{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:43:16Z","timestamp":1790912596787,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T00:00:00Z","timestamp":1556841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"John and Birthe Meyer Foundation"},{"name":"Research Foundation of the Heart Centre, Rigshospitalet"},{"name":"Research Council at Rigshospitalet"},{"name":"The Hallas-M\u00f8ller Emerging Investigator Novo Nordisk","award":["NNF17OC0031204"],"award-info":[{"award-number":["NNF17OC0031204"]}]},{"DOI":"10.13039\/100007460","name":"Arvid Nilsson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007460","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lundbeck Foundation Initiative for Integrative Psychiatric Research"},{"name":"Danish National Biobank"},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Syncope is a common condition associated with frequent hospitalization or visits to the emergency department. Family aggregation and twin studies have shown that syncope has a heritable component. We investigated whether common genetic variants predispose to syncope and collapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We used genome-wide association data on syncope on 408\u00a0961 individuals with European ancestry from the UK Biobank study. In a replication study, we used the Integrative Psychiatric Research Consortium (iPSYCH) cohort (n\u2009=\u200986\u00a0189), to investigate the risk of incident syncope stratified by genotype carrier status. We report on a genome-wide significant locus located on chromosome 2q32.1 [odds ratio = 1.13, 95% confidence interval (CI) 1.10\u20131.17, P\u2009=\u20095.8\u2009\u00d7\u200910\u221215], with lead single nucleotide polymorphism rs12465214 in proximity to the gene zinc finger protein 804a (ZNF804A). This association was also shown in the iPSYCH cohort, where homozygous carriers of the C allele conferred an increased hazard ratio (1.30, 95% CI 1.15\u20131.46, P\u2009=\u20091.68\u2009\u00d7\u200910\u22125) of incident syncope. Quantitative polymerase chain reaction analysis showed ZNF804A to be expressed most abundantly in brain tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We identified a genome-wide significant locus (rs12465214) associated with syncope and collapse. The association was replicated in an independent cohort. This is the first genome-wide association study to associate a locus with syncope and collapse.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cvr\/cvz106","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T11:13:42Z","timestamp":1556190822000},"page":"138-148","source":"Crossref","is-referenced-by-count":19,"title":["Genome-wide association study identifies locus at chromosome 2q32.1 associated with syncope and collapse"],"prefix":"10.1093","volume":"116","author":[{"given":"Katra","family":"Hadji-Turdeghal","sequence":"first","affiliation":[{"name":"Laboratory for Molecular Cardiology, Department of Cardiology, The Heart Centre, Rigshospitalet (Copenhagen University Hospital), Copenhagen, Denmark"},{"name":"Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark"},{"name":"Department of Biomedical Sciences, University of Copenhagen, Copenhagen, 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