{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:57:53Z","timestamp":1790758673644,"version":"4.1.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Foundation of Flanders","award":["FWO, G077622N"],"award-info":[{"award-number":["FWO, G077622N"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study investigated whether antiresorptive drug (ARD) therapy is associated with lamina dura (LD) thickening, defined as a radiographic increase in the thickness of the normally thin, radiopaque cortical line surrounding the tooth root. It further evaluated whether LD thickening serves as a radiographic marker and risk indicator for medication-related osteonecrosis of the jaw (MRONJ).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Panoramic radiographs from 65 ARD-treated patients (University Hospital Leuven) and 65 age- and sex-matched controls were analyzed. Inclusion criteria were prior oncological diagnosis, high-dose intravenous ARD, and radiographs before and after therapy. Three blinded oral and maxillofacial radiologists categorized LD appearance into 4 grades: (0) not\/barely visible, (1) normal, (2) mild thickening, and (3) marked thickening. Group differences and longitudinal changes were evaluated using appropriate non-parametric and time-to-event analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 130 participants, LD thickness remained stable in controls but increased in ARD-treated patients (P\u2009&amp;lt;\u2009.001). Within the ARD group, LD thickening changed over time (P\u2009&amp;lt;\u2009.001): 30.6% showed no change, 55.4% developed mild thickening, and 13.8% marked thickening. Controls showed minimal change (P\u2009=\u2009.011), with 9.2% developing mild thickening. Kaplan-Meier analysis estimated a median time to LD thickening of 27\u2009months, with a higher thickening probability in ARD-treated patients than controls (P\u2009&amp;lt;\u2009.001). Lamina dura thickening was not directly associated with MRONJ (P\u2009=\u2009.39).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lamina dura thickening is strongly associated with long-term ARD exposure and shows progressive changes. Although not directly associated with MRONJ in this cohort, it may still represent a potential risk indicator, warranting confirmation in further studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/dmfr\/twag029","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:40:37Z","timestamp":1779252037000},"page":"722-731","source":"Crossref","is-referenced-by-count":0,"title":["Lamina dura thickening in patients on antiresorptive therapy as a radiographic risk indicator of medication-related osteonecrosis of the jaw: a retrospective longitudinal cohort study"],"prefix":"10.1093","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5384-7262","authenticated-orcid":false,"given":"Sonya","family":"Radi","sequence":"first","affiliation":[{"name":"OMFS-IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, KU Leuven , 3000 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