{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T21:01:31Z","timestamp":1786914091768,"version":"build-2736575974"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Surgery is the standard treatment for medication-related osteonecrosis of the jaw (MRONJ). However, there are few reports on the appropriate extent of the bone resection. This pilot study explores the feasibility of a new method for estimating the extent of resection using bone single-photon emission CT (SPECT)-standardized uptake value (SUV).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively analysed 8 MRONJ patients who underwent curettage (n\u2009=\u20092), curettage with removal of the separated sequestrum (n\u2009=\u20092), or marginal resection (n\u2009=\u20094) as part of extensive surgery. The resected regions were compared with the regions estimated using SPECT-SUV. The agreement between the SPECT cold region and the resected region was evaluated using the Dice coefficient (defined as the ratio of 2\u00d7 overlap volume to resected volume plus SPECT cold region volume), overlap ratio, and volume ratio. The inclusion of CT findings (osteolytic, gap- and irregular-type periosteal reactions, and mixed-type osteosclerosis) in the estimated region was also evaluated. Additionally, histopathological findings from 3 marginal resection cases were used to validate the estimated region.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In all cases, the resected region included the cold regions observed on bone SPECT, with radiotracer accumulation confirmed around the resected region. CT-osteolytic regions were included within the estimated region. The Dice coefficient was 0.53\u2009\u00b1\u20090.10, the overlap ratio was 86.7\u2009\u00b1\u20097.2%, and the volume ratio was 235.0\u2009\u00b1\u200974.7%. Histopathological analysis revealed significant osteocyte necrosis in cold regions, whereas areas with an SUV of 9 displayed normal osteocytes, newly formed bone, and mild inflammatory cell infiltration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study suggests that the setting of the SPECT cold region using bone SPECT-SUV may allow for the estimation of the extent of resection in early-to-intermediate-stage MRONJ.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/dmfr\/twaf032","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T14:43:06Z","timestamp":1744728186000},"page":"495-501","source":"Crossref","is-referenced-by-count":2,"title":["Pilot study of a novel resection extent determination method using bone single-photon emission CT\u2014standardized uptake value in medication-related osteonecrosis of the jaw"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1217-047X","authenticated-orcid":false,"given":"Naoya","family":"Hayashi","sequence":"first","affiliation":[{"name":"Division of Radiology, Department of Medical Technology, Kochi Medical School Hospital , Kochi 783-8505,","place":["Japan"]},{"name":"Department of Medical Radiological Technology, Faculty of Health Sciences, Kyorin University , Tokyo 181-8612,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norikazu","family":"Matsutomo","sequence":"additional","affiliation":[{"name":"Department of Medical Radiological Technology, Faculty of Health Sciences, Kyorin University , Tokyo 181-8612,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryotaro","family":"Tokorodani","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Medical Technology, Kochi Medical School Hospital , Kochi 783-8505,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuha","family":"Fukami","sequence":"additional","affiliation":[{"name":"Department of Medical Radiological Technology, Faculty of Health Sciences, Kyorin University , Tokyo 181-8612,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Nishimori","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University , Kochi 783-8505,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kie","family":"Nakatani","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University , Kochi 783-8505,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University , Kochi 783-8505,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Equipment of Support Planning Office, Kochi University , Nankoku 783-8505,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Kochi Medical School, Kochi University , Nankoku 783-8505,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Yamagami","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University , Kochi 783-8505,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University , Kochi 783-8505,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Medical Radiological Technology, Faculty of Health Sciences, Kyorin University , Tokyo 181-8612,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"2025082903525242600_twaf032-B1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.tripleo.2008.09.019","article-title":"Positron-emission tomography imaging in the diagnosis of bisphosphonate-related osteonecrosis of the 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