{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:45:43Z","timestamp":1789202743576,"version":"build-2803163510"},"reference-count":161,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":268,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Hodge Centre for Neuropsychiatric Immunology Seed Corn"},{"name":"Cardiff University Systems Immunity Research Institute"},{"DOI":"10.13039\/100018601","name":"Wales Cancer Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Alzheimer\u2019s disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia. Early symptoms include the loss of memory and mild cognitive ability; however, as the disease progresses, these symptoms can present with increased severity manifesting as mood and behaviour changes, disorientation, and a loss of motor\/body control. AD is one of the leading causes of death in the UK, and with an ever-increasing ageing society, patient numbers are predicted to rise posing a significant global health emergency. AD is a complex neurophysiological disorder where pathology is characterized by the deposition and aggregation of misfolded amyloid-beta (A\u03b2)-protein that in-turn promotes excessive tau-protein production which together drives neuronal cell dysfunction, neuroinflammation, and neurodegeneration. It is widely accepted that AD is driven by a combination of both genetic and immunological processes with recent data suggesting that adaptive immune cell activity within the parenchyma occurs throughout disease. The mechanisms behind these observations remain unclear but suggest that manipulating the adaptive immune response during AD may be an effective therapeutic strategy. Using immunotherapy for AD treatment is not a new concept as the only two approved treatments for AD use antibody-based approaches to target A\u03b2. However, these have been shown to only temporarily ease symptoms or slow progression highlighting the urgent need for newer treatments. This review discusses the role of the adaptive immune system during AD, how microbial infections may be contributing to inflammatory immune activity and suggests how adaptive immune processes can pose as therapeutic targets for this devastating disease.<\/jats:p>","DOI":"10.1093\/discim\/kyad015","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T15:12:33Z","timestamp":1695741153000},"source":"Crossref","is-referenced-by-count":7,"title":["The association of microbial infection and adaptive immune cell activation in Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9280-5281","authenticated-orcid":false,"given":"Mathew","family":"Clement","sequence":"first","affiliation":[{"name":"Division of Infection and Immunity, Systems Immunity University Research Institute, Cardiff University , Cardiff , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"2023101015000392900_CIT0001","volume-title":"Deaths","author":"Office for National Statistics"},{"key":"2023101015000392900_CIT0002","volume-title":"Dementia UK report","author":"Alzheimer\u2019s Society"},{"key":"2023101015000392900_CIT0003","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.3390\/molecules25245789","article-title":"Comprehensive review on Alzheimer\u2019s disease: causes and treatment","volume":"25","author":"Breijyeh","year":"2020","journal-title":"Molecules"},{"key":"2023101015000392900_CIT0004","volume-title":"Symptoms of Alzheimer\u2019s disease","author":"Alzheimer\u2019s Society"},{"key":"2023101015000392900_CIT0005","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1093\/brain\/awad005","article-title":"Anti-amyloid antibody therapies in Alzheimer\u2019s disease","volume":"146","author":"Perneczky","year":"2023","journal-title":"Brain"},{"key":"2023101015000392900_CIT0006","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/d41573-023-00004-0","article-title":"FDA approves second anti-amyloid antibody for Alzheimer disease","volume":"22","author":"Mullard","year":"2023","journal-title":"Nat Rev Drug Discov"},{"key":"2023101015000392900_CIT0007","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41586-022-05474-7","article-title":"Brain borders at the central stage of neuroimmunology","volume":"612","author":"Rustenhoven","year":"2022","journal-title":"Nature"},{"key":"2023101015000392900_CIT0008","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/bs.mie.2016.10.013","article-title":"Analyzing amyloid-beta peptide modulation profiles and binding sites of gamma-secretase modulators","volume-title":"Enzymology at the Membrane Interface: Intramembrane Proteases","author":"Trambauer","year":"2017"},{"key":"2023101015000392900_CIT0009","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3233\/JAD-2010-1221","article-title":"Alzheimer\u2019s disease and the amyloid-beta peptide","volume":"19","author":"Murphy","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"2023101015000392900_CIT0010","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1016\/j.immuni.2022.10.016","article-title":"Emerging roles of innate and adaptive immunity in Alzheimer\u2019s disease","volume":"55","author":"Chen","year":"2022","journal-title":"Immunity"},{"key":"2023101015000392900_CIT0011","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1038\/ncomms7176","article-title":"Microglia constitute a barrier that prevents neurotoxic protofibrillar Abeta42 hotspots around plaques","volume":"6","author":"Condello","year":"2015","journal-title":"Nat Commun"},{"key":"2023101015000392900_CIT0012","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/nn1335","article-title":"Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches","volume":"7","author":"Tsai","year":"2004","journal-title":"Nat Neurosci"},{"key":"2023101015000392900_CIT0013","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1001\/jamaneurol.2013.5847","article-title":"Amyloid-beta and tau: the trigger and bullet in Alzheimer disease pathogenesis","volume":"71","author":"Bloom","year":"2014","journal-title":"JAMA Neurol"},{"key":"2023101015000392900_CIT0014","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/s41593-020-0687-6","article-title":"Synergy between amyloid-beta and tau in Alzheimer\u2019s disease","volume":"23","author":"Busche","year":"2020","journal-title":"Nat