-page":"e005645.","DOI":"10.1161\/JAHA.112.005645","article-title":"Extent of mitochondrial hexokinase II dissociation during ischemia correlates with mitochondrial cytochrome c release, reactive oxygen species production, and infarct size on reperfusion","volume":"2","author":"Pasdois","year":"2012","journal-title":"J Am Heart Assoc"},{"key":"2019072309501523200_cvz004-B32","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1161\/CIRCRESAHA.111.244962","article-title":"Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis","volume":"108","author":"Smeele","year":"2011","journal-title":"Circ Res"},{"key":"2019072309501523200_cvz004-B33","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1161\/CIRCRESAHA.110.223115","article-title":"Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia\/reperfusion injury","volume":"108","author":"Wu","year":"2011","journal-title":"Circ Res"},{"key":"2019072309501523200_cvz004-B34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2017.06.016","article-title":"The role of succinate and ROS in reperfusion injury\u2014a critical appraisal","volume":"110","author":"Andrienko","year":"2017","journal-title":"J Mol Cell Cardiol"},{"key":"2019072309501523200_cvz004-B35","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0008-6363(97)00106-5","article-title":"Prevention of ischemic rigor contracture during coronary occlusion by inhibition of Na+\u2013H+ exchange","volume":"35","author":"Garcia-Dorado","year":"1997","journal-title":"Cardiovasc Res"},{"key":"2019072309501523200_cvz004-B36","first-page":"17","article-title":"Protective effect of HOE642, a selective blocker of Na+-H+ exchange, against the development of rigor contracture in rat ventricular myocytes","volume":"85","author":"Ruiz-Meana","year":"2000","journal-title":"Exp Physiol"},{"key":"2019072309501523200_cvz004-B37","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.cardiores.2003.12.012","article-title":"The first minutes of reperfusion: a window of opportunity for cardioprotection","volume":"61","author":"Piper","year":"2004","journal-title":"Cardiovasc Res"},{"key":"2019072309501523200_cvz004-B38","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1152\/ajpheart.00035.2003","article-title":"Cariporide preserves mitochondrial proton gradient and delays ATP depletion in cardiomyocytes during ischemic conditions","volume":"285","author":"Ruiz-Meana","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2019072309501523200_cvz004-B39","first-page":"2","article-title":"Sodium Glucose Transporter 2 (SGLT2) inhibition does not protect the myocardium from acute ischemic reperfusion injury but modulates post-ischemic mitochondrial function","volume":"6","author":"Jespersen","year":"2017","journal-title":"Cardiovasc Pharmacol Open Access"},{"key":"2019072309501523200_cvz004-B40","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jacbts.2017.07.003","article-title":"Empagliflozin prevents worsening of cardiac function in an experimental model of pressure overload-induced heart failure","volume":"2","author":"Byrne","year":"2017","journal-title":"JACC Basic Transl Sci"},{"key":"2019072309501523200_cvz004-B41","doi-asserted-by":"crossref","first-page":"e00239.","DOI":"10.1002\/prp2.239","article-title":"Inhibition of SGLT2 alleviates diabetic nephropathy by suppressing high glucose-induced oxidative stress in type 1 diabetic mice","volume":"4","author":"Hatanaka","year":"2016","journal-title":"Pharmacol Res Perspect"},{"key":"2019072309501523200_cvz004-B42","doi-asserted-by":"crossref","first-page":"e0158810.","DOI":"10.1371\/journal.pone.0158810","article-title":"Dapagliflozin, SGLT2 inhibitor, attenuates renal ischemia-reperfusion injury","volume":"11","author":"Chang","year":"2016","journal-title":"PLoS One"},{"key":"2019072309501523200_cvz004-B43","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1113\/jphysiol.1990.sp018221","article-title":"Extracellular H+ inactivation of Na+\u2010H+ exchange in the sheep cardiac Purkinje fibre","volume":"428","author":"Vaughan-Jones","year":"1990","journal-title":"J Physiol (Lond)"},{"key":"2019072309501523200_cvz004-B44","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1113\/jphysiol.1994.sp020251","article-title":"Effect of metabolic inhibitors and second messengers upon Na+-H+ exchange in the sheep cardiac Purkinje fibre","volume":"478","author":"Wu","year":"1994","journal-title":"J Physiol"},{"key":"2019072309501523200_cvz004-B45","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1161\/01.CIR.89.6.2787","article-title":"New Na+-H+ exchange inhibitor HOE 694 improves postischemic function and high-energy phosphate resynthesis and reduces Ca21 overload in isolated perfused rabbit heart","volume":"89","author":"Hendrikx","year":"1994","journal-title":"Circulation"},{"key":"2019072309501523200_cvz004-B46","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1161\/01.CIR.0000075270.13497.2B","article-title":"Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy","volume":"107","author":"Arad","year":"2003","journal-title":"Circulation"},{"key":"2019072309501523200_cvz004-B47","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1177\/1074248418755120","article-title":"Inhibition of Na+\/H+ exchanger with EMD 87580 does not confer greater cardioprotection beyond preconditioning on ischemia\u2013reperfusion injury in normal dogs","volume":"23","author":"Kingma","year":"2018","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"2019072309501523200_cvz004-B48","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1111\/bph.12899","article-title":"The role of hexokinase in cardioprotection\u2014mechanism and potential for translation","volume":"172","author":"Halestrap","year":"2015","journal-title":"Br J Pharmacol"},{"key":"2019072309501523200_cvz004-B49","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1111\/bph.12363","article-title":"Targeting hexokinase II to mitochondria to modulate energy metabolism and reduce ischaemia-reperfusion injury in heart","volume":"171","author":"Nederlof","year":"2014","journal-title":"Br J Pharmacol"},{"key":"2019072309501523200_cvz004-B50","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0008-6363(03)00259-1","article-title":"Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects","volume":"58","author":"Peart","year":"2003","journal-title":"Cardiovasc Res"},{"key":"2019072309501523200_cvz004-B51","doi-asserted-by":"crossref","first-page":"H2694","DOI":"10.1152\/ajpheart.2000.279.6.H2694","article-title":"Differential role of sarcolemmal and mitochondrial K(ATP) channels in adenosine-enhanced ischemic preconditioning","volume":"279","author":"Toyoda","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/115\/10\/1533\/28981221\/cvz004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T17:34:35Z","timestamp":1662744875000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/115\/10\/1533\/5288517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,12]]},"references-count":51,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,1,12]]},"published-print":{"date-parts":[[2019,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvz004","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,8,1]]},"published":{"date-parts":[[2019,1,12]]}}}