{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:03:50Z","timestamp":1788631430442,"version":"build-2803163510"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,3,9]],"date-time":"2019-03-09T00:00:00Z","timestamp":1552089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Ministry of Education, Science, and Culture, Tokyo"},{"name":"Grants-in-Aid for Scientific Research","award":["17K16011"],"award-info":[{"award-number":["17K16011"]}]},{"name":"Grants-in-Aid for Scientific Research","award":["17K09590"],"award-info":[{"award-number":["17K09590"]}]},{"name":"JST CREST","award":["JPMJCR17H5"],"award-info":[{"award-number":["JPMJCR17H5"]}]},{"name":"Intractable Diseases Overcome Research Project"},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"DOI":"10.1093\/cvr\/cvz066","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T07:25:43Z","timestamp":1551943543000},"page":"1244-1255","source":"Crossref","is-referenced-by-count":88,"title":["Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia\u2013reperfusion injury by inhibiting monocyte-mediated inflammation in mice"],"prefix":"10.1093","volume":"115","author":[{"given":"Masaki","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Matoba","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ichiro","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Development, and Translational Research, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arihide","family":"Okahara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Funamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Development, and Translational Research, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaku","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Development, and Translational Research, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tsutsui","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Egashira","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Development, and Translational Research, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,9]]},"reference":[{"key":"2019052205000984600_cvz066-B1","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart Disease and Stroke Statistics\u20142018 update: a report from the American Heart Association","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"key":"2019052205000984600_cvz066-B2","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1056\/NEJMoa1208200","article-title":"Door-to-balloon time and mortality among patients undergoing primary PCI","volume":"369","author":"Menees","year":"2013","journal-title":"N Engl J Med"},{"key":"2019052205000984600_cvz066-B3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: a neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J Clin Invest"},{"key":"2019052205000984600_cvz066-B4","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/eurheartj\/eht090","article-title":"Myocardial reperfusion injury: looking beyond primary PCI","volume":"34","author":"Frohlich","year":"2013","journal-title":"Eur Heart J"},{"key":"2019052205000984600_cvz066-B5","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1152\/physrev.00024.2007","article-title":"Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury","volume":"88","author":"Murphy","year":"2008","journal-title":"Physiol Rev"},{"key":"2019052205000984600_cvz066-B6","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cardiores.2003.10.011","article-title":"Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury","volume":"61","author":"Vinten-Johansen","year":"2004","journal-title":"Cardiovasc Res"},{"key":"2019052205000984600_cvz066-B7","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nrcardio.2011.38","article-title":"Innate immune signaling in cardiac ischemia","volume":"8","author":"Arslan","year":"2011","journal-title":"Nat Rev Cardiol"},{"key":"2019052205000984600_cvz066-B8","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1084\/jem.20070885","article-title":"The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions","volume":"204","author":"Nahrendorf","year":"2007","journal-title":"J Exp Med"},{"key":"2019052205000984600_cvz066-B9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijcard.2016.12.182","article-title":"Monocyte subsets in myocardial infarction: a review","volume":"231","author":"Arfvidsson","year":"2017","journal-title":"Int J Cardiol"},{"key":"2019052205000984600_cvz066-B10","doi-asserted-by":"crossref","first-page":"29601.","DOI":"10.1038\/srep29601","article-title":"Nanoparticle-mediated delivery of irbesartan induces cardioprotection from myocardial ischemia-reperfusion injury by antagonizing monocyte-mediated