{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:06:14Z","timestamp":1792659974181,"version":"4.5.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["NHLBI R01"],"award-info":[{"award-number":["NHLBI R01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["HL95077"],"award-info":[{"award-number":["HL95077"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["HL114120"],"award-info":[{"award-number":["HL114120"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["HL131017"],"award-info":[{"award-number":["HL131017"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["UO1 HL 134764"],"award-info":[{"award-number":["UO1 HL 134764"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>In regenerative medicine, cellular cardiomyoplasty is one of the promising options for treating myocardial infarction (MI); however, the efficacy of such treatment has shown to be limited due to poor survival and\/or functional integration of implanted cells. Within the heart, the adhesion between cardiac myocytes (CMs) is mediated by N-cadherin (CDH2) and is critical for the heart to function as an electromechanical syncytium. In this study, we have investigated whether the reparative potency of human-induced pluripotent stem cell-derived cardiac myocytes (hiPSC-CMs) can be enhanced through CDH2 overexpression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>CDH2-hiPSC-CMs and control wild-type (WT)-hiPSC-CMs were cultured in myogenic differentiation medium for 28\u2009days. Using a mouse MI model, the cell survival\/engraftment rate, infarct size, and cardiac functions were evaluated post-MI, at Day 7 or Day 28. In vitro, conduction velocities were significantly greater in CDH2-hiPSC-CMs than in WT-hiPSC-CMs. While, in vivo, measurements of cardiac functions: left ventricular (LV) ejection fraction, reduction in infarct size, and the cell engraftment rate were significantly higher in CDH2-hiPSC-CMs treated MI group than in WT-hiPSC-CMs treated MI group. Mechanistically, paracrine activation of ERK signal transduction pathway by CDH2-hiPSC-CMs, significantly induced neo-vasculogenesis, resulting in a higher survival of implanted cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Collectively, these data suggest that CDH2 overexpression enhances not only the survival\/engraftment of cultured CDH2-hiPSC-CMs, but also the functional integration of these cells, consequently, the augmentation of the reparative properties of implanted CDH2-hiPSC-CMs in the failing hearts.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cvr\/cvz179","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T11:21:59Z","timestamp":1563967319000},"page":"671-685","source":"Crossref","is-referenced-by-count":44,"title":["N-cadherin overexpression enhances the reparative potency of human-induced pluripotent stem cell-derived cardiac myocytes in infarcted mouse hearts"],"prefix":"10.1093","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3210-2701","authenticated-orcid":false,"given":"Xi","family":"Lou","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall G094J, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall G094J, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengming","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall G094J, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir G","family":"Fast","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall G094J, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mani T","family":"Valarmathi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall G094J, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5217-7789","authenticated-orcid":false,"given":"Wuqiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall G094J, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall G094J, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,7,26]]},"reference":[{"key":"2021061511390252900_cvz179-B1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/01.RES.83.1.15","article-title":"Survey of studies examining mammalian cardiomyocyte DNA synthesis","volume":"83","author":"Soonpaa","year":"1998","journal-title":"Circ Res"},{"key":"2021061511390252900_cvz179-B2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0092-8674(00)81691-8","article-title":"Stem cells: a new lease on life","volume":"100","author":"Fuchs","year":"2000","journal-title":"Cell"},{"key":"2021061511390252900_cvz179-B3","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1172\/JCI12150","article-title":"Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells","volume":"107","author":"Jackson","year":"2001","journal-title":"J Clin Invest"},{"key":"2021061511390252900_cvz179-B4","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.stem.2014.11.009","article-title":"Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells","volume":"15","author":"Ye","year":"2014","journal-title":"Cell Stem Cell"},{"key":"2021061511390252900_cvz179-B5","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s10741-016-9576-1","article-title":"New strategies for improving stem cell therapy in ischemic heart disease","volume":"21","author":"Huang","year":"2016","journal-title":"Heart Fail Rev"},{"key":"2021061511390252900_cvz179-B6","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1161\/CIRCRESAHA.117.312486","article-title":"Preclinical studies of stem cell therapy for heart disease","volume":"122","author":"Tompkins","year":"2018","journal-title":"Circ Res"},{"key":"2021061511390252900_cvz179-B7","doi-asserted-by":"crossref","first-page":"143.","DOI":"10.21037\/atm.2017.01.44","article-title":"Solving the puzzle of pluripotent stem cell-derived cardiomyocyte maturation: