{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:59:37Z","timestamp":1793055577759,"version":"4.5.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"CAMS Innovation Fund for Medical Sciences"},{"name":"CIFMS","award":["2016-12M-1-009"],"award-info":[{"award-number":["2016-12M-1-009"]}]},{"name":"Innovative Research Foundation of Peking Union Medical College","award":["2016-1002-01-03"],"award-info":[{"award-number":["2016-1002-01-03"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370223"],"award-info":[{"award-number":["81370223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573957"],"award-info":[{"award-number":["81573957"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670337"],"award-info":[{"award-number":["81670337"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project of the Ministry of Science and Technology of China","doi-asserted-by":"crossref","award":["2014ZX09101042001"],"award-info":[{"award-number":["2014ZX09101042001"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"crossref"}]},{"name":"programme of China Scholarships Council","award":["201706210393"],"award-info":[{"award-number":["201706210393"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Naturally secreted nanovesicles, known as exosomes, play important roles in stem cell-mediated cardioprotection. We have previously demonstrated that atorvastatin (ATV) pretreatment improved the cardioprotective effects of mesenchymal stem cells (MSCs) in a rat model of acute myocardial infarction (AMI). The aim of this study was to investigate if exosomes derived from ATV-pretreated MSCs exhibit more potent cardioprotective function in a rat model of AMI and if so to explore the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Exosomes were isolated from control MSCs (MSC-Exo) and ATV-pretreated MSCs (MSCATV-Exo) and were then delivered to endothelial cells and cardiomyocytes in vitro under hypoxia and serum deprivation (H\/SD) condition or in vivo in an acutely infarcted Sprague-Dawley rat heart. Regulatory genes and pathways activated by ATV pretreatment were explored using genomics approaches and functional studies. In vitro, MSCATV-Exo accelerated migration, tube-like structure formation, and increased survival of endothelial cells but not cardiomyocytes, whereas the exosomes derived from MSCATV-Exo-treated endothelial cells prevented cardiomyocytes from H\/SD-induced apoptosis. In a rat AMI model, MSCATV-Exo resulted in improved recovery in cardiac function, further reduction in infarct size and reduced cardiomyocyte apoptosis compared to MSC-Exo. In addition, MSCATV-Exo promoted angiogenesis and inhibited the elevation of IL-6 and TNF-\u03b1 in the peri-infarct region. Mechanistically, we identified lncRNA H19 as a mediator of the role of MSCATV-Exo in regulating expression of miR-675 and activation of proangiogenic factor VEGF and intercellular adhesion molecule-1. Consistently, the cardioprotective effects of MSCATV-Exo was abrogated when lncRNA H19 was depleted in the ATV-pretreated MSCs and was mimicked by overexpression of lncRNA H19.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Exosomes obtained from ATV-pretreated MSCs have significantly enhanced therapeutic efficacy for treatment of AMI possibly through promoting endothelial cell function. LncRNA H19 mediates, at least partially, the cardioprotective roles of MSCATV-Exo in promoting angiogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvz139","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T15:16:54Z","timestamp":1558019814000},"page":"353-367","source":"Crossref","is-referenced-by-count":334,"title":["Atorvastatin enhances the therapeutic efficacy of mesenchymal stem cells-derived exosomes in acute myocardial infarction via up-regulating long non-coding RNA H19"],"prefix":"10.1093","volume":"116","author":[{"given":"Peisen","family":"Huang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167 Bei Li Shi Road, Xicheng District, Beijing 100037, People's Republic of China"},{"name":"McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"},{"name":"Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"},{"name":"Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167 Bei Li Shi Road, Xicheng District, Beijing 100037, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaqiu","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167 Bei Li Shi Road, Xicheng District, Beijing 100037, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167 Bei Li Shi Road, Xicheng District, Beijing 100037, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167 Bei Li Shi Road, Xicheng District, Beijing 