{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:20Z","timestamp":1792785860192,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31100273"],"award-info":[{"award-number":["31100273"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Eastern Talent Plan Leading Project"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mammalian torpor imposes unique metabolic constraints, yet the mechanisms of nitrogen metabolism during this state remain unclear. In this study, we show that the urea cycle is selectively regulated rather than broadly suppressed in torpid bats. A significantly increased abundance of carbamoyl-phosphate synthase 1 (CPS1) maintained its functional capacity during torpor and arousal in Myotis ricketti. Proteomic analyses and confocal microscopy identified a specific association and co-localization between CPS1 and agmatinase (AGMAT), an ATP-independent enzyme involved in nitrogen metabolism. Co-localization of CPS1 and AGMAT was also observed in torpid Rhinolophus ferrumequinum, a phylogenetically distant species. Fluorescence resonance energy transfer (FRET) further supported an indirect CPS1-AGMAT interaction. Most urea cycle enzymes exhibited stable or only moderately reduced expression during bat torpor, and metabolic profiling demonstrated sustained nitrogen flux. Together, these findings reveal a conserved adaptive mechanism that maintains urea cycle function, potentially enhancing osmotic stability and energy efficiency during prolonged fasting and water scarcity.<\/jats:p>","DOI":"10.1093\/cz\/zoag002","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T08:22:07Z","timestamp":1767687727000},"page":"703-713","source":"Crossref","is-referenced-by-count":0,"title":["Interaction of carbamoyl-phosphate synthase 1 with agmatinase in the liver of torpid bats"],"prefix":"10.1093","volume":"72","author":[{"given":"Yangyang","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Brain Functional Genomics of Shanghai and Ministry of Education, School of Life Sciences, East China Normal University , Shanghai 200062 ,","place":["China"]},{"name":"Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai 200031 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Chung","family":"Liao","sequence":"additional","affiliation":[{"name":"Proteomics Research Center, National Yang-Ming University , Taipei 11221 , ,","place":["Taiwan China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences , Guangzhou 510260 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Lv","sequence":"additional","affiliation":[{"name":"Key Laboratory of Brain Functional Genomics of Shanghai and Ministry of Education, School of Life Sciences, East China Normal University , Shanghai 200062 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Brain Functional Genomics of Shanghai and Ministry of Education, School of Life Sciences, East China Normal University , Shanghai 200062 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Life Sciences, East China Normal University , Shanghai 200062 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, East China Normal University , Shanghai 200062 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Ni","sequence":"additional","affiliation":[{"name":"School of Life Sciences, East China Normal University , Shanghai 200062 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guimei","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Eco-Chongming, School of Life Sciences, East China Normal University , Shanghai 200062 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7856-4488","authenticated-orcid":false,"given":"Haipeng","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai 200031 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5156-9887","authenticated-orcid":false,"given":"Yi-Hsuan","family":"Pan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Brain Functional Genomics of Shanghai and Ministry of Education, School of Life Sciences, East China Normal University , Shanghai 200062 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"issue":"2","key":"2026102300232646300_zoag002-B1","doi-asserted-by":"crossref","first-page":"jeb160606","DOI":"10.1242\/jeb.160606","article-title":"Molecular interactions underpinning the phenotype of hibernation in mammals","volume":"222","author":"Andrews","year":"2019","journal-title":"J Exp Biol"},{"issue":"7","key":"2026102300232646300_zoag002-B2","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/S0021-9258(18)69923-5","article-title":"Comparative biochemistry of urea synthesis. 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