{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:23:55Z","timestamp":1783419835533,"version":"3.54.6"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study was undertaken to generate high-quality radiographic annotations of initial proximal carious lesions based on micro-CT scans. Specifically, we projected manually and automatically acquired annotations of micro-CT scans onto corresponding traditional dental radiographs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We utilized the Diagnostic Insights for Radiographic Early-caries with micro-CT (ACTA-DIRECT) dataset of manually annotated initial proximal carious lesions in micro-CT scans and radiographs, the former serving as reference-standard. Production of high-quality radiographic annotations entailed the following: (1) acquiring a reference-standard (for a semi-automated approach) or generating a fully automated micro-CT-based annotation (for a fully automated approach); (2) simulating the corresponding radiograph by projecting the micro-CT scan to find the suitable projection parameters; and (3) superimposing micro-CT-based caries annotations onto radiographs, using identical projection parameters. To evaluate the subsequent accuracy of the annotations on radiograph, we assessed the sensitivity, specificity, and International Caries Classification and Management System (ICCMS) staging of micro-CT-based automated annotations. Projection accuracy was qualitatively gauged.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Micro-CT-based automated annotations outperformed conventional annotations achieving a sensitivity of 50% (95% CI: 42%-59%) compared to 42% (95% CI: 34%-51%) and specificity of 99% (95% CI: 96%-100%) compared to 92% (95% CI: 87%-94%). Among correctly identified micro-CT-based automated annotations, 94% (61\/65) were also accurately classified; and 80% of micro-CT projections were ranked as suitably similar to corresponding radiographs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Micro-CT imaging offers resource-rich depictions, enabling more accurate annotations than those achievable through conventional means. By projecting micro-CT-based annotations of initial proximal caries onto radiographs, some limitations of the conventional radiograph annotation process may be overcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/dmfr\/twae058","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T04:52:56Z","timestamp":1738644776000},"page":"320-328","source":"Crossref","is-referenced-by-count":2,"title":["Microtomography to traditional dental radiograph: projecting 3-dimensional initial proximal caries lesion annotations for enhanced radiographic delineation"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6727-2516","authenticated-orcid":false,"given":"Ricardo E","family":"Gonzalez-Valenzuela","sequence":"first","affiliation":[{"name":"Department of Oral Radiology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU Amsterdam , Amsterdam 1182 DB,","place":["The Netherlands"]},{"name":"Department of Biomedical Engineering and Physics, Academic Medical Center University of Amsterdam (AMC) , Amsterdam 1105 AZ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8550-6638","authenticated-orcid":false,"given":"Quoc T D","family":"Vu","sequence":"additional","affiliation":[{"name":"Department of Oral Radiology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU Amsterdam , Amsterdam 1182 DB,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9275-5942","authenticated-orcid":false,"given":"Pascal","family":"Mettes","sequence":"additional","affiliation":[{"name":"VISlab, Informatics Institute, University of Amsterdam (UvA) , Amsterdam 1098 XH,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8794-552X","authenticated-orcid":false,"given":"Bruno G","family":"Loos","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU Amsterdam , Amsterdam 1182 DB,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1414-6313","authenticated-orcid":false,"given":"Henk","family":"Marquering","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Physics, Academic Medical Center University of Amsterdam (AMC) , Amsterdam 1105 AZ,","place":["The Netherlands"]},{"name":"Department of Radiology and Nuclear Medicine, Academic Medical Center University of Amsterdam (AMC) , Amsterdam 1105 AZ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0718-6763","authenticated-orcid":false,"given":"Erwin","family":"Berkhout","sequence":"additional","affiliation":[{"name":"Department of Oral Radiology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU Amsterdam , Amsterdam 1182 DB,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"2025042903513067200_twae058-B1","first-page":"661","article-title":"Policy and practice. 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