{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:19Z","timestamp":1792785859151,"version":"4.5.0"},"reference-count":118,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Laboratory of SFGA on The Giant Panda"},{"DOI":"10.13039\/100012542","name":"Science and Technology Project of Sichuan Province","doi-asserted-by":"publisher","award":["2025ZNSFSC0252"],"award-info":[{"award-number":["2025ZNSFSC0252"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Microbiome-mediated longevity mechanisms in conservation wildlife remain largely uncharacterized, particularly in species with specialized diets where host\u2013microbe coevolution plays essential compensatory roles. We conducted cross-sectional metagenomic profiling of gut microbiota in 82 captive giant pandas (Ailuropoda melanoleuca) spanning juvenile, adult, and geriatric cohorts. The cohort included 14 long-lived individuals (\u226525 years). Our approach integrated enterotype analysis, functional pathway characterization, and lactic acid bacteria (LAB) isolation. Age-specific compositional shifts occurred throughout the lifespan, characterized by reciprocal dominance between Bacillota (declining from 84.77% to 10.26%) and Pseudomonadota (increasing from 12.74% to 81.86%). Streptococcus dominated adolescent microbiomes, followed by a transition to cellulose-degrading taxa in young adults. Enterotype analysis revealed 4 distinct community types with age-dependent succession patterns. Long-lived pandas exhibited elevated abundance of Akkermansia muciniphila, Bifidobacterium longum, Lactobacillus intestinalis, and Ruminococcus gnavus. Functional profiling revealed age-dependent shifts from nucleotide and amino acid biosynthesis in young animals to lipid metabolism and amino acid degradation in aged individuals. Carbohydrate-active enzyme analysis demonstrated enrichment of cellulolytic enzymes (such as GH3, GH5, and GH9) in long-lived adults. Biosynthetic gene cluster profiling revealed progressive age-associated accumulation of genes encoding NRPS, RiPP-like, arylpolyene, and terpene biosynthetic pathways. Culture-based isolation from fecal samples of long-lived giant pandas yielded 98 LAB strains representing 8 species (Lactobacillus johnsonii, Limosilactobacillus reuteri, L. intestinalis, among others), including 89 non-hemolytic strains that were sensitive to 6 common antibiotics. These findings suggest potential cross-species conservation of microbiome-longevity mechanisms, with implications for understanding physiological adaptations in specialist herbivores and applications in conservation medicine.<\/jats:p>","DOI":"10.1093\/cz\/zoaf074","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:37:18Z","timestamp":1763645838000},"page":"616-638","source":"Crossref","is-referenced-by-count":0,"title":["Gut microbiome-driven longevity mechanisms in giant pandas: age-associated gut microbial shifts, functional pathways, and probiotic insights"],"prefix":"10.1093","volume":"72","author":[{"given":"Feiyun","family":"Huang","sequence":"first","affiliation":[{"name":"Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, No. 24 South Section 1 , Yihuan Road, Chengdu 610065, Sichuan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwei","family":"Jin","sequence":"additional","affiliation":[{"name":"China Conservation and Research Center for the Giant Panda, Key Laboratory of SFGA on The Giant Panda , No. 1375 Xiongmao Avenue, Chenghua District, Chengdu 610057, Sichuan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawang","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Nanchang University , No. 999 Xuefu Avenue, Honggutan New District, Nanchang 330031, Jiangxi Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Wu","sequence":"additional","affiliation":[{"name":"China Conservation and Research Center for the Giant Panda, Key Laboratory of SFGA on The Giant Panda , No. 1375 Xiongmao Avenue, Chenghua District, Chengdu 610057, Sichuan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoyuan","family":"Gan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, No. 24 South Section 1 , Yihuan Road, Chengdu 610065, Sichuan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjingyi","family":"Chang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, No. 24 South Section 1 , Yihuan Road, Chengdu 610065, Sichuan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihao","family":"Tan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, No. 24 South Section 1 , Yihuan Road, Chengdu 610065, Sichuan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, No. 24 South Section 1 , Yihuan Road, Chengdu 610065, Sichuan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rengui","family":"Li","sequence":"additional","affiliation":[{"name":"China Conservation and Research Center for the Giant Panda, Key Laboratory of SFGA on The Giant Panda , No. 1375 Xiongmao Avenue, Chenghua District, Chengdu 610057, Sichuan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desheng","family":"Li","sequence":"additional","affiliation":[{"name":"China Conservation and Research Center for the Giant Panda, Key Laboratory of SFGA on The Giant Panda , No. 1375 Xiongmao Avenue, Chenghua District, Chengdu 610057, Sichuan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, No. 24 South Section 1 , Yihuan Road, Chengdu 610065, Sichuan ,","place":["China"]},{"name":"The Conservation of Endangered Wildlife Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University , No. 24 South Section 1, Yihuan Road, Chengdu 610065, Sichuan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"issue":"6","key":"2026102300234251800_zoaf074-B1","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1136\/gutjnl-2020-323071","article-title":"Gut microbiota-derived metabolites as central regulators in metabolic disorders","volume":"70","author":"Agus","year":"2021","journal-title":"Gut"},{"issue":"11","key":"2026102300234251800_zoaf074-B2","doi-asserted-by":"crossref","first-page":"114891","DOI":"10.1016\/j.celrep.2024.114891","article-title":"A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity","volume":"43","author":"Alexander","year":"2024","journal-title":"Cell Rep"},{"key":"2026102300234251800_zoaf074-B3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/9781119048961.ch10","article-title":"Production of high-quality probiotics by fermentation","author":"Anandharaj","year":"2017","journal-title":"Microbial Functional Foods and Nutraceuticals"},{"issue":"1","key":"2026102300234251800_zoaf074-B4","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s40168-018-0489-1","article-title":"The queen's gut refines with age: longevity phenotypes in a social insect model","volume":"6","author":"Anderson","year":"2018","journal-title":"Microbiome"},{"key":"2026102300234251800_zoaf074-B5","first-page":"410","article-title":"Global genetic diversity of human gut microbiome species is related to geographic location and host health","volume":"198","author":"Andreu-S\u00e1nchez","year":"2025","journal-title":"Cell"},{"issue":"1","key":"2026102300234251800_zoaf074-B6","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/s41467-024-55668-y","article-title":"Metagenome-guided culturomics for the targeted enrichment of gut microbes","volume":"16","author":"Armetta","year":"2025","journal-title":"Nat Commun"},{"key":"2026102300234251800_zoaf074-B7","doi-asserted-by":"crossref","first-page":"1345330","DOI":"10.3389\/frmbi.2023.1345330","article-title":"Lactobacillus johnsonii and host communication: insight into modulatory mechanisms during health and disease","volume":"2","author":"Arzola-Mart\u00ednez","year":"2024","journal-title":"Front Microbiomes"},{"issue":"8","key":"2026102300234251800_zoaf074-B8","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/s41591-019-0504-5","article-title":"Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice","volume":"25","author":"B\u00e1rcena","year":"2019","journal-title":"Nat Med"},{"key":"2026102300234251800_zoaf074-B9","doi-asserted-by":"crossref","first-page":"e65088","DOI":"10.7554\/eLife.65088","article-title":"Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3","volume":"10","author":"Beghini","year":"2021","journal-title":"Elife"},{"issue":"11","key":"2026102300234251800_zoaf074-B10","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.cub.2016.04.016","article-title":"Gut microbiota and extreme longevity","volume":"26","author":"Biagi","year":"2016","journal-title":"Curr Biol"},{"issue":"W1","key":"2026102300234251800_zoaf074-B11","doi-asserted-by":"crossref","first-page":"W46","DOI":"10.1093\/nar\/gkad344","article-title":"antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation","volume":"51","author":"Blin","year":"2023","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"2026102300234251800_zoaf074-B12","doi-asserted-by":"crossref","first-page":"fiy120","DOI":"10.1093\/femsec\/fiy120","article-title":"Streptomyces, shared microbiome member of soil and gut, as \u2018old friends' against colon cancer","volume":"94","author":"Bolourian","year":"2018","journal-title":"Fems Microbiol Ecol"},{"issue":"1","key":"2026102300234251800_zoaf074-B13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nmeth.3176","article-title":"Fast and sensitive protein alignment using DIAMOND","volume":"12","author":"Buchfink","year":"2015","journal-title":"Nat Methods"},{"issue":"10","key":"2026102300234251800_zoaf074-B14","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41575-022-00631-9","article-title":"Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms","volume":"19","author":"Cani","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"12","key":"2026102300234251800_zoaf074-B15","doi-asserted-by":"crossref","first-page":"5825","DOI":"10.1093\/molbev\/msab293","article-title":"eggNOG-mapper v2: functional annotation, orthology assignments, and domain prediction at the metagenomic scale","volume":"38","author":"Cantalapiedra","year":"2021","journal-title":"Mol Biol Evol"},{"issue":"2","key":"2026102300234251800_zoaf074-B16","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1002\/imt2.107","article-title":"Ultrafast one-pass FASTQ data preprocessing, quality control, and deduplication using fastp","volume":"2","author":"Chen","year":"2023","journal-title":"iMeta"},{"issue":"2","key":"2026102300234251800_zoaf074-B17","doi-asserted-by":"crossref","first-page":"fuad014","DOI":"10.1093\/femsre\/fuad014","article-title":"Ruminococcus gnavus: friend or foe for human health","volume":"47","author":"Crost","year":"2023","journal-title":"FEMS Microbiol