{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:30:35Z","timestamp":1760711435165,"version":"3.37.3"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Medication-related osteonecrosis of the jaw (MRONJ) and jaw metastasis might share similar clinical and radiographic characteristics, with both demonstrating F-18 fluorodeoxyglucose (FDG) uptake on PET-CT. Prostate-specific membrane antigen (PSMA) PET-CT is used to demonstrate prostate cancer dissemination. Unlike FDG PET-CT, PSMA PET-CT is more specific to cancer than to inflammation. Therefore, we hypothesized that it might be a useful tool to differentiate between MRONJ and jaw metastasis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All files of prostate cancer patients diagnosed with MRONJ and with available PSMA PET-CT studies were retrieved. A similar number of solid cancer patients with MRONJ and with available FDG PET-CT studies served as a second study group. All studies were reviewed by 2 blinded co-investigators (L.D. and M.F.).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Seventeen patients who underwent PSMA PET-CT (24 studies) and 15 patients who underwent FDG PET-CT (29 studies) met the inclusion criteria. All patients with FDG PET-CT studies showed pathological uptake at the site of MRONJ in at least one of their studies versus only 23.5% of patients in the PSMA PET-CT group (P\u2009&amp;lt;\u2009.001). FDG PET-CT studies showed pathological uptake in 89.6% of the studies compared with only 20.8% in the PSMA PET-CT group (P\u2009&amp;lt;\u2009.001). The mean standardized uptake value (SUVmax) and the mean uptake volume in the FDG PET-CT group were significantly higher compared with the PSMA PET-CT group (P\u2009&amp;lt;\u2009.001 and P\u2009&amp;lt;\u2009.005, respectively). The interclass correlation coefficient for all parameters was higher than 0.95.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>PSMA PET-CT is useful to differentiate between MRONJ and jaw metastasis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/dmfr\/twae034","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T21:00:55Z","timestamp":1722546055000},"page":"497-500","source":"Crossref","is-referenced-by-count":1,"title":["The diagnostic value of prostate-specific membrane antigen PET-CT in differentiating medication-related osteonecrosis of the jaw and metastasis to the jawbone"],"prefix":"10.1093","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5195-382X","authenticated-orcid":false,"given":"Karin","family":"Kur","sequence":"first","affiliation":[{"name":"Oral Medicine Unit, Sheba Medical Center, Tel-Hashomer 5265601 ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erofili","family":"Papadopoulou","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of Athens, Athens 11527 ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meital","family":"Nidam","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Institute, Sheba Medical Center, Tel-Hashomer 5265601 ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Fertouk","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Institute, Sheba Medical Center, Tel-Hashomer 5265601 ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Binyamini","sequence":"additional","affiliation":[{"name":"The Maurice and Gabriela Goldschleger School of Dental Medicine, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv 6997801 ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvina","family":"Friedlander Barenboim","sequence":"additional","affiliation":[{"name":"Oral Medicine Unit, Sheba Medical Center, Tel-Hashomer 5265601 ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Towy Sorel","family":"Lazarovitci","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Sheba Medical Center, Tel-Hashomer 5265601 ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liran","family":"Domachevsky","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Institute, Sheba Medical Center, Tel-Hashomer 5265601 ,","place":["Israel"]},{"name":"Faculty of Health and Medical Sciences, Tel Aviv University , Tel Aviv 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