inflammation","volume":"6","author":"Nakano","year":"2016","journal-title":"Sci Rep"},{"key":"2019052205000984600_cvz066-B11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/cvr\/cvy200","article-title":"PPAR\u03b3-targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte\/macrophage polarization in preclinical animal models","volume":"115","author":"Tokutome","year":"2019","journal-title":"Cardiovasc Res"},{"key":"2019052205000984600_cvz066-B12","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1172\/JCI119457","article-title":"The cytokine-adhesion molecule cascade in ischemia\/reperfusion injury of the rat kidney. Inhibition by a soluble P-selectin ligand","volume":"99","author":"Takada","year":"1997","journal-title":"J Clin Invest"},{"key":"2019052205000984600_cvz066-B13","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1172\/JCI115427","article-title":"Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion","volume":"88","author":"Ma","year":"1991","journal-title":"J Clin Invest"},{"key":"2019052205000984600_cvz066-B14","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/jlb.62.3.292","article-title":"Monoclonal antibody to ICAM-1 preserves postischemic blood flow and reduces infarct size after ischemia-reperfusion in rabbit","volume":"62","author":"Zhao","year":"1997","journal-title":"J Leukoc Biol"},{"key":"2019052205000984600_cvz066-B15","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1161\/ATVBAHA.107.140723","article-title":"Toll-like receptors 2-deficient mice are protected against postischemic coronary endothelial dysfunction","volume":"27","author":"Favre","year":"2007","journal-title":"ATVB"},{"key":"2019052205000984600_cvz066-B16","doi-asserted-by":"crossref","first-page":"e000683.","DOI":"10.1161\/JAHA.113.000683","article-title":"Role of extracellular RNA and TLR3-Trif signaling in myocardial ischemia-reperfusion injury","volume":"3","author":"Chen","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"2019052205000984600_cvz066-B17","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1161\/01.CIR.0000112575.66565.84","article-title":"Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice","volume":"109","author":"Oyama","year":"2004","journal-title":"Circulation"},{"key":"2019052205000984600_cvz066-B18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1042\/CS20140444","article-title":"Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse","volume":"129","author":"Parapanov","year":"2015","journal-title":"Clin Sci"},{"key":"2019052205000984600_cvz066-B19","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbadis.2012.08.008","article-title":"CpG-ODN, the TLR9 agonist, attenuates myocardial ischemia\/reperfusion injury: involving activation of PI3K\/Akt signaling","volume":"1832","author":"Cao","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"2019052205000984600_cvz066-B20","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1161\/CIRCULATIONAHA.105.000901","article-title":"Inhibition of Toll-like receptor 4 with eritoran attenuates myocardial ischemia-reperfusion injury","volume":"114","author":"Shimamoto","year":"2006","journal-title":"Circulation"},{"key":"2019052205000984600_cvz066-B21","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jjcc.2017.03.005","article-title":"Nanoparticle-mediated drug delivery system for atherosclerotic cardiovascular disease","volume":"70","author":"Matoba","year":"2017","journal-title":"J Cardiol"},{"key":"2019052205000984600_cvz066-B22","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/CIRCULATIONAHA.113.002870","article-title":"Nanoparticle-mediated delivery of pitavastatin inhibits atherosclerotic plaque destabilization\/rupture in mice by regulating the recruitment of inflammatory monocytes","volume":"129","author":"Katsuki","year":"2014","journal-title":"Circulation"},{"key":"2019052205000984600_cvz066-B23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1161\/HYPERTENSIONAHA.110.157032","article-title":"Nanoparticle-mediated delivery of pitavastatin into lungs ameliorates the development and induces regression of monocrotaline-induced pulmonary artery hypertension","volume":"57","author":"Chen","year":"2011","journal-title":"Hypertension"},{"key":"2019052205000984600_cvz066-B24","doi-asserted-by":"crossref","first-page":"e0132451.","DOI":"10.1371\/journal.pone.0132451","article-title":"A new therapeutic modality for acute myocardial infarction: nanoparticle-mediated delivery of pitavastatin induces cardioprotection from ischemia-reperfusion injury via activation of PI3K\/Akt pathway and anti-inflammation in a rat model","volume":"10","author":"Nagaoka","year":"2015","journal-title":"PLoS