100037, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Xiong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167 Bei Li Shi Road, Xicheng District, Beijing 100037, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guihao","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167 Bei Li Shi Road, Xicheng District, Beijing 100037, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Qian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167 Bei Li Shi Road, Xicheng District, Beijing 100037, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Jin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167 Bei Li Shi Road, Xicheng District, Beijing 100037, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167 Bei Li Shi Road, Xicheng District, Beijing 100037, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University, Chapel Hill and Raleigh, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Qian","sequence":"additional","affiliation":[{"name":"McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"},{"name":"Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejin","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167 Bei Li Shi Road, Xicheng District, Beijing 100037, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"2021061511390229500_cvz139-B1","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/S0140-6736(17)31833-0","article-title":"Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"390","year":"2017","journal-title":"Lancet"},{"key":"2021061511390229500_cvz139-B2","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0140-6736(17)32152-9","article-title":"Global, regional, and national age-sex specific mortality for 264 causes of death, 1980\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"390","year":"2017","journal-title":"Lancet"},{"key":"2021061511390229500_cvz139-B3","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/35070587","article-title":"Bone marrow cells regenerate infarcted myocardium","volume":"410","author":"Orlic","year":"2001","journal-title":"Nature"},{"key":"2021061511390229500_cvz139-B4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1161\/CIRCULATIONAHA.112.131110","article-title":"Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction","volume":"127","author":"Williams","year":"2013","journal-title":"Circulation"},{"key":"2021061511390229500_cvz139-B5","doi-asserted-by":"crossref","first-page":"1.","DOI":"10.1155\/2016\/2725670","article-title":"Therapeutic potential of stem cells strategy for cardiovascular diseases","volume":"2016","author":"Lee","year":"2016","journal-title":"Stem Cells Int"},{"key":"2021061511390229500_cvz139-B6","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1161\/CIRCRESAHA.116.304386","article-title":"Meta-analysis of cell therapy trials for patients with heart failure","volume":"116","author":"Fisher","year":"2015","journal-title":"Circ Res"},{"key":"2021061511390229500_cvz139-B7","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1161\/CIRCRESAHA.114.304792","article-title":"Adult bone marrow cell therapy for ischemic heart disease: evidence and insights from randomized controlled trials","volume":"117","author":"Afzal","year":"2015","journal-title":"Circ Res"},{"key":"2021061511390229500_cvz139-B8","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1016\/j.bbapap.2013.01.032","article-title":"Stem cells: insights into the secretome","volume":"1834","author":"Makridakis","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"2021061511390229500_cvz139-B9","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.108.176826","article-title":"Paracrine mechanisms in adult stem cell signaling and therapy","volume":"103","author":"Gnecchi","year":"2008","journal-title":"Circ Res"},{"key":"2021061511390229500_cvz139-B10","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1161\/CIRCRESAHA.108.186742","article-title":"1-overexpressing mesenchymal stem cells accelerate bone marrow stem cell mobilization via paracrine activation of SDF-1alpha\/CXCR4 signaling to promote myocardial repair","volume":"103","author":"Haider","year":"2008","journal-title":"Circ Res"},{"key":"2021061511390229500_cvz139-B11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10059-010-0001-7","article-title":"Mesenchymal stem cells modified with stromal cell-derived factor 1 alpha improve cardiac remodeling via paracrine activation of hepatocyte growth factor in a rat model of myocardial infarction","volume":"29","author":"Tang","year":"2010","journal-title":"Mol Cells"},{"key":"2021061511390229500_cvz139-B12","doi-asserted-by":"crossref","first-page":"231.","DOI":"10.3389\/fphar.2016.00231","article-title":"MSCs-derived exosomes: cell-secreted nanovesicles with regenerative