Neurosci"},{"key":"2023101015000392900_CIT0015","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.jalz.2016.01.012","article-title":"Molecular genetics of early-onset Alzheimer\u2019s disease revisited","volume":"12","author":"Cacace","year":"2016","journal-title":"Alzheimers Dement"},{"key":"2023101015000392900_CIT0016","doi-asserted-by":"crossref","first-page":"784958","DOI":"10.3389\/fpubh.2021.784958","article-title":"Genetic risk factors for Alzheimer\u2019s disease in racial\/ethnic minority populations in the U.S.: a scoping review","volume":"9","author":"Rubin","year":"2021","journal-title":"Front Public Health"},{"key":"2023101015000392900_CIT0017","doi-asserted-by":"crossref","first-page":"e12155","DOI":"10.1002\/dad2.12155","article-title":"Insight into the genetic etiology of Alzheimer\u2019s disease: a comprehensive review of the role of rare variants","volume":"13","author":"Hoogmartens","year":"2021","journal-title":"Alzheimers Dement (Amst)"},{"key":"2023101015000392900_CIT0018","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New insights into the genetic etiology of Alzheimer\u2019s disease and related dementias","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat Genet"},{"key":"2023101015000392900_CIT0019","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3389\/fnagi.2019.00337","article-title":"Friend, foe or both? Immune activity in Alzheimer\u2019s disease","volume":"11","author":"Frost","year":"2019","journal-title":"Front Aging Neurosci"},{"key":"2023101015000392900_CIT0020","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature20412","article-title":"The road to restoring neural circuits for the treatment of Alzheimer\u2019s disease","volume":"539","author":"Canter","year":"2016","journal-title":"Nature"},{"key":"2023101015000392900_CIT0021","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein-E type-4 allele and the risk of Alzheimers-disease in late-onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"2023101015000392900_CIT0022","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/ana.21843","article-title":"APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging","volume":"67","author":"Morris","year":"2010","journal-title":"Ann Neurol"},{"key":"2023101015000392900_CIT0023","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature24016","article-title":"ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy","volume":"549","author":"Shi","year":"2017","journal-title":"Nature"},{"key":"2023101015000392900_CIT0024","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","article-title":"Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model","volume":"53","author":"Yoshiyama","year":"2007","journal-title":"Neuron"},{"key":"2023101015000392900_CIT0025","doi-asserted-by":"crossref","first-page":"E1807","DOI":"10.1073\/pnas.1220484110","article-title":"ApoE influences amyloid-beta (Abeta) clearance despite minimal apoE\/Abeta association in physiological conditions","volume":"110","author":"Verghese","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023101015000392900_CIT0026","doi-asserted-by":"crossref","first-page":"e13511","DOI":"10.1111\/acel.13511","article-title":"Insights into T-cell dysfunction in Alzheimer\u2019s disease","volume":"20","author":"Dai","year":"2021","journal-title":"Aging Cell"},{"key":"2023101015000392900_CIT0027","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41586-020-2247-3","article-title":"APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline","volume":"581","author":"Montagne","year":"2020","journal-title":"Nature"},{"key":"2023101015000392900_CIT0028","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41586-018-0368-8","article-title":"Functional aspects of meningeal lymphatics in ageing and Alzheimer\u2019s disease","volume":"560","author":"Da Mesquita","year":"2018","journal-title":"Nature"},{"key":"2023101015000392900_CIT0029","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/s41593-018-0213-2","article-title":"Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration","volume":"21","author":"Herisson","year":"2018","journal-title":"Nat Neurosci"},{"key":"2023101015000392900_CIT0030","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jneuroim.2003.10.049","article-title":"Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system","volume":"146","author":"Shaked","year":"2004","journal-title":"J Neuroimmunol"},{"key":"2023101015000392900_CIT0031","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/s12974-021-02308-7","article-title":"CD4+ effector T cells accelerate Alzheimer\u2019s disease in mice","volume":"18","author":"Machhi","year":"2021","journal-title":"J Neuroinflammation"},{"key":"2023101015000392900_CIT0032","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000486200","article-title":"Extravascular CD3+ T cells in brains of Alzheimer disease patients correlate with tau but not with amyloid pathology: an immunohistochemical study","volume":"18","author":"Merlini","year":"2018","journal-title":"Neurodegener Dis"},{"key":"2023101015000392900_CIT0033","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbi.2020.05.070","article-title":"CD8(+) T-cells infiltrate Alzheimer\u2019s disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice","volume":"89","author":"Unger","year":"2020","journal-title":"Brain Behav Immun"},{"key":"2023101015000392900_CIT0034","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging: an evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"2023101015000392900_CIT0035","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41586-023-05788-0","article-title":"Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy","volume":"615","author":"Chen","year":"2023","journal-title":"Nature"},{"key":"2023101015000392900_CIT0036","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41586-019-1895-7","article-title":"Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer\u2019s disease","volume":"577","author":"Gate","year":"2020","journal-title":"Nature"},{"key":"2023101015000392900_CIT0037","doi-asserted-by":"crossref","first-page":"E1316","DOI":"10.1073\/pnas.1525466113","article-title":"The adaptive immune system restrains Alzheimer\u2019s disease pathogenesis by modulating microglial