Rev"},{"issue":"6218","key":"2026102300234251800_zoaf074-B18","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1126\/science.1260580","article-title":"Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation","volume":"347","author":"Cullen","year":"2015","journal-title":"Science"},{"key":"2026102300234251800_zoaf074-B19","doi-asserted-by":"crossref","first-page":"127248","DOI":"10.1016\/j.micres.2022.127248","article-title":"Streptomyces genus as a source of probiotics and its potential for its use in health","volume":"266","author":"Cuozzo","year":"2023","journal-title":"Microbiol Res"},{"issue":"8","key":"2026102300234251800_zoaf074-B20","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","article-title":"The role of short-chain fatty acids in microbiota-gut-brain communication","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"2026102300234251800_zoaf074-B21","doi-asserted-by":"crossref","first-page":"9590","DOI":"10.1038\/s41598-017-10287-0","article-title":"Unraveling the gut microbiome of the long-lived naked mole-rat","volume":"7","author":"Debebe","year":"2017","journal-title":"Sci Rep"},{"issue":"10","key":"2026102300234251800_zoaf074-B22","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.tim.2022.04.004","article-title":"Insights into endogenous Bifidobacterium species in the human gut microbiota during adulthood","volume":"30","author":"Derrien","year":"2022","journal-title":"Trends Microbiol"},{"issue":"6","key":"2026102300234251800_zoaf074-B23","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/j.1654-1103.2003.tb02228.x","article-title":"VEGAN, a package of R functions for community ecology","volume":"14","author":"Dixon","year":"2003","journal-title":"J Veg Sci"},{"issue":"1","key":"2026102300234251800_zoaf074-B24","doi-asserted-by":"crossref","first-page":"14332","DOI":"10.1038\/ncomms14332","article-title":"Bacillus subtilis biofilm extends Caenorhabditis elegans longevity through downregulation of the insulin-like signalling pathway","volume":"8","author":"Donato","year":"2017","journal-title":"Nat Commun"},{"issue":"6246","key":"2026102300234251800_zoaf074-B25","doi-asserted-by":"crossref","first-page":"1254766","DOI":"10.1126\/science.1254766","article-title":"Small molecules from the human microbiota","volume":"349","author":"Donia","year":"2015","journal-title":"Science"},{"issue":"6","key":"2026102300234251800_zoaf074-B26","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/mi.2017.13","article-title":"Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation","volume":"10","author":"Fonseca","year":"2017","journal-title":"Mucosal Immunol"},{"issue":"2","key":"2026102300234251800_zoaf074-B27","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41587-018-0009-7","article-title":"A human gut bacterial genome and culture collection for improved metagenomic analyses","volume":"37","author":"Forster","year":"2019","journal-title":"Nat Biotechnol"},{"issue":"10","key":"2026102300234251800_zoaf074-B28","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging: a new immune\u2013metabolic viewpoint for age-related diseases","volume":"14","author":"Franceschi","year":"2018","journal-title":"Nat Rev Endocrinol"},{"issue":"23","key":"2026102300234251800_zoaf074-B29","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1093\/bioinformatics\/bts565","article-title":"CD-HIT: accelerated for clustering the next-generation sequencing data","volume":"28","author":"Fu","year":"2012","journal-title":"Bioinformatics"},{"key":"2026102300234251800_zoaf074-B30","doi-asserted-by":"crossref","first-page":"169381","DOI":"10.1155\/2015\/169381","article-title":"Bioaccessible antioxidants in milk fermented by Bifidobacterium longum subsp. longum strains","volume":"2015","author":"Gagnon","year":"2015","journal-title":"Biomed Res Int"},{"issue":"1","key":"2026102300234251800_zoaf074-B31","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s12866-021-02248-5","article-title":"Antioxidant activity of Lactobacillus plantarum NJAU-01 in an animal model of aging","volume":"21","author":"Ge","year":"2021","journal-title":"BMC Microbiol"},{"issue":"11","key":"2026102300234251800_zoaf074-B32","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/s43587-022-00306-9","article-title":"Toward an improved definition of a healthy microbiome for healthy aging","volume":"2","author":"Ghosh","year":"2022","journal-title":"Nat Aging"},{"issue":"10","key":"2026102300234251800_zoaf074-B33","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3390\/genes10100827","article-title":"Comparative study of gut microbiota in wild and captive giant pandas (Ailuropoda melanoleuca)","volume":"10","author":"Guo","year":"2019","journal-title":"Genes (Basel)"},{"issue":"2","key":"2026102300234251800_zoaf074-B34","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41591-024-03405-9","article-title":"The gut\u2013brain axis underlying hepatic encephalopathy in liver cirrhosis","volume":"31","author":"He","year":"2025","journal-title":"Nat Med"},{"issue":"26","key":"2026102300234251800_zoaf074-B35","doi-asserted-by":"crossref","first-page":"12672","DOI":"10.1073\/pnas.1904099116","article-title":"Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide","volume":"116","author":"Henke","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2026102300234251800_zoaf074-B36","doi-asserted-by":"crossref","first-page":"5141","DOI":"10.1038\/s41467-021-25315-x","article-title":"The