{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:21:08Z","timestamp":1771374068226,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Despite proton pump inhibitors being a powerful therapeutic tool, laparoscopic fundoplication (LF) has proven successful in the treatment of gastroesophageal reflux disease (GERD), through mechanical augmentation of a weak antireflux barrier and the advantages of minimally invasive access. A critical patient selection for LF, based on thorough preoperative assessment, is important for the management of GERD-patients. The purpose of this study is to provide an overview on the management of GERD-patients treated by primary LF in a specialized center and to illustrate the possible outcome after several years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients were selected after going through diagnostic workup consisting of patient\u2019s history and physical examination, upper gastrointestinal endoscopy, assessment of gastrointestinal Quality of Life Index, screening for somatoform disorders, functional assessment by esophageal manometry, (impedance)-24-hour-pH-monitoring, and selective radiographic studies. The indication for LF was based on EAES-guidelines. Either a floppy and short Nissen fundoplication was performed or a posterior Toupet-hemifundoplication was chosen. A long-term follow-up assessment was attempted after surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, n\u2009=\u20091131 patients were evaluated (603 males; 528 females; mean age; 48.3\u00a0years; and mean body mass index: 27). The mean duration between onset of symptoms and surgery was 8\u00a0years. Nissen: n\u2009=\u2009873, Toupet: n\u2009=\u2009258; conversion rateerativ: 0.5%; morbidity 4%, mortality: 1 (1131). Mean follow-up (n\u2009=\u2009898; 79%): 5.6 years; pre\/post-op results: esophagitis: 66%\/12.1%; Gastrointestinal Quality of Life Index: median: 92\/119; daily proton pump inhibitors-intake after surgery: 8%; and operative revisions 4.3%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In conclusion, our data show that careful patient selection for laparoscopic fundoplication and well-established technical concepts of mechanical sphincter augmentation can provide satisfying results in the majority of patients with severe GERD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/dote\/doab032","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T08:40:27Z","timestamp":1621327227000},"source":"Crossref","is-referenced-by-count":10,"title":["Primary laparoscopic fundoplication in selected patients with gastroesophageal reflux disease"],"prefix":"10.1093","volume":"35","author":[{"given":"K H","family":"Fuchs","sequence":"first","affiliation":[{"name":"Laboratory for Interventional and Experimental Endoscopy, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Breithaupt","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, St. Elisabethen Krankenhaus, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Varga","sequence":"additional","affiliation":[{"name":"AGAPLESION Markus Krankenhaus, Department of General and Visceral Surgery, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Babic","sequence":"additional","affiliation":[{"name":"University of Cologne, Department of General-, Visceral-and Cancer Surgery, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, St. Elisabethen Krankenhaus, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Meining","sequence":"additional","affiliation":[{"name":"Laboratory for Interventional and Experimental Endoscopy, University of W\u00fcrzburg, W\u00fcrzburg, Germany"},{"name":"University of W\u00fcrzburg, Zentrum Innere Medizin, Head of Gastroenterology, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"2022011119225816300_ref1","first-page":"138","article-title":"Laparoscopic Nissen fundoplication: preliminary report","volume":"1","author":"Dallemagne","year":"1991","journal-title":"Surg Laparosc Endosc"},{"key":"2022011119225816300_ref2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00000658-198607000-00002","article-title":"Nissen fundoplication for gastro-esophageal reflux disease. Evaluation of primary repair in 100 consecutive patients","volume":"204","author":"DeMeester","year":"1986","journal-title":"Ann Surg"},{"issue":"1","key":"2022011119225816300_ref3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/00000658-199807000-00007","article-title":"The treatment of gastroesophageal reflux disease with laparoscopic Nissen fundoplication","volume":"228","author":"Peters","year":"1998","journal-title":"Ann Surg"},{"key":"2022011119225816300_ref4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1046\/j.1365-2168.1999.00969.x","article-title":"Prospective randomized double-blind trial between laparoscopic Nissen fundoplication and anterior partial fundoplication","volume":"86","author":"Watson","year":"1999","journal-title":"Br J Surg"},{"key":"2022011119225816300_ref5","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1007\/s11605-007-0195-y","article-title":"Long-term results (6-10 years) of laparoscopic fundoplication","volume-title":"J Gastrointest Surg","author":"Zaninotto","year":"2007"},{"key":"2022011119225816300_ref6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00464-007-9546-8","article-title":"Laparoscopic fundoplication: Nissen versus Toupet two-year outcome of prospective randomized study of 200 patients regarding preoperative esophaegal motility","volume":"22","author":"Strate","year":"2008","journal-title":"Surg Endosc"},{"issue":"3","key":"2022011119225816300_ref7","doi-asserted-by":"crossref","first-page":"332","DOI":"10.4293\/108680810X12924466007007","article-title":"The evolution and long-term results of laparoscopic antireflux