{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T19:18:14Z","timestamp":1770491894728,"version":"3.49.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Esophageal baseline impedance (BI) acquired during esophageal contraction (contractile segment impedance [CSI]) is proposed to improve BI accuracy in gastroesophageal reflux disease (GERD). We evaluated associations between CSI and conventional and novel GERD metrics. We analyzed high-resolution impedance manometry (HRIM) and ambulatory pH-impedance studies from 51 patients (58.6\u2009\u00b1\u20091.5\u00a0years; 26% F) with GERD symptoms studied off antisecretory therapy. Patients with achalasia or absent contractility were excluded. CSI (averaged across 10 swallows) and BI-HRIM (from the resting landmark phase) were acquired from the distal impedance sensors (distal sensor and 5\u00a0cm above the lower esophageal sphincter). Acid exposure time (AET) and mean nocturnal baseline impedance (MNBI) were calculated. Associations between CSI, BI-HRIM, MNBI, and AET were evaluated using correlation (Pearson) and receiver operating characteristic (ROC) analysis. Presenting symptoms included heartburn (67%), regurgitation (12%), cough (12%), and chest pain (10%). CSI-distal and CSI-5 each correlated with BI-HRIM, AET, and distal MNBI. Associations with AET were numerically stronger for CSI-distal (r\u2009=\u2009\u22120.46) and BI-HRIM-distal (r\u2009=\u2009\u22120.44) than CSI-5 (r\u2009=\u2009\u22120.33), BI-HRIM-5 (r\u2009=\u2009\u22120.28), or distal MNBI (r\u2009&amp;lt;\u2009\u22120.36). When compared to AET &amp;lt;4%, patients with AET &amp;gt;6% had significantly lower CSI-distal and BI-HRIM-distal values but not CSI-5, BI-HRIM-5, or MNBI. ROC areas under the curve for AET &amp;gt;6% were numerically higher for CSI-distal (0.81) than BI-HRIM-distal (0.77), distal MNBI (0.68\u20130.75), CSI-5 (0.68), or BI-HRIM-5 (0.68). CSI from HRIM studies inversely correlates with pathologic AET and has potential to augment the evaluation of GERD.<\/jats:p>","DOI":"10.1093\/dote\/doaa063","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T07:34:04Z","timestamp":1593588844000},"source":"Crossref","is-referenced-by-count":10,"title":["Esophageal contractile segment impedance from high-resolution impedance manometry correlates with mean nocturnal baseline impedance and acid exposure time from 24-hour pH-impedance monitoring"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6571-9927","authenticated-orcid":false,"given":"Anthony","family":"Horton","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Duke University School of Medicine, Durham, NC, USA"},{"name":"Division of Gastroenterology, Durham Veterans Affairs Medical Center, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shai","family":"Posner","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Duke University School of Medicine, Durham, NC, USA"},{"name":"Division of Gastroenterology, Durham Veterans Affairs Medical Center, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Duke University School of Medicine, Durham, NC, USA"},{"name":"Division of Gastroenterology, Durham Veterans Affairs Medical Center, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Cornejo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Durham Veterans Affairs Medical Center, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Davis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Durham Veterans Affairs Medical Center, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Fields","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Durham Veterans Affairs Medical Center, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thasha","family":"McIntosh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Durham Veterans Affairs Medical Center, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziad","family":"Gellad","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Duke University School of Medicine, Durham, NC, USA"},{"name":"Division of Gastroenterology, Durham Veterans Affairs Medical Center, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Shimpi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C Prakash","family":"Gyawali","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Washington University School of Medicine, St Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7214-5901","authenticated-orcid":false,"given":"Amit","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Duke University School of Medicine, Durham, NC, USA"},{"name":"Division of Gastroenterology, Durham Veterans Affairs Medical Center, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"key":"2020120702532705400_ref1","doi-asserted-by":"crossref","DOI":"10.14309\/ajg.0000000000000734","article-title":"American College of Gastroenterology clinical guideline: clinical use of esophageal physiologic testing","author":"Gyawali","year":"2020","journal-title":"Am J Gastroenterol"},{"key":"2020120702532705400_ref2","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/ajg.2012.444","article-title":"Guidelines for the diagnosis and management of gastroesophageal reflux disease","volume":"108","author":"Katz","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"2020120702532705400_ref3","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1001\/jama.2018.1144","article-title":"Gastroesophageal reflux 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to optimally apply impedance in the evaluation of esophageal Dysmotility","volume":"18","author":"Patel","year":"2016","journal-title":"Curr Gastroenterol Rep"},{"key":"2020120702532705400_ref33","first-page":"e13736","article-title":"Fragmented and failed swallows on esophageal high-resolution manometry associate with abnormal reflux burden better than weak swallows","author":"Rogers","year":"2019","journal-title":"Neurogastroenterol Motil"}],"container-title":["Diseases of the 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