{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:47:18Z","timestamp":1753876038862,"version":"3.41.2"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Peptic esophagitis can occur as a complication of laparoscopic Heller-Dor surgery (LHD) among patients with esophageal achalasia. The goal of this study was to identify the characteristics of patients who have developed peptic esophagitis following LHD surgery along with the risk factors associated with the occurrence of peptic esophagitis. Among the 447 cases consisting of esophageal achalasia patients who underwent LHD as the primary surgery, we compared the patient background, pathophysiology, symptoms, and surgical outcomes according to whether or not peptic esophagitis occurred following surgery. We also attempted to use univariate and multivariate analyses to identify the risk factors for peptic esophagitis occurring following surgery. Esophagitis following surgery was confirmed in 67 cases (15.0%). With respect to the patient backgrounds for cases in which peptic esophagitis had occurred, a significantly higher number were male patients, with a significantly high occurrence of mucosal perforation during surgery in terms of surgical outcomes, along with a high occurrence of esophageal hiatal hernias in terms of postoperative course (P = 0.045, 0.041, and 0.022, respectively). However, there were no significant differences in terms of age, BMI, disease duration, preoperative symptoms, esophageal manometric findings, esophageal barium findings, and esophageal clearance. A multivariate analysis indicated independent risk factors for the occurrence of peptic esophagitis following LHD as being male, the occurrence of mucosal perforation during surgery, and the occurrence of esophageal hiatal hernias. Peptic esophagitis occurred following LHD in 15% of cases. Independent risk factors for the occurrence of peptic esophagitis following LHD included being male, the occurrence of mucosal perforation during surgery, and the occurrence of esophageal hiatal hernias following surgery.<\/jats:p>","DOI":"10.1093\/dote\/doab050","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T06:30:39Z","timestamp":1627021839000},"source":"Crossref","is-referenced-by-count":1,"title":["Risk factors for the occurrence of peptic esophagitis following laparoscopic Heller-Dor surgery for esophageal achalasia"],"prefix":"10.1093","volume":"35","author":[{"given":"Kazuto","family":"Tsuboi","sequence":"first","affiliation":[{"name":"Department of Surgery, Fuji City General Hospital, Shizuoka, Japan"},{"name":"Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiaki","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Omura","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan"},{"name":"Department of Surgery, Nishisaitama-Chuo National Hospital, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se-Ryung","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Akimoto","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Sakashita","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Kashiwagi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Fuji City General Hospital, Shizuoka, 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