{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:36:50Z","timestamp":1772138210152,"version":"3.50.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"vor","delay-in-days":267,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wellcome Seed","award":["213697\/Z\/18\/Z"],"award-info":[{"award-number":["213697\/Z\/18\/Z"]}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/V031767\/1"],"award-info":[{"award-number":["MR\/V031767\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UK New Investigator Research","award":["MR\/V031767\/1"],"award-info":[{"award-number":["MR\/V031767\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Systemic lupus erythematosus (SLE) is an autoimmune disease predominated by auto-antibodies that recognise cellular components. Pleural involvement is the most common SLE-related lung disease. Natural antibodies are rapidly secreted by innate-like B cells following perturbation of homeostasis and are important in the early stages of immune activation. The serous cavities are home to large numbers of innate-like B cells present both within serous fluid and resident within fat-associated lymphoid clusters (FALCs). FALCs are important hubs for B-cell activation and local antibody secretion within the body cavities. Patients with SLE can develop anti-phospholipid antibodies and in rare situations develop alveolar haemorrhage. Utilising delivery of the hydrocarbon oil pristane in C57BL\/6 mice as a model of SLE we identify a rapid expansion of pleural cavity B cells as early as day 3 after intra-peritoneal pristane delivery. Following pristane delivery, pericardial B1 B cells are proliferative, express the plasma-cell surface marker CD138, and secrete both innate and class-switched antibodies highlighting that this cavity niche may play an unrecognised role in the initiation of lupus pleuritis.<\/jats:p>","DOI":"10.1093\/discim\/kyad017","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T12:21:23Z","timestamp":1695644483000},"source":"Crossref","is-referenced-by-count":3,"title":["Pericardial and mediastinal fat-associated lymphoid clusters are rapidly activated in an alkane-induced model of systemic lupus erythematosus"],"prefix":"10.1093","volume":"2","author":[{"given":"Karolina","family":"Bentkowska","sequence":"first","affiliation":[{"name":"Division of Biomedical and Life Science, Lancaster University , Lancaster , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Hardgrave","sequence":"additional","affiliation":[{"name":"Division of Biomedical and Life Science, Lancaster University , Lancaster , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Division of Biomedical and Life Science, Lancaster University , Lancaster , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gresty","sequence":"additional","affiliation":[{"name":"Division of Biomedical and Life Science, Lancaster University , Lancaster , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethany","family":"Marsden","sequence":"additional","affiliation":[{"name":"Division of Biomedical and Life Science, Lancaster University , Lancaster , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Macharia","sequence":"additional","affiliation":[{"name":"Division of Biomedical and Life Science, Lancaster University , Lancaster , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0608-8966","authenticated-orcid":false,"given":"Lucy","family":"Jackson-Jones","sequence":"additional","affiliation":[{"name":"Division of Biomedical and Life Science, Lancaster University , Lancaster , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"key":"2023102510322884600_CIT0001","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.berh.2009.01.002","article-title":"Respiratory manifestations of systemic lupus erythematosus: old and new concepts","volume":"23","author":"Pego-Reigosa","year":"2009","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2023102510322884600_CIT0002","doi-asserted-by":"crossref","first-page":"75","DOI":"10.5152\/eurjrheum.2015.0085","article-title":"The clinical significance of antiphospholipid antibodies in systemic lupus erythematosus","volume":"3","author":"Unlu","year":"2016","journal-title":"Eur J Rheumatol"},{"key":"2023102510322884600_CIT0003","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1378\/chest.84.6.714","article-title":"Lupus pleuritis. 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