surgery for the treatment of gastroesophageal reflux disease","volume":"14","author":"Davis","year":"2010","journal-title":"JSLS"},{"issue":"suppl","key":"2022011119225816300_ref8","doi-asserted-by":"crossref","first-page":"S 67","DOI":"10.1007\/s11605-009-1020-6","article-title":"Is there a role for anything other than a Nissen\u2019s operation ?","volume":"14","author":"Fein","year":"2010","journal-title":"J Gastrointest Surg"},{"key":"2022011119225816300_ref9","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1002\/bjs.7174","article-title":"Systematic review and metaanalysis of laparoscopic Nissen versus Toupet fundoplication for gastro-esophageal reflux disease","volume":"97","author":"Broeders","year":"2010","journal-title":"Br J Surg"},{"issue":"6","key":"2022011119225816300_ref10","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1001\/archsurg.137.6.649","article-title":"A prospective randomized trial of laparoscopic polytetrafluoroethylene (PTFE) patch repair vs simple cruroplasty for large hiatal hernia","volume":"137","author":"Frantzides","year":"2002","journal-title":"Arch Surg"},{"issue":"Suppl 3A","key":"2022011119225816300_ref11","doi-asserted-by":"publisher","first-page":"192S","DOI":"10.1016\/s0002-9343(03)00224-9","article-title":"Stretta: an effective, minimally invasive treatment for gastroesophageal reflux disease","volume":"115","author":"Triadafilopoulos","year":"2003  18","journal-title":"Am J Med"},{"issue":"6","key":"2022011119225816300_ref12","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1136\/gut.2004.058354","article-title":"Long term failure of endoscopic gastroplication (EndoCinch)","volume":"54","author":"Schiefke","year":"2005","journal-title":"Gut"},{"issue":"3","key":"2022011119225816300_ref13","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s13304-018-0569-6","article-title":"Magnetic sphincter augmentation for gastroesophageal reflux disease: review of clinical studies","volume":"70","author":"Asti","year":"2018","journal-title":"Updates Surg"},{"issue":"7","key":"2022011119225816300_ref14","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.1007\/s00464-015-4539-5","article-title":"Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD: long-term 3-year results","volume":"30","author":"Rodr\u00edguez","year":"2016","journal-title":"Surg Endosc"},{"key":"2022011119225816300_ref15","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1007\/s00464-014-3431-z","article-title":"EAES recommendations for the management of gastroesophageal reflux disease","volume":"28","author":"Fuchs","year":"2014","journal-title":"Surg Endosc"},{"key":"2022011119225816300_ref16","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S1091-255X(99)80079-1","article-title":"Laparoscopic Toupet fundoplication is an inadequate procedure for patients with severe reflux disease","volume":"3","author":"Horvath","year":"1999","journal-title":"J Gastrointest Surg"},{"key":"2022011119225816300_ref17","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s11605-007-0161-8","article-title":"The durability of laparoscopic Nissen fundoplication: 11-year outcome","volume":"11","author":"Morgenthal","year":"2007","journal-title":"J Gastrointest Surg"},{"key":"2022011119225816300_ref18","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1001\/jama.2017.10981","article-title":"Association between laparoscopic Antireflux surgery and recurrence of gastroesophageal reflux","volume":"318","author":"Maret-Ouda","year":"2017","journal-title":"JAMA"},{"issue":"12","key":"2022011119225816300_ref19","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1007\/s00464-005-0163-0","article-title":"Techniques and results of laparoscopic antireflux surgery in Germany","volume":"19","author":"H\u00fcttl","year":"2005","journal-title":"Surg Endosc"},{"issue":"11","key":"2022011119225816300_ref20","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1007\/s00464-006-0042-3","article-title":"The rise and fall of antireflux surgery in the United States","volume":"20","author":"Finks","year":"2006","journal-title":"Surg Endosc"},{"issue":"9","key":"2022011119225816300_ref21","doi-asserted-by":"publisher","first-page":"2943","DOI":"10.1007\/s00464-011-1646-9","article-title":"Value of preoperative esophageal function studies before laparoscopic antireflux surgery","volume":"25","author":"Chan","year":"2011","journal-title":"Surg Endosc"},{"key":"2022011119225816300_ref22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/dote\/8.3.211","article-title":"Pathophysiologic spectrum in patients with gastroesophageal reflux disease in a surgical GI function laboratory","volume":"8","author":"Fuchs","year":"1995","journal-title":"Dis Esophagus"},{"issue":"2","key":"2022011119225816300_ref23","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1002\/bjs.1800820229","article-title":"Gastrointestinal quality of life index: development, validation and application of a new instrument","volume":"82","author":"Eypasch","year":"1995","journal-title":"Br J Surg"},{"key":"2022011119225816300_ref24","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1007\/s11605-008-0754-x","article-title":"Hiatal hernia, lower Esophageal sphincter incompetence, and effectiveness of Nissen fundoplication in the Spectrum of gastroesophageal reflux disease","volume":"13","author":"Lord","year":"2009","journal-title":"J Gastrointest Surg"},{"issue":"4","key":"2022011119225816300_ref25","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.jamcollsurg.2013.05.023","article-title":"Preoperative diagnostic workup before antireflux surgery: an evidence and experience-based consensus of the Esophageal diagnostic advisory panel","volume":"217","author":"Jobe","year":"2013","journal-title":"J