function","volume":"113","author":"Marsh","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023101015000392900_CIT0038","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s40478-015-0251-x","article-title":"Reduced beta-amyloid pathology in an APP transgenic mouse model of Alzheimer\u2019s disease lacking functional B and T cells","volume":"3","author":"Spani","year":"2015","journal-title":"Acta Neuropathol Commun"},{"key":"2023101015000392900_CIT0039","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.4049\/jimmunol.1200947","article-title":"IFN-gamma production by amyloid beta-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer\u2019s disease","volume":"190","author":"Browne","year":"2013","journal-title":"J Immunol"},{"key":"2023101015000392900_CIT0040","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.isci.2019.05.039","article-title":"CD4 T cells induce a subset of MHCII-expressing microglia that attenuates alzheimer pathology","volume":"16","author":"Mittal","year":"2019","journal-title":"iScience"},{"key":"2023101015000392900_CIT0041","doi-asserted-by":"crossref","first-page":"e75786","DOI":"10.1371\/journal.pone.0075786","article-title":"Th17 cell-mediated neuroinflammation is involved in neurodegeneration of abeta1-42-induced Alzheimer\u2019s disease model rats","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"2023101015000392900_CIT0042","doi-asserted-by":"crossref","first-page":"1154699","DOI":"10.3389\/fimmu.2023.1154699","article-title":"T cell aging and Alzheimer\u2019s disease","volume":"14","author":"Guo","year":"2023","journal-title":"Front Immunol"},{"key":"2023101015000392900_CIT0043","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.3389\/fimmu.2017.01578","article-title":"Tregs: where we are and what comes next","volume":"8","author":"Zhao","year":"2017","journal-title":"Front Immunol"},{"key":"2023101015000392900_CIT0044","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3233\/JAD-2010-091696","article-title":"PD1 negative and PD1 positive CD4+ T regulatory cells in mild cognitive impairment and Alzheimer\u2019s disease","volume":"21","author":"Saresella","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"2023101015000392900_CIT0045","doi-asserted-by":"crossref","first-page":"7967","DOI":"10.1038\/ncomms8967","article-title":"Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer\u2019s disease pathology","volume":"6","author":"Baruch","year":"2015","journal-title":"Nat Commun"},{"key":"2023101015000392900_CIT0046","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nm.4022","article-title":"PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer\u2019s disease","volume":"22","author":"Baruch","year":"2016","journal-title":"Nat Med"},{"key":"2023101015000392900_CIT0047","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.arr.2017.08.005","article-title":"The role of the immune system in Alzheimer disease: etiology and treatment","volume":"40","author":"Jevtic","year":"2017","journal-title":"Ageing Res Rev"},{"key":"2023101015000392900_CIT0048","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1002\/eji.201344432","article-title":"Transient Treg-cell depletion in adult mice results in persistent self-reactive CD4(+) T-cell responses","volume":"44","author":"Nystrom","year":"2014","journal-title":"Eur J Immunol"},{"key":"2023101015000392900_CIT0049","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.neuron.2014.12.068","article-title":"Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology","volume":"85","author":"Guillot-Sestier","year":"2015","journal-title":"Neuron"},{"key":"2023101015000392900_CIT0050","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.4049\/jimmunol.2100565","article-title":"IL-10 as a Th2 cytokine: differences between mice and humans","volume":"207","author":"Rasquinha","year":"2021","journal-title":"J Immunol"},{"key":"2023101015000392900_CIT0051","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.nbd.2008.12.015","article-title":"Abeta-specific Th2 cells provide cognitive and pathological benefits to Alzheimer\u2019s mice without infiltrating the CNS","volume":"34","author":"Cao","year":"2009","journal-title":"Neurobiol Dis"},{"key":"2023101015000392900_CIT0052","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.3389\/fimmu.2018.02169","article-title":"Determination of T follicular helper cell fate by dendritic cells","volume":"9","author":"Krishnaswamy","year":"2018","journal-title":"Front Immunol"},{"key":"2023101015000392900_CIT0053","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13195-018-0412-9","article-title":"IgM response against amyloid-beta in aging: a potential peripheral protective mechanism","volume":"10","author":"Agrawal","year":"2018","journal-title":"Alzheimers Res Ther"},{"key":"2023101015000392900_CIT0054","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1007\/s11481-020-09908-9","article-title":"Immune and inflammatory determinants underlying Alzheimer\u2019s disease pathology","volume":"15","author":"Baulch","year":"2020","journal-title":"J Neuroimmune Pharmacol"},{"key":"2023101015000392900_CIT0055","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrd4296","article-title":"Interleukin-21: a double-edged sword with therapeutic potential","volume":"13","author":"Spolski","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"2023101015000392900_CIT0056","doi-asserted-by":"crossref","first-page":"854889","DOI":"10.3389\/fimmu.2022.854889","article-title":"Editorial: new insights into b cell subsets in health and disease","volume":"13","author":"Somers","year":"2022","journal-title":"Front Immunol"},{"key":"2023101015000392900_CIT0057","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1038\/s41467-021-22479-4","article-title":"Therapeutic B-cell depletion reverses progression of Alzheimer\u2019s disease","volume":"12","author":"Kim","year":"2021","journal-title":"Nat Commun"},{"key":"2023101015000392900_CIT0058","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3389\/fcimb.2020.00231","article-title":"Targeting natural killer cells for improved immunity and control of the adaptive immune