{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:17:33Z","timestamp":1790713053990,"version":"4.1.0"},"reference-count":153,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T00:00:00Z","timestamp":1566604800000},"content-version":"am","delay-in-days":4,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research Foundation","doi-asserted-by":"crossref","award":["148401"],"award-info":[{"award-number":["148401"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["18-0022032"],"award-info":[{"award-number":["18-0022032"]}],"id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Heart diseases are a major cause of morbidity and mortality world-wide. Lysyl oxidase (LOX) and related LOX-like (LOXL) isoforms play a vital role in remodelling the extracellular matrix (ECM). The LOX family controls ECM formation by cross-linking collagen and elastin chains. LOX\/LOXL proteins are copper-dependent amine oxidases that catalyse the oxidation of lysine, causing cross-linking between the lysine moieties of lysine-rich proteins. Dynamic changes in LOX and LOXL protein-expression occur in a variety of cardiac pathologies; these changes are believed to be central to the associated tissue-fibrosis. An awareness of the potential pathophysiological importance of LOX has led to the evaluation of interventions that target LOX\/LOXL proteins for heart-disease therapy. The purposes of this review article are: (i) to summarize the basic biochemistry and enzyme function of LOX and LOXL proteins; (ii) to consider their tissue and species distribution; and (iii) to review the results of experimental studies of the roles of LOX and LOXL proteins in heart disease, addressing involvement in the mechanisms, pathophysiology and therapeutic responses based on observations in patient samples and relevant animal models. Therapeutic targeting of LOX family enzymes has shown promising results in animal models, but small-molecule approaches have been limited by non-specificity and off-target effects. Biological approaches show potential promise but are in their infancy. While there is strong evidence for LOX-family protein participation in heart failure, myocardial infarction, cardiac hypertrophy, dilated cardiomyopathy, atrial fibrillation and hypertension, as well as potential interest as therapeutic targets, the precise involvement of LOX-family proteins in heart disease requires further investigation.<\/jats:p>","DOI":"10.1093\/cvr\/cvz176","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T15:22:25Z","timestamp":1565796145000},"source":"Crossref","is-referenced-by-count":32,"title":["Role of the lysyl oxidase enzyme family in cardiac function and disease"],"prefix":"10.1093","author":[{"given":"Doa\u2019a","family":"Al-u\u2019datt","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Physiology, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"},{"name":"Montreal Heart Institute, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9000-9495","authenticated-orcid":false,"given":"Bruce G","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"},{"name":"Montreal Heart Institute, Montreal, Quebec, Canada"},{"name":"Department of Medicine, Universit\u00e9 de Montreal, Montreal, Quebec, Canada"},{"name":"Department of Biochemistry and Molecular Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5565-3311","authenticated-orcid":false,"given":"Stanley","family":"Nattel","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"},{"name":"Montreal Heart Institute, Montreal, Quebec, Canada"},{"name":"Department of Medicine, Universit\u00e9 de Montreal, Montreal, Quebec, Canada"},{"name":"Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,8,20]]},"reference":[{"key":"2019091012441544200_cvz176-B1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.hfc.2011.08.012","article-title":"Changes in the myocardial interstitium and contribution to the progression of heart failure","volume":"8","author":"Eckhouse","year":"2012","journal-title":"Heart Fail Clin"},{"key":"2019091012441544200_cvz176-B2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.yjmcc.2013.10.017","article-title":"Adverse fibrosis in the aging heart depends on signaling between myeloid and mesenchymal cells; role of inflammatory fibroblasts","volume":"70","author":"Cieslik","year":"2014","journal-title":"J Mol Cell 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