{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T11:23:29Z","timestamp":1778066609919,"version":"3.51.4"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:00:00Z","timestamp":1758326400000},"content-version":"vor","delay-in-days":262,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"BBSRC PhD scholarship","award":["BB\/H016163\/1"],"award-info":[{"award-number":["BB\/H016163\/1"]}]},{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["19430"],"award-info":[{"award-number":["19430"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Neutrophils are innate immune cells that play a central role in the inflammatory response. They produce an array of destructive molecules and anti-microbial proteases that characterize the cells as front-line defenders, crucial to host defence. It is now appreciated that neutrophils produce and respond to a variety of inflammatory signals and are able to regulate both the innate and adaptive immune responses. However, the mechanisms by which neutrophils respond to different inflammatory signals to regulate their own function and the functions of other immune cells are incompletely defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we performed RNA sequencing of healthy human neutrophils exposed for 1\u2005h to a range of pro-inflammatory cytokines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Granulocyte\/macrophage colony-stimulating factor and tumour necrosis factor alpha induced significant changes in 1651 and 693 genes, respectively (adj. P &amp;lt; 0.05) including activation of genes regulating apoptosis and encoding cytokines and chemokines that can drive the differentiation and activation of CD4 T-cells. Stimulation of neutrophils with granulocyte colony-stimulating factor, interferon alpha, interferon gamma, interleukin-1 beta, or interleukin-8 resulted in expression of discrete gene sets and differential activation of signalling pathways including changes in cell adhesion and migration, immune receptor expression, apoptosis, and production of pro-inflammatory prostaglandins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This work defines the differential gene expression patterns in neutrophils exposed to different regulatory cytokines. This is important in both increasing our understanding of the role of neutrophils in driving innate and adaptive immune responses and, importantly, for deconvoluting the neutrophil gene expression signatures observed in inflammatory diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/discim\/kyaf013","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T11:54:36Z","timestamp":1758196476000},"source":"Crossref","is-referenced-by-count":6,"title":["Cytokine-induced transcriptional changes in human neutrophils reveal immune regulatory plasticity"],"prefix":"10.1093","volume":"4","author":[{"given":"Huw B","family":"Thomas","sequence":"first","affiliation":[{"name":"Institute of Integrative Biology, University of Liverpool , Liverpool ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven W","family":"Edwards","sequence":"additional","affiliation":[{"name":"Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool , Liverpool ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0442-3134","authenticated-orcid":false,"given":"Helen L","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Life Course and Medical Sciences, University of Liverpool , Liverpool ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,20]]},"reference":[{"key":"2026010605321423700_kyaf013-B1","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1093\/rheumatology\/keq045","article-title":"Neutrophil function in inflammation and inflammatory diseases","volume":"49","author":"Wright","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"2026010605321423700_kyaf013-B2","doi-asserted-by":"crossref","first-page":"649693","DOI":"10.3389\/fimmu.2021.649693","article-title":"Neutrophils in the pathogenesis of rheumatoid 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