response","volume":"10","author":"Pierce","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"2023101015000392900_CIT0059","doi-asserted-by":"crossref","first-page":"502","DOI":"10.4049\/jimmunol.2000037","article-title":"Depletion of NK cells improves cognitive function in the Alzheimer disease mouse model","volume":"205","author":"Zhang","year":"2020","journal-title":"J Immunol"},{"key":"2023101015000392900_CIT0060","doi-asserted-by":"crossref","first-page":"1004885","DOI":"10.3389\/fimmu.2022.1004885","article-title":"Alzheimer\u2019s disease alters the transcriptomic profile of natural killer cells at single-cell resolution","volume":"13","author":"Qi","year":"2022","journal-title":"Front Immunol"},{"key":"2023101015000392900_CIT0061","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fimmu.2020.00012","article-title":"Dissection of the human T-cell receptor gamma gene repertoire in the brain and peripheral blood identifies age- and Alzheimer\u2019s disease-associated clonotype profiles","volume":"11","author":"Aliseychik","year":"2020","journal-title":"Front Immunol"},{"key":"2023101015000392900_CIT0062","doi-asserted-by":"crossref","first-page":"577428","DOI":"10.1016\/j.jneuroim.2020.577428","article-title":"Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells","volume":"349","author":"Priya","year":"2020","journal-title":"J Neuroimmunol"},{"key":"2023101015000392900_CIT0063","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1038\/s41467-018-05322-1","article-title":"Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation","volume":"9","author":"Bonacina","year":"2018","journal-title":"Nat Commun"},{"key":"2023101015000392900_CIT0064","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.nbd.2013.04.009","article-title":"Apolipoprotein E and its mimetic peptide suppress Th1 and Th17 responses in experimental autoimmune encephalomyelitis","volume":"56","author":"Wei","year":"2013","journal-title":"Neurobiol Dis"},{"key":"2023101015000392900_CIT0065","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1006\/cimm.1994.1302","article-title":"Apolipoprotein E inhibition of proliferation of mitogen-activated T lymphocytes: production of interleukin 2 with reduced biological activity","volume":"159","author":"Kelly","year":"1994","journal-title":"Cell Immunol"},{"key":"2023101015000392900_CIT0066","first-page":"2496s","article-title":"Suppression of lymphocyte activation by plasma lipoproteins","volume":"43","author":"Macy","year":"1983","journal-title":"Cancer Res"},{"key":"2023101015000392900_CIT0067","doi-asserted-by":"crossref","first-page":"870","DOI":"10.2174\/1567205014666170317113606","article-title":"Impact of cytokines and chemokines on Alzheimer\u2019s disease neuropathological hallmarks","volume":"14","author":"Domingues","year":"2017","journal-title":"Curr Alzheimer Res"},{"key":"2023101015000392900_CIT0068","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40035-016-0054-4","article-title":"The dual roles of cytokines in Alzheimer\u2019s disease: update on interleukins, TNF-alpha, TGF-beta and IFN-gamma","volume":"5","author":"Zheng","year":"2016","journal-title":"Transl Neurodegener"},{"key":"2023101015000392900_CIT0069","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/s41593-023-01257-z","article-title":"Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer\u2019s disease","volume":"26","author":"De Schepper","year":"2023","journal-title":"Nat Neurosci"},{"key":"2023101015000392900_CIT0070","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/ni1415","article-title":"Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells","volume":"8","author":"Hur","year":"2007","journal-title":"Nat Immunol"},{"key":"2023101015000392900_CIT0071","doi-asserted-by":"crossref","first-page":"949340","DOI":"10.3389\/fncel.2022.949340","article-title":"Type-I interferons in Alzheimer\u2019s disease and other tauopathies","volume":"16","author":"Sanford","year":"2022","journal-title":"Front Cell Neurosci"},{"key":"2023101015000392900_CIT0072","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nri3787","article-title":"Type I interferons in infectious disease","volume":"15","author":"McNab","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"2023101015000392900_CIT0073","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.neurobiolaging.2013.10.089","article-title":"Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer\u2019s disease","volume":"35","author":"Taylor","year":"2014","journal-title":"Neurobiol Aging"},{"key":"2023101015000392900_CIT0074","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1172\/JCI133737","article-title":"Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease","volume":"130","author":"Roy","year":"2020","journal-title":"J Clin Invest"},{"key":"2023101015000392900_CIT0075","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.immuni.2022.03.018","article-title":"Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid beta plaques","volume":"55","author":"Roy","year":"2022","journal-title":"Immunity"},{"key":"2023101015000392900_CIT0076","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1038\/s41598-020-59917-0","article-title":"Abrogation of type-I interferon signalling alters the microglial response to Abeta(1-42)","volume":"10","author":"Moore","year":"2020","journal-title":"Sci Rep"},{"key":"2023101015000392900_CIT0077","doi-asserted-by":"crossref","first-page":"108398","DOI":"10.1016\/j.celrep.2020.108398","article-title":"Tau pathology drives dementia risk-associated gene networks toward chronic inflammatory states and immunosuppression","volume":"33","author":"Rexach","year":"2020","journal-title":"Cell Rep"},{"key":"2023101015000392900_CIT0078","doi-asserted-by":"crossref","first-page":"fcz022","DOI":"10.1093\/braincomms\/fcz022","article-title":"Genetic variability in response to amyloid beta deposition influences Alzheimer\u2019s disease risk","volume":"1","author":"Salih","year":"2019","journal-title":"Brain Commun"},{"key":"2023101015000392900_CIT0079","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/s41586-020-2681-2","article-title":"The innate immunity protein IFITM3 modulates gamma-secretase in Alzheimer\u2019s