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We investigated foetal human heart single-cell transcriptomes from mid-gestational healthy and anti-SSA\/Ro associated congenital heart block (CHB) samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Three healthy foetal human hearts (19th to 22nd week of gestation) and one foetal heart affected by autoimmune-associated CHB (21st week of gestation) were subjected to enzymatic dissociation using the Langendorff preparation to obtain single-cell suspensions followed by 10\u00d7 Genomics- and Illumina-based single-cell RNA-sequencing (scRNA-seq). In addition to the myocytes, fibroblasts, immune cells, and other minor cell types, previously uncharacterized diverse sub-populations of endothelial cells were identified in the human heart. Differential gene expression analysis revealed increased and heterogeneous interferon responses in varied cell types of the CHB heart compared with the healthy controls. In addition, we also identified matrisome transcripts enriched in CHB stromal cells that potentially contribute to extracellular matrix deposition and subsequent fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These data provide an information-rich resource to further our understanding of human heart development, which, as illustrated by comparison to a heart exposed to a maternal autoimmune environment, can be leveraged to provide insight into the pathogenesis of disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/cvr\/cvz257","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T15:24:49Z","timestamp":1569943489000},"page":"1446-1457","source":"Crossref","is-referenced-by-count":117,"title":["Cell atlas of the foetal human heart and implications for autoimmune-mediated congenital heart 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