{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:57:39Z","timestamp":1789498659675,"version":"build-2803163510"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Eosinophilic esophagitis, gastritis, duodenitis, and colitis are rare diseases. Few studies have been able to accumulate sufficiently large number of patients to analyze their clinical epidemiology. The aim of the present epidemiologic study was to examine the prevalence and concordant occurrence of gastrointestinal (GI) eosinophilia. Using a database of histopathologic records, a cross-sectional study among 302,061 patients undergoing bidirectional endoscopy evaluated the concordant occurrence of esophageal, gastric, duodenal, and colonic eosinophilia. The prevalence rates (PRs) of GI eosinophilia were expressed per 1,000 study subjects with their 95% Poisson confidence intervals (CIs). The concordant occurrence of various forms of GI eosinophilia was compared to their overall occurrence in the study population by calculating odds ratios (ORs) and their 95% CI. The database contained 3,008 patients with esophageal eosinophilia (PR\u2009=\u20099.96, 9.61\u201310.32), 366 patients with gastric eosinophilia (1.21, 1.09\u20131.34), 10 patients with duodenal eosinophilia (0.03, 0.02\u20130.06), and 124 patients with colonic eosinophilia (0.41, 0.34\u20130.49). The occurrence of esophageal eosinophilia was associated with an increased occurrence of gastric eosinophilia (OR\u2009=\u20093.58, 2.06\u20136.23), duodenal (40.22, 12.61\u2013128.31), and colonic eosinophilia (8.12, 4.26\u201315.49). Similarly, we also found statistically significant associations between gastric eosinophilia and duodenal or colonic eosinophilia, and between duodenal and colonic eosinophilia. In the adult, as in the pediatric population, patients with any type of GI eosinophilia are at an increased risk for simultaneously harboring eosinophilia at multiple sites of their GI tract. With the exception of esophageal eosinophilia, however, other forms of GI eosinophilia are rarely diagnosed.<\/jats:p>","DOI":"10.1093\/dote\/doaa064","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T07:22:39Z","timestamp":1594797759000},"source":"Crossref","is-referenced-by-count":10,"title":["Prevalence and concordant occurrence of esophageal, gastric, duodenal, and colonic eosinophilia"],"prefix":"10.1093","volume":"33","author":[{"given":"Amnon","family":"Sonnenberg","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Portland VA Medical Center and Oregon Health & Science University, Portland, OR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin O","family":"Turner","sequence":"additional","affiliation":[{"name":"Inform Diagnostics, Irving, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Singhal","sequence":"additional","affiliation":[{"name":"Inform Diagnostics, Irving, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M","family":"Genta","sequence":"additional","affiliation":[{"name":"Inform Diagnostics, Irving, TX, USA"},{"name":"Department of Pathology, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"2020101202143632600_ref1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/MPG.0000000000000865","article-title":"Prevalence of eosinophilic gastritis, gastroenteritis, and colitis: estimates from a national administrative database","volume":"62","author":"Jensen","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2020101202143632600_ref2","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.cgh.2017.05.050","article-title":"Prevalence of eosinophilic gastroenteritis and colitis in a population-based study, from 2012 to 2017","volume":"15","author":"Mansoor","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2020101202143632600_ref3","doi-asserted-by":"crossref","first-page":"984","DOI":"10.14309\/ajg.0000000000000228","article-title":"Increasing rates of diagnosis, substantial co-occurrence, and variable treatment patterns of eosinophilic gastritis, gastroenteritis, and colitis based on 10-year data across a multicenter consortium","volume":"114","author":"Pesek","year":"2019","journal-title":"Am J Gastroenterol"},{"key":"2020101202143632600_ref4","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/ajg.2014.47","article-title":"Esophageal eosinophilia is increased in rural areas with low population density: results from a national pathology database","volume":"109","author":"Jensen","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"2020101202143632600_ref5","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/apt.13273","article-title":"Seasonal variation in detection of esophageal eosinophilia and eosinophilic esophagitis","volume":"42","author":"Jensen","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"2020101202143632600_ref6","doi-asserted-by":"crossref","first-page":"e12370","DOI":"10.1111\/hel.12370","article-title":"The influence of Helicobacter pylori on the ethnic distribution of esophageal eosinophilia","volume":"22","author":"Sonnenberg","year":"2017","journal-title":"Helicobacter"},{"key":"2020101202143632600_ref7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/PAP.0b013e318229bfe2","article-title":"Histopathologic diagnosis of eosinophilic conditions in the gastrointestinal tract","volume":"18","author":"Hurrell","year":"2011","journal-title":"Adv Anat Pathol"},{"key":"2020101202143632600_ref8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.gtc.2014.02.007","article-title":"Histopathologic features of eosinophilic esophagitis and eosinophilic gastrointestinal diseases","volume":"43","author":"Collins","year":"2014","journal-title":"Gastroenterol Clin North Am"},{"key":"2020101202143632600_ref9","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/apt.14558","article-title":"Quantification of the duodenal eosinophil content in adults: a necessary step for an evidence-based diagnosis of duodenal eosinophilia","volume":"47","author":"Genta","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"2020101202143632600_ref10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/apt.13441","article-title":"Systematic review with meta-analysis: the incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies","volume":"43","author":"Arias","year":"2016","journal-title":"Aliment Pharmacol Ther"},{"key":"2020101202143632600_ref11","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S0016-5107(04)00179-8","article-title":"Biopsy specimen acquisition in patients with newly diagnosed peptic ulcer disease as determined from a national endoscopic database","volume":"59","author":"Harewood","year":"2004","journal-title":"Gastrointest Endosc"}],"container-title":["Diseases of the 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