potential","volume":"7","author":"Marote","year":"2016","journal-title":"Front Pharmacol"},{"key":"2021061511390229500_cvz139-B13","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s10741-016-9576-1","article-title":"New strategies for improving stem cell therapy in ischemic heart disease","volume":"21","author":"Huang","year":"2016","journal-title":"Heart Fail Rev"},{"key":"2021061511390229500_cvz139-B14","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.scr.2009.12.003","article-title":"Exosome secreted by MSC reduces myocardial ischemia\/reperfusion injury","volume":"4","author":"Lai","year":"2010","journal-title":"Stem Cell Res"},{"key":"2021061511390229500_cvz139-B15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/ten.teb.2014.0300","article-title":"Emerging roles for extracellular vesicles in tissue engineering and regenerative medicine","volume":"21","author":"Lamichhane","year":"2015","journal-title":"Tissue Eng Part B Rev"},{"key":"2021061511390229500_cvz139-B16","first-page":"1372","article-title":"Roles of exosomes in cardioprotection","volume":"38","author":"Barile","year":"2017","journal-title":"Eur Heart J"},{"key":"2021061511390229500_cvz139-B17","first-page":"1659","article-title":"Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way","volume":"46","author":"Zhu","year":"2018","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"2021061511390229500_cvz139-B18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1161\/CIRCRESAHA.116.304360","article-title":"Identification of therapeutic covariant microRNA clusters in hypoxia-treated cardiac progenitor cell exosomes using systems biology","volume":"116","author":"Gray","year":"2015","journal-title":"Circ Res"},{"key":"2021061511390229500_cvz139-B19","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1093\/eurheartj\/ehn167","article-title":"Atorvastatin treatment improves survival and effects of implanted mesenchymal stem cells in post-infarct swine hearts","volume":"29","author":"Yang","year":"2008","journal-title":"Eur Heart J"},{"key":"2021061511390229500_cvz139-B20","doi-asserted-by":"crossref","first-page":"e65702.","DOI":"10.1371\/journal.pone.0065702","article-title":"Atorvastatin enhance efficacy of mesenchymal stem cells treatment for swine myocardial infarction via activation of nitric oxide synthase","volume":"8","author":"Song","year":"2013","journal-title":"PLoS One"},{"key":"2021061511390229500_cvz139-B21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2012.03.006","article-title":"Statins and stem cell modulation","volume":"12","author":"Xu","year":"2013","journal-title":"Ageing Res Rev"},{"key":"2021061511390229500_cvz139-B22","first-page":"1058","article-title":"Intravenous administration of atorvastatin-pretreated mesenchymal stem cells improves cardiac performance after acute myocardial infarction: role of CXCR4","volume":"7","author":"Li","year":"2015","journal-title":"Am J Transl Res"},{"key":"2021061511390229500_cvz139-B23","doi-asserted-by":"crossref","first-page":"37405","DOI":"10.1074\/jbc.M110.149468","article-title":"Statins promote the degradation of extracellular amyloid-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion","volume":"285","author":"Tamboli","year":"2010","journal-title":"J Biol Chem"},{"key":"2021061511390229500_cvz139-B24","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1161\/CIRCRESAHA.116.310374","article-title":"Fabrication of synthetic mesenchymal stem cells for the treatment of acute myocardial infarction in mice","volume":"120","author":"Luo","year":"2017","journal-title":"Circ Res"},{"key":"2021061511390229500_cvz139-B25","doi-asserted-by":"crossref","first-page":"13724.","DOI":"10.1038\/ncomms13724","article-title":"Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome","volume":"8","author":"Tang","year":"2017","journal-title":"Nat Commun"},{"key":"2021061511390229500_cvz139-B26","doi-asserted-by":"crossref","DOI":"10.1002\/0471143030.cb0322s30","article-title":"Isolation and characterization of exosomes from cell culture supernatants and biological fluids","author":"Thery","year":"2006","journal-title":"Curr Protoc Cell Biol"},{"key":"2021061511390229500_cvz139-B27","first-page":"4160","article-title":"AMPK-mediated cardioprotection of atorvastatin relates to the reduction of apoptosis and activation of autophagy in infarcted rat hearts","volume":"8","author":"Li","year":"2016","journal-title":"Am J Transl Res"},{"key":"2021061511390229500_cvz139-B28","doi-asserted-by":"crossref","first-page":"10977","DOI":"10.1074\/jbc.M111.324616","article-title":"Sphingolipid-modulated exosome secretion promotes clearance of amyloid-beta by