microbiome extends host evolutionary potential","volume":"12","author":"Henry","year":"2021","journal-title":"Nat Commun"},{"issue":"8","key":"2026102300234251800_zoaf074-B37","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic","volume":"11","author":"Hill","year":"2014","journal-title":"Nat Rev Gastro Hepat"},{"issue":"2","key":"2026102300234251800_zoaf074-B38","doi-asserted-by":"crossref","first-page":"e30126","DOI":"10.1371\/journal.pone.0030126","article-title":"Dirichlet multinomial mixtures: generative models for microbial metagenomics","volume":"7","author":"Holmes","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"2026102300234251800_zoaf074-B39","doi-asserted-by":"crossref","first-page":"9158","DOI":"10.1038\/s41598-019-45453-z","article-title":"Field trial of a probiotic bacteria to protect bats from white-nose syndrome","volume":"9","author":"Hoyt","year":"2019","journal-title":"Sci Rep"},{"key":"2026102300234251800_zoaf074-B40","doi-asserted-by":"crossref","first-page":"116851","DOI":"10.1016\/j.lwt.2024.116851","article-title":"Exploring advanced antimicrobial effects of Pediococcus pentosaceus and Lactococcus lactis derived from Bufo gargarizans: in vitro analysis and in vivo evaluation in mice","volume":"210","author":"Huang","year":"2024","journal-title":"LWT"},{"issue":"7","key":"2026102300234251800_zoaf074-B41","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.3390\/foods14071181","article-title":"Marine-derived Enterococcus faecalis HY0110 as a next-generation functional food probiotic: comprehensive in vitro and in vivo bioactivity evaluation and synergistic fermentation of Periplaneta americana extract powder","volume":"14","author":"Huang","year":"2025","journal-title":"Foods"},{"issue":"1","key":"2026102300234251800_zoaf074-B42","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s40168-023-01657-0","article-title":"PandaGUT provides new insights into bacterial diversity, function, and resistome landscapes with implications for conservation","volume":"11","author":"Huang","year":"2023","journal-title":"Microbiome"},{"issue":"21","key":"2026102300234251800_zoaf074-B43","doi-asserted-by":"crossref","first-page":"21777","DOI":"10.18632\/aging.103990","article-title":"The immune and metabolic changes with age in giant panda blood by combined transcriptome and DNA methylation analysis","volume":"12","author":"Huang","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"12","key":"2026102300234251800_zoaf074-B44","doi-asserted-by":"crossref","first-page":"e0021321","DOI":"10.1128\/JCM.00213-21","article-title":"Overview of changes to the clinical and laboratory standards institute performance standards for antimicrobial susceptibility testing, M100, 31st edition","volume":"59","author":"Humphries","year":"2021","journal-title":"J Clin Microbiol"},{"issue":"1","key":"2026102300234251800_zoaf074-B45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1471-2105-11-119","article-title":"Prodigal: prokaryotic gene recognition and translation initiation site identification","volume":"11","author":"Hyatt","year":"2010","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"2026102300234251800_zoaf074-B46","doi-asserted-by":"crossref","first-page":"42355","DOI":"10.1038\/srep42355","article-title":"Complexity of the Ruminococcus flavefaciens FD-1 cellulosome reflects an expansion of family-related protein-protein interactions","volume":"7","author":"Israeli-Ruimy","year":"2017","journal-title":"Sci Rep"},{"key":"2026102300234251800_zoaf074-B47","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1017\/CBO9780511542244.016","volume-title":"Giant Pandas: Biology, Veterinary Medicine and Management","author":"Janssen","year":"2006"},{"issue":"11","key":"2026102300234251800_zoaf074-B48","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1039\/D5FO00992H","article-title":"Bifidobacterium longum BL300 alleviates DSS-induced colitis by promoting IgA-mediated gut microbiota homeostasis","volume":"16","author":"Jin","year":"2025","journal-title":"Food Funct"},{"issue":"4","key":"2026102300234251800_zoaf074-B49","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jcpa.2011.08.001","article-title":"Dental abnormalities in eight captive giant pandas (Ailuropoda melanoleuca) in China","volume":"146","author":"Jin","year":"2012","journal-title":"J Comp Pathol"},{"issue":"9","key":"2026102300234251800_zoaf074-B50","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1007\/s10068-024-01631-y","article-title":"The role of Bifidobacterium in longevity and the future of probiotics","volume":"33","author":"Ku","year":"2024","journal-title":"Food Sci Biotechnol"},{"key":"2026102300234251800_zoaf074-B51","first-page":"20161553","article-title":"Probiotic treatment restores protection against lethal fungal infection lost during amphibian captivity","volume":"283","author":"Kueneman","year":"2016","journal-title":"P Roy Soc B-biol Sci"},{"issue":"1","key":"2026102300234251800_zoaf074-B52","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/bbb\/zbac172","article-title":"Enhancement of IgA production by membrane vesicles derived from Bifidobacterium longum subsp. infantis","volume":"87","author":"Kurata","year":"2022","journal-title":"Biosci Biotechnol