disease","volume":"586","author":"Hur","year":"2020","journal-title":"Nature"},{"key":"2023101015000392900_CIT0080","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41593-023-01315-6","article-title":"Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience","volume":"26","author":"Udeochu","year":"2023","journal-title":"Nat Neurosci"},{"key":"2023101015000392900_CIT0081","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.neuron.2023.04.006","article-title":"Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration","volume":"111","author":"Festa","year":"2023","journal-title":"Neuron"},{"key":"2023101015000392900_CIT0082","doi-asserted-by":"crossref","first-page":"e167417","DOI":"10.1172\/JCI167417","article-title":"Brain microglia serve as a persistent HIV reservoir despite durable antiretroviral therapy","volume":"133","author":"Tang","year":"2023","journal-title":"J Clin Invest"},{"key":"2023101015000392900_CIT0083","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.neuron.2022.12.029","article-title":"Virus exposure and neurodegenerative disease risk across national biobanks","volume":"111","author":"Levine","year":"2023","journal-title":"Neuron"},{"key":"2023101015000392900_CIT0084","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3390\/vaccines9060679","article-title":"Overwhelming evidence for a major role for herpes simplex virus type 1 (HSV1) in Alzheimer\u2019s disease (AD): underwhelming evidence against","volume":"9","author":"Itzhaki","year":"2021","journal-title":"Vaccines (Basel)"},{"key":"2023101015000392900_CIT0085","doi-asserted-by":"crossref","first-page":"e13473","DOI":"10.1111\/apha.13473","article-title":"Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID-19","volume":"229","author":"Steardo","year":"2020","journal-title":"Acta Physiol (Oxf)"},{"key":"2023101015000392900_CIT0086","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.tins.2006.06.002","article-title":"Viral infections in the developing and mature brain","volume":"29","author":"van den Pol","year":"2006","journal-title":"Trends Neurosci"},{"key":"2023101015000392900_CIT0087","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neuron.2018.05.023","article-title":"Multiscale analysis of independent Alzheimer\u2019s cohorts finds disruption of molecular, genetic, and clinical networks by human herpesvirus","volume":"99","author":"Readhead","year":"2018","journal-title":"Neuron"},{"key":"2023101015000392900_CIT0088","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2990.1982.tb00273.x","article-title":"Neuronal and lymphocytic populations in human trigeminal ganglia: implications for ageing and for latent virus","volume":"8","author":"Ball","year":"1982","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2023101015000392900_CIT0089","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/path.2449","article-title":"Herpes simplex virus type 1 DNA is located within Alzheimer\u2019s disease amyloid plaques","volume":"217","author":"Wozniak","year":"2009","journal-title":"J Pathol"},{"key":"2023101015000392900_CIT0090","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/path.1711670403","article-title":"Herpes simplex virus type 1 DNA is present in specific regions of brain from aged people with and without senile dementia of the Alzheimer type","volume":"167","author":"Jamieson","year":"1992","journal-title":"J Pathol"},{"key":"2023101015000392900_CIT0091","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3233\/JAD-2009-0963","article-title":"Alzheimer\u2019s disease-specific tau phosphorylation is induced by herpes simplex virus type 1","volume":"16","author":"Wozniak","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"2023101015000392900_CIT0092","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3233\/JAD-2008-14301","article-title":"Neuronal cytoskeletal dynamic modification and neurodegeneration induced by infection with herpes simplex virus type 1","volume":"14","author":"Zambrano","year":"2008","journal-title":"J Alzheimers Dis"},{"key":"2023101015000392900_CIT0093","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jalz.2014.04.522","article-title":"Reactivated herpes simplex infection increases the risk of Alzheimer\u2019s disease","volume":"11","author":"Lovheim","year":"2015","journal-title":"Alzheimers Dement"},{"key":"2023101015000392900_CIT0094","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3233\/JAD-220287","article-title":"Potential involvement of varicella zoster virus in Alzheimer\u2019s disease via reactivation of quiescent herpes simplex virus type 1","volume":"88","author":"Cairns","year":"2022","journal-title":"J Alzheimers Dis"},{"key":"2023101015000392900_CIT0095","doi-asserted-by":"crossref","first-page":"e12119","DOI":"10.1002\/trc2.12119","article-title":"Herpesvirus infections, antiviral treatment, and the risk of dementia-a registry-based cohort study in Sweden","volume":"7","author":"Lopatko Lindman","year":"2021","journal-title":"Alzheimers Dement (N Y)"},{"key":"2023101015000392900_CIT0096","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/infdis\/jiu437","article-title":"Cytomegalovirus infection and risk of Alzheimer disease in older black and white individuals","volume":"211","author":"Barnes","year":"2015","journal-title":"J Infect Dis"},{"key":"2023101015000392900_CIT0097","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/infdis\/jit210","article-title":"Virological and immunological characteristics of human cytomegalovirus infection associated with Alzheimer disease","volume":"208","author":"Lurain","year":"2013","journal-title":"J Infect Dis"},{"key":"2023101015000392900_CIT0098","doi-asserted-by":"crossref","first-page":"e96779","DOI":"10.1371\/journal.pone.0096779","article-title":"Increased inflammatory response in cytomegalovirus seropositive patients with Alzheimer\u2019s disease","volume":"9","author":"Westman","year":"2014","journal-title":"PLoS One"},{"key":"2023101015000392900_CIT0099","doi-asserted-by":"crossref","first-page":"939","DOI":"10.3233\/JAD-161305","article-title":"Interaction between cytomegalovirus and herpes simplex virus type 1 associated with the risk of Alzheimer\u2019s disease development","volume":"61","author":"Lovheim","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"2023101015000392900_CIT0100","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fimmu.2019.00078","article-title":"Cytokine-mediated