One"},{"key":"2019052205000984600_cvz066-B25","doi-asserted-by":"crossref","first-page":"20467","DOI":"10.1038\/srep20467","article-title":"Nanoparticle-mediated targeting of cyclosporine A enhances cardioprotection against ischemia- reperfusion injury through inhibition of mitochondrial permeability transition pore opening","volume":"6","author":"Ikeda","year":"2016","journal-title":"Sci Rep"},{"key":"2019052205000984600_cvz066-B26","doi-asserted-by":"crossref","first-page":"e003872.","DOI":"10.1161\/JAHA.116.003872","article-title":"Nanoparticle-mediated delivery of mitochondrial division inhibitor 1 to the myocardium protects the heart from ischemia-reperfusion injury through inhibition of mitochondria outer membrane permeabilization: a new therapeutic modality for acute myocardial infarction","volume":"5","author":"Ishikita","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"2019052205000984600_cvz066-B27","doi-asserted-by":"crossref","first-page":"e0162425.","DOI":"10.1371\/journal.pone.0162425","article-title":"A translational study of a new therapeutic approach for acute myocardial infarction: nanoparticle-mediated delivery of pitavastatin into reperfused myocardium reduces ischemia-reperfusion injury in a preclinical porcine model","volume":"11","author":"Ichimura","year":"2016","journal-title":"PLoS One"},{"key":"2019052205000984600_cvz066-B28","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1093\/cvr\/cvy039","article-title":"Cardioprotection by ischemic postconditioning and cyclic guanosine monophosphate-elevating agents involves cardiomyocyte nitric oxide-sensitive guanylyl cyclase","volume":"114","author":"Frankenreiter","year":"2018","journal-title":"Cardiovasc Res"},{"key":"2019052205000984600_cvz066-B29","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1097\/CCM.0b013e3181e7c5c9","article-title":"A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis","volume":"38","author":"Rice","year":"2010","journal-title":"Crit Care Med"},{"key":"2019052205000984600_cvz066-B30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/SHK.0b013e3181f48942","article-title":"Combination of imipenem and TAK-242, a Toll-like receptor 4 signal transduction inhibitor, improves survival in a murine model of polymicrobial sepsis","volume":"35","author":"Sha","year":"2011","journal-title":"Shock"},{"key":"2019052205000984600_cvz066-B31","doi-asserted-by":"crossref","first-page":"896.","DOI":"10.1038\/srep00896","article-title":"Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia","volume":"2","author":"Suzuki","year":"2012","journal-title":"Sci Rep"},{"key":"2019052205000984600_cvz066-B32","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/jcbfm.2014.240","article-title":"TAK-242, an antagonist for Toll-like receptor 4, protects against acute cerebral ischemia\/reperfusion injury in mice","volume":"35","author":"Hua","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"key":"2019052205000984600_cvz066-B33","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/cvr\/cvn291","article-title":"Role of high-mobility group box 1 protein in post-infarction healing process and left ventricular remodelling","volume":"81","author":"Kohno","year":"2008","journal-title":"Cardiovasc Res"},{"key":"2019052205000984600_cvz066-B34","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1126\/science.1230719","article-title":"Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure","volume":"339","author":"Swirski","year":"2013","journal-title":"Science"},{"key":"2019052205000984600_cvz066-B35","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1536\/ihj.16-457","article-title":"Nanoparticle-mediated delivery of pitavastatin to monocytes\/macrophages inhibits left ventricular remodeling after acute myocardial infarction by inhibiting monocyte-mediated inflammation","volume":"58","author":"Mao","year":"2017","journal-title":"Int Heart J"},{"key":"2019052205000984600_cvz066-B36","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.atherosclerosis.2011.12.030","article-title":"Differential expression of Toll-like receptor 4 and human monocyte subsets in acute myocardial infarction","volume":"221","author":"Kashiwagi","year":"2012","journal-title":"Atherosclerosis"},{"key":"2019052205000984600_cvz066-B37","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1042\/CS20070379","article-title":"Local expression of Toll-like receptor 4 at the site of ruptured plaques in patients with acute myocardial infarction","volume":"115","author":"Ishikawa","year":"2008","journal-title":"Clin Sci"},{"key":"2019052205000984600_cvz066-B38","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jss.2013.11.1086","article-title":"The