{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:46:34Z","timestamp":1753875994258,"version":"3.41.2"},"reference-count":48,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T00:00:00Z","timestamp":1561161600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Taiwan\u2019s Ministry of Science and Technology","doi-asserted-by":"crossref","award":["MoST 106-231-B-011-010","MoST 104-2314-B-303-014-MY3"],"award-info":[{"award-number":["MoST 106-231-B-011-010","MoST 104-2314-B-303-014-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Taiwan Protein Project","award":["MoST 105-0210-01-12-01"],"award-info":[{"award-number":["MoST 105-0210-01-12-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The myocardial ischaemia\/reperfusion (I\/R) injury is almost inevitable since reperfusion is the only established treatment for acute myocardial infarction (AMI). To date there is no effective strategy available for reducing the I\/R injury. Our aim was to elucidate the mechanisms underlying myocardial I\/R injury and to develop a new strategy for attenuating the damage it causes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Using a mouse model established by ligation of left anterior descending artery, we found an increase in activity of protein tyrosine phosphatases (PTPs) in myocardium during I\/R. Treating the I\/R-mice with a pan-PTP inhibitor phenyl vinyl sulfone attenuated I\/R damage, suggesting PTP activation to be harmful in I\/R. Through analysing RNAseq data, we showed PTPs being abundantly expressed in mouse myocardium. By exposing primary cardiomyocytes ablated with specific endogenous PTPs by RNAi to hypoxia\/reoxygenation (H\/R), we found a role that PTP-PEST (PTPN12) plays to promote cell death under H\/R stress. Auranofin, a drug being used in clinical practice for treating rheumatoid arthritis, may target PTP-PEST thus suppressing its activity. We elucidated the molecular basis for Auranofin-induced inactivation of PTP-PEST by structural studies, and then examined its effect on myocardial I\/R injury. In the mice receiving Auranofin before reperfusion, myocardial PTP activity was suppressed, leading to restored phosphorylation of PTP-PEST substrates, including ErbB-2 that maintains the survival signalling of the heart. In line with the inhibition of PTP-PEST activity, the Auranofin-treated I\/R-mice had smaller infarct size and better cardiac function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>PTP-PEST contributes to part of the damages resulting from myocardial I\/R. The drug Auranofin, potentially acting through the PTP-PEST-ErbB-2 signalling axis, reduces myocardial I\/R injury. Based on this finding, Auranofin could be used in the development of new treatments that manage I\/R injury in patients with AMI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvz165","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T07:10:25Z","timestamp":1560841825000},"source":"Crossref","is-referenced-by-count":8,"title":["Targeting protein tyrosine phosphatase PTP-PEST (PTPN12) for therapeutic intervention in acute myocardial infarction"],"prefix":"10.1093","author":[{"given":"Chiu-Fen","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 707 Chung-Yang Road Sec. 3, Hualien 970, Taiwan"},{"name":"Doctoral Degree Program in Translational Medicine, Tzu Chi University and Academia Sinica"},{"name":"Institute of Biological Chemistry, Academia Sinica, 128 Academia Road Sec. 2, Nankang, Taipei 115, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, 128 Academia Road Sec. 2, Nankang, Taipei 115, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jai Prakash","family":"Singh","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, 128 Academia Road Sec. 2, Nankang, Taipei 115, Taiwan"},{"name":"Chemical Biology and Molecular Biophysics, Taiwan International Graduate program, Academia Sinica, 128 Academia Road Sec. 2, Nankang, Taipei 115, Taiwan"},{"name":"Institute of Chemistry, National Tsing-Hua University, 101 Kuang-Fu Road Sec. 2, Hsinchu 300, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Fang","family":"Hsu","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, 128 Academia Road Sec. 2, Nankang, Taipei 115, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Wen","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, 128 Academia Road Sec. 2, Nankang, Taipei 115, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, 128 Academia Road Sec. 2, Nankang, Taipei 115, Taiwan"},{"name":"Institute of Biochemical Sciences, National Taiwan University, 1 Roosevelt Road Sec. 4, Taipei 106, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Wei","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, 128 Academia Road Sec. 2, Nankang, Taipei 115, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szu-Ni","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, 128 Academia Road Sec. 2, Nankang, Taipei 115, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rou-Ho","family":"Shih","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road Sec. 2, Nankang, Taipei 115, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang-Te Danny","family":"Hsu","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Academia Sinica, 128 Academia Road Sec. 2, Nankang, Taipei 115, Taiwan"},{"name":"Chemical Biology and Molecular Biophysics, Taiwan International Graduate program, Academia Sinica, 128 Academia Road Sec. 2, Nankang, Taipei 115, Taiwan"},{"name":"Institute of Biochemical Sciences, National Taiwan University, 1 Roosevelt Road 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