induction and regulation of tissue damage during cytomegalovirus infection","volume":"10","author":"Clement","year":"2019","journal-title":"Front Immunol"},{"key":"2023101015000392900_CIT0101","first-page":"2022.09.15.508120","article-title":"SARS-CoV-2 and HSV-1 induce amyloid aggregation in human CSF","author":"Christ","year":"2022","journal-title":"bioRxiv"},{"key":"2023101015000392900_CIT0102","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1021\/acschemneuro.1c00584","article-title":"Indication of neurodegenerative cascade initiation by amyloid-like aggregate-forming EBV proteins and peptide in Alzheimer\u2019s disease","volume":"12","author":"Tiwari","year":"2021","journal-title":"ACS Chem Neurosci"},{"key":"2023101015000392900_CIT0103","doi-asserted-by":"crossref","first-page":"816098","DOI":"10.3389\/fmolb.2021.816098","article-title":"Epstein-Barr virus and neurological diseases","volume":"8","author":"Zhang","year":"2021","journal-title":"Front Mol Biosci"},{"key":"2023101015000392900_CIT0104","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.abj8222","article-title":"Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis","volume":"375","author":"Bjornevik","year":"2022","journal-title":"Science"},{"key":"2023101015000392900_CIT0105","doi-asserted-by":"crossref","first-page":"100046","DOI":"10.1016\/j.crneur.2022.100046","article-title":"Unraveling the links between neurodegeneration and Epstein-Barr virus-mediated cell cycle dysregulation","volume":"3","author":"Tiwari","year":"2022","journal-title":"Curr Res Neurobiol"},{"key":"2023101015000392900_CIT0106","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neurobiolaging.2013.06.024","article-title":"Herpes virus in Alzheimer\u2019s disease: relation to progression of the disease","volume":"35","author":"Carbone","year":"2014","journal-title":"Neurobiol Aging"},{"key":"2023101015000392900_CIT0107","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s13365-020-00868-7","article-title":"Coronaviruses and the central nervous system","volume":"26","author":"Morgello","year":"2020","journal-title":"J Neurovirol"},{"key":"2023101015000392900_CIT0108","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1056\/NEJMcibr2210069","article-title":"Cognitive deficits in long covid-19","volume":"387","author":"Venkataramani","year":"2022","journal-title":"N Engl J Med"},{"key":"2023101015000392900_CIT0109","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1016\/j.cell.2022.06.008","article-title":"Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation","volume":"185","author":"Fernandez-Castaneda","year":"2022","journal-title":"Cell"},{"key":"2023101015000392900_CIT0110","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3233\/JAD-220717","article-title":"Association of COVID-19 with new-onset Alzheimer\u2019s disease","volume":"89","author":"Wang","year":"2022","journal-title":"J Alzheimers Dis"},{"key":"2023101015000392900_CIT0111","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1093\/gerona\/glaa131","article-title":"APOE e4 genotype predicts severe COVID-19 in the UK Biobank Community Cohort","volume":"75","author":"Kuo","year":"2020","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2023101015000392900_CIT0112","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.stem.2020.12.018","article-title":"ApoE-isoform-dependent SARS-CoV-2 neurotropism and cellular response","volume":"28","author":"Wang","year":"2021","journal-title":"Cell Stem Cell"},{"key":"2023101015000392900_CIT0113","doi-asserted-by":"crossref","first-page":"8226","DOI":"10.3390\/ijms22158226","article-title":"The effects of abeta(1-42) binding to the SARS-CoV-2 spike protein S1 subunit and angiotensin-converting enzyme 2","volume":"22","author":"Hsu","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2023101015000392900_CIT0114","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.3390\/ijerph20032146","article-title":"Links between COVID-19 and Alzheimer\u2019s disease-what do we already know","volume":"20","author":"Rudnicka-Drozak","year":"2023","journal-title":"Int J Environ Res Public Health"},{"key":"2023101015000392900_CIT0115","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.3390\/ijms22041687","article-title":"Protein expression of angiotensin-converting enzyme 2 (ACE2) is upregulated in brains with Alzheimer\u2019s disease","volume":"22","author":"Ding","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2023101015000392900_CIT0116","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1016\/j.ajpath.2013.01.053","article-title":"Abeta43 is the earliest-depositing Abeta species in APP transgenic mouse brain and is converted to Abeta41 by two active domains of ACE","volume":"182","author":"Zou","year":"2013","journal-title":"Am J Pathol"},{"key":"2023101015000392900_CIT0117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-190848","article-title":"Is Alzheimer\u2019s disease a liver disease of the brain","volume":"75","author":"Bassendine","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"2023101015000392900_CIT0118","doi-asserted-by":"crossref","first-page":"e0179312","DOI":"10.1371\/journal.pone.0179312","article-title":"Association of Alzhemier\u2019s disease with hepatitis C among patients with bipolar disorder","volume":"12","author":"Lin","year":"2017","journal-title":"PLoS One"},{"key":"2023101015000392900_CIT0119","doi-asserted-by":"crossref","first-page":"e197978","DOI":"10.1001\/jamanetworkopen.2019.7978","article-title":"Association of altered liver enzymes with Alzheimer disease diagnosis, cognition, neuroimaging measures, and cerebrospinal fluid biomarkers","volume":"2","author":"Nho","year":"2019","journal-title":"JAMA Netw Open"},{"key":"2023101015000392900_CIT0120","doi-asserted-by":"crossref","first-page":"12422","DOI":"10.1128\/JVI.01660-14","article-title":"Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins","volume":"88","author":"Lee","year":"2014","journal-title":"J Virol"},{"key":"2023101015000392900_CIT0121","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nm0418-376","article-title":"A tale of two diseases: aging HIV patients inspire a closer look at Alzheimer\u2019s