{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:24:25Z","timestamp":1790389465415,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Agence Nationale pour la Recherche","award":["ANR-08-Genopat-031"],"award-info":[{"award-number":["ANR-08-Genopat-031"]}]},{"name":"Agence Nationale pour la Recherche","award":["ANR-12-EMMA-0009"],"award-info":[{"award-number":["ANR-12-EMMA-0009"]}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"Fonds Europ\u00e9en de D\u00e9veloppement R\u00e9gional","doi-asserted-by":"crossref","award":["#43457"],"award-info":[{"award-number":["#43457"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"name":"R\u00e9gion Languedoc-Roussillon","award":["#098976"],"award-info":[{"award-number":["#098976"]}]},{"name":"SATT AxLR","award":["#099482"],"award-info":[{"award-number":["#099482"]}]},{"name":"Eurobiodev","award":["#099483"],"award-info":[{"award-number":["#099483"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Regulated cell death is a main contributor of myocardial ischaemia-reperfusion (IR) injury during acute myocardial infarction. In this context, targeting apoptosis could be a potent therapeutical strategy. In a previous study, we showed that DAXX (death-associated protein) was essential for transducing the FAS-dependent apoptotic signal during IR injury. The present study aims at evaluating the cardioprotective effects of a synthetic peptide inhibiting FAS:DAXX interaction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>An interfering peptide was engineered and then coupled to the Tat cell penetrating peptide (Tat-DAXXp). Its internalization and anti-apoptotic properties were demonstrated in primary cardiomyocytes. Importantly, an intravenous bolus injection of Tat-DAXXp (1\u2009mg\/kg) 5\u2009min before reperfusion in a murine myocardial IR model decreased infarct size by 48% after 24\u2009h of reperfusion. In addition, Tat-DAXXp was still efficient after a 30-min delayed administration, and was completely degraded and eliminated within 24\u2009h thereby reducing risks of potential side effects. Importantly, Tat-DAXXp reduced mouse early post-infarction mortality by 67%. Mechanistically, cardioprotection was supported by both anti-apoptotic and pro-survival effects, and an improvement of myocardial functional recovery as evidenced in ex vivo experiments.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study demonstrates that a single dose of Tat-DAXXp injected intravenously at the onset of reperfusion leads to a strong cardioprotection in vivo by inhibiting IR injury validating Tat-DAXXp as a promising candidate for therapeutic application.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvz145","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T19:25:21Z","timestamp":1558639521000},"page":"633-644","source":"Crossref","is-referenced-by-count":23,"title":["A novel therapeutic peptide targeting myocardial reperfusion injury"],"prefix":"10.1093","volume":"116","author":[{"given":"Prisca","family":"Boisgu\u00e9rin","sequence":"first","affiliation":[{"name":"CRBM, Univ. 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