piece by piece","volume":"5","author":"Lundy","year":"2017","journal-title":"Ann Transl Med"},{"key":"2021061511390252900_cvz179-B8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ebiom.2017.01.029","article-title":"Stem cell technology in cardiac regeneration: a pluripotent stem cell promise","volume":"16","author":"Duelen","year":"2017","journal-title":"EBioMedicine"},{"key":"2021061511390252900_cvz179-B9","doi-asserted-by":"crossref","first-page":"410","DOI":"10.5966\/sctm.2015-0288","article-title":"Strategies and challenges to myocardial replacement therapy","volume":"5","author":"Feric","year":"2016","journal-title":"Stem Cells Transl Med"},{"key":"2021061511390252900_cvz179-B10","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.008460","article-title":"Comparison of mesenchymal stem cell efficacy in ischemic versus nonischemic dilated cardiomyopathy","volume":"7","author":"Tompkins","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"2021061511390252900_cvz179-B11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.amjcard.2004.03.034","article-title":"Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction","volume":"94","author":"Chen","year":"2004","journal-title":"Am J Cardiol"},{"key":"2021061511390252900_cvz179-B12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0140-6736(05)67861-0","article-title":"Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial","volume":"367","author":"Janssens","year":"2006","journal-title":"Lancet"},{"key":"2021061511390252900_cvz179-B13","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/35070587","article-title":"Bone marrow cells regenerate infarcted myocardium","volume":"410","author":"Orlic","year":"2001","journal-title":"Nature"},{"key":"2021061511390252900_cvz179-B14","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1161\/CIRCRESAHA.112.269894","article-title":"Bioenergetic and functional consequences of cellular therapy: activation of endogenous cardiovascular progenitor cells","volume":"111","author":"Xiong","year":"2012","journal-title":"Circ Res"},{"key":"2021061511390252900_cvz179-B15","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1007\/s00018-012-0942-4","article-title":"Regenerating functional heart tissue for myocardial repair","volume":"69","author":"Alcon","year":"2012","journal-title":"Cell Mol Life Sci"},{"key":"2021061511390252900_cvz179-B16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ejheart.2005.12.003","article-title":"Clinical trials update from the American Heart Association: REPAIR-AMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, and PROACTIVE","volume":"8","author":"Cleland","year":"2006","journal-title":"Eur J Heart Fail"},{"key":"2021061511390252900_cvz179-B17","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nmeth.2999","article-title":"Chemically defined generation of human cardiomyocytes","volume":"11","author":"Burridge","year":"2014","journal-title":"Nat Methods"},{"key":"2021061511390252900_cvz179-B18","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nmeth.3448","article-title":"Chemically defined, albumin-free human cardiomyocyte generation","volume":"12","author":"Lian","year":"2015","journal-title":"Nat Methods"},{"key":"2021061511390252900_cvz179-B19","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.stemcr.2013.10.004","article-title":"Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes","volume":"1","author":"Feinberg","year":"2013","journal-title":"Stem Cell Rep"},{"key":"2021061511390252900_cvz179-B20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.addr.2015.04.019","article-title":"Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues","volume":"96","author":"Feric","year":"2016","journal-title":"Adv Drug Deliv Rev"},{"key":"2021061511390252900_cvz179-B21","doi-asserted-by":"crossref","first-page":"342ps13","DOI":"10.1126\/scitranslmed.aad2304","article-title":"Distilling complexity to advance cardiac tissue engineering","volume":"8","author":"Ogle","year":"2016","journal-title":"Sci Transl Med"},{"key":"2021061511390252900_cvz179-B22","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1749-6632.2009.05077.x","article-title":"The integrative aspects of cardiac physiology and their implications for cell-based therapy","volume":"1188","author":"Pijnappels","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"2021061511390252900_cvz179-B23","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1387\/ijdb.041793ld","article-title":"N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling","volume":"48","author":"Derycke","year":"2004","journal-title":"Int J Dev Biol"},{"key":"2021061511390252900_cvz179-B24","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1161\/01.RES.0000181132.11393.18","article-title":"Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis","volume":"97","author":"Li","year":"2005","journal-title":"Circ Res"},{"key":"2021061511390252900_cvz179-B25","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.yexmp.2015.12.009","article-title":"Reduced expression of adherens and gap junction proteins can have a fundamental role in the development of heart failure following cardiac hypertrophy in rats","volume":"100","author":"dos Santos","year":"2016","journal-title":"Exp Mol Pathol"},{"key":"2021061511390252900_cvz179-B26","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/01.RES.0000156274.72390.2c","article-title":"Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure","volume":"96","author":"Kostetskii","year":"2005","journal-title":"Circ Res"},{"key":"2021061511390252900_cvz179-B27","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10059-010-0107-y","article-title":"Inhibiting