{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:02:29Z","timestamp":1777528949305,"version":"3.51.4"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Harvard-Longwood Research Training in Vascular Surgery"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["5T32 HL007734-22"],"award-info":[{"award-number":["5T32 HL007734-22"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"American Heart Association Post-Doctoral","award":["#19POST34400059"],"award-info":[{"award-number":["#19POST34400059"]}]},{"name":"Foundation \u2018De Drie Lichten\u2019"},{"name":"Prins Bernhard Cultural Foundation and Michael-van Vloten Foundation"},{"DOI":"10.13039\/100013148","name":"Mendez National Institute of Transplantation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013148","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Leenards Foundation"},{"name":"American Heart Association Grant-in-Aid","award":["16GRNT27090006"],"award-info":[{"award-number":["16GRNT27090006"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01HL133500"],"award-info":[{"award-number":["1R01HL133500"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AG036712"],"award-info":[{"award-number":["AG036712"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DK090629"],"award-info":[{"award-number":["DK090629"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Charoen Pokphand Group"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Therapies to prevent vein graft disease, a major problem in cardiovascular and lower extremity bypass surgeries, are currently lacking. Short-term preoperative protein restriction holds promise as an effective preconditioning method against surgical stress in rodent models, but whether it can improve vein graft patency after bypass surgery is undetermined. Here, we hypothesized that short-term protein restriction would limit vein graft disease via up-regulation of cystathionine \u03b3-lyase and increased endogenous production of the cytoprotective gaseous signalling molecule hydrogen sulfide.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Low-density lipoprotein receptor knockout mice were preconditioned for 1 week on a high-fat high-cholesterol (HFHC) diet with or without protein prior to left common carotid interposition vein graft surgery with caval veins from donor mice on corresponding diets. Both groups were returned to a complete HFHC diet post-operatively, and vein grafts analysed 4 or 28\u2009days later. A novel global transgenic cystathionine \u03b3-lyase overexpressing mouse model was also employed to study effects of genetic overexpression on graft patency. Protein restriction decreased vein graft intimal\/media+adventitia area and thickness ratios and intimal smooth muscle cell infiltration 28\u2009days post-operatively, and neutrophil transmigration 4\u2009days post-operatively. Protein restriction increased cystathionine \u03b3-lyase protein expression in aortic and caval vein endothelial cells (ECs) and frequency of lung EC producing hydrogen sulfide. The cystathionine \u03b3-lyase inhibitor propargylglycine abrogated protein restriction-mediated protection from graft failure and the increase in hydrogen sulfide-producing ECs, while cystathionine \u03b3-lyase transgenic mice displayed increased hydrogen sulfide production capacity and were protected from vein graft disease independent of diet.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>One week of protein restriction attenuates vein graft disease via increased cystathionine \u03b3-lyase expression and hydrogen sulfide production, and decreased early inflammation. Dietary or pharmacological interventions to increase cystathionine \u03b3-lyase or hydrogen sulfide may thus serve as new and practical strategies to improve vein graft durability.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvz086","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T22:15:36Z","timestamp":1553724936000},"page":"416-428","source":"Crossref","is-referenced-by-count":31,"title":["Short-term preoperative protein restriction attenuates vein graft disease via induction of cystathionine \u03b3-lyase"],"prefix":"10.1093","volume":"116","author":[{"given":"Kaspar M","family":"Trocha","sequence":"first","affiliation":[{"name":"Department of Surgery and the Heart and Vascular Center, Brigham & Women\u2019s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA"},{"name":"Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-2068","authenticated-orcid":false,"given":"Peter","family":"Kip","sequence":"additional","affiliation":[{"name":"Department of Surgery and the Heart and Vascular Center, Brigham & Women\u2019s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA"},{"name":"Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA"},{"name":"Einthoven Laboratory for Experimental Vascular Medicine and Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Surgery and the Heart and Vascular Center, Brigham & Women\u2019s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R","family":"MacArthur","sequence":"additional","affiliation":[{"name":"Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Humberto","family":"Trevi\u00f1o-Villarreal","sequence":"additional","affiliation":[{"name":"Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alban","family":"Longchamp","sequence":"additional","affiliation":[{"name":"Department of Surgery and the Heart and Vascular Center, Brigham & Women\u2019s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA"},{"name":"Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Toussaint","sequence":"additional","affiliation":[{"name":"VIB-UGent Center for Inflammation Research, and Department of Internal Medicine and Pediatrics, Ghent University, Belgium"},{"name":"Department of Internal Medicine, Ghent University, Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart N","family":"Lambrecht","sequence":"additional","affiliation":[{"name":"VIB-UGent Center for Inflammation Research, and Department of Internal Medicine and Pediatrics, Ghent University, Belgium"},{"name":"Department of Internal Medicine, Ghent University, Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3648-9130","authenticated-orcid":false,"given":"Margreet R","family":"de Vries","sequence":"additional","affiliation":[{"name":"Einthoven Laboratory for Experimental Vascular Medicine and Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6853-5760","authenticated-orcid":false,"given":"Paul H A","family":"Quax","sequence":"additional","affiliation":[{"name":"Einthoven Laboratory for Experimental Vascular Medicine and Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C Keith","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Department of Surgery and the Heart and Vascular Center, Brigham & Women\u2019s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,3,29]]},"reference":[{"key":"2021061511385856100_cvz086-B1","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1001\/jama.297.9.986","article-title":"Aging, adiposity, and calorie restriction","volume":"297","author":"Fontana","year":"2007","journal-title":"JAMA"},{"key":"2021061511385856100_cvz086-B2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1161\/CIRCULATIONAHA.110.972166","article-title":"Consumption of added sugars and indicators of cardiovascular disease risk among US 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