{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:31:33Z","timestamp":1775093493363,"version":"3.50.1"},"reference-count":98,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":289,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Commission under the NextGeneration EU program","award":["PNRR ECS00000017 -\u201dTHE - Tuscany Health Ecosystem"],"award-info":[{"award-number":["PNRR ECS00000017 -\u201dTHE - Tuscany Health Ecosystem"]}]},{"name":"European Commission under the NextGeneration EU program","award":["PNRR ECS00000017 -\u201dTHE - Tuscany Health Ecosystem"],"award-info":[{"award-number":["PNRR ECS00000017 -\u201dTHE - Tuscany Health Ecosystem"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Rett syndrome (RTT) is a neurodevelopmental disorder occurring almost exclusively in females and leading to a variety of impairments and disabilities from mild to severe. In &amp;gt;95% cases, RTT is due to mutations in the X-linked gene MECP2, but the molecular mechanisms determining RTT are unknown at present, and the complexity of the system is challenging. To facilitate and provide guidance to the unraveling of those mechanisms, we developed a database resource for the visualization and analysis of the genomic landscape in the context of wild-type or mutated Mecp2 gene in the mouse model. Our resource allows for the exploration of differential dynamics of gene expression and the prediction of new potential MECP2 target genes to decipher the RTT disorder molecular mechanisms.<\/jats:p>\n               <jats:p>Database URL: https:\/\/biomedinfo.di.unipi.it\/rett-database\/<\/jats:p>","DOI":"10.1093\/database\/baae109","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T16:26:21Z","timestamp":1729095981000},"source":"Crossref","is-referenced-by-count":2,"title":["RettDb: the Rett syndrome omics database to navigate the Rett syndrome genomic landscape"],"prefix":"10.1093","volume":"2024","author":[{"given":"Nico","family":"Cillari","sequence":"first","affiliation":[{"name":"Unit of Cell and Developmental Biology, Department of Biology , University of Pisa, S.S.12 Abetone e Brennero 4, Pisa 56127,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Neri","sequence":"additional","affiliation":[{"name":"Unit of Cell and Developmental Biology, Department of Biology , University of Pisa, S.S.12 Abetone e Brennero 4, Pisa 56127,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Pisanti","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Pisa , Largo B. Pontecorvo 3, Pisa 56127,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Milazzo","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Pisa , Largo B. Pontecorvo 3, Pisa 56127,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9812-579X","authenticated-orcid":false,"given":"Ugo","family":"Borello","sequence":"additional","affiliation":[{"name":"Unit of Cell and Developmental Biology, Department of Biology , University of Pisa, S.S.12 Abetone e Brennero 4, Pisa 56127,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"2025030713452957500_R1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-023-02169-6","article-title":"Global prevalence of Rett syndrome: systematic review and meta-analysis","volume":"12","author":"Petriti","year":"2023","journal-title":"Syst Rev"},{"key":"2025030713452957500_R2","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1080\/09638280150504171","article-title":"Rett syndrome: clinical characteristics and recent genetic 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