{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:17:58Z","timestamp":1787008678644,"version":"build-2736575974"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100016149","name":"Seoul National University Dental Hospital","doi-asserted-by":"publisher","award":["08-2019-0004"],"award-info":[{"award-number":["08-2019-0004"]}],"id":[{"id":"10.13039\/501100016149","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the diagnostic performance of quantitative parameters derived from twin-beam dual-energy computed tomography (TB-DECT) in distinguishing benign from malignant palatal salivary gland tumours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 45 patients with pathologically confirmed palatal salivary gland tumours (23 benign, 22 malignant), all of whom underwent contrast-enhanced TB-DECT. Quantitative and qualitative imaging features were analysed using TB-DECT images. Quantitative parameters included iodine concentration (IC), normalized IC (NIC), effective atomic number (Z), electron density (Rho), dual-energy index (DEI), and the slope of the spectral attenuation curve (\u03bbHU). Statistical analyses were performed to identify predictors of malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Tumour size did not differ significantly between groups. However, malignant tumours showed significantly higher Hounsfield units (HU) at 1-minute post-contrast (P\u2009=\u20090.050). Among DECT parameters, IC, NIC, Z, DEI, and \u03bbHU were significantly elevated in malignant tumours (P\u2009&amp;lt;\u2009.05). Univariate logistic regression showed significant associations of malignancy with IC (OR, 1.609; P\u2009=\u2009.020), DEI_N (OR, 65.605; P\u2009=\u2009.025), \u03bbHU (OR, 3.494; P\u2009=\u2009.033), and HU at 66\u2009keV (OR, 1.028; P\u2009=\u2009.009). Multivariate analysis was limited by multicollinearity and small sample size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TB-DECT-derived parameters, especially IC, DEI, and \u03bbHU, may aid in differentiating malignant from benign palatal salivary gland tumours. Virtual monochromatic images at low keV levels can enhance discrimination between malignant and benign lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/dmfr\/twaf059","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T15:47:32Z","timestamp":1755186452000},"page":"597-604","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic performance of quantitative parameters derived from twin-beam dual-energy CT for differentiating benign and malignant salivary gland tumors of the palate"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-9451","authenticated-orcid":false,"given":"Gyu-Dong","family":"Jo","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Seoul National University Dental Hospital , Seoul, 03080,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8771-0392","authenticated-orcid":false,"given":"Kyung-Hoe","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, School of Dentistry and Dental Research Institute, Seoul National University , Seoul, 03080,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5977-6634","authenticated-orcid":false,"given":"Won-Jin","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, School of Dentistry and Dental Research Institute, Seoul National University , Seoul, 03080,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3406-0645","authenticated-orcid":false,"given":"Min-Suk","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, School of Dentistry and Dental Research Institute, Seoul National University , Seoul, 03080,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7223-9262","authenticated-orcid":false,"given":"Sam-Sun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, School of Dentistry and Dental Research Institute, Seoul National University , Seoul, 03080,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0218-5304","authenticated-orcid":false,"given":"Jo-Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, School of Dentistry and Dental Research Institute, Seoul National University , Seoul, 03080,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"2025092701271040200_twaf059-B1","volume-title":"Oral and Maxillofacial Pathology","author":"Neville","year":"2022","edition":"5th ed"},{"key":"2025092701271040200_twaf059-B2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijom.2016.09.021","article-title":"Salivary gland tumours in a northern Chinese population: a 50-year retrospective study of 7190 cases","volume":"46","author":"Gao","year":"2017","journal-title":"Int J Oral Maxillofac Surg"},{"key":"2025092701271040200_twaf059-B3","doi-asserted-by":"crossref","first-page":"472.e11","DOI":"10.1016\/j.crad.2020.10.019","article-title":"A triple-classification radiomics model for the differentiation of pleomorphic adenoma, Warthin tumour, and malignant salivary gland tumours on the basis of diffusion-weighted imaging","volume":"76","author":"Shao","year":"2021","journal-title":"Clin Radiol"},{"key":"2025092701271040200_twaf059-B4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1148\/rg.2021200102","article-title":"Dual-energy CT images: pearls and