{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:55:22Z","timestamp":1777586122641,"version":"3.51.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T00:00:00Z","timestamp":1590192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Competitive State Research Financing"},{"name":"Sohlberg Foundation for Paediatric Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,18]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Variable endoscopic and histological findings of esophageal lining are often detected in celiac disease, with unknown significance. We investigated the frequency and significance of such abnormalities in children. Macroscopic esophageal findings as reported by endoscopist and histological results by pathologist were compared between 316 celiac disease patients and 378 disease controls who had undergone upper gastrointestinal endoscopy with systematic esophageal biopsy sampling. Association between esophageal abnormalities and other clinical and histological characteristics of the disease was evaluated in celiac disease patients. Endoscopic esophageal findings were reported least often (3.8%) of all diseases in celiac disease, whereas histopathologic abnormalities were frequent (16.8%, n\u2009=\u200953). Children with celiac disease and esophageal histopathology reported more reflux than those with normal esophagus (5.7 vs. 0.8%, P\u2009=\u20090.032), whereas the groups were comparable in the frequency and severity of other symptoms, demographic data, prevalence of celiac disease-associated and other coexisting chronic conditions, family history of celiac disease, anthropometric and laboratory parameters, and degree of villous atrophy. Only 2 (3.7%) out of the 53 children with histologic findings had esophageal symptoms at diagnosis, and altogether seven were treated with acid blockers. Four children had increased number (\u226515 eosinophils per high-power field) of esophageal eosinophils, but none of them had definite eosinophilic esophagitis. The remaining 45 children had only unspecific inflammation in the esophagus and reported no esophageal problems during a median of 6.9\u00a0years follow-up. To conclude, although relatively common, histopathological esophageal findings in celiac disease are mostly unspecific and without major clinical significance even in a long-term follow-up.<\/jats:p>","DOI":"10.1093\/dote\/doaa033","type":"journal-article","created":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T00:16:46Z","timestamp":1590193006000},"source":"Crossref","is-referenced-by-count":6,"title":["Prevalence and clinical significance of esophageal abnormalities in children with celiac disease"],"prefix":"10.1093","volume":"33","author":[{"given":"Meri","family":"Smolander","sequence":"first","affiliation":[{"name":"Centre for Child Health Research, Tampere University, Tampere, Finland, and Tampere University Hospital, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuli","family":"Nurminen","sequence":"additional","affiliation":[{"name":"Centre for Child Health Research, Tampere University, Tampere, Finland, and Tampere University Hospital, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marleena","family":"Repo","sequence":"additional","affiliation":[{"name":"Centre for Child Health Research, Tampere University, Tampere, Finland, and Tampere University Hospital, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Kivel\u00e4","sequence":"additional","affiliation":[{"name":"Centre for Child Health Research, Tampere University, Tampere, Finland, and Tampere University Hospital, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juho E","family":"Kivist\u00f6","sequence":"additional","affiliation":[{"name":"Allergy Centre, Tampere University Hospital, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauliina","family":"Hiltunen","sequence":"additional","affiliation":[{"name":"Centre for Child Health Research, Tampere University, Tampere, Finland, and Tampere University Hospital, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heini","family":"Huhtala","sequence":"additional","affiliation":[{"name":"Faculty of Social Sciences, University of Tampere, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satu-Liisa","family":"Pauniaho","sequence":"additional","affiliation":[{"name":"Emergency Division, Tampere University Hospital, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalle","family":"Kurppa","sequence":"additional","affiliation":[{"name":"Centre for Child Health Research, Tampere University, Tampere, Finland, and Tampere University Hospital, Tampere, Finland"},{"name":"Allergy Centre, Tampere University Hospital, Tampere, Finland"},{"name":"Department of Pediatrics, Sein\u00e4joki University Hospital, Sein\u00e4joki, Finland"},{"name":"The University Consortium of Sein\u00e4joki, Sein\u00e4joki, 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