{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:04:26Z","timestamp":1792116266013,"version":"4.4.0"},"reference-count":264,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":200,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GL 991\/1-1"],"award-info":[{"award-number":["GL 991\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The term Tc17 cells refers to interleukin 17 (IL-17)-producing CD8+ T cells. While IL-17 is an important mediator of mucosal defense, it is also centrally involved in driving the inflammatory response in immune-mediated diseases, such as psoriasis, multiple sclerosis, and inflammatory bowel disease. In this review, we aim to gather the current knowledge on the phenotypic and transcriptional profile, the in vitro and in vivo generation of Tc17 cells, and the evidence pointing towards a relevant role of Tc17 cells in human diseases such as infectious diseases, cancer, and immune-mediated diseases.<\/jats:p>","DOI":"10.1093\/discim\/kyad010","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T22:59:34Z","timestamp":1689807574000},"source":"Crossref","is-referenced-by-count":18,"title":["Friend or Foe \u2013 Tc17 cell generation and current evidence for their importance in human disease"],"prefix":"10.1093","volume":"2","author":[{"given":"Anna Veronika","family":"Hipp","sequence":"first","affiliation":[{"name":"Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, University Medical Center Freiburg, Faculty of Medicine , Freiburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertram","family":"Bengsch","sequence":"additional","affiliation":[{"name":"Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, University Medical Center Freiburg, Faculty of Medicine , Freiburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5236-7459","authenticated-orcid":false,"given":"Anna-Maria","family":"Globig","sequence":"additional","affiliation":[{"name":"Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, University Medical Center Freiburg, Faculty of Medicine , Freiburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"2023080322121410200_CIT0001","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.jaci.2014.11.001","article-title":"The 3 major types of innate and adaptive cell-mediated effector immunity","volume":"135","author":"Annunziato","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"2023080322121410200_CIT0002","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00005-014-0293-y","article-title":"Heterogeneity in the differentiation and function of CD8+ T cells","volume":"62","author":"Mittr\u00fccker","year":"2014","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"2023080322121410200_CIT0003","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1084\/jem.20181778","article-title":"TCF-1 limits the formation of Tc17 cells via repression of the MAF\u2013ROR\u03b3t 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