pitfalls","volume":"41","author":"Parakh","year":"2021","journal-title":"Radiographics"},{"key":"2025092701271040200_twaf059-B5","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1148\/radiol.2015142631","article-title":"Dual- and multi-energy CT: principles, technical approaches, and clinical applications","volume":"276","author":"McCollough","year":"2015","journal-title":"Radiology"},{"key":"2025092701271040200_twaf059-B6","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.nic.2017.03.002","article-title":"Dual-energy computed tomography: physical principles, approaches to scanning, usage, and implementation: part 1","volume":"27","author":"Forghani","year":"2017","journal-title":"Neuroimaging Clin N Am"},{"key":"2025092701271040200_twaf059-B7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/RLI.0000000000000257","article-title":"Initial results of a single-source dual-energy computed tomography technique using a split-filter","volume":"51","author":"Euler","year":"2016","journal-title":"Invest Radiol"},{"key":"2025092701271040200_twaf059-B8","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/mp.12000","article-title":"Dual-energy CT quantitative imaging: a comparison study between twin-beam and dual-source CT scanners","volume":"44","author":"Almeida","year":"2017","journal-title":"Med Phys"},{"key":"2025092701271040200_twaf059-B9","doi-asserted-by":"crossref","first-page":"W100","DOI":"10.2214\/AJR.18.20527","article-title":"Diagnostic accuracy of dual-energy CT for evaluation of renal masses: systematic review and meta-analysis","volume":"212","author":"Salameh","year":"2019","journal-title":"AJR Am J Roentgenol"},{"key":"2025092701271040200_twaf059-B10","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.21037\/qims-21-650","article-title":"Using quantitative parameters derived from pretreatment dual-energy computed tomography to predict histopathologic features in head and neck squamous cell carcinoma","volume":"12","author":"Shen","year":"2022","journal-title":"Quant Imaging Med Surg"},{"key":"2025092701271040200_twaf059-B11","doi-asserted-by":"crossref","first-page":"588","DOI":"10.21037\/qims.2018.07.07","article-title":"Diagnostic value of single-source dual-energy spectral computed tomography in differentiating parotid gland tumors: initial results","volume":"8","author":"Li","year":"2018","journal-title":"Quant Imaging Med Surg"},{"key":"2025092701271040200_twaf059-B12","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/j.acra.2023.08.024","article-title":"Evaluation of quantitative dual-energy computed tomography parameters for differentiation of parotid gland tumors","volume":"31","author":"Wang","year":"2024","journal-title":"Acad Radiol"},{"key":"2025092701271040200_twaf059-B13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ejrad.2017.02.005","article-title":"Dual-energy CT can detect malignant lymph nodes in rectal cancer","volume":"90","author":"Al-Najami","year":"2017","journal-title":"Eur J Radiol"},{"key":"2025092701271040200_twaf059-B14","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s00330-022-09033-6","article-title":"Diagnosing cervical lymph node metastasis in oral squamous cell carcinoma based on third-generation dual-source, dual-energy computed tomography","volume":"33","author":"Luo","year":"2023","journal-title":"Eur Radiol"},{"key":"2025092701271040200_twaf059-B15","author":"Siemens Healthineers"},{"key":"2025092701271040200_twaf059-B16","doi-asserted-by":"crossref","first-page":"e38276","DOI":"10.1097\/MD.0000000000038276","article-title":"Optimizing twin-beam dual-energy CT reconstruction: quantitative consistency and stability assessment in reference to 120 kV: an observational study","volume":"103","author":"Niu","year":"2024","journal-title":"Medicine (Baltimore)"},{"key":"2025092701271040200_twaf059-B17","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3348\/jksr.2021.0193","article-title":"Comparison of true and virtual non-contrast images of liver obtained with single-source twin beam and dual-source dual-energy CT","volume":"84","author":"Lee","year":"2023","journal-title":"J Korean Soc Radiol"},{"key":"2025092701271040200_twaf059-B18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s12880-022-00924-0","article-title":"Magnetic resonance imaging of parotid gland tumors: a pictorial essay","volume":"22","author":"Kim","year":"2022","journal-title":"BMC Med Imaging"}],"container-title":["Dentomaxillofacial Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/dmfr\/advance-article-pdf\/doi\/10.1093\/dmfr\/twaf059\/64045855\/twaf059.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/dmfr\/article-pdf\/54\/7\/597\/64045855\/twaf059.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/dmfr\/article-pdf\/54\/7\/597\/64045855\/twaf059.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:27:20Z","timestamp":1758950840000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dmfr\/article\/54\/7\/597\/8234493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,14]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/dmfr\/twaf059","relation":{},"ISSN":["0250-832X","1476-542X"],"issn-type":[{"value":"0250-832X","type":"print"},{"value":"1476-542X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,8,14]]}}}