Am Coll Surg"},{"key":"2022011119225816300_ref26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/dote\/dox022","article-title":"Foregut symptoms, somatoform tendencies, and the selection of patients for antireflux surgery","volume":"30","author":"Fuchs","year":"2017","journal-title":"Dis Esophagus"},{"issue":"3","key":"2022011119225816300_ref27","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1159\/000502796","article-title":"Clinical presentation of gastroesophageal reflux disease: a prospective study on symptom diversity and modification of questionnaire application","volume":"38","author":"Broderick","year":"2020","journal-title":"Dig Dis"},{"key":"2022011119225816300_ref28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00464-005-0174-x","article-title":"Clinical results of laparoscopic fundoplication ten years after surgery","volume":"20","author":"Dallemagne","year":"2006","journal-title":"Surg Endosc"},{"key":"2022011119225816300_ref29","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1007\/s11605-008-0659-8","article-title":"Ten year outcome of laparoscopic antireflux procedures","volume":"12","author":"Fein","year":"2008","journal-title":"J Gastrointest Surg"},{"key":"2022011119225816300_ref30","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1007\/s00464-002-9158-2","article-title":"Laparoscopic antirefluxsurgery: disease-related quality of life assessment before and after surgery in GERD patients with and without Barrett\u2019s esophagus","volume":"17","author":"Kamolz","year":"2003","journal-title":"Surg Endosc"},{"issue":"2","key":"2022011119225816300_ref31","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s11605-017-3480-4","article-title":"Primary and redo antireflux surgery: outcomes and lessons learned","volume":"22","author":"Singhal","year":"2018","journal-title":"J Gastrointest Surg"},{"key":"2022011119225816300_ref32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1365-2036.2007.03372.x","article-title":"Review: the pathophysiology of gastro-esophageal reflux disease","volume":"26","author":"Boeckxstaens","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"issue":"9","key":"2022011119225816300_ref33","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1136\/gut.2008.175810","article-title":"Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease","volume":"58","author":"Savarino","year":"2009","journal-title":"Gut"},{"issue":"3","key":"2022011119225816300_ref34","doi-asserted-by":"publisher","first-page":"388","DOI":"10.3748\/wjg.v25.i3.388","article-title":"Do patients with gastroesophageal reflux disease and somatoform tendencies benefit from antireflux surgery?","volume":"25","author":"Fuchs","year":"2019  21","journal-title":"World J Gastroenterol"},{"issue":"8","key":"2022011119225816300_ref35","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1007\/s11605-009-0873-z","article-title":"Surgical reintervention after failed antireflux surgery: a systematic review of the literature","volume":"13","author":"Furn\u00e9e","year":"2009","journal-title":"J Gastrointest Surg"},{"issue":"16","key":"2022011119225816300_ref36","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1056\/NEJMoa1811424","article-title":"Randomized trial of medical versus surgical treatment for refractory heartburn","volume":"381","author":"Spechler","year":"2019  17","journal-title":"N Engl J Med"},{"issue":"3","key":"2022011119225816300_ref37","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/PL00021300","article-title":"A prospective multicenter study on laparoscopic treatment of gastroesophageal reflux disease in Italy: type of surgery, conversions, complications, and early results. Study Group for the Laparoscopic Treatment of gastroesophageal reflux disease of the Italian Society of Endoscopic Surgery (SICE)","volume":"14","author":"Zaninotto","year":"2000","journal-title":"Surg Endosc"},{"issue":"4","key":"2022011119225816300_ref38","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1001\/archsurg.143.4.359","article-title":"Complications in antireflux surgery: national-based analysis of laparoscopic and open fundoplications","volume":"143","author":"Rantanen","year":"2008","journal-title":"Arch Surg"},{"issue":"2","key":"2022011119225816300_ref39","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1007\/s00464-010-1219-3","article-title":"Outcomes after repair of the intrathoracic stomach: objective follow-up of up to 5 years","volume":"25","author":"Mittal","year":"2011","journal-title":"Surg Endosc"},{"issue":"5","key":"2022011119225816300_ref40","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1007\/s11605-007-0163-6","article-title":"Recurrent heartburn after laparoscopic fundoplication is not always recurrent reflux","volume":"11","author":"Thompson","year":"2007","journal-title":"J Gastrointest Surg"}],"container-title":["Diseases of the Esophagus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/35\/1\/doab032\/42098656\/doab032.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/dote\/article-pdf\/35\/1\/doab032\/42098656\/doab032.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T20:53:03Z","timestamp":1641934383000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dote\/article\/doi\/10.1093\/dote\/doab032\/6277415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,18]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,5,18]]},"published-print":{"date-parts":[[2022,1,7]]}},"URL":"https:\/\/doi.org\/10.1093\/dote\/doab032","relation":{},"ISSN":["1120-8694","1442-2050"],"issn-type":[{"value":"1120-8694","type":"print"},{"value":"1442-2050","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1]]},"published":{"date-parts":[[2021,5,18]]},"article-number":"doab032"}}