N-cadherin-mediated adhesion affects gap junction communication in isolated rat hearts","volume":"30","author":"Zhu","year":"2010","journal-title":"Mol Cells"},{"key":"2021061511390252900_cvz179-B28","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.bbrc.2013.07.081","article-title":"N-Cadherin is a prospective cell surface marker of human mesenchymal stem cells that have high ability for cardiomyocyte differentiation","volume":"438","author":"Ishimine","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"2021061511390252900_cvz179-B29","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.bbrc.2006.10.126","article-title":"N-cadherin is a useful marker for the progenitor of cardiomyocytes differentiated from mouse ES cells in serum-free condition","volume":"351","author":"Honda","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"2021061511390252900_cvz179-B30","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1161\/CIRCRESAHA.117.311565","article-title":"Translational research in cardiovascular repair: a call for a paradigm shift","volume":"122","author":"Chamuleau","year":"2018","journal-title":"Circ Res"},{"key":"2021061511390252900_cvz179-B31","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1161\/CIRCRESAHA.108.175174","article-title":"Genetic enhancement of stem cell engraftment, survival, and efficacy","volume":"102","author":"Penn","year":"2008","journal-title":"Circ Res"},{"key":"2021061511390252900_cvz179-B32","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nprot.2012.150","article-title":"Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt\/beta-catenin signaling under fully defined conditions","volume":"8","author":"Lian","year":"2013","journal-title":"Nat Protoc"},{"key":"2021061511390252900_cvz179-B33","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/CIRCHEARTFAILURE.114.001317","article-title":"Derivation and high engraftment of patient-specific cardiomyocyte sheet using induced pluripotent stem cells generated from adult cardiac fibroblast","volume":"8","author":"Zhang","year":"2015","journal-title":"Circ Heart Fail"},{"key":"2021061511390252900_cvz179-B34","doi-asserted-by":"crossref","first-page":"H327","DOI":"10.1152\/ajpheart.00688.2017","article-title":"Spheroids of cardiomyocytes derived from human-induced pluripotent stem cells improve recovery from myocardial injury in mice","volume":"315","author":"Mattapally","year":"2018","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2021061511390252900_cvz179-B35","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1161\/CIRCRESAHA.116.310277","article-title":"Myocardial tissue engineering with cells derived from human-induced pluripotent stem cells and a native-like, high-resolution, 3-dimensionally printed scaffold","volume":"120","author":"Gao","year":"2017","journal-title":"Circ Res"},{"key":"2021061511390252900_cvz179-B36","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/cvr\/cvy207","article-title":"Y-27632 preconditioning enhances transplantation of human induced pluripotent stem cell-derived cardiomyocytes in myocardial infarction mice","volume":"115","author":"Zhao","year":"2019","journal-title":"Cardiovasc Res"},{"key":"2021061511390252900_cvz179-B37","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1161\/CIRCRESAHA.117.311504","article-title":"CCND2 overexpression enhances the regenerative potency of human induced pluripotent stem cell-derived cardiomyocytes: remuscularization of injured ventricle","volume":"122","author":"Zhu","year":"2018","journal-title":"Circ Res"},{"key":"2021061511390252900_cvz179-B38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1089\/ten.tea.2016.0539","article-title":"Functional tissue engineering: a prevascularized cardiac muscle construct for validating human mesenchymal stem cells engraftment potential in vitro","volume":"24","author":"Valarmathi","year":"2018","journal-title":"Tissue Eng Part A"},{"key":"2021061511390252900_cvz179-B39","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.mayocp.2014.02.014","article-title":"Breakthroughs in cell therapy for heart disease: focus on cardiosphere-derived cells","volume":"89","author":"Marban","year":"2014","journal-title":"Mayo Clin Proc"},{"key":"2021061511390252900_cvz179-B40","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1161\/CIRCULATIONAHA.114.015231","article-title":"Microfluidic single-cell analysis of transplanted human induced pluripotent stem cell-derived cardiomyocytes after acute myocardial infarction","volume":"132","author":"Ong","year":"2015","journal-title":"Circulation"},{"key":"2021061511390252900_cvz179-B41","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/mt.2011.202","article-title":"N-cadherin determines individual variations in the therapeutic efficacy of human umbilical cord blood-derived mesenchymal stem cells in a rat model of myocardial infarction","volume":"20","author":"Lee","year":"2012","journal-title":"Mol Ther"},{"key":"2021061511390252900_cvz179-B42","doi-asserted-by":"crossref","first-page":"1909346.","DOI":"10.1155\/2018\/1909346","article-title":"Recent progress in stem cell modification for cardiac regeneration","volume":"2018","author":"Lemcke","year":"2018","journal-title":"Stem Cells Int"},{"key":"2021061511390252900_cvz179-B43","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000484649","article-title":"N-cadherin-mediated activation of PI3K\/Akt-GSK-3beta signaling attenuates nucleus pulposus cell apoptosis under high-magnitude compression","volume":"44","author":"Li","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"2021061511390252900_cvz179-B44","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.jvs.2010.05.096","article-title":"Inhibition