{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:01:26Z","timestamp":1790071286312,"version":"4.0.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/10966-6"],"award-info":[{"award-number":["2019\/10966-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/05636-4"],"award-info":[{"award-number":["2020\/05636-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"USDA-APHIS","award":["AP21IS000000C003"],"award-info":[{"award-number":["AP21IS000000C003"]}]},{"DOI":"10.13039\/100006031","name":"United States - Israel Binational Agricultural Research and Development Fund","doi-asserted-by":"publisher","award":["IS-5180-19"],"award-info":[{"award-number":["IS-5180-19"]}],"id":[{"id":"10.13039\/100006031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006031","name":"United States - Israel Binational Agricultural Research and Development Fund","doi-asserted-by":"publisher","award":["2019\/07285-7"],"award-info":[{"award-number":["2019\/07285-7"]}],"id":[{"id":"10.13039\/100006031","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The New World Screwworm, Cochliomyia hominivorax (Calliphoridae), is the most important myiasis-causing species in America. Screwworm myiasis is a zoonosis that can cause severe lesions in livestock, domesticated and wild animals, and occasionally in people. Beyond the sanitary problems associated with this species, these infestations negatively impact economic sectors, such as the cattle industry. Here, we present a chromosome-scale assembly of C. hominivorax\u2019s genome, organized in 6 chromosome-length and 515 unplaced scaffolds spanning 534 Mb. There was a clear correspondence between the D. melanogaster linkage groups A\u2013E and the chromosomal-scale scaffolds. Chromosome quotient (CQ) analysis identified a single scaffold from the X chromosome that contains most of the orthologs of genes that are on the D. melanogaster fourth chromosome (linkage group F or dot chromosome). CQ analysis also identified potential X and Y unplaced scaffolds and genes. Y-linkage for selected regions was confirmed by PCR with male and female DNA. Some of the long chromosome-scale scaffolds include Y-linked sequences, suggesting misassembly of these regions. These resources will provide a basis for future studies aiming at understanding the biology and evolution of this devastating obligate parasite.<\/jats:p>","DOI":"10.1093\/dnares\/dsac042","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T10:18:56Z","timestamp":1668248336000},"source":"Crossref","is-referenced-by-count":15,"title":["A chromosomal-scale reference genome of the New World Screwworm,\n                    <i>Cochliomyia hominivorax<\/i>"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7559-0154","authenticated-orcid":false,"given":"Sophie","family":"Tandonnet","sequence":"first","affiliation":[{"name":"Departamento de Gen\u00e9tica e Biologia Evolutiva, Instituto de Bioci\u00eancias, Universidade de S\u00e3o Paulo (USP) , S\u00e3o Paulo, SP 05508-090 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3447-0778","authenticated-orcid":false,"given":"Flavia","family":"Krsticevic","sequence":"additional","affiliation":[{"name":"Department of Entomology, Robert H. Smith Faculty of Agriculture, Food and Environment, Hebrew University of Jerusalem , Rehovot 7610001 , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0823-0591","authenticated-orcid":false,"given":"Tatiana","family":"Basika","sequence":"additional","affiliation":[{"name":"Department of Entomology and Plant Pathology, North Carolina State University, Campus Box 7613, Raleigh, NC 27695-7613 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8508-4554","authenticated-orcid":false,"given":"Philippos A","family":"Papathanos","sequence":"additional","affiliation":[{"name":"Department of Entomology, Robert H. Smith Faculty of Agriculture, Food and Environment, Hebrew University of Jerusalem , Rehovot 7610001 , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4286-3504","authenticated-orcid":false,"given":"Tatiana T","family":"Torres","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica e Biologia Evolutiva, Instituto de Bioci\u00eancias, Universidade de S\u00e3o Paulo (USP) , S\u00e3o Paulo, SP 05508-090 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6536-4735","authenticated-orcid":false,"given":"Maxwell J","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Entomology and Plant Pathology, North Carolina State University, Campus Box 7613, Raleigh, NC 27695-7613 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,12]]},"reference":[{"key":"2023011214450894000_CIT0001","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4236\/ojvm.2020.106007","article-title":"Myiasis by Cochliomyia hominivorax (Coquerel, 1958): a neglected zoonosis in Brazil","volume":"10","author":"Barros","year":"2020","journal-title":"Open J. Vet. Med."},{"key":"2023011214450894000_CIT0002","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1749-6632.2000.tb05289.x","article-title":"Screwworm eradication in the Americas","volume":"916","author":"Wyss","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2023011214450894000_CIT0003","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/eea.12607","article-title":"Review of research advances in the screwworm eradication program over the past 25 years","volume":"164","author":"Scott","year":"2017","journal-title":"Entomol. Exp. Appl."},{"key":"2023011214450894000_CIT0004","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1186\/s13071-020-04433-3","article-title":"Molecular basis of resistance to organophosphate insecticides in the New World screw-worm fly","volume":"13","author":"Tandonnet","year":"2020","journal-title":"Parasit. Vectors"},{"key":"2023011214450894000_CIT0005","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/978-94-011-1554-4_12","article-title":"Diptera causing myiasis in man.","volume-title":"Medical insects and arachnids","author":"Hall","year":"1993"},{"key":"2023011214450894000_CIT0006","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1673\/031.011.0114","article-title":"Factors of susceptibility of human myiasis caused by the New World screw-worm, Cochliomyia hominivorax in Sao Goncalo, Rio de Janeiro, Brazil","volume":"11","author":"Batista-da-Silva","year":"2011","journal-title":"J. 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Dis."},{"key":"2023011214450894000_CIT0010","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/1-4020-4051-2_24","article-title":"Impact of screwworm eradication programmes using the sterile insect technique.","volume-title":"Sterile insect technique. Principles and practice in area-wide integrated pest management","author":"Vargas-Teran","year":"2005"},{"key":"2023011214450894000_CIT0011","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/jme\/tjy049","article-title":"Screwworm (Diptera: Calliphoridae) in the United States: response to and Elimination of the 2016-2017 Outbreak in Florida","volume":"55","author":"Skoda","year":"2018","journal-title":"J. Med. 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Entomol. Soc. 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