disease","volume":"24","author":"Chakradhar","year":"2018","journal-title":"Nat Med"},{"key":"2023101015000392900_CIT0122","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/S2666-7568(22)00067-8","article-title":"Prevalence of Alzheimer\u2019s disease and related dementias among older US Medicare beneficiaries with and without HIV: a successive cross-sectional study","volume":"3","author":"Yu","year":"2022","journal-title":"Lancet Health Longevit"},{"key":"2023101015000392900_CIT0123","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3389\/fncel.2018.00307","article-title":"HIV neuroinfection and Alzheimer\u2019s disease: similarities and potential links","volume":"12","author":"Canet","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"2023101015000392900_CIT0124","doi-asserted-by":"crossref","first-page":"e77972","DOI":"10.1371\/journal.pone.0077972","article-title":"HIV-1 tat interacts with and regulates the localization and processing of amyloid precursor protein","volume":"8","author":"Kim","year":"2013","journal-title":"PLoS One"},{"key":"2023101015000392900_CIT0125","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1038\/s41467-017-01795-8","article-title":"HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration","volume":"8","author":"Chai","year":"2017","journal-title":"Nat Commun"},{"key":"2023101015000392900_CIT0126","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1212\/WNL.0b013e3181c5b445","article-title":"CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease","volume":"73","author":"Clifford","year":"2009","journal-title":"Neurology"},{"key":"2023101015000392900_CIT0127","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1756-6606-4-23","article-title":"Antiretroviral medications disrupt microglial phagocytosis of beta-amyloid and increase its production by neurons: implications for HIV-associated neurocognitive disorders","volume":"4","author":"Giunta","year":"2011","journal-title":"Mol Brain"},{"key":"2023101015000392900_CIT0128","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/01.aids.0000161770.06158.5c","article-title":"Brain deposition of beta-amyloid is a common pathologic feature in HIV positive patients","volume":"19","author":"Green","year":"2005","journal-title":"AIDS"},{"key":"2023101015000392900_CIT0129","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s11481-009-9152-8","article-title":"Increased accumulation of intraneuronal amyloid beta in HIV-infected patients","volume":"4","author":"Achim","year":"2009","journal-title":"J Neuroimmune Pharmacol"},{"key":"2023101015000392900_CIT0130","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1002\/hbm.23326","article-title":"Extracting patterns of morphometry distinguishing HIV associated neurodegeneration from mild cognitive impairment via group cardinality constrained classification","volume":"37","author":"Zhang","year":"2016","journal-title":"Hum Brain Mapp"},{"key":"2023101015000392900_CIT0131","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1086\/649899","article-title":"HIV infection and aging independently affect brain function as measured by functional magnetic resonance imaging","volume":"201","author":"Ances","year":"2010","journal-title":"J Infect Dis"},{"key":"2023101015000392900_CIT0132","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/jgs.17606","article-title":"Comparison of rates of dementia among older adult recipients of two, one, or no vaccinations","volume":"70","author":"Wiemken","year":"2022","journal-title":"J Am Geriatr Soc"},{"key":"2023101015000392900_CIT0133","article-title":"Causal evidence that herpes zoster vaccination prevents a proportion of dementia cases","author":"Eyting","year":"2023","journal-title":"medRxiv"},{"key":"2023101015000392900_CIT0134","doi-asserted-by":"crossref","first-page":"eaau3333","DOI":"10.1126\/sciadv.aau3333","article-title":"Porphyromonas gingivalis in Alzheimer\u2019s disease brains: evidence for disease causation and treatment with small-molecule inhibitors","volume":"5","author":"Dominy","year":"2019","journal-title":"Sci Adv"},{"key":"2023101015000392900_CIT0135","doi-asserted-by":"crossref","first-page":"105292","DOI":"10.1016\/j.nbd.2021.105292","article-title":"Bacterial sepsis increases hippocampal fibrillar amyloid plaque load and neuroinflammation in a mouse model of Alzheimer\u2019s disease","volume":"152","author":"Basak","year":"2021","journal-title":"Neurobiol Dis"},{"key":"2023101015000392900_CIT0136","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.1038\/s41598-019-42286-8","article-title":"Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice","volume":"9","author":"Zhao","year":"2019","journal-title":"Sci Rep"},{"key":"2023101015000392900_CIT0137","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1574-695X.2006.00154.x","article-title":"Chlamydophila (Chlamydia) pneumoniae in the Alzheimer\u2019s brain","volume":"48","author":"Gerard","year":"2006","journal-title":"FEMS Immunol Med Microbiol"},{"key":"2023101015000392900_CIT0138","doi-asserted-by":"crossref","first-page":"73","DOI":"10.31083\/j.jin2102073","article-title":"Infectious agents and Alzheimer\u2019s disease","volume":"21","author":"Piekut","year":"2022","journal-title":"J Integr Neurosci"},{"key":"2023101015000392900_CIT0139","doi-asserted-by":"crossref","first-page":"691136","DOI":"10.3389\/fncel.2021.691136","article-title":"Microbial infections are a risk factor for neurodegenerative diseases","volume":"15","author":"Lotz","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"2023101015000392900_CIT0140","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.jalz.2018.06.3040","article-title":"The antimicrobial protection hypothesis of Alzheimer\u2019s disease","volume":"14","author":"Moir","year":"2018","journal-title":"Alzheimers Dement"},{"key":"2023101015000392900_CIT0141","doi-asserted-by":"crossref","first-page":"e9505","DOI":"10.1371\/journal.pone.0009505","article-title":"The Alzheimer\u2019s disease-associated amyloid beta-protein is an antimicrobial peptide","volume":"5","author":"Soscia","year":"2010","journal-title":"PLoS One"},{"key":"2023101015000392900_CIT0142","doi-asserted-by":"crossref","first-page":"340ra72","DOI":"10.1126\/scitranslmed.aaf1059","article-title":"Amyloid-beta