{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:34:32Z","timestamp":1792596872572,"version":"4.5.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,14]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Per oral endoscopic myotomy (POEM) is a safe and effective treatment for esophageal motility disorder in treatment-na\u00efve patients as well as salvage therapy. Though type II achalasia, compared to other subtypes, is reported to have a more favorable outcome with pneumatic dilation (PD) or Heller myotomy (HM), it is unclear whether achalasia subtype predicts symptom response to POEM. We aimed to evaluate whether type II achalasia is associated with a comparably favorable outcome following POEM. We performed a retrospective review of patients with esophageal motility disorder who were referred for POEM from April 2014 to June 2017. The main outcome was clinical success based on Eckardt score\u2009\u22643 and its association with subtype and safety. A total of 63 patients (mean age 51\u00a0years [SD 15]; 63% male) underwent a total of 68 POEMs with median of 263\u00a0days follow-up. Of these, 45 (71.3%) patients were type II achalasia. In all, 29 (46%) patients were treatment-na\u00efve and 34 (54%) patients had previous endoscopic or surgical therapy including botulinum toxin injection in 16 (25%), PD in 10 (16%), both botulinum toxin injection and PD in 8 (13%) and HM in 3 (5%). Technical success was 100% and clinical success was achieved in 51 (81%) patients. The rate of clinical success was higher in patients with type II achalasia compared to the other subtypes (88.9% vs. 61.1% [P\u2009=\u20090.028]) and type II achalasia patients required fewer redo POEM (2.2% vs. 22.2% [P\u2009=\u20090.021]). Multivariate logistic regression analysis demonstrated the positive prediction of clinical success for type II achalasia following POEM (P\u2009=\u20090.046). As observed with PD and HM, type II achalasia was associated with a favorable clinical outcome following POEM.<\/jats:p>","DOI":"10.1093\/dote\/doaa107","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T14:02:59Z","timestamp":1605189779000},"source":"Crossref","is-referenced-by-count":11,"title":["Type II achalasia is associated with a comparably favorable outcome following per oral endoscopic myotomy"],"prefix":"10.1093","volume":"34","author":[{"given":"Yutaka","family":"Tomizawa","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Harborview Medical Center, University of Washington, Seattle, WA, USA"},{"name":"Division of Gastroenterology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadim","family":"Mahmud","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Dasher","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R","family":"Triggs","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Saumoy","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary W","family":"Falk","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory G","family":"Ginsberg","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"2021061405192818600_ref1","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1056\/NEJMoa1010502","article-title":"Pneumatic dilation versus laparoscopic Heller's myotomy for idiopathic achalasia","volume":"364","author":"Boeckxstaens","year":"2011","journal-title":"N Engl J Med"},{"key":"2021061405192818600_ref2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1055\/s-0029-1244080","article-title":"Peroral endoscopic myotomy (POEM) for esophageal 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