Biochem"},{"issue":"1","key":"2026102300234251800_zoaf074-B53","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1128\/CMR.00014-14","article-title":"The rebirth of culture in microbiology through the example of culturomics to study human gut microbiota","volume":"28","author":"Lagier","year":"2015","journal-title":"Clin Microbiol Rev"},{"issue":"4","key":"2026102300234251800_zoaf074-B54","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"issue":"1","key":"2026102300234251800_zoaf074-B55","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/s41467-023-36633-7","article-title":"Population-level impacts of antibiotic usage on the human gut microbiome","volume":"14","author":"Lee","year":"2023","journal-title":"Nat Commun"},{"issue":"10","key":"2026102300234251800_zoaf074-B56","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1093\/bioinformatics\/btv033","article-title":"MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph","volume":"31","author":"Li","year":"2015","journal-title":"Bioinformatics"},{"issue":"2","key":"2026102300234251800_zoaf074-B57","doi-asserted-by":"crossref","first-page":"fiaa255","DOI":"10.1093\/femsec\/fiaa255","article-title":"Microeco: an R package for data mining in microbial community ecology","volume":"97","author":"Liu","year":"2021","journal-title":"FEMS Microbiol Ecol"},{"issue":"3","key":"2026102300234251800_zoaf074-B58","doi-asserted-by":"crossref","first-page":"e00252","DOI":"10.1128\/msystems.00252-23","article-title":"Age-related alterations in metabolome and microbiome provide insights in dietary transition in giant pandas","volume":"8","author":"Liu","year":"2023","journal-title":"Msystems"},{"issue":"1","key":"2026102300234251800_zoaf074-B59","doi-asserted-by":"crossref","first-page":"2426623","DOI":"10.1080\/19490976.2024.2426623","article-title":"Biosynthetic potential of the gut microbiome in longevous populations","volume":"16","author":"Liu","year":"2024","journal-title":"Gut Microbes"},{"issue":"1","key":"2026102300234251800_zoaf074-B60","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1002\/imt2.83","article-title":"EasyAmplicon: an easy-to-use, open-source, reproducible, and community-based pipeline for amplicon data analysis in microbiome research","volume":"2","author":"Liu","year":"2023","journal-title":"iMeta"},{"key":"2026102300234251800_zoaf074-B61","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.7717\/peerj-cs.104","article-title":"Bracken: estimating species abundance in metagenomics data","volume":"3","author":"Lu","year":"2017","journal-title":"PeerJ Comput Sci"},{"issue":"8","key":"2026102300234251800_zoaf074-B62","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.3390\/ani15081182","article-title":"Exploring captive giant panda reproduction: maternal and offspring factor correlations from 324 breeding events","volume":"15","author":"Luo","year":"2025","journal-title":"Animals (Basel)"},{"issue":"4","key":"2026102300234251800_zoaf074-B63","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.jbiotec.2012.07.006","article-title":"Science and technology for the mastership of probiotic applications in food products","volume":"162","author":"Makinen","year":"2012","journal-title":"J Biotechnol"},{"issue":"1","key":"2026102300234251800_zoaf074-B64","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1039\/D0NP00027B","article-title":"New developments in RiPP discovery, enzymology and engineering","volume":"38","author":"Montalb\u00e1n-L\u00f3pez","year":"2021","journal-title":"Nat Prod Rep"},{"issue":"6688","key":"2026102300234251800_zoaf074-B65","doi-asserted-by":"crossref","first-page":"eadj9223","DOI":"10.1126\/science.adj9223","article-title":"Cryptic diversity of cellulose-degrading gut bacteria in industrialized humans","volume":"383","author":"Mora\u00efs","year":"2024","journal-title":"Science"},{"key":"2026102300234251800_zoaf074-B66","doi-asserted-by":"publisher","author":"Nickols","year":"2024","DOI":"10.1101\/2024.12.13.628459"},{"issue":"1","key":"2026102300234251800_zoaf074-B67","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/s41467-025-56449-x","article-title":"Metagenomic global survey and in-depth genomic analyses of Ruminococcus gnavus reveal differences across host lifestyle and health status","volume":"16","author":"Nooij","year":"2025","journal-title":"Nat Commun"},{"issue":"4","key":"2026102300234251800_zoaf074-B68","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/s43587-023-00389-y","article-title":"Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures","volume":"3","author":"Pang","year":"2023","journal-title":"Nat Aging"},{"issue":"4","key":"2026102300234251800_zoaf074-B69","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat Methods"},{"key":"2026102300234251800_zoaf074-B70","doi-asserted-by":"crossref","first-page":"106253","DOI":"10.1016\/j.fbio.2025.106253","article-title":"Probiotics: health benefits, microencapsulation, and viability, combination with natural compounds, and applications in foods","volume":"66","author":"Peruzzolo","year":"2025","journal-title":"Food Biosci"},{"issue":"11","key":"2026102300234251800_zoaf074-B71","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1128\/AEM.04050-14","article-title":"Akkermansia muciniphila adheres to enterocytes and strengthens the integrity of the epithelial cell layer","volume":"81","author":"Reunanen","year":"2015","journal-title":"Appl