microglia","volume":"287","author":"Yuyama","year":"2012","journal-title":"J Biol Chem"},{"key":"2021061511390229500_cvz139-B29","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1161\/CIRCRESAHA.111.246108","article-title":"Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities","volume":"110","author":"Dutta","year":"2012","journal-title":"Circ Res"},{"key":"2021061511390229500_cvz139-B30","doi-asserted-by":"crossref","first-page":"e12931.","DOI":"10.1111\/acel.12931","article-title":"Aged-senescent cells contribute to impaired heart regeneration","volume":"18","author":"Lewis-McDougall","year":"2019","journal-title":"Aging Cell"},{"key":"2021061511390229500_cvz139-B31","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature10600","article-title":"Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders","volume":"479","author":"Baker","year":"2011","journal-title":"Nature"},{"key":"2021061511390229500_cvz139-B32","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/cbin.10301","article-title":"Long non-coding RNAs with low expression levels in cells are enriched in secreted exosomes","volume":"38","author":"Gezer","year":"2014","journal-title":"Cell Biol Int"},{"key":"2021061511390229500_cvz139-B33","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.fob.2014.04.007","article-title":"Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer","volume":"4","author":"Takahashi","year":"2014","journal-title":"FEBS Open Bio"},{"key":"2021061511390229500_cvz139-B34","doi-asserted-by":"crossref","first-page":"155.","DOI":"10.1186\/s12943-015-0426-x","article-title":"CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA","volume":"14","author":"Conigliaro","year":"2015","journal-title":"Mol Cancer"},{"key":"2021061511390229500_cvz139-B35","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1159\/000485354","article-title":"Long non-coding RNA H19 protects H9c2 cells against hypoxia-induced injury by targeting microRNA-139","volume":"44","author":"Gong","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"2021061511390229500_cvz139-B36","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1161\/CIRCULATIONAHA.116.023116","article-title":"Altered DNA methylation of long noncoding RNA H19 in calcific aortic valve disease promotes mineralization by silencing NOTCH1","volume":"134","author":"Hadji","year":"2016","journal-title":"Circulation"},{"key":"2021061511390229500_cvz139-B37","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1161\/CIRCULATIONAHA.117.032184","article-title":"H19 induces abdominal aortic aneurysm development and progression","volume":"138","author":"Li","year":"2018","journal-title":"Circulation"},{"key":"2021061511390229500_cvz139-B38","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/cvr\/cvy206","article-title":"Long non-coding RNA H19 regulates endothelial cell aging via inhibition of STAT3 signalling","volume":"115","author":"Hofmann","year":"2019","journal-title":"Cardiovasc Res"},{"key":"2021061511390229500_cvz139-B39","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1101\/gad.234419.113","article-title":"The H19 long noncoding RNA gives rise to microRNAs miR-675-3p and miR-675-5p to promote skeletal muscle differentiation and regeneration","volume":"28","author":"Dey","year":"2014","journal-title":"Genes Dev"},{"key":"2021061511390229500_cvz139-B40","first-page":"1780","article-title":"miR-141 modulates osteoblastic cell proliferation by regulating the target gene of lncRNA H19 and lncRNA H19-derived miR-675","volume":"8","author":"He","year":"2016","journal-title":"Am J Transl Res"},{"key":"2021061511390229500_cvz139-B41","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00109-013-1110-5","article-title":"Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model","volume":"92","author":"Bian","year":"2014","journal-title":"J Mol Med"},{"key":"2021061511390229500_cvz139-B42","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1161\/CIRCULATIONAHA.112.114173","article-title":"Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension","volume":"126","author":"Lee","year":"2012","journal-title":"Circulation"},{"key":"2021061511390229500_cvz139-B43","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ijcard.2014.12.043","article-title":"Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection","volume":"182","author":"Yu","year":"2015","journal-title":"Int J Cardiol"},{"key":"2021061511390229500_cvz139-B44","doi-asserted-by":"crossref","first-page":"51","DOI":"10.5966\/sctm.2016-0038","article-title":"Exosomes derived from Akt-modified human umbilical cord mesenchymal stem cells improve cardiac regeneration and promote angiogenesis via activating platelet-derived