interaction between Toll-like receptor 4 signaling pathway and hypoxia-inducible factor 1\u03b1 in lung ischemia-reperfusion injury","volume":"188","author":"Zhou","year":"2014","journal-title":"J Surg Res"},{"key":"2019052205000984600_cvz066-B39","doi-asserted-by":"crossref","first-page":"e0154708.","DOI":"10.1371\/journal.pone.0154708","article-title":"Unilateral partial nephrectomy with warm ischemia results in acute hypoxia inducible factor 1-alpha (HIF-1\u03b1) and Toll-like receptor 4 (TLR4) overexpression in a porcine model","volume":"11","author":"Zhang","year":"2016","journal-title":"PLoS One"},{"key":"2019052205000984600_cvz066-B40","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.pan.2012.02.015","article-title":"Hypoxia-inducible factor-1 up-regulates the expression of Toll-like receptor 4 in pancreatic cancer cells under hypoxic conditions","volume":"12","author":"Fan","year":"2012","journal-title":"Pancreatology"},{"key":"2019052205000984600_cvz066-B41","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1124\/mol.105.019695","article-title":"A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits Toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling","volume":"69","author":"Ii","year":"2006","journal-title":"Mol Pharmacol"},{"key":"2019052205000984600_cvz066-B42","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1124\/mol.110.068064","article-title":"TAK-242 (Resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules","volume":"79","author":"Matsunaga","year":"2011","journal-title":"Mol Pharmacol"},{"key":"2019052205000984600_cvz066-B43","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.surg.2017.08.025","article-title":"Inhibition of Toll-like receptor 4 ameliorates experimental postischemic injury in the cholestatic liver through inhibition of high-mobility group box protein b1 (HMGB1) signaling","volume":"163","author":"Yokoi","year":"2018","journal-title":"Surgery"},{"key":"2019052205000984600_cvz066-B44","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.bbrc.2018.06.020","article-title":"Reno-protective effects of TAK-242 on acute kidney injury in a rat model","volume":"503","author":"Mohammad","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"2019052205000984600_cvz066-B45","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.4049\/jimmunol.178.6.3731","article-title":"TLR4-mediated survival of macrophages is MyD88 dependent and requires TNF-\u03b1 autocrine signalling","volume":"178","author":"Lombardo","year":"2007","journal-title":"J Immunol"},{"key":"2019052205000984600_cvz066-B46","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bbrc.2016.07.078","article-title":"Platelet-derived high-mobility group box 1 promotes recruitment and suppresses apoptosis of monocytes","volume":"478","author":"Vogel","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"2019052205000984600_cvz066-B47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin Immunol"},{"key":"2019052205000984600_cvz066-B48","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrd3203","article-title":"Targeting Toll-like receptors: emerging therapeutics?","volume":"9","author":"Hennessy","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"2019052205000984600_cvz066-B49","first-page":"187","article-title":"Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype","volume":"38","author":"Horckmans","year":"2017","journal-title":"Eur Heart J"},{"key":"2019052205000984600_cvz066-B50","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.stem.2015.04.008","article-title":"Myocardial infarction activates CCR2+ hematopoietic stem and progenitor cells","volume":"16","author":"Dutta","year":"2015","journal-title":"Cell Stem Cell"},{"key":"2019052205000984600_cvz066-B51","doi-asserted-by":"crossref","first-page":"857","DOI":"10.4049\/jimmunol.1300790","article-title":"TLR4 Signaling augments monocyte chemotaxis by regulating G protein-coupled receptor kinase 2 translocation","volume":"191","author":"Liu","year":"2013","journal-title":"J Immunol"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/115\/7\/1244\/28679694\/cvz066.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T07:26:35Z","timestamp":1558509995000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/115\/7\/1244\/5372719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,9]]},"references-count":51,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,3,9]]},"published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvz066","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,6,1]]},"published":{"date-parts":[[2019,3,9]]}}}