Environ Microbiol"},{"issue":"1","key":"2026102300234251800_zoaf074-B72","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1038\/s41467-018-05470-4","article-title":"Microbial tryptophan catabolites in health and disease","volume":"9","author":"Roager","year":"2018","journal-title":"Nat Commun"},{"issue":"7885","key":"2026102300234251800_zoaf074-B73","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41586-021-03832-5","article-title":"Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians","volume":"599","author":"Sato","year":"2021","journal-title":"Nature"},{"issue":"3","key":"2026102300234251800_zoaf074-B74","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/cbic.201500474","article-title":"Aryl polyenes, a highly abundant class of bacterial natural products, are functionally related to antioxidative carotenoids","volume":"17","author":"Sch\u00f6ner","year":"2016","journal-title":"Chembiochem"},{"issue":"6","key":"2026102300234251800_zoaf074-B75","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol"},{"issue":"3","key":"2026102300234251800_zoaf074-B76","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1002\/imt2.191","article-title":"SeqKit2: a Swiss army knife for sequence and alignment processing","volume":"3","author":"Shen","year":"2024","journal-title":"Imeta"},{"issue":"1","key":"2026102300234251800_zoaf074-B77","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12866-019-1494-7","article-title":"Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice","volume":"19","author":"Smith","year":"2019","journal-title":"BMC Microbiol"},{"key":"2026102300234251800_zoaf074-B78","doi-asserted-by":"crossref","first-page":"e27014","DOI":"10.7554\/eLife.27014","article-title":"Regulation of life span by the gut microbiota in the short-lived African turquoise killifish","volume":"6","author":"Smith","year":"2017","journal-title":"Elife"},{"issue":"78","key":"2026102300234251800_zoaf074-B79","doi-asserted-by":"crossref","first-page":"78ps12","DOI":"10.1126\/scitranslmed.3001626","article-title":"Community health care: therapeutic opportunities in the human microbiome","volume":"3","author":"Sonnenburg","year":"2011","journal-title":"Sci Transl Med"},{"key":"2026102300234251800_zoaf074-B80","doi-asserted-by":"crossref","first-page":"1306458","DOI":"10.3389\/fimmu.2024.1306458","article-title":"The effects of Pediococcus acidilactici MA18\/5M on growth performance, gut integrity, and immune response using in vitro and in vivo Pacific salmonid models","volume":"15","author":"Soto-D\u00e1vila","year":"2024","journal-title":"Front Immunol"},{"key":"2026102300234251800_zoaf074-B81","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.biocon.2016.03.035","article-title":"Microbiomes, metagenomics, and primate conservation: new strategies, tools, and applications","volume":"199","author":"Stumpf","year":"2016","journal-title":"Biol Conserv"},{"issue":"1","key":"2026102300234251800_zoaf074-B82","doi-asserted-by":"crossref","first-page":"2449111","DOI":"10.1080\/19490976.2024.2449111","article-title":"Lactobacillus intestinalis facilitates tumor-derived CCL5 to recruit dendritic cell and suppress colorectal tumorigenesis","volume":"17","author":"Sun","year":"2025","journal-title":"Gut Microbes"},{"issue":"10","key":"2026102300234251800_zoaf074-B83","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1093\/bioinformatics\/btm098","article-title":"UniRef: comprehensive and non-redundant UniProt reference clusters","volume":"23","author":"Suzek","year":"2007","journal-title":"Bioinformatics"},{"key":"2026102300234251800_zoaf074-B84","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1017\/9781108692571.007","volume-title":"Bears of the World: Ecology, Conservation and Management","author":"Swaisgood","year":"2020"},{"issue":"1","key":"2026102300234251800_zoaf074-B85","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12866-024-03353-x","article-title":"Probiotic potential of Streptomyces levis strain HFM-2 isolated from human gut and its antibiofilm properties against pathogenic bacteria","volume":"24","author":"Verma","year":"2024","journal-title":"BMC Microbiol"},{"issue":"2","key":"2026102300234251800_zoaf074-B86","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1039\/C5NP00035A","article-title":"Insights into the chemical logic and enzymatic machinery of NRPS assembly lines","volume":"33","author":"Walsh","year":"2016","journal-title":"Nat Prod Rep"},{"key":"2026102300234251800_zoaf074-B87","first-page":"e01799","article-title":"Queen bee gut microbiota extends honeybee lifespan by inhibiting insulin signaling","volume":"90","author":"Wang","year":"2024","journal-title":"Appl Environ Microb"},{"issue":"9","key":"2026102300234251800_zoaf074-B88","doi-asserted-by":"crossref","first-page":"816","DOI":"10.3390\/insects13090772","article-title":"The comparison of antioxidant performance, immune performance, IIS activity and gut microbiota composition between queen and worker bees revealed the mechanism of different lifespan of female casts in the honeybee","volume":"13","author":"Wang","year":"2022","journal-title":"Insects"},{"issue":"5","key":"2026102300234251800_zoaf074-B89","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.tibtech.2018.10.003","article-title":"Natural products from mammalian gut