peptide protects against microbial infection in mouse and worm models of Alzheimer\u2019s disease","volume":"8","author":"Kumar","year":"2016","journal-title":"Sci Transl Med"},{"key":"2023101015000392900_CIT0143","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.neuron.2018.11.043","article-title":"Alzheimer\u2019s disease-associated beta-amyloid is rapidly seeded by herpesviridae to protect against brain infection","volume":"100","author":"Eimer","year":"2018","journal-title":"Neuron"},{"key":"2023101015000392900_CIT0144","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40035-022-00292-3","article-title":"Immunotherapy for Alzheimer\u2019s disease: targeting beta-amyloid and beyond","volume":"11","author":"Song","year":"2022","journal-title":"Transl Neurodegener"},{"key":"2023101015000392900_CIT0145","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1212\/01.WNL.0000159740.16984.3C","article-title":"Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial","volume":"64","author":"Gilman","year":"2005","journal-title":"Neurology"},{"key":"2023101015000392900_CIT0146","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13024-018-0299-8","article-title":"Advances in developing novel therapeutic strategies for Alzheimer\u2019s disease","volume":"13","author":"Cao","year":"2018","journal-title":"Mol Neurodegener"},{"key":"2023101015000392900_CIT0147","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11910-021-01125-y","article-title":"Critical appraisal of amyloid lowering agents in AD","volume":"21","author":"Decourt","year":"2021","journal-title":"Curr Neurol Neurosci Rep"},{"key":"2023101015000392900_CIT0148","volume-title":"Genentech\u2019s Anti-Amyloid Beta Antibody Gantenerumab Granted FDA Breakthrough Therapy Designation in Alzheimer\u2019s Disease","author":"Genentech","year":"2021"},{"key":"2023101015000392900_CIT0149","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in early Alzheimer\u2019s disease","volume":"388","author":"van Dyck","year":"2023","journal-title":"N Engl J Med"},{"key":"2023101015000392900_CIT0150","volume-title":"Gantenerumab Mystery: How Did It Lose Potency in Phase 3?","author":"ALZFORUM","year":"2022"},{"key":"2023101015000392900_CIT0151","volume-title":"Lilly\u2019s Donanemab Significantly Slowed Cognitive and Functional Decline in Phase 3 Study of Early Alzheimer\u2019s Disease","author":"Lilly","year":"2023"},{"key":"2023101015000392900_CIT0152","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s13195-022-01110-8","article-title":"Gantenerumab: an anti-amyloid monoclonal antibody with potential disease-modifying effects in early Alzheimer\u2019s disease","volume":"14","author":"Bateman","year":"2022","journal-title":"Alzheimers Res Ther"},{"key":"2023101015000392900_CIT0153","volume-title":"Administration, FDA Grants Accelerated Approval for Alzheimer\u2019s Drug","author":"U.S. Food and Drug","year":"2021"},{"key":"2023101015000392900_CIT0154","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/S0140-6736(22)02480-1","article-title":"Lecanemab for Alzheimer\u2019s disease: tempering hype and hope","volume":"400","author":"Lancet","year":"2022","journal-title":"Lancet"},{"key":"2023101015000392900_CIT0155","doi-asserted-by":"crossref","first-page":"p1580","DOI":"10.1136\/bmj.p1580","article-title":"Alzheimer\u2019s disease: Lecanemab gets full FDA approval and black box safety warning","volume":"382","author":"Mahase","year":"2023","journal-title":"BMJ"},{"key":"2023101015000392900_CIT0156","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s40478-022-01447-z","article-title":"Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer\u2019s disease","volume":"10","author":"Faridar","year":"2022","journal-title":"Acta Neuropathol Commun"},{"key":"2023101015000392900_CIT0157","doi-asserted-by":"crossref","first-page":"7668","DOI":"10.7150\/thno.75965","article-title":"Adoptive therapy with amyloid-beta specific regulatory T cells alleviates Alzheimer\u2019s disease","volume":"12","author":"Yang","year":"2022","journal-title":"Theranostics"},{"key":"2023101015000392900_CIT0158","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/cei\/uxac084","article-title":"The potential for treg-enhancing therapies in nervous system pathologies","volume":"211","author":"Olson","year":"2023","journal-title":"Clin Exp Immunol"},{"key":"2023101015000392900_CIT0159","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1093\/brain\/awz053","article-title":"Neurological toxicities associated with chimeric antigen receptor T-cell therapy","volume":"142","author":"Rubin","year":"2019","journal-title":"Brain"},{"key":"2023101015000392900_CIT0160","doi-asserted-by":"crossref","first-page":"641809","DOI":"10.3389\/fnins.2020.641809","article-title":"Corrigendum: T cell responses to neural autoantigens are similar in Alzheimer\u2019s disease patients and age-matched healthy controls","volume":"14","author":"Dhanwani","year":"2020","journal-title":"Front Neurosci"},{"key":"2023101015000392900_CIT0161","doi-asserted-by":"crossref","first-page":"e060159","DOI":"10.1002\/alz.060159","article-title":"Protective association of HLA-DRB1*04 subtypes in neurodegenerative diseases implicates acetylated tau PHF6 sequences","volume":"18","author":"Guen","year":"2022","journal-title":"Alzheimers Dement"}],"container-title":["Discovery Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/discovimmunology\/advance-article-pdf\/doi\/10.1093\/discim\/kyad015\/51764682\/kyad015.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/discovimmunology\/article-pdf\/2\/1\/kyad015\/51990476\/kyad015.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/discovimmunology\/article-pdf\/2\/1\/kyad015\/51990476\/kyad015.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T12:40:02Z","timestamp":1730032802000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/discovimmunology\/article\/doi\/10.1093\/discim\/kyad015\/7282398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":161,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/discim\/kyad015","relation":{},"ISSN":["2754-2483"],"issn-type":[{"value":"2754-2483","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2023,1,1]]},"article-number":"kyad015"}}