{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T22:54:40Z","timestamp":1786834480327,"version":"build-2736575974"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Jining Key Research and Development Program","award":["2024YXNS194"],"award-info":[{"award-number":["2024YXNS194"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the diagnostic ability of relative values of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion kurtosis imaging (DKI) quantitative parameters for salivary gland tumours (SGTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 107 patients with histopathologically confirmed SGTs (18 malignant [MTs], 38 pleomorphic adenomas [PAs], 31 Warthin tumours [WTs], 20 basal cell adenomas [BCAs]) underwent MRI with DKI and DCE-MRI sequences. Quantitative parameters included DCE-MRI-derived volume transfer constant (Ktrans), rate constant (Kep), fractional volume of the extravascular-extracellular space (Ve), plasma fraction (Vp), and DKI-derived mean kurtosis (MK) and mean diffusion (MD).The receiver operating characteristic (ROC) curve were used for statistical analysis. Statistical significance was set at P\u2009&amp;lt;\u20090.05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PAs exhibited the lowest MK (0.49\u2009\u00b1\u20090.15) among all groups (P\u2009&amp;lt;\u20090.05). Compared to WTs, PAs showed lower Kep (366.89 [260.06, 568.32]\u00d710\u2212\u00b3 min\u22121), higher MD (2.02\u2009\u00b1\u20090.42\u2009\u00d7\u200910\u2212\u00b3 mm2\/s), and higher Ve (551.83 [388.10, 883.19]\u00d710\u2212\u00b3). PAs also displayed higher Ve, lower Kep, and lower Vp (85.42 [20.53, 332.72])\u00d710\u2212\u00b3) than BCAs, and lower Vp with higher Ve than MTs (all P\u2009&amp;lt;\u20090.05). WTs had significantly lower Ve (218.86 [142.07, 341.76]\u00d710\u2212\u00b3) than MTs (P\u2009=\u20090.001). BCAs demonstrated lower MK (0.61\u2009\u00b1\u20090.23) and higher MD (1.97\u2009\u00b1\u20090.44\u2009\u00d7\u200910\u2212\u00b3 mm2\/s) compared to WTs and MTs (P\u2009&amp;lt;\u20090.05), alongside lower Ktrans (355.25 [211.88, 506.92]\u00d710\u2212\u00b3 min\u22121) and Ve (380.89 [271.28, 589.53]\u00d710\u2212\u00b3) than WTs (P\u2009&amp;lt;\u20090.05). Logistic regression analysis revealed enhanced discrimination: MK+Ve (AUC\u2009=\u20090.895) and MK\u2009+\u2009MD\u2009+\u2009Ve\u2009+\u2009Kep (AUC\u2009=\u20090.936) differentiated PAs from WTs; Kep\u2009+\u2009Vp\u2009+\u2009Ve distinguished PAs from BCAs (AUC\u2009=\u20090.843); MD\u2009+\u2009MK\u2009+\u2009Vp separated PAs from MTs (AUC\u2009=\u20090.854); Ktrans\u2009+\u2009MK differentiated WTs from BCAs (AUC\u2009=\u20090.856).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DKI and DCE-MRI parameters complement each other, enabling accurate SGT subtype differentiation. Combined use of these parameters achieves high diagnostic accuracy, and a stepwise diagnostic flowchart was designed to facilitate systematic discrimination among the four tumour types.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/dmfr\/twaf078","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:14:21Z","timestamp":1761664461000},"page":"194-206","source":"Crossref","is-referenced-by-count":1,"title":["Dynamic contrast-enhanced MRI and diffusion kurtosis imaging for the differentiation of salivary gland tumours"],"prefix":"10.1093","volume":"55","author":[{"given":"Jinru","family":"Yu","sequence":"first","affiliation":[{"name":"Radiological Medical College, Shandong First Medical University (Shandong Academy of Medical Sciences) , Jinan, 250117,","place":["China"]},{"name":"Department of Radiology, Jining No. 1 People\u2019s Hospital Affiliated to Shandong First Medical University , Jining, Shandong 272000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Jining No. 1 People\u2019s Hospital Affiliated to Shandong First Medical University , Jining, Shandong 272000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2760-7788","authenticated-orcid":false,"given":"Ning","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Jining No. 1 People\u2019s Hospital Affiliated to Shandong First Medical University , Jining, Shandong 272000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Jining No. 1 People\u2019s Hospital Affiliated to Shandong First Medical University , Jining, Shandong 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