microbiota","volume":"37","author":"Wang","year":"2019","journal-title":"Trends Biotechnol"},{"issue":"36","key":"2026102300234251800_zoaf074-B90","doi-asserted-by":"crossref","first-page":"2303457","DOI":"10.1002\/advs.202303457","article-title":"Lactobacillus intestinalis primes epithelial cells to suppress colitis-related Th17 response by host-microbe retinoic acid biosynthesis","volume":"10","author":"Wang","year":"2023","journal-title":"Adv Sci"},{"key":"2026102300234251800_zoaf074-B91","doi-asserted-by":"crossref","first-page":"110148","DOI":"10.1016\/j.fsi.2025.110148","article-title":"Host-derived Pediococcus acidilactici B49: a promising probiotic for immunomodulation and disease control in largemouth bass (Micropterus salmoides)","volume":"158","author":"Wang","year":"2025","journal-title":"Fish Shellfish Immunol"},{"issue":"20","key":"2026102300234251800_zoaf074-B92","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1111\/mec.14278","article-title":"Gut microbiomes of free-ranging and captive Namibian cheetahs: diversity, putative functions and occurrence of potential pathogens","volume":"26","author":"Wasimuddin","year":"2017","journal-title":"Mol Ecol"},{"issue":"12","key":"2026102300234251800_zoaf074-B93","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.3390\/microorganisms10122345","article-title":"Degradation of cellulose and hemicellulose by ruminal microorganisms","volume":"10","author":"Weimer","year":"2022","journal-title":"Microorganisms"},{"key":"2026102300234251800_zoaf074-B94","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.biocon.2018.11.016","article-title":"The microbiome in threatened species conservation","volume":"229","author":"West","year":"2019","journal-title":"Biol Conserv"},{"key":"2026102300234251800_zoaf074-B95","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3389\/fmicb.2016.00661","article-title":"Dietary shifts may trigger dysbiosis and mucous stools in giant pandas (Ailuropoda melanoleuca)","volume":"7","author":"Williams","year":"2016","journal-title":"Front Microbiol"},{"issue":"2","key":"2026102300234251800_zoaf074-B96","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s42255-021-00348-0","article-title":"Gut microbiome pattern reflects healthy ageing and predicts survival in humans","volume":"3","author":"Wilmanski","year":"2021","journal-title":"Nat Metab"},{"issue":"5","key":"2026102300234251800_zoaf074-B97","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1007\/s12602-024-10263-x","article-title":"Probiotic Pediococcus acidilactici strains exert anti-inflammatory effects by regulating intracellular signaling pathways in LPS-induced RAW 264.7 cells","volume":"17","author":"Woo","year":"2025","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"1","key":"2026102300234251800_zoaf074-B98","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s13059-019-1891-0","article-title":"Improved metagenomic analysis with Kraken 2","volume":"20","author":"Wood","year":"2019","journal-title":"Genome Biol"},{"issue":"6052","key":"2026102300234251800_zoaf074-B99","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1208344","article-title":"Linking long-term dietary patterns with gut microbial enterotypes","volume":"334","author":"Wu","year":"2011","journal-title":"Science"},{"issue":"1","key":"2026102300234251800_zoaf074-B100","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41522-022-00366-0","article-title":"Gut microbiota as an antioxidant system in centenarians associated with high antioxidant activities of gut-resident Lactobacillus","volume":"8","author":"Wu","year":"2022","journal-title":"NPJ Biofilms Microbi"},{"issue":"4","key":"2026102300234251800_zoaf074-B101","doi-asserted-by":"crossref","first-page":"e00325","DOI":"10.1128\/mSystems.00325-19","article-title":"A cross-sectional study of compositional and functional profiles of gut microbiota in Sardinian centenarians","volume":"4","author":"Wu","year":"2019","journal-title":"mSystems"},{"key":"2026102300234251800_zoaf074-B102","doi-asserted-by":"crossref","first-page":"103938","DOI":"10.1016\/j.jff.2020.103938","article-title":"Anti-aging effect of the combination of Bifidobacterium longum and B. animalis in a d-galactose-treated mice","volume":"69","author":"Xia","year":"2020","journal-title":"J Funct Foods"},{"issue":"1","key":"2026102300234251800_zoaf074-B103","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s40168-021-01108-8","article-title":"Human gut-derived B. longum subsp. longum strains protect against aging in a D-galactose-induced aging mouse model","volume":"9","author":"Xiao","year":"2021","journal-title":"Microbiome"},{"issue":"24","key":"2026102300234251800_zoaf074-B104","doi-asserted-by":"crossref","first-page":"10855","DOI":"10.1039\/D3FO01651J","article-title":"Pediococcus acidilactici (pA1c\u00ae) alleviates obesity-related dyslipidemia and inflammation in Wistar rats by activating beta-oxidation and modulating the gut microbiota","volume":"14","author":"Yavorov-Dayliev","year":"2023","journal-title":"Food Funct"},{"issue":"9","key":"2026102300234251800_zoaf074-B105","doi-asserted-by":"crossref","first-page":"2200739","DOI":"10.1002\/mnfr.202200739","article-title":"Gut microbiota-derived indole derivatives alleviate neurodegeneration in aging through activating GPR30\/AMPK\/SIRT1 pathway","volume":"67","author":"Yin","year":"2023","journal-title":"Mol