{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:36:36Z","timestamp":1778938596273,"version":"3.51.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"KFH Foundation for Preventive Medicine","award":["SFB 1054\/B01"],"award-info":[{"award-number":["SFB 1054\/B01"]}]},{"name":"KFH Foundation for Preventive Medicine","award":["RU 695\/6-1"],"award-info":[{"award-number":["RU 695\/6-1"]}]},{"DOI":"10.13039\/100010663","name":"ERC","doi-asserted-by":"publisher","award":["322865"],"award-info":[{"award-number":["322865"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>B-cell lymphoma\/leukaemia 10 (Bcl10) is a member of the CARMA-Bcl10-MALT1 signalosome, linking angiotensin (Ang) II, and antigen-dependent immune-cell activation to nuclear factor kappa-B signalling. We showed earlier that Bcl10 plays a role in Ang II-induced cardiac fibrosis and remodelling, independent of blood pressure. We now investigated the role of Bcl10 in Ang II-induced renal damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Bcl10 knockout mice (Bcl10 KO) and wild-type (WT) controls were given 1% NaCl in the drinking water and Ang II (1.44\u2009mg\/kg\/day) for 14\u2009days. Additionally, Bcl10 KO or WT kidneys were transplanted onto WT mice that were challenged by the same protocol for 7\u2009days. Kidneys of Ang II-treated Bcl10 KO mice developed less fibrosis and showed fewer infiltrating cells. Nevertheless, neutrophil gelatinase-associated lipocalin (Ngal) and kidney injury molecule (Kim)1 expression was higher in the kidneys of Ang II-treated Bcl10 KO mice, indicating exacerbated tubular damage. Furthermore, albuminuria was significantly higher in Ang II-treated Bcl10 KO mice accompanied by reduced glomerular nephrin expression and podocyte number. Ang II-treated WT mice transplanted with Bcl10 KO kidney showed more albuminuria and renal Ngal, compared to WT- &gt; WT kidney-transplanted mice, as well as lower podocyte number but similar fibrosis and cell infiltration. Interestingly, mice lacking Bcl10 in the kidney exhibited less Ang II-induced cardiac hypertrophy than controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bcl10 has multi-faceted actions in Ang II-induced renal damage. On the one hand, global Bcl10 deficiency ameliorates renal fibrosis and cell infiltration; on the other hand, lack of renal Bcl10 aggravates albuminuria and podocyte damage. These data suggest that Bcl10 maintains podocyte integrity and renal function.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cvr\/cvz169","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T13:12:44Z","timestamp":1561468364000},"source":"Crossref","is-referenced-by-count":4,"title":["B-cell lymphoma\/leukaemia 10 and angiotensin II-induced kidney injury"],"prefix":"10.1093","author":[{"given":"Lajos","family":"Mark\u00f3","sequence":"first","affiliation":[{"name":"Experimental and Clinical Research Center, a cooperation of Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany and Max Delbr\u00fcck Center for Molecular Medicine, 13125 Berlin, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin, Germany"},{"name":"Berlin Institute of Health (BIH), Berlin, Germany"},{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon-Keun","family":"Park","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Henke","sequence":"additional","affiliation":[{"name":"Helios Clinic Damp, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Rong","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Hannover, Germany"},{"name":"Transplantation Center, Zunyi Medical College, Zunyi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Balogh","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, a cooperation of Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany and Max Delbr\u00fcck Center for Molecular Medicine, 13125 Berlin, Germany"},{"name":"DZHK (German Centre for 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Health (BIH), Berlin, Germany"},{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Max-Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Wilck","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, a cooperation of Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany and Max Delbr\u00fcck Center for Molecular Medicine, 13125 Berlin, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin, Germany"},{"name":"Berlin Institute of Health (BIH), Berlin, Germany"},{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Ruland","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical 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Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich C","family":"Luft","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, a cooperation of Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany and Max Delbr\u00fcck Center for Molecular Medicine, 13125 Berlin, Germany"},{"name":"Max-Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Dechend","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, a cooperation of Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany and Max Delbr\u00fcck Center for Molecular Medicine, 13125 Berlin, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin, Germany"},{"name":"Berlin Institute of Health (BIH), Berlin, Germany"},{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, 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