of N-cadherin retards smooth muscle cell migration and intimal thickening via induction of apoptosis","volume":"52","author":"Lyon","year":"2010","journal-title":"J Vasc Surg"},{"key":"2021061511390252900_cvz179-B45","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1161\/01.ATV.0000163183.27658.4b","article-title":"N-cadherin-dependent cell-cell contacts promote human saphenous vein smooth muscle cell survival","volume":"25","author":"Koutsouki","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021061511390252900_cvz179-B46","doi-asserted-by":"crossref","first-page":"939.","DOI":"10.1186\/s12885-018-4845-0","article-title":"N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer","volume":"18","author":"Mrozik","year":"2018","journal-title":"BMC Cancer"},{"key":"2021061511390252900_cvz179-B47","doi-asserted-by":"crossref","first-page":"8131","DOI":"10.18632\/oncotarget.14101","article-title":"N-cadherin promotes thyroid tumorigenesis through modulating major signaling pathways","volume":"8","author":"Da","year":"2017","journal-title":"Oncotarget"},{"key":"2021061511390252900_cvz179-B48","doi-asserted-by":"crossref","first-page":"e5046.","DOI":"10.1371\/journal.pone.0005046","article-title":"Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes","volume":"4","author":"Kita-Matsuo","year":"2009","journal-title":"PLoS One"},{"key":"2021061511390252900_cvz179-B49","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3727\/096368916X692870","article-title":"Intramyocardially transplanted neonatal cardiomyocytes (NCMs) show structural and electrophysiological maturation and integration and dose-dependently stabilize function of infarcted rat hearts","volume":"26","author":"Maass","year":"2017","journal-title":"Cell Transplant"},{"key":"2021061511390252900_cvz179-B50","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1083\/jcb.119.1.179","article-title":"Inhibition of gap junction and adherens junction assembly by connexin and A-CAM antibodies","volume":"119","author":"Meyer","year":"1992","journal-title":"J Cell Biol"},{"key":"2021061511390252900_cvz179-B51","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/cvr\/cvt213","article-title":"Electrophysiological integration and action potential properties of transplanted cardiomyocytes derived from induced pluripotent stem cells","volume":"100","author":"Halbach","year":"2013","journal-title":"Cardiovasc Res"},{"key":"2021061511390252900_cvz179-B52","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.3727\/096368914X685799","article-title":"Functional and electrical integration of induced pluripotent stem cell-derived cardiomyocytes in a myocardial infarction rat heart","volume":"24","author":"Higuchi","year":"2015","journal-title":"Cell Transplant"},{"key":"2021061511390252900_cvz179-B53","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ccep.2015.03.012","article-title":"Arrhythmia in stem cell transplantation","volume":"7","author":"Almeida","year":"2015","journal-title":"Card Electrophysiol Clin"},{"key":"2021061511390252900_cvz179-B54","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.yjmcc.2012.06.007","article-title":"Time-course of the electrophysiological maturation and integration of transplanted cardiomyocytes","volume":"53","author":"Halbach","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"2021061511390252900_cvz179-B55","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ijcard.2017.03.099","article-title":"Making human cardiomyocytes up to date: derivation, maturation state and perspectives","volume":"241","author":"Kolanowski","year":"2017","journal-title":"Int J Cardiol"},{"key":"2021061511390252900_cvz179-B56","doi-asserted-by":"crossref","first-page":"50.","DOI":"10.3389\/fcell.2017.00050","article-title":"Naturally engineered maturation of cardiomyocytes","volume":"5","author":"Scuderi","year":"2017","journal-title":"Front Cell Dev Biol"},{"key":"2021061511390252900_cvz179-B57","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1161\/CIRCULATIONAHA.116.024145","article-title":"Defined engineered human myocardium with advanced maturation for applications in heart failure modeling and repair","volume":"135","author":"Tiburcy","year":"2017","journal-title":"Circulation"},{"key":"2021061511390252900_cvz179-B58","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41586-018-0016-3","article-title":"Advanced maturation of human cardiac tissue grown from pluripotent stem cells","volume":"556","author":"Ronaldson-Bouchard","year":"2018","journal-title":"Nature"}],"container-title":["Cardiovascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cardiovascres\/advance-article-pdf\/doi\/10.1093\/cvr\/cvz179\/29008687\/cvz179.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/116\/3\/671\/38636474\/cardiovascres_116_3_671.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cardiovascres\/article-pdf\/116\/3\/671\/38636474\/cardiovascres_116_3_671.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T11:39:47Z","timestamp":1623757187000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cardiovascres\/article\/116\/3\/671\/5539699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,26]]},"references-count":58,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,7,26]]},"published-print":{"date-parts":[[2020,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/cvr\/cvz179","relation":{},"ISSN":["0008-6363","1755-3245"],"issn-type":[{"value":"0008-6363","type":"print"},{"value":"1755-3245","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,3,1]]},"published":{"date-parts":[[2019,7,26]]}}}