Nutr Food Res"},{"issue":"9","key":"2026102300234251800_zoaf074-B106","doi-asserted-by":"crossref","first-page":"e0222292","DOI":"10.1371\/journal.pone.0222292","article-title":"Genome-wide analysis of methylation in giant pandas with cataract by methylation-dependent restriction-site associated DNA sequencing (MethylRAD)","volume":"14","author":"You","year":"2019","journal-title":"PLoS One"},{"key":"2026102300234251800_zoaf074-B107","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.aninu.2023.04.012","article-title":"Lactobacillus johnsonii N5 from heat stress-resistant pigs improves gut mucosal immunity and barrier in dextran sodium sulfate-induced colitis","volume":"15","author":"Yuan","year":"2023","journal-title":"Animal Nutrition"},{"issue":"6","key":"2026102300234251800_zoaf074-B108","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.14336\/AD.2023.0325","article-title":"Potential effects of Akkermansia Muciniphila in aging and aging-related diseases: current evidence and perspectives","volume":"14","author":"Zeng","year":"2023","journal-title":"Aging Dis"},{"issue":"5","key":"2026102300234251800_zoaf074-B109","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/s41396-018-0051-y","article-title":"Age-associated microbiome shows the giant panda lives on hemicelluloses, not on cellulose","volume":"12","author":"Zhang","year":"2018","journal-title":"ISME J"},{"issue":"19","key":"2026102300234251800_zoaf074-B110","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.3390\/ani12192587","article-title":"Possible effects of early maternal separation on the gut microbiota of captive adult giant pandas","volume":"12","author":"Zhang","year":"2022","journal-title":"Animals (Basel)"},{"issue":"1","key":"2026102300234251800_zoaf074-B111","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s43587-020-00014-2","article-title":"Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities","volume":"1","author":"Zhang","year":"2021","journal-title":"Nat Aging"},{"issue":"10","key":"2026102300234251800_zoaf074-B112","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.3390\/microorganisms11102580","article-title":"The effects of Lactobacillus johnsonii on diseases and its potential applications","volume":"11","author":"Zhang","year":"2023","journal-title":"Microorganisms"},{"key":"2026102300234251800_zoaf074-B113","doi-asserted-by":"crossref","first-page":"1369402","DOI":"10.3389\/fmicb.2024.1369402","article-title":"Impact of Pediococcus acidilactici GLP06 supplementation on gut microbes and metabolites in adult beagles: a comparative analysis","volume":"15","author":"Zhao","year":"2024","journal-title":"Front Microbiol"},{"issue":"43","key":"2026102300234251800_zoaf074-B114","doi-asserted-by":"crossref","first-page":"17714","DOI":"10.1073\/pnas.1017956108","article-title":"Evidence of cellulose metabolism by the giant panda gut microbiome","volume":"108","author":"Zhu","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"2026102300234251800_zoaf074-B115","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.chom.2020.01.010","article-title":"Xenosiderophore utilization promotes Bacteroides thetaiotaomicron resilience during colitis","volume":"27","author":"Zhu","year":"2020","journal-title":"Cell Host Microbe"},{"issue":"2","key":"2026102300234251800_zoaf074-B116","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1017\/S0952836901000139","article-title":"The reproductive strategy of giant pandas (Ailuropoda melanoleuca): infant growth and development and mother\u2013infant relationships","volume":"253","author":"Zhu","year":"2001","journal-title":"J Zool"},{"issue":"6","key":"2026102300234251800_zoaf074-B117","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2018.08.041","article-title":"Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features","volume":"174","author":"Zmora","year":"2018","journal-title":"Cell"},{"issue":"3","key":"2026102300234251800_zoaf074-B118","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3390\/vetsci7030112","article-title":"Lactobacillus johnsonii L531 ameliorates Escherichia coli-induced cell damage via inhibiting NLRP3 inflammasome activity and promoting ATG5\/ATG16L1-mediated autophagy in porcine mammary epithelial cells","volume":"7","author":"Zou","year":"2020","journal-title":"Vet Sci"}],"container-title":["Current Zoology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cz\/advance-article-pdf\/doi\/10.1093\/cz\/zoaf074\/65448180\/zoaf074.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cz\/article-pdf\/72\/5\/616\/65448180\/zoaf074.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cz\/article-pdf\/72\/5\/616\/65448180\/zoaf074.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:23:59Z","timestamp":1792729439000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cz\/article\/72\/5\/616\/8339601"}},"subtitle":[],"editor":[{"given":"Zu-Shi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,11,21]]},"references-count":118,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,11,21]]},"published-print":{"date-parts":[[2026,10,23]]}},"URL":"https:\/\/doi.org\/10.1093\/cz\/zoaf074","relation":{},"ISSN":["1674-5507","2396-9814"],"issn-type":[{"value":"1674-5507","type":"print"},{"value":"2396-9814","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2025,11,21]]}}}