growth factor D","volume":"6","author":"Ma","year":"2017","journal-title":"Stem Cells Transl Med"},{"key":"2021061511390229500_cvz139-B45","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5785436","article-title":"Potential role of exosomes in mending a broken heart: nanoshuttles propelling future clinical therapeutics forward","volume":"2017","author":"Dougherty","year":"2017","journal-title":"Stem Cells Int"},{"key":"2021061511390229500_cvz139-B46","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/cvr\/cvu167","article-title":"Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction","volume":"103","author":"Barile","year":"2014","journal-title":"Cardiovasc Res"},{"key":"2021061511390229500_cvz139-B47","doi-asserted-by":"crossref","first-page":"45200","DOI":"10.18632\/oncotarget.16778","article-title":"Mesenchymal stem cells release exosomes that transfer miRNAs to endothelial cells and promote angiogenesis","volume":"8","author":"Gong","year":"2017","journal-title":"Oncotarget"},{"key":"2021061511390229500_cvz139-B48","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1161\/CIRCRESAHA.116.310557","article-title":"Angiogenic mechanisms of human CD34(+) stem cell exosomes in the repair of ischemic hindlimb","volume":"120","author":"Mathiyalagan","year":"2017","journal-title":"Circ Res"},{"key":"2021061511390229500_cvz139-B49","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1161\/CIRCRESAHA.117.305990","article-title":"Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction","volume":"117","author":"Khan","year":"2015","journal-title":"Circ Res"},{"key":"2021061511390229500_cvz139-B50","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature15756","article-title":"Tumour exosome integrins determine organotropic metastasis","volume":"527","author":"Hoshino","year":"2015","journal-title":"Nature"},{"key":"2021061511390229500_cvz139-B51","doi-asserted-by":"crossref","first-page":"106.","DOI":"10.3390\/cancers11010106","article-title":"Connexins and integrins in exosomes","volume":"11","author":"Shimaoka","year":"2019","journal-title":"Cancers (Basel)"},{"key":"2021061511390229500_cvz139-B52","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/cvr\/cvz040","article-title":"Mesenchymal stromal cell-derived exosomes attenuate myocardial ischemia-reperfusion injury through miR-182-regulated macrophage polarization","volume":"115","author":"Zhao","year":"2019","journal-title":"Cardiovasc Res"},{"key":"2021061511390229500_cvz139-B53","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1159\/000090831","article-title":"The H19 gene: regulation and function of a non-coding RNA","volume":"113","author":"Gabory","year":"2006","journal-title":"Cytogenet Genome Res"},{"key":"2021061511390229500_cvz139-B54","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.18632\/oncotarget.1913","article-title":"Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer","volume":"5","author":"Li","year":"2014","journal-title":"Oncotarget"},{"key":"2021061511390229500_cvz139-B55","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/ng.168","article-title":"Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians","volume":"40","author":"Smits","year":"2008","journal-title":"Nat Genet"},{"key":"2021061511390229500_cvz139-B56","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1159\/000480028","article-title":"Long noncoding RNA H19\/miR-675 axis promotes gastric cancer via FADD\/Caspase 8\/Caspase 3 signaling pathway","volume":"42","author":"Yan","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"2021061511390229500_cvz139-B57","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/01.CIR.0000048892.83521.58","article-title":"Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part I: aging arteries: a \u201cset up\u201d for vascular disease","volume":"107","author":"Lakatta","year":"2003","journal-title":"Circulation"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvz139\/28839798\/cvz139.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/116\/2\/353\/38636262\/cardiovascres_116_2_353.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/116\/2\/353\/38636262\/cardiovascres_116_2_353.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:06:10Z","timestamp":1721261170000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/116\/2\/353\/5497485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,22]]},"references-count":57,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,5,22]]},"published-print":{"date-parts":[[2020,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvz139","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,2,1